Q63008

PR
Gene name
Slc5a5 (Nis)
Protein name
Sodium/iodide cotransporter
Names
Na(+)/I(-) cotransporter, Sodium-iodide symporter, Na(+)/I(-) symporter, Solute carrier family 5 member 5
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:114613
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

539-618 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q63008

Entry ID Method Resolution Chain Position Source
7UUY EM 330 A A 2-618 PDB
7UUZ EM 320 A A 2-618 PDB
7UV0 EM 310 A A 2-618 PDB
AF-Q63008-F1 Predicted AlphaFoldDB

No variants for Q63008

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q63008

No associated diseases with Q63008

1 regional properties for Q63008

Type Name Position InterPro Accession
conserved_site Sodium/solute symporter, conserved site 161 - 186 IPR018212

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
iodide transmembrane transporter activity Enables the transfer of iodide ions from one side of a membrane to the other.
sodium:iodide symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in).
symporter activity Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

9 GO annotations of biological process

Name Definition
anion transmembrane transport The process in which an anion is transported across a membrane.
cellular response to cAMP Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
cellular response to gonadotropin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.
iodide transmembrane transport The process in which iodide is transported across a membrane.
iodide transport The directed movement of iodide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
sodium ion transmembrane transport A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
sodium ion transport The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
thyroid hormone generation The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2M3M2 SLC5A9 Sodium/glucose cotransporter 4 Homo sapiens (Human) PR
Q49B93 Slc5a12 Sodium-coupled monocarboxylate transporter 2 Mus musculus (Mouse) PR
Q5BL81 slc5a8 Sodium-coupled monocarboxylate transporter 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MEGAEAGARA TFGAWDYGVF ATMLLVSTGI GLWVGLARGG QRSADDFFTG GRQLAAVPVG
70 80 90 100 110 120
LSLAASFMSA VQVLGVPAEA ARYGLKFLWM CAGQLLNSLL TAFLFLPIFY RLGLTSTYQY
130 140 150 160 170 180
LELRFSRAVR LCGTLQYLVA TMLYTGIVIY APALILNQVT GLDIWASLLS TGIICTLYTT
190 200 210 220 230 240
VGGMKAVVWT DVFQVVVMLV GFWVILARGV ILLGGPRNVL SLAQNHSRIN LMDFDPDPRS
250 260 270 280 290 300
RYTFWTFIVG GTLVWLSMYG VNQAQVQRYV ACHTEGKAKL ALLVNQLGLF LIVASAACCG
310 320 330 340 350 360
IVMFVYYKDC DPLLTGRISA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG TLSTASTSIN
370 380 390 400 410 420
AMAAVTVEDL IKPRMPGLAP RKLVFISKGL SFIYGSACLT VAALSSLLGG GVLQGSFTVM
430 440 450 460 470 480
GVISGPLLGA FTLGMLLPAC NTPGVLSGLA AGLAVSLWVA VGATLYPPGE QTMGVLPTSA
490 500 510 520 530 540
AGCTNDSVLL GPPGATNASN GIPSSGMDTG RPALADTFYA ISYLYYGALG TLTTMLCGAL
550 560 570 580 590 600
ISYLTGPTKR SSLGPGLLWW DLARQTASVA PKEDTATLEE SLVKGPEDIP AVTKKPPGLK
610
PGAETHPLYL GHDVETNL