P22137

PR
Gene name
CHC1 (YGL206C)
Protein name
Clathrin heavy chain
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YGL206C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1588-1653 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P22137

Entry ID Method Resolution Chain Position Source
AF-P22137-F1 Predicted AlphaFoldDB

16 variants for P22137

Variant ID(s) Position Change Description Diseaes Association Provenance
s07-107465 15 M>T No SGRP
s07-107093 139 A>V No SGRP
s07-106755 252 E>K No SGRP
s07-106442 356 I>T No SGRP
s07-106092 473 P>S No SGRP
s07-106044 489 H>N No SGRP
s07-105732 593 V>I No SGRP
s07-105311 733 V>A No SGRP
s07-104964 849 N>D No SGRP
s07-104264 1082 E>G No SGRP
s07-104256 1085 G>S No SGRP
s07-104183 1109 N>S No SGRP
s07-104073 1146 V>L No SGRP
s07-103946 1188 K>R No SGRP
s07-103862 1216 E>G No SGRP
s07-102959 1517 G>A No SGRP

No associated diseases with P22137

9 regional properties for P22137

Type Name Position InterPro Accession
repeat Clathrin, heavy chain/VPS, 7-fold repeat 543 - 689 IPR000547-1
repeat Clathrin, heavy chain/VPS, 7-fold repeat 692 - 834 IPR000547-2
repeat Clathrin, heavy chain/VPS, 7-fold repeat 839 - 978 IPR000547-3
repeat Clathrin, heavy chain/VPS, 7-fold repeat 985 - 1130 IPR000547-4
repeat Clathrin, heavy chain/VPS, 7-fold repeat 1134 - 1275 IPR000547-5
repeat Clathrin, heavy chain/VPS, 7-fold repeat 1280 - 1426 IPR000547-6
repeat Clathrin, heavy chain/VPS, 7-fold repeat 1429 - 1588 IPR000547-7
domain Clathrin, heavy chain, linker, core motif 339 - 360 IPR015348
repeat Clathrin, heavy chain, propeller repeat 151 - 189 IPR022365

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side
  • Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side
  • Cytoplasmic face of coated pits and vesicles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
actin cortical patch An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae.
clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex.
clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network.
clathrin complex A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface.
clathrin vesicle coat A clathrin coat found on a vesicle.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
clathrin light chain binding Binding to a clathrin light chain.
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

6 GO annotations of biological process

Name Definition
clathrin coat assembly The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage.
cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
Golgi to endosome transport The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
receptor-mediated endocytosis An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q00610 CLTC Clathrin heavy chain 1 Homo sapiens (Human) PR
Q68FD5 Cltc Clathrin heavy chain 1 Mus musculus (Mouse) PR
P11442 Cltc Clathrin heavy chain 1 Rattus norvegicus (Rat) PR
P34574 chc-1 Probable clathrin heavy chain 1 Caenorhabditis elegans PR
10 20 30 40 50 60
MSDLPIEFTE LVDLMSLGIS PQFLDFRSTT FESDHFVTVR ETKDGTNSVA IVDLAKGNEV
70 80 90 100 110 120
TRKNMGGDSA IMHPSQMVIS VRANGTIVQI FNLETKSKLK SFTLDEPVIF WRWLSETTLG
130 140 150 160 170 180
FVTARSILTS NVFDGNVNAK PQLLTLRHAN LNNTQIINFV ANKNLDWFAV VGILQENGRI
190 200 210 220 230 240
AGRIQLFSKQ RNISQAIDGH VAIFTNILLE GNGSTPVQVF VTGNRNATTG AGELRIIEID
250 260 270 280 290 300
HDASLPSQYQ KETTDIFFPP DATNDFPIAV QVSEKYGIIY LLTKYGFIHL YELETGTNLF
310 320 330 340 350 360
VNRITAESVF TAAPYNHENG IACINKKGQV LAVEISTSQI VPYILNKLSN VALALIVATR
370 380 390 400 410 420
GGLPGADDLF QKQFESLLLQ NDYQNAAKVA ASSTSLRNQN TINRLKNIQA PPGAISPILL
430 440 450 460 470 480
YFSTLLDKGK LNKEETIELA RPVLQQDRKQ LFEKWLKEDK LECSEELGDI VKPFDTTLAL
490 500 510 520 530 540
ACYLRAGAHA KVISCLAELQ QFEKIIPYCQ KVGYQPNFLV LISSLIRSSP DRASEFAVSL
550 560 570 580 590 600
LQNPETASQI DIEKIADLFF SQNHIQQGTS LLLDALKGDT PDQGHLQTRV LEVNLLHAPQ
610 620 630 640 650 660
VADAILGNNI FSHYDKPTIA SLSEKAGLYQ RALENYTDIK DIKRCVVHTN ALPIDWLVGY
670 680 690 700 710 720
FGKLNVEQSL ACLKALMDNN IQANIQTVVQ VATKFSDLIG PSTLIKLFED YNATEGLYYY
730 740 750 760 770 780
LASLVNLTED KDVVYKYIEA AAKMKQYREI ERIVKDNNVY DPERVKNFLK DANLEDQLPL
790 800 810 820 830 840
VIVCDRFDFV HEMILYLYKS QNLKFIETYV QQVNPSKTAQ VVGALLDMDC DEAFIQSLLQ
850 860 870 880 890 900
SVLGQVPINE LTTEVEKRNR LKILLPFLEQ SLSQGIQDQA VYNALAKIYI DSNNSPEKFL
910 920 930 940 950 960
KENDQYDTLD VGHYCEKRDP YLAYIAYEKG QNDDDLIRIT NENSMYKYQA RYLLERSDLD
970 980 990 1000 1010 1020
LWNKVLNQEN IHRRQLIDSV ISVGIPELTD PEPVSLTVQA FMTNGLKLEL IELLEKIILE
1030 1040 1050 1060 1070 1080
PSPFNENVAL QGLLLLSAIK YEPTKVSSYI EKLDNYDADE IAPLCIEHDL KEEAFEIYDK
1090 1100 1110 1120 1130 1140
HEMYGKALKV LIEDIMSLDR AASYADKINT PELWSQIGTA QLDGLRIPDA IESYIKAEDP
1150 1160 1170 1180 1190 1200
SNYENVIDIA EQAGKYEELI PFLLMARKTL KEPKIDGALI LAYAELNKIH EIENLLAGSN
1210 1220 1230 1240 1250 1260
VANLDHVGDK LFENKEYKAA RLCYSAVSNY SKLASTLVYL GDYQAAVDTA RKASNIKVWK
1270 1280 1290 1300 1310 1320
LVNDACIEKK EFKLAQICGL NLIVHAEELD ELVERYESNG YFEELISLFE AGLGLERAHM
1330 1340 1350 1360 1370 1380
GMFTELAILY SKYEPDKTFE HLKLFWSRIN IPKVIRAVEQ AHLWSELVFL YAHYDEWDNA
1390 1400 1410 1420 1430 1440
ALTLIEKSTK DLDHAYFKEV VVKVSNLEIY YKAINFYVKF HPSLLVDLLT SLTPRLDIPR
1450 1460 1470 1480 1490 1500
TVKIFSKSDN LPLIKPFLIN VLPKNNSVVN QAYHDLMIEE EDYKALQDAV DSYDKFDQLG
1510 1520 1530 1540 1550 1560
LASRLESHKL IFFKKIGALL YRRNKKWAKS LSILKEEKLW KDAIETAAIS QDPKVVEALL
1570 1580 1590 1600 1610 1620
TYFVETGNRE GFVALLYAAY NLVRIEFVLE ISWMNSLEDY IKPFEISIKK EQNDSIKKIT
1630 1640 1650
EELAKKSGSN EEHKDGQPLM LMNSAMNVQP TGF