Q5ZK36

PR
Gene name
ING3 (RCJMB04_13g20)
Protein name
Inhibitor of growth protein 3
Names
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:417762
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

120-369 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5ZK36

Entry ID Method Resolution Chain Position Source
AF-Q5ZK36-F1 Predicted AlphaFoldDB

No variants for Q5ZK36

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5ZK36

No associated diseases with Q5ZK36

5 regional properties for Q5ZK36

Type Name Position InterPro Accession
domain Zinc finger, PHD-type 361 - 406 IPR001965
conserved_site Zinc finger, PHD-type, conserved site 362 - 405 IPR019786
domain Zinc finger, PHD-finger 359 - 408 IPR019787
domain Inhibitor of growth protein, N-terminal histone-binding 3 - 104 IPR024610
domain ING3, PHD domain 361 - 405 IPR042020

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
NuA4 histone acetyltransferase complex A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
Swr1 complex A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
methylated histone binding Binding to a histone in which a residue has been modified by methylation.

5 GO annotations of biological process

Name Definition
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
histone H2A acetylation The modification of histone H2A by the addition of an acetyl group.
histone H4 acetylation The modification of histone H4 by the addition of an acetyl group.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NXR8 ING3 Inhibitor of growth protein 3 Homo sapiens (Human) PR
Q5HZG4 Taf3 Transcription initiation factor TFIID subunit 3 Mus musculus (Mouse) PR
Q498T3 Ing3 Inhibitor of growth protein 3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MLYLEDYLEM IEQLPMDLRD RFTEMREMDL QVQNAMDQLE QRVNEFFMNA KKNKPEWREE
70 80 90 100 110 120
QMTSIKKDYY KALEDADEKV QLANQIYDLV DRHLRKLDQE LAKFKMELEA DNAGITEILE
130 140 150 160 170 180
RRSLELDTPS QPVNNHHAHS HTPVEKRKHN PSSHHGATDH VPEKKFKSEA LLSTLTSDAS
190 200 210 220 230 240
KENTPGRRNN NSSSSSNNAY NTNSSQPLAS YNLGSLSSGS GAGAITMAAA QAVQATAQMK
250 260 270 280 290 300
EGRRTSSLKA SYEAFKNNDF QLGREFSLSR DSTGYSSSAL ASTLTQTLSS SSTDSRSGRK
310 320 330 340 350 360
SKNNNKSSSQ QSSSSSSSSS LSSCSSSSAL AQELSQQTAV IPESDSNSQV DWTYDPNEPR
370 380 390 400 410
YCICNQVSYG EMVGCDNQDC PIEWFHYGCV GLTEAPKGKW YCPQCTAAMK RRGSRHK