AiPD: Autoinhibited Protein Database

Q14847

Gene name	LASP1 (MLN50)
Protein name	LIM and SH3 domain protein 1
Names	LASP-1, Metastatic lymph node gene 50 protein, MLN 50
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3927
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

39-232 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

39-232 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q14847

Entry ID	Method	Resolution	Chain	Position	Source
3I35	X-ray	140 A	A	202-261	PDB
AF-Q14847-F1	Predicted				AlphaFoldDB

169 variants for Q14847

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs775146501 CA8526712	3	P>S		No	ClinGen ExAC gnomAD
CA8526714 rs763719175	6	A>T		No	ClinGen ExAC gnomAD
CA398794397 rs1215161687	7	R>Q		No	ClinGen TOPMed
rs773847283 CA8526715	9	G>R		No	ClinGen ExAC TOPMed gnomAD
rs773847283 CA8526716	9	G>S		No	ClinGen ExAC TOPMed gnomAD
rs767991655 CA8526717	12	V>L		No	ClinGen ExAC TOPMed gnomAD
CA8526718 rs750816831	14	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1266304412 CA398794684	17	K>R		No	ClinGen TOPMed gnomAD
TCGA novel	22	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398797240 rs1397391463	31	H>R		No	ClinGen TOPMed
TCGA novel	33	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398797258 rs1463495033	33	E>K		No	ClinGen TOPMed
CA398797337 rs1338757796	38	T>I		No	ClinGen gnomAD
rs1167673173 CA398797511	47	Y>S		No	ClinGen TOPMed
rs745862833 CA8526744	48	E>K		No	ClinGen ExAC gnomAD
rs1219560733 CA398797651	53	C>S		No	ClinGen gnomAD
rs201222670 CA8526745	54	N>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA8526746 rs779939948	55	A>S		No	ClinGen ExAC gnomAD
CA398797691 rs779939948	55	A>T		No	ClinGen ExAC gnomAD
rs1450523315 CA398797705 COSM186116	55	A>V	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1598110043 CA398801346	65	V>A		No	ClinGen Ensembl
CA8526774 rs746452006	69	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1367862145 CA398801398	73	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA290348517 rs191762190	75	K>R		No	ClinGen 1000Genomes
rs1567698458 CA398801416	76	Q>*		No	ClinGen Ensembl
rs1351843364 CA398801447	80	L>I		No	ClinGen TOPMed
rs1385782338 CA398801462	82	S>G		No	ClinGen gnomAD
CA8526776 rs776937950 COSM417567	83	Q>*	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA398783495 rs950459854	85	R>C		No	ClinGen gnomAD
rs950459854 CA290341037	85	R>G		No	ClinGen gnomAD
rs1567700593 CA398783522	87	K>R		No	ClinGen Ensembl
rs1334244431 CA398783543	88	E>V		No	ClinGen TOPMed
rs1004237588 CA290341038	93	N>S		No	ClinGen TOPMed
CA398783729 rs1382523808	97	G>C		No	ClinGen TOPMed
rs1226333009 CA398783813	100	V>I		No	ClinGen TOPMed gnomAD
rs1280405349 CA398783846	101	V>E		No	ClinGen gnomAD
rs1198134743 CA398783849	102	A>T		No	ClinGen gnomAD
CA290341041 rs780162081	104	T>M		No	ClinGen TOPMed gnomAD
rs1237348127 CA398783983	106	E>K		No	ClinGen gnomAD
rs1482520945 CA398784058	108	Q>*		No	ClinGen gnomAD
rs1425393927 CA398784141	111	K>R		No	ClinGen gnomAD
CA398784185 rs1477923925	113	T>A		No	ClinGen gnomAD
rs1169460584 CA398784230	114	Q>L		No	ClinGen gnomAD
CA290341060 rs999729187	115	D>Y		No	ClinGen Ensembl
rs1395862785 CA398790705	120	I>L		No	ClinGen TOPMed gnomAD
TCGA novel	121	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398790751 rs1311412575	122	Y>H		No	ClinGen gnomAD
CA398790772 rs1342730772	123	H>N		No	ClinGen gnomAD
CA290355119 rs895231634	130	R>C		No	ClinGen gnomAD
rs199579508 CA8526828	130	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8526829 rs749988404	131	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1209938913 CA398791053	133	P>L		No	ClinGen gnomAD
rs755621366 CA290355132	134	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA290355139 rs755117655 CA398791116	135	G>R		No	ClinGen TOPMed gnomAD
rs779695951 CA8526831	136	G>C		No	ClinGen ExAC gnomAD
CA8526833 rs755476623	137	E>Q		No	ClinGen ExAC gnomAD
CA290355151 rs968078826	138	G>V		No	ClinGen Ensembl
CA8526836 rs772214083	139	M>I		No	ClinGen ExAC gnomAD
rs201941467 CA290355167	139	M>R		No	ClinGen Ensembl
CA8526835 rs151189344	139	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA8526837 rs777903945	140	E>G		No	ClinGen ExAC gnomAD
rs1172266377 CA398791239	140	E>K		No	ClinGen TOPMed gnomAD
CA8526838 rs747103046	141	P>S		No	ClinGen ExAC gnomAD
rs776689372 CA8526840	143	R>C		No	ClinGen ExAC gnomAD
CA8526841 rs762918588	143	R>H		No	ClinGen ExAC gnomAD
CA8526843 rs768616192	144	R>G		No	ClinGen ExAC TOPMed gnomAD
rs761633094 CA8526844	144	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA8526842 rs768616192	144	R>W		No	ClinGen ExAC TOPMed gnomAD
CA8526845 rs61739902	145	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA8526847 rs750041565	146	S>L		No	ClinGen ExAC TOPMed gnomAD
rs755457528 CA398792546	149	G>C		No	ClinGen ExAC gnomAD
CA8526851 rs755457528	149	G>S		No	ClinGen ExAC gnomAD
CA8526852 rs779434714	150	S>G		No	ClinGen ExAC gnomAD
rs1420751062 CA398792704	153	R>Q		No	ClinGen TOPMed gnomAD
rs372318670 CA8526853	153	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA398792731 rs778100520	154	R>P		No	ClinGen ExAC TOPMed gnomAD
CA8526855 rs778100520	154	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs758729512 CA8526854	154	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs771111886 CA8526857	155	P>A		No	ClinGen ExAC gnomAD
rs1398376554 CA398792891	158	Q>E		No	ClinGen gnomAD
CA398792898 rs1301234050	158	Q>R		No	ClinGen gnomAD
rs141965663 CA290355246	159	Q>*		No	ClinGen ESP TOPMed
CA8526859 rs781298203	160	Q>H		No	ClinGen ExAC gnomAD
CA290355252 rs909629195	161	P>S		No	ClinGen Ensembl
CA8526860 rs745915600 COSM376662	162	H>Y	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA8526861 rs768510382	163	H>N		No	ClinGen ExAC gnomAD
rs774280750 CA8526862	163	H>P		No	ClinGen ExAC TOPMed gnomAD
rs774280750 CA8526863	163	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1266195752 CA398793066	165	P>A		No	ClinGen gnomAD
CA8526864 rs771967177	165	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1240622860 CA398793095	166	T>A		No	ClinGen gnomAD
CA398793128 rs1440812116	166	T>I		No	ClinGen TOPMed gnomAD
CA398793120 rs1440812116	166	T>S		No	ClinGen TOPMed gnomAD
rs189899021 CA8526866	169	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA398793638 rs1598122900	172	Q>R		No	ClinGen Ensembl
rs746812416 CA8526904	174	P>T		No	ClinGen ExAC gnomAD
rs145728465 CA8526905	178	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1327225752 COSM560531 CA398793845	180	A>S	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1327225752 CA398793843	180	A>T		No	ClinGen TOPMed gnomAD
rs1214385228 CA398793866	181	Q>*		No	ClinGen TOPMed
rs1430153450 CA398793872	181	Q>R		No	ClinGen gnomAD
CA8526908 rs570515212	183	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs775089350 CA8526909	184	G>D		No	ClinGen ExAC gnomAD
CA398793932 rs1320783445	184	G>S		No	ClinGen TOPMed gnomAD
CA290355783 rs933341626	185	G>D		No	ClinGen Ensembl
rs1598122959 CA919837211	186	Y>*		No	ClinGen Ensembl
rs764593162 CA8526911	186	Y>*		No	ClinGen ExAC
CA290355790 rs1050836075	187	K>Q		No	ClinGen Ensembl
rs1346244264 CA398794041	187	K>R		No	ClinGen gnomAD
rs1598122967 CA398794091	188	E>G		No	ClinGen Ensembl
CA8526912 rs774786306	190	A>T		No	ClinGen ExAC gnomAD
CA398794191 rs1447188951	191	A>P		No	ClinGen TOPMed gnomAD
CA290355798 rs889386404	191	A>V		No	ClinGen Ensembl
CA398794235 rs1239885165	193	V>A		No	ClinGen gnomAD
CA398794237 rs1194193321	194	S>P		No	ClinGen gnomAD
CA8526913 rs762297618	194	S>Y		No	ClinGen ExAC gnomAD
rs767994718 CA8526914	195	I>L		No	ClinGen ExAC gnomAD
rs149423570 CA8526916	195	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs767994718 CA8526915	195	I>V		No	ClinGen ExAC gnomAD
CA8526917 rs150234754	197	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8526918 rs753952992	197	R>H		No	ClinGen ExAC TOPMed gnomAD
rs779122230 CA8526920	199	A>T		No	ClinGen ExAC gnomAD
rs751612653 CA8526921	200	P>S		No	ClinGen ExAC TOPMed gnomAD
rs751612653 CA398794413	200	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1369405563 CA398794432	201	G>S		No	ClinGen TOPMed gnomAD
rs757228800 CA8526922	202	G>R		No	ClinGen ExAC TOPMed gnomAD
CA398794520 CA398794525 rs1350353736	204	G>R		No	ClinGen TOPMed gnomAD
CA290357701 rs975363624	206	R>Q		No	ClinGen Ensembl
CA398797734 rs1325306453	208	R>H		No	ClinGen gnomAD
COSM1195558 CA290357731 rs998335975	209	A>V	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
rs17856397 CA290357752	210	V>A		No	ClinGen Ensembl
CA398797783 rs1320968178	210	V>L		No	ClinGen TOPMed
CA290357763 rs1048609858	212	D>N		No	ClinGen TOPMed
CA398797964 rs1338054828	214	S>I		No	ClinGen TOPMed
CA290357771 rs371774517	216	A>V		No	ClinGen ESP TOPMed
rs1426740416 COSM436475 CA398798070	217	D>A	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA398798095 rs910068298	217	D>E		No	ClinGen TOPMed gnomAD
rs1261144597 COSM978513 CA398798060	217	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA398798101 rs766205981	218	E>K		No	ClinGen ExAC TOPMed gnomAD
CA8526964 rs766205981	218	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA290357796 rs17850916	220	E>A		No	ClinGen Ensembl
CA8526965 rs753578708	221	V>I		No	ClinGen ExAC gnomAD
rs1362797661 CA398798294	222	S>F		No	ClinGen gnomAD
CA398798503 rs1380025676	227	D>V		No	ClinGen gnomAD
TCGA novel	227	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1305612413 CA398798544	228	T>A		No	ClinGen gnomAD
CA8526970 rs367911500	230	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA398798687 rs747508790	231	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1243601222 CA398798682	231	N>S		No	ClinGen TOPMed
TCGA novel	234	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1338240925 CA398798902	236	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1260357693 CA398798956	237	D>N		No	ClinGen TOPMed gnomAD
CA398798996 rs1215608849	238	G>S		No	ClinGen gnomAD
rs1254220401 CA398799075	240	M>L		No	ClinGen gnomAD
CA8526975 rs770146375	240	M>T		No	ClinGen ExAC TOPMed gnomAD
CA290357845 rs1002551655	243	T>M		No	ClinGen gnomAD
CA8526979 rs199894168	246	R>C		No	ClinGen 1000Genomes ExAC gnomAD
rs375075155 CA8526980	246	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs766261412 CA8526981	248	G>S		No	ClinGen ExAC TOPMed gnomAD
CA8526983 rs754705774	249	D>N		No	ClinGen ExAC gnomAD
CA8526985 rs752358552	250	T>M		No	ClinGen ExAC TOPMed gnomAD
rs765000625 CA8526984	250	T>S		No	ClinGen ExAC gnomAD
rs1315315803 CA398800166	251	G>E		No	ClinGen gnomAD
TCGA novel	251	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	252	M>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs146092528 CA8526988	254	P>L		No	ClinGen ESP ExAC gnomAD
CA398800386 rs746248272	258	V>L		No	ClinGen ExAC TOPMed gnomAD
CA8526991 rs746248272	258	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	259	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q14847

5 regional properties for Q14847

Type	Name	Position	InterPro Accession
repeat	Nebulin repeat	61 - 95	IPR000900-1
repeat	Nebulin repeat	97 - 131	IPR000900-2
domain	SH3 domain	202 - 261	IPR001452
domain	Zinc finger, LIM-type	3 - 63	IPR001781
domain	Lasp1, SH3 domain	203 - 261	IPR035630

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cell cortex Cytoplasm, cytoskeleton	Associated with the F-actin rich cortical cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cortical actin cytoskeleton	The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).

4 GO annotations of molecular function

Name	Definition
actin filament binding	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
ion transmembrane transporter activity	Enables the transfer of an ion from one side of a membrane to the other.
metal ion binding	Binding to a metal ion.

1 GO annotations of biological process

Name	Definition
ion transport	The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3B7M5	LASP1	LIM and SH3 domain protein 1	Bos taurus (Bovine)	PR
Q61792	Lasp1	LIM and SH3 domain protein 1	Mus musculus (Mouse)	PR
Q99MZ8	Lasp1	LIM and SH3 domain protein 1	Rattus norvegicus (Rat)	PR
P34416	F42H10.3	LIM and SH3 domain protein F42H10.3	Caenorhabditis elegans	PR

10	20	30	40	50	60
MNPNCARCGK	IVYPTEKVNC	LDKFWHKACF	HCETCKMTLN	MKNYKGYEKK	PYCNAHYPKQ
70	80	90	100	110	120
SFTMVADTPE	NLRLKQQSEL	QSQVRYKEEF	EKNKGKGFSV	VADTPELQRI	KKTQDQISNI
130	140	150	160	170	180
KYHEEFEKSR	MGPSGGEGME	PERRDSQDGS	SYRRPLEQQQ	PHHIPTSAPV	YQQPQQQPVA
190	200	210	220	230	240
QSYGGYKEPA	APVSIQRSAP	GGGGKRYRAV	YDYSAADEDE	VSFQDGDTIV	NVQQIDDGWM
250	260
YGTVERTGDT	GMLPANYVEA	I