Q63042

PR
Gene name
Gfer (Alr)
Protein name
FAD-linked sulfhydryl oxidase ALR
Names
Augmenter of liver regeneration
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:27100
EC number
1.8.3.2: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-116 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q63042

Entry ID Method Resolution Chain Position Source
1OQC X-ray 180 A A/B/C/D 74-198 PDB
3R7C X-ray 240 A A/B/C/D 74-198 PDB
AF-Q63042-F1 Predicted AlphaFoldDB

No variants for Q63042

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q63042

No associated diseases with Q63042

1 regional properties for Q63042

Type Name Position InterPro Accession
domain ERV/ALR sulfhydryl oxidase domain 88 - 189 IPR017905

Functions

Description
EC Number 1.8.3.2 With oxygen as acceptor
Subcellular Localization
  • Mitochondrion intermembrane space
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
flavin-linked sulfhydryl oxidase activity Catalysis of the formation of disulfide bridges in proteins using FAD as the electron acceptor.
growth factor activity The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
protein-disulfide reductase activity Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.

11 GO annotations of biological process

Name Definition
cellular response to actinomycin D Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus.
cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
cellular response to toxic substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
cellular response to tumor necrosis factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
liver development The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
liver regeneration The regrowth of lost or destroyed liver.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of natural killer cell mediated cytotoxicity Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.
negative regulation of oxidative stress-induced neuron death Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death.
positive regulation of DNA biosynthetic process Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.
response to lipopolysaccharide Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12284 ERV2 FAD-linked sulfhydryl oxidase ERV2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P55789 GFER FAD-linked sulfhydryl oxidase ALR Homo sapiens (Human) PR
P56213 Gfer FAD-linked sulfhydryl oxidase ALR Mus musculus (Mouse) PR
10 20 30 40 50 60
MAAPSEPAGF PRGSRFSFLP GGAHSEMTDD LVTDARGRGA RHRKDNAPAA APAPKGLEHG
70 80 90 100 110 120
KRPCRACVDF KSWMRTQQKR DIKFREDCPQ DREELGRNTW AFLHTLAAYY PDMPTPEQQQ
130 140 150 160 170 180
DMAQFIHIFS KFYPCEECAE DIRKRIDRSQ PDTSTRVSFS QWLCRLHNEV NRKLGKPDFD
190
CSRVDERWRD GWKDGSCD