P34574

PR
Gene name
chc-1 (T20G5.1)
Protein name
Probable clathrin heavy chain 1
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_T20G5.1
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1585-1673 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P34574

Entry ID Method Resolution Chain Position Source
AF-P34574-F1 Predicted AlphaFoldDB

No variants for P34574

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P34574

No associated diseases with P34574

3 regional properties for P34574

Type Name Position InterPro Accession
domain Neurotransmitter-gated ion-channel transmembrane domain 242 - 489 IPR006029
domain Neurotransmitter-gated ion-channel ligand-binding domain 29 - 234 IPR006202
conserved_site Neurotransmitter-gated ion-channel, conserved site 153 - 167 IPR018000

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Membrane, coated pit ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasmic face of coated pits and vesicles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

12 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex.
clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network.
clathrin complex A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface.
clathrin-coated endocytic vesicle A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic side of plasma membrane The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
endocytic vesicle A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
mitotic spindle A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
clathrin light chain binding Binding to a clathrin light chain.
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

8 GO annotations of biological process

Name Definition
apical protein localization Any process in which a protein is transported to, or maintained in, apical regions of the cell.
cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
embryo development ending in birth or egg hatching The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
positive regulation of clathrin-dependent endocytosis Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.
receptor-mediated endocytosis An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P22137 CHC1 Clathrin heavy chain Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q00610 CLTC Clathrin heavy chain 1 Homo sapiens (Human) PR
Q68FD5 Cltc Clathrin heavy chain 1 Mus musculus (Mouse) PR
P11442 Cltc Clathrin heavy chain 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MALPIKFHEH LQLPNAGIRV PNITFSNVTM ESDKNIVVRE MIGDQQQVVI IDLADTANPT
70 80 90 100 110 120
RRPISADSVI MHPTAKILAL KSGKTLQIFN IELKAKVKAH QNVEDVVYWK WISEKTIALV
130 140 150 160 170 180
SDTAVYHWSI EGDAAPVKMF DRHQSLAGTQ IINYRADAEN KWLVLIGISA KDSRVVGSMQ
190 200 210 220 230 240
LYSTERKVSQ PIEGHAACFV RFKVDGNQNP SNLFCFSVKT DNGGKLHVIE VGTPAAGNTP
250 260 270 280 290 300
FQKKNVDVPY TADTAGDFPV SMQVSAKQGI IYLVTKQGYV HLYDVESGTR IYSNRISTDT
310 320 330 340 350 360
VFVTCEYTAT GGIMGINRKG QVLSVSIDEA NLVPFVTNQL QNPDLALKLA VRCDLPGAEE
370 380 390 400 410 420
LFVRKFNLLF SNGQFGESAK VAASAPQGIL RTPATIQKFQ QCPSTGPGPS PLLQYFGILL
430 440 450 460 470 480
DQGKLNKYET LELCRPVLAQ GRKELITKWL NDQKLECCEE LGDLIKPHDV NTALSVYLRG
490 500 510 520 530 540
NVPHKVVQSF AETGQFDKIV MYAKRVGFQP DYLFQLRQIL RNSNPDHGAK FAQLLVSESE
550 560 570 580 590 600
NGEPLADLSQ IIDCFMEVQA VQPCTSFLLE VLKGDKPEEG HLQTRLLEMN LLAAPAVADA
610 620 630 640 650 660
ILANKMFSHY DRAAIGQLCE KAGLLQRALE HFTDLYDIKR TVVHTHLLKP DWLVGYFGSL
670 680 690 700 710 720
SVEDSVECLK AMLTQNIRQN LQVVVQIASK YHEQLGADKL IEMFENHKSY EGLFYFLGSI
730 740 750 760 770 780
VNFSQDPEVH FKYIQAATRT GQIKEVERIC RESQCYDAER VKNFLKEAKL NDQLPLIIVC
790 800 810 820 830 840
DRHNMVHDLV LYLYRNQLQK YIEVFVQKVN AARLPIVVGA LLDVDCSEDA IKQLIINTRG
850 860 870 880 890 900
KFDIDELVEE VEKRNRLKLL NHWLESKIQE GATDAATHNA MAKIYIDSNN NPERFLKENP
910 920 930 940 950 960
YYDSKVVGKY CEKRDPHYAF LSYERGQCDA ELINVCNENS LFKNLARYLV KRRDFTLWEQ
970 980 990 1000 1010 1020
VLNEENVHRR QLIDQVVQTA LSETQDPEDI SVTVKAFMAA DLPNELIELL EKIVLDNSAF
1030 1040 1050 1060 1070 1080
SEHRNLQNLL ILTAMRADRT RVMEYIQKLD NYDAPDIANI AITSELYEEA FAIFKKFDVN
1090 1100 1110 1120 1130 1140
SSAINVLIEN VNNLDRAYEF AEKCNQSDVW ASLAKAQLQQ NLVKEAVDSF IKADDPGAYM
1150 1160 1170 1180 1190 1200
EVVNKCSQTE HWEDLVRYLQ MARKKSRESY IETELVFALA KTGRLTELEE FIAGPNHAQI
1210 1220 1230 1240 1250 1260
GQIGDRCFDN GMFDSAKILF NNVSNFAKLS VTLVRLGEYQ GAVDAARKAN STKTWKQVCF
1270 1280 1290 1300 1310 1320
SCVENGEFRL AQMCGLHIVV HADELEELIN FYQDRGHFEE LIALLEAALG LERAHMGMFT
1330 1340 1350 1360 1370 1380
ELAILYSKYK PEKMREHLEL FWSRVNIPKV LRAAEQAHLW SELVFLYDKY EEYDNAALTM
1390 1400 1410 1420 1430 1440
MQHPTESWRE QHFKEVIAKV ANVELYYKAM QFYLDYKPLL LNDLLTVLSP RLDHSRTVLF
1450 1460 1470 1480 1490 1500
FNKLKQIPLV KPYLRQVQNL NNKAINEALN QLLIDEEDHA GLRSSIEAQD NFDNITLAQQ
1510 1520 1530 1540 1550 1560
LEKHPLVEFR RISAYLFKGN NRWKQSIELC KKDKLYKDAM EYAAESRNGE LAEELLSFFL
1570 1580 1590 1600 1610 1620
DEKLYDCFAA SLYHCYDLLH PDVIMELAWK HKIMDYAMPY MIQVMRDYQT RLEKLERSEH
1630 1640 1650 1660 1670 1680
ERKEEKAEQQ QNNGMTMEPQ LMLTYGAPAP QMTYPGTTGG YGGQPAYGQP GQPGYNAPGF
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