Q49B93
Gene name |
Slc5a12 (Smct2) |
Protein name |
Sodium-coupled monocarboxylate transporter 2 |
Names |
Electroneutral sodium monocarboxylate cotransporter, Low-affinity sodium-lactate cotransporter, Solute carrier family 5 member 12 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:241612 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q49B93
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q49B93-F1 | Predicted | AlphaFoldDB |
17 variants for Q49B93
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs27474008 | 12 | V>A | No | EVA | |
| rs3388571065 | 54 | A>D | No | EVA | |
| rs3388577153 | 68 | L>P | No | EVA | |
| rs3388570732 | 113 | E>V | No | EVA | |
| rs240051390 | 125 | Y>C | No | EVA | |
| rs3388577113 | 157 | N>K | No | EVA | |
| rs3392033258 | 172 | Y>S | No | EVA | |
| rs3392033244 | 222 | R>L | No | EVA | |
| rs3388574063 | 241 | I>F | No | EVA | |
| rs214234465 | 293 | S>C | No | EVA | |
| rs3388577144 | 342 | F>C | No | EVA | |
| rs3388579102 | 375 | K>N | No | EVA | |
| rs3388572060 | 486 | A>S | No | EVA | |
| rs3388572486 | 508 | S>G | No | EVA | |
| rs242174242 | 572 | L>P | No | EVA | |
| rs3388575865 | 597 | Q>R | No | EVA | |
| rs258939752 | 610 | N>K | No | EVA |
No associated diseases with Q49B93
1 regional properties for Q49B93
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Sodium-coupled monocarboxylate transporter 2, solute-binding domain | 3 - 527 | IPR042700 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| lactate transmembrane transporter activity | Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. |
| symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2M3M2 | SLC5A9 | Sodium/glucose cotransporter 4 | Homo sapiens (Human) | PR |
| Q63008 | Slc5a5 | Sodium/iodide cotransporter | Rattus norvegicus (Rat) | PR |
| Q5BL81 | slc5a8 | Sodium-coupled monocarboxylate transporter 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRVKNFEAWD | YVVFAGLFVI | SSGIGVFFAI | KERKKTTSRE | FLVGGRQMSF | GPVALSLTAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FMSAVTVLGT | PAEVYRFGAS | FFLFLISYVF | VVFFTSELFL | PVFYRSGITS | TYEYLQLRFN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KPVRYAATII | YIVQTILYTG | VVVYAPALAL | NQVTGFNLWA | SVFATGIVCT | FYCSLGGLKA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VVWTDAFQMV | VMIVGFLTVL | IQGSNHVGGF | NNVLEKAGNG | SRLHIVDFDV | DPLRRHTFWT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ITIGGTFTWL | GVYGVNQSTI | QRCISCKTEK | HAKLALYFNL | LGLWIIVACA | VFSGLIMYSH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FKDCDPWTSG | VISAPDQLMP | YFVMEIFATM | PGLPGLFVAC | AFSGTLSTVA | ASINALATVT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FEDFVKSCFP | HLSDKLSTWI | SKGLCILFGI | MCTSMAVVAS | LMGSVVQAAL | SIHGMCGGPM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LGLFTLGLVF | PFVNWKGALG | GLLTGITLSF | WVAIGSFIYP | APESKTLPLP | LSTEHCVELN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ITTTVAPQIS | SRPVLADTWY | SLSYLYFSAV | GCLGCIAAGI | IISFLTGKQR | GKDIDPLLIR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PVCNLFCFWS | KKYKTLCWCG | VQHDRETEQD | YLDSGSAWKQ | GVESGLQNGL | KQDTLAQIPG |
| 610 | |||||
| YNPKEKSYSN | SVPEKTTYF |