Q61792

PR
Gene name
Lasp1 (Mln50)
Protein name
LIM and SH3 domain protein 1
Names
LAG-3, Activation-induced cytidine deaminase-linked autoimmunity protein, Aida, LASP-1, Metastatic lymph node gene 50 protein, MLN 50
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:16796
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

117-223 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q61792

Entry ID Method Resolution Chain Position Source
AF-Q61792-F1 Predicted AlphaFoldDB

16 variants for Q61792

Variant ID(s) Position Change Description Diseaes Association Provenance
rs240015106 3 P>L No EVA
rs3402837451 5 C>S No EVA
rs3389210950 29 C>Y No EVA
rs3389201407 59 K>M No EVA
rs3389191383 64 M>I No EVA
rs3389208917 96 K>* No EVA
rs3402972646 102 A>P No EVA
rs3389133359 107 L>P No EVA
rs3389172099 110 I>V No EVA
rs3389133323 126 F>I No EVA
rs3389133390 128 K>M No EVA
rs3389199845 146 A>T No EVA
rs3389198889 150 S>C No EVA
rs3389168348 197 I>L No EVA
rs3389205202 207 K>* No EVA
rs3389199830 232 V>A No EVA

No associated diseases with Q61792

5 regional properties for Q61792

Type Name Position InterPro Accession
repeat Nebulin repeat 61 - 95 IPR000900-1
repeat Nebulin repeat 97 - 131 IPR000900-2
domain SH3 domain 204 - 263 IPR001452
domain Zinc finger, LIM-type 3 - 63 IPR001781
domain Lasp1, SH3 domain 205 - 263 IPR035630

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cell cortex
  • Cytoplasm, cytoskeleton
  • Associated with the F-actin rich cortical cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cortical actin cytoskeleton The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).

3 GO annotations of molecular function

Name Definition
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
ion transmembrane transporter activity Enables the transfer of an ion from one side of a membrane to the other.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
ion transport The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3B7M5 LASP1 LIM and SH3 domain protein 1 Bos taurus (Bovine) PR
Q14847 LASP1 LIM and SH3 domain protein 1 Homo sapiens (Human) PR
Q99MZ8 Lasp1 LIM and SH3 domain protein 1 Rattus norvegicus (Rat) PR
P34416 F42H10.3 LIM and SH3 domain protein F42H10.3 Caenorhabditis elegans PR
10 20 30 40 50 60
MNPNCARCGK IVYPTEKVNC LDKYWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ
70 80 90 100 110 120
SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRI KKTQDQISNI
130 140 150 160 170 180
KYHEEFEKSR MGPSGGEGVE PERREAQDSS SYRRPTEQQQ PQPHHIPTSA PVYQQPQQQQ
190 200 210 220 230 240
MTSSYGGYKE PAAPVSIQRS APGGGGKRYR AVYDYSAADE DEVSFQDGDT IVNVQQIDDG
250 260
WMYGTVERTG DTGMLPANYV EAI