Q5HZG4

PR
Gene name
Taf3
Protein name
Transcription initiation factor TFIID subunit 3
Names
140 kDa TATA box-binding protein-associated factor, TBP-associated factor 3, Transcription initiation factor TFIID 140 kDa subunit, TAF(II)140, TAF140, TAFII-140, TAFII140
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:209361
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

261-331 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q5HZG4

Entry ID Method Resolution Chain Position Source
2K16 NMR - A 857-924 PDB
2K17 NMR - A 857-924 PDB
AF-Q5HZG4-F1 Predicted AlphaFoldDB

45 variants for Q5HZG4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3391016694 22 G>S No EVA
rs3391126712 23 W>C No EVA
rs3391263180 28 L>P No EVA
rs3388526788 30 A>S No EVA
rs3388526817 31 C>S No EVA
rs3391240124 31 C>W No EVA
rs3388526096 159 E>K No EVA
rs221463856 224 T>I No EVA
rs253982450 227 V>M No EVA
rs3388529708 231 V>M No EVA
rs238560000 232 R>H No EVA
rs223788223 236 R>S No EVA
rs261074340 237 A>T No EVA
rs3388528056 242 P>S No EVA
rs235592852 245 Q>E No EVA
rs3388525869 257 L>I No EVA
rs247535792 267 S>P No EVA
rs3388529684 269 T>S No EVA
rs3388527967 282 K>I No EVA
rs3388528825 282 K>Q No EVA
rs3388528690 287 K>N No EVA
rs3388525908 291 S>T No EVA
rs3388529706 294 R>K No EVA
rs3388527990 334 P>S No EVA
rs215986810 353 V>I No EVA
rs3388529240 380 K>R No EVA
rs3388528833 392 I>N No EVA
rs3388525843 398 R>C No EVA
rs3391261490 400 C>Y No EVA
rs261408256 433 A>T No EVA
rs240282143 456 S>G No EVA
rs3391240367 478 A>G No EVA
rs3391267343 672 A>E No EVA
rs27133814 685 M>V No EVA
rs3391228924 752 P>T No EVA
rs3388529729 763 R>S No EVA
rs3388526054 764 L>W No EVA
rs3388532069 778 S>N No EVA
rs3388528108 788 P>T No EVA
rs3388529644 810 S>G No EVA
rs3388526843 810 S>N No EVA
rs3388525632 812 T>S No EVA
rs3391016680 824 V>G No EVA
rs3388528085 825 C>F No EVA
rs243455785 927 R>K No EVA

No associated diseases with Q5HZG4

4 regional properties for Q5HZG4

Type Name Position InterPro Accession
domain Zinc finger, PHD-type 869 - 915 IPR001965
domain Bromodomain associated domain 3 - 79 IPR006565
conserved_site Zinc finger, PHD-type, conserved site 870 - 914 IPR019786
domain Zinc finger, PHD-finger 867 - 917 IPR019787

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
male germ cell nucleus The nucleus of a male germ cell, a reproductive cell in males.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.

4 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
p53 binding Binding to one of the p53 family of proteins.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
transcription regulator inhibitor activity A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification.

9 GO annotations of biological process

Name Definition
maintenance of protein location in nucleus Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus.
mRNA transcription by RNA polymerase II The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
negative regulation of DNA-binding transcription factor activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of transcription initiation by RNA polymerase II Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
RNA polymerase II preinitiation complex assembly The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZK36 ING3 Inhibitor of growth protein 3 Gallus gallus (Chicken) PR
Q9NXR8 ING3 Inhibitor of growth protein 3 Homo sapiens (Human) PR
Q498T3 Ing3 Inhibitor of growth protein 3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MCESYSRSLL RVSVAQICQA LGWDSVQLSA CHLLTDVLQR YLQQLGRGCH RYSELYGRTD
70 80 90 100 110 120
PILDDVGEAF QLMGVNLHEL EDYIHNIEPV TFPHQIPSFP VSKNNVLQFP QPGSKDAEER
130 140 150 160 170 180
KDYIPDYLPP IVSSQEEEEE EQVPTDGGTS AEAMQVPLEE DDEMEEEEVI NDENFLGKRP
190 200 210 220 230 240
LDSPEVEEMP SMKRPRLLST KGDSLDVVLL EAREPLSSIN PQKTPPVLSP VRVQDRADLA
250 260 270 280 290 300
PPSPQPPMLA PFAKSQLPIA KPLETKSFTP KTKTKASSPG QKTKSPKAAL SPARLGSPIR
310 320 330 340 350 360
SPKTIPKEKK SPGRSKSPKS PKSPKIVAHV PQTPVRPETP NRTPSAMVVE KTVKETIPVM
370 380 390 400 410 420
KPTQTPPEVV KLNIEMQPKK PVVTDKTIDD SIDAVIARAC AEREPDPFEF SSGSESEGDT
430 440 450 460 470 480
FTSPKRISGS ECATPKASTS SNNFTKSLAT PLPLSSGTSS SDNSWTMDAS IDEVVRKAKL
490 500 510 520 530 540
GAPSNMPPTF PYISSPSISP PTPEPLHKGY EEKAKLPSSV DVKKKLKKEL KTKLKKKEKQ
550 560 570 580 590 600
RDRERERERN KERSKEKDKM REREKEKEAG KELKYPWREL MKDEDSDPYK FKIKEFEDID
610 620 630 640 650 660
AAKVRLKDGI VRREREKHKD KKKDRERSKR EKDKRERERL KEKNREDKIK APPTQLVLPP
670 680 690 700 710 720
KEMALPLFSP SAVRVPAMLP AFSPMLPEKL FEEKEKPKEK ERKKDKKEKK KKKEKEKEKE
730 740 750 760 770 780
KKEREREKER REREKREKEK EKHKHEKIKV EPVIPAPSPV IPRLTLRVGA GQDKIVISKV
790 800 810 820 830 840
VPAPEAKPAP SLNRPKTPPP APVPIPVRVS PTPLQPPLLT QAAVCPALMP SPAPALSGIG
850 860 870 880 890 900
SAKAPVRSVV TETVSTYVIR DEWGNQIWIC PGCNKPDDGS PMIGCDDCDD WYHWPCVGIM
910 920 930
AAPPEEMQWF CPKCANKIKK DKKHKKRKHR AH