| amyloid precursor protein catabolic process |
The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. |
| amyloid-beta formation |
The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP). |
| amyloid-beta metabolic process |
The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP). |
| apoptotic signaling pathway |
The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. |
| brain morphogenesis |
The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| calcium ion transport |
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| cardiac muscle contraction |
Muscle contraction of cardiac muscle tissue. |
| cell fate specification |
The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. |
| dorsal/ventral neural tube patterning |
The process in which the neural tube is regionalized in the dorsoventral axis. |
| embryonic limb morphogenesis |
The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. |
| endoplasmic reticulum calcium ion homeostasis |
Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings. |
| forebrain development |
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). |
| hair follicle development |
The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open. |
| hematopoietic progenitor cell differentiation |
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. |
| intracellular signal transduction |
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| learning or memory |
The acquisition and processing of information and/or the storage and retrieval of this information over time. |
| locomotion |
Self-propelled movement of a cell or organism from one location to another. |
| lung alveolus development |
The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. |
| membrane protein ectodomain proteolysis |
The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). |
| membrane protein intracellular domain proteolysis |
The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain. |
| memory |
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). |
| mitochondrion-endoplasmic reticulum membrane tethering |
The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles. |
| myeloid leukocyte differentiation |
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. |
| negative regulation of apoptotic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| negative regulation of apoptotic signaling pathway |
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. |
| negative regulation of epidermal growth factor-activated receptor activity |
Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity. |
| negative regulation of protein phosphorylation |
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein. |
| negative regulation of transcription by RNA polymerase II |
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| negative regulation of ubiquitin-dependent protein catabolic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process. |
| negative regulation of ubiquitin-protein transferase activity |
Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity. |
| neuroinflammatory response |
The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents. |
| neuron cellular homeostasis |
The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. |
| Notch receptor processing |
The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor. |
| Notch signaling pathway |
The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| positive regulation of apoptotic process |
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of catalytic activity |
Any process that activates or increases the activity of an enzyme. |
| positive regulation of coagulation |
Any process that activates or increases the frequency, rate or extent of coagulation. |
| positive regulation of extrinsic apoptotic signaling pathway via death domain receptors |
Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| positive regulation of receptor recycling |
Any process that activates or increases the frequency, rate or extent of receptor recycling. |
| protein maturation |
Any process leading to the attainment of the full functional capacity of a protein. |
| protein metabolic process |
The chemical reactions and pathways involving a protein. Includes protein modification. |
| protein processing |
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. |
| protein transport |
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of calcium import into the mitochondrion |
Any process that modulates the frequency, rate or extent of calcium import into the mitochondrion. |
| regulation of epidermal growth factor-activated receptor activity |
Any process that modulates the frequency, rate or extent of EGF-activated receptor activity. |
| regulation of protein binding |
Any process that modulates the frequency, rate or extent of protein binding. |
| regulation of synaptic plasticity |
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. |
| skin morphogenesis |
The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. |
| somitogenesis |
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. |
| T cell activation involved in immune response |
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. |
| T cell receptor signaling pathway |
The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. |
| thymus development |
The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. |
