AiPD: Autoinhibited Protein Database

Q5VZE5

Gene name	NAA35 (EGAP, MAK10)
Protein name	N-alpha-acetyltransferase 35, NatC auxiliary subunit
Names	Embryonic growth-associated protein homolog, Protein MAK10 homolog
Species	Homo sapiens (Human)
KEGG Pathway	hsa:60560
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

520-590 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

520-590 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q5VZE5

Entry ID	Method	Resolution	Chain	Position	Source
7MX2	EM	364 A	B	1-725	PDB
7RB3	EM	310 A	B	28-725	PDB
AF-Q5VZE5-F1	Predicted				AlphaFoldDB

355 variants for Q5VZE5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA5107002 rs201727123	2	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5107003 rs770582929	5	A>P		No	ClinGen ExAC gnomAD
rs1376360183 CA374012191	6	S>Y		No	ClinGen gnomAD
CA196028038 rs148048804	10	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA374012257 rs1339684979	15	E>D		No	ClinGen gnomAD
rs760110240 CA5107008	15	E>G		No	ClinGen ExAC gnomAD
TCGA novel	15	E>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5107009 rs763748433	16	L>V		No	ClinGen ExAC TOPMed gnomAD
CA5107010 rs753435532	17	S>R		No	ClinGen ExAC gnomAD
CA196028039 rs75312270	20	E>G		No	ClinGen Ensembl
CA5107011 rs757669473	21	K>E		No	ClinGen ExAC gnomAD
TCGA novel	21	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5107013 rs750780761	22	M>I		No	ClinGen ExAC TOPMed gnomAD
CA5107012 rs779182959	22	M>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	22	M>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374012301 rs779182959	22	M>V		No	ClinGen ExAC TOPMed gnomAD
CA374012326 rs1328236099	25	S>N		No	ClinGen TOPMed
rs1587542520 COSM1625204 CA374012333	26	N>D	liver [Cosmic]	No	ClinGen cosmic curated Ensembl
CA196028040 rs909301177	26	N>S		No	ClinGen TOPMed gnomAD
rs141793339 CA5107014	28	N>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1410927580 CA374012389	34	Q>E		No	ClinGen TOPMed gnomAD
rs1434423007 CA374012397	35	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	38	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA196028041 rs972084249	38	E>D		No	ClinGen Ensembl
rs1348985667 CA374012426	39	A>T		No	ClinGen TOPMed gnomAD
rs747094178 CA5107016	41	R>G		No	ClinGen ExAC gnomAD
CA196029687 rs370006365	52	K>N		No	ClinGen ESP
CA5107067 rs752722386	63	I>V		No	ClinGen ExAC gnomAD
rs756160916 CA5107068	73	G>C		No	ClinGen ExAC gnomAD
rs577757092 CA5107070	75	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5107069 rs777879548	75	I>T		No	ClinGen ExAC TOPMed gnomAD
CA196029944 rs1052522576	76	G>*		No	ClinGen Ensembl
CA374012742 rs1396175245	80	N>D		No	ClinGen gnomAD
TCGA novel	82	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1219644995 CA374012762	83	V>I		No	ClinGen TOPMed
CA5107071 rs186312968	84	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5107073 rs374811138	85	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA196029945 rs374811138	85	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA196029946 rs1027964774	87	E>K		No	ClinGen Ensembl
TCGA novel	89	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs867549458 CA196029947	90	I>M		No	ClinGen Ensembl
CA5107074 rs768650366	90	I>V		No	ClinGen ExAC gnomAD
CA5107075 rs781120262	91	K>E		No	ClinGen ExAC gnomAD
CA374012816 rs1210796653	91	K>R		No	ClinGen gnomAD
rs532785405 CA5107096	92	D>G		No	ClinGen 1000Genomes ExAC gnomAD
CA5107097 rs781017755	93	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1473769434 CA374012850	94	T>I		No	ClinGen TOPMed gnomAD
rs1473769434 CA374012849	94	T>S		No	ClinGen TOPMed gnomAD
TCGA novel	95	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374012859 rs1175789443	96	K>E		No	ClinGen gnomAD
rs369617303 CA5107098	97	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1433370143 CA374012870	97	I>T		No	ClinGen gnomAD
CA374012885 rs1177818091 COSM487628	99	D>A	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	99	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5107099 rs769588153	101	T>I		No	ClinGen ExAC gnomAD
rs1169371539 CA374012908	103	P>S		No	ClinGen gnomAD
rs1407932954 CA374012927	106	I>T		No	ClinGen gnomAD
CA5107101 rs150816044	106	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1587573803 CA374012936	107	G>V		No	ClinGen Ensembl
CA5107102 rs374479341	109	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA374012966 rs1220015376	112	C>S		No	ClinGen gnomAD
CA5107105 rs41283649	116	L>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5107104 rs41283649	116	L>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1110740 rs144270495 CA5107121	118	T>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA5107124 rs775977172	123	H>Y		No	ClinGen ExAC gnomAD
TCGA novel	124	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA196030339 rs1039079430	127	Q>R		No	ClinGen gnomAD
CA196030340 COSM197759 rs773291296	131	T>M	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA5107129 rs765264658	133	L>P		No	ClinGen ExAC gnomAD
rs140125010 CA5107130	135	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1440385653 CA374013144	136	H>R		No	ClinGen gnomAD
rs267602297 CA196030341	136	H>Y		No	ClinGen Ensembl
TCGA novel	138	P>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374013162 rs1321522157	139	D>H		No	ClinGen gnomAD
CA5107132 rs766499285	141	I>M		No	ClinGen ExAC gnomAD
rs1230527682 CA374013203	144	P>L		No	ClinGen gnomAD
CA5107134 rs371200239	144	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA196030342 rs759509980	145	A>T		No	ClinGen Ensembl
rs149812553 CA374013209	146	M>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5107135 rs149812553	146	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA196030344 rs1021831791	150	A>V		No	ClinGen Ensembl
CA374013247 rs1196112294	151	L>P		No	ClinGen TOPMed
rs753785955 CA5107136	153	I>V		No	ClinGen ExAC gnomAD
CA374013292 rs1421179110	158	D>H		No	ClinGen gnomAD
CA5107139 rs374901096	160	A>S		No	ClinGen ESP ExAC gnomAD
CA374013306 rs374901096	160	A>T		No	ClinGen ESP ExAC gnomAD
CA374013394 rs1473714235	172	E>G		No	ClinGen gnomAD
rs201748422 CA5107183	178	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA374013472 rs372488081	180	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA196031904 rs931510949	183	K>Q		No	ClinGen TOPMed
CA374013505 rs1253824838	185	A>S		No	ClinGen TOPMed
CA196031905 rs1048515551	185	A>V		No	ClinGen TOPMed
CA5107185 rs751063091	186	N>S		No	ClinGen ExAC gnomAD
CA196031906 rs906143601	187	S>G		No	ClinGen TOPMed
CA196031907 rs200590081	187	S>I		No	ClinGen 1000Genomes TOPMed
rs907711874 CA196031908	190	D>H		No	ClinGen Ensembl
TCGA novel	190	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	196	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	199	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1564300679 CA374013668	207	R>I		No	ClinGen Ensembl
TCGA novel	209	K>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	212	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374013760 rs1564301637	219	R>G		No	ClinGen Ensembl
CA374013770 rs1474521915	220	D>G		No	ClinGen gnomAD
CA196032065 rs909755126	222	E>Q		No	ClinGen TOPMed
CA374013788 rs1179193080	223	V>I		No	ClinGen TOPMed
rs377076239 CA196032134	228	Q>E		No	ClinGen ESP
rs1481849782 CA374013848	229	Q>H		No	ClinGen gnomAD
TCGA novel	232	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5107226 rs760373850	234	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1249457935 CA374013885	235	S>G		No	ClinGen gnomAD
rs201019890 CA5107227	235	S>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	238	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	239	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374013934 rs1392754201 CA374013933	242	V>L		No	ClinGen TOPMed gnomAD
rs1392754201 CA374013932	242	V>M		No	ClinGen TOPMed gnomAD
CA5107229 rs200371490	245	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5107230 rs765683563	248	I>V		No	ClinGen ExAC gnomAD
CA374013978 rs1446369131	249	A>V		No	ClinGen gnomAD
rs1372799082 CA374013980	250	F>I		No	ClinGen gnomAD
CA374013987 rs1241369564	251	T>P		No	ClinGen TOPMed
rs1222360856	255	T>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760165501 CA5107244	258	V>I		No	ClinGen ExAC gnomAD
CA5107245 rs760165501	258	V>L		No	ClinGen ExAC gnomAD
CA5107246 rs776297747	259	A>G		No	ClinGen ExAC TOPMed gnomAD
CA373929526 rs1215139066	259	A>T		No	ClinGen gnomAD
CA5107248 rs368919696	261	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	263	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5107249 rs750796057	264	L>W		No	ClinGen ExAC gnomAD
rs763613794 CA5107250	265	M>V		No	ClinGen ExAC gnomAD
rs751698413 CA5107252	269	A>V		No	ClinGen ExAC gnomAD
CA5107254 rs781294752	270	D>G		No	ClinGen ExAC gnomAD
TCGA novel CA373929860 rs1587607891	270	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
CA373929906 rs1564302692	271	L>H		No	ClinGen Ensembl
TCGA novel	272	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5107255 rs147227765	273	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA195491285 rs201778443	274	A>V		No	ClinGen TOPMed gnomAD
CA195491293 rs966706045	275	I>T		No	ClinGen Ensembl
CA373929980 rs1380913352	275	I>V		No	ClinGen TOPMed
CA373930021 rs1369261710	276	H>R		No	ClinGen TOPMed
TCGA novel	279	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5107257 rs201461279	279	L>S		No	ClinGen 1000Genomes ExAC gnomAD
rs978515280 CA195491337	280	H>D		No	ClinGen Ensembl
CA373930128 rs1429207032	280	H>P		No	ClinGen gnomAD
CA373930137 rs1270165452	280	H>Q		No	ClinGen gnomAD
rs1429207032 CA373930129	280	H>R		No	ClinGen gnomAD
rs978515280 CA373930125	280	H>Y		No	ClinGen Ensembl
TCGA novel	281	H>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745654883 CA5107258	281	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1294728639 CA373930200	283	I>V		No	ClinGen gnomAD
CA373930227 rs1235591820	284	Q>R		No	ClinGen TOPMed gnomAD
rs1291836069 CA373930273	285	A>V		No	ClinGen gnomAD
rs150925033 CA5107259	286	Q>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	288	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373930348 rs1205379353	289	T>A		No	ClinGen gnomAD
CA195491364 rs939258797	290	T>A		No	ClinGen Ensembl
CA373933894 rs1477466983	293	D>V		No	ClinGen gnomAD
CA5107303 rs755639844	294	H>D		No	ClinGen ExAC TOPMed gnomAD
CA373933902 rs1274104523	294	H>Q		No	ClinGen gnomAD
rs141991899 CA5107304	296	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5107305 rs748991357	298	M>I		No	ClinGen ExAC gnomAD
rs1280467212 CA373933971	304	V>A		No	ClinGen TOPMed
rs1196022308 CA373933986	306	Q>R		No	ClinGen gnomAD
rs1348192210 CA373934038	314	P>H		No	ClinGen TOPMed
rs973931955 CA195506987	315	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1414798985 CA373934059	318	K>E		No	ClinGen TOPMed
CA5107309 rs772643338	319	I>V		No	ClinGen ExAC gnomAD
CA195507044 rs910221060	322	R>G		No	ClinGen Ensembl
rs1292395648 CA373934092	322	R>S		No	ClinGen TOPMed gnomAD
rs760774532 CA5107311	326	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1408491461 CA373934136	328	Y>C		No	ClinGen TOPMed
rs200918536 CA5107312	334	D>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	334	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373934190 rs1339583336	336	I>V		No	ClinGen gnomAD
CA5107313 rs776668929	338	T>S		No	ClinGen ExAC gnomAD
CA373934213 rs1469828383	339	V>A		No	ClinGen TOPMed
rs1409944750 CA373934216	340	C>R		No	ClinGen TOPMed
CA373934229 rs1242915293	341	E>D		No	ClinGen gnomAD
rs1337179415 CA373934223	341	E>K		No	ClinGen gnomAD
rs765375299 CA5107315	342	V>A		No	ClinGen ExAC gnomAD
rs928421958 CA195507076	342	V>I		No	ClinGen TOPMed
rs751374102 CA5107316	343	V>L		No	ClinGen ExAC TOPMed gnomAD
rs751374102 CA373934235	343	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1208687656 CA373934281	349	H>R		No	ClinGen TOPMed
CA5107319 rs532139527	352	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs760758863 CA5107339	356	C>Y		No	ClinGen ExAC gnomAD
CA373934569 rs1374236376	358	F>V		No	ClinGen gnomAD
CA195512346 rs977506062	365	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1235625552 CA373934632	366	L>F		No	ClinGen gnomAD
CA5107344 rs760888314	368	R>S		No	ClinGen ExAC gnomAD
CA373934682 rs1564319473	370	L>V		No	ClinGen Ensembl
rs1434612844 CA373934712	372	Q>P		No	ClinGen TOPMed
CA373935858 rs1244504344	374	T>A		No	ClinGen gnomAD
CA5107361 rs761778458	375	F>L		No	ClinGen ExAC gnomAD
rs145858134 CA5107360	375	F>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	377	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1169713270 CA373935882	378	D>H		No	ClinGen gnomAD
rs1403321234 CA373935901	380	K>R		No	ClinGen TOPMed
CA5107364 COSM487629 rs758052966	385	T>A	kidney [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA373935937 rs1325553662	385	T>I		No	ClinGen gnomAD
CA373935954 rs1362628040	388	M>L		No	ClinGen gnomAD
CA5107366 rs751936215	391	M>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	393	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1364512196 CA373935999	394	D>N		No	ClinGen gnomAD
rs927859010 CA195514864	394	D>V		No	ClinGen TOPMed
rs1217118223 CA373936014	396	L>F		No	ClinGen gnomAD
CA5107369 rs748647154	397	R>Q		No	ClinGen ExAC gnomAD
CA5107368 rs368206549	397	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA5107370 rs756626893	398	S>A		No	ClinGen ExAC TOPMed gnomAD
CA5107371 rs777775451	398	S>C		No	ClinGen ExAC gnomAD
rs1243833302 CA373936040	401	S>G		No	ClinGen gnomAD
rs1487270946 CA373936048	402	P>S		No	ClinGen gnomAD
CA373936058 rs1192617459	403	P>L		No	ClinGen gnomAD
CA195514898 rs906608648	407	P>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA5107374 rs774661421	408	K>R		No	ClinGen ExAC gnomAD
rs1486569564 CA373936108	409	C>W		No	ClinGen gnomAD
CA373936110 rs1189868314	410	Y>H		No	ClinGen gnomAD
CA5107389 rs753094969	411	L>I		No	ClinGen ExAC gnomAD
CA5107390 rs756649494	412	Y>C		No	ClinGen ExAC gnomAD
rs1177807938 CA373936136	414	N>H		No	ClinGen gnomAD
rs1200869917 CA373936142	414	N>K		No	ClinGen TOPMed
CA5107391 COSM1463414 rs559244542	417	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA373936209 rs1350969113	420	C>F		No	ClinGen gnomAD
rs369185828 CA373936234	422	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs369185828 CA5107394	422	D>N	Variant assessed as Somatic; 0.0001848 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA5107395 rs746141069	423	S>F		No	ClinGen ExAC gnomAD
rs150339845 CA5107396	424	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA195516513 rs912376290	425	V>I		No	ClinGen TOPMed gnomAD
CA373936361 rs773153171	430	R>P		No	ClinGen ExAC TOPMed gnomAD
rs773153171 CA5107400	430	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs138043991 COSM1463415 CA5107398	430	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1418041090 CA373937769	432	F>L		No	ClinGen gnomAD
rs769593258 CA373937810	433	C>W		No	ClinGen ExAC gnomAD
CA373937854 rs1295024064	435	L>V		No	ClinGen TOPMed
CA5107421 rs777400340	438	I>N		No	ClinGen ExAC gnomAD
CA373938097 rs1377421765	444	A>T		No	ClinGen gnomAD
TCGA novel	444	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5107423 rs770844217	447	R>K		No	ClinGen ExAC gnomAD
rs1375802073 CA373938197	448	D>E		No	ClinGen gnomAD
rs773922665 CA195524355	449	K>N		No	ClinGen ExAC TOPMed gnomAD
CA5107425 rs758983734	451	G>C		No	ClinGen ExAC gnomAD
CA195524363 rs1037012998	453	I>T		No	ClinGen Ensembl
TCGA novel	455	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5107426 rs771731209	458	A>T		No	ClinGen ExAC gnomAD
rs866159273 CA195524371	458	A>V		No	ClinGen Ensembl
rs200547619 CA195524386	462	D>N		No	ClinGen 1000Genomes
rs760431639 CA5107447	466	K>R		No	ClinGen ExAC gnomAD
rs774561710 CA195524685	467	V>F		No	ClinGen Ensembl
rs768187404 CA5107448	469	A>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	469	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs987736995 CA195524698	470	A>V		No	ClinGen gnomAD
CA5107450 rs376370532	474	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs112636800 CA195524704	477	K>T		No	ClinGen Ensembl
rs761826871 CA195524712	483	Q>H		No	ClinGen TOPMed gnomAD
rs773815159 CA5107452	483	Q>R		No	ClinGen ExAC gnomAD
rs1228602961 CA373938819	485	L>S		No	ClinGen TOPMed
CA373938865 rs1363874532	487	C>F		No	ClinGen TOPMed
TCGA novel	490	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373938960 rs1202483021	492	V>L		No	ClinGen gnomAD
CA195524716 COSM3433324 rs1053906232	498	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA5107454 COSM1110745 rs766530749	498	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA5107456 rs755296908	499	I>T		No	ClinGen ExAC gnomAD
CA373939123 rs1156849814	499	I>V		No	ClinGen gnomAD
CA373939199 rs1456209990	502	Q>R		No	ClinGen TOPMed
CA373939384 rs1170750392	511	E>K		No	ClinGen TOPMed
CA373939452 rs1240077060	513	Y>C		No	ClinGen gnomAD
rs753649635 CA5107458	515	M>I		No	ClinGen ExAC gnomAD
CA373939476 rs1304380499	515	M>L		No	ClinGen gnomAD
TCGA novel	519	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	524	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1458815651 CA373940370	527	E>K		No	ClinGen gnomAD
rs1458815651 CA373940373	527	E>Q		No	ClinGen gnomAD
rs557691690 CA373940427	531	A>P		No	ClinGen ExAC TOPMed gnomAD
rs557691690 CA5107477	531	A>T		No	ClinGen ExAC TOPMed gnomAD
CA5107481 rs779797378	539	R>C		No	ClinGen ExAC TOPMed gnomAD
CA373940522 rs779797378	539	R>G		No	ClinGen ExAC TOPMed gnomAD
rs761127695 CA5107483	541	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	544	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	549	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373940647 rs1399709820	549	R>S		No	ClinGen gnomAD
rs1437801735 CA373940755	558	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA373940762 rs1295860760	559	S>G		No	ClinGen gnomAD
CA5107484 rs780818669	560	S>N		No	ClinGen ExAC gnomAD
rs148208830 CA195526056 COSM106864	563	T>K	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	563	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	564	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770577267	567	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs529676661 CA5107488	567	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs766371180 CA5107501	570	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1241675206 CA373940998	573	S>N		No	ClinGen gnomAD
rs1311636717 CA373941007	574	R>G		No	ClinGen TOPMed
rs1240962246 CA373941029	576	I>V		No	ClinGen TOPMed
rs1329837849 CA373941052	578	M>R		No	ClinGen TOPMed
CA195526605 rs969888381	578	M>V		No	ClinGen TOPMed gnomAD
CA373941176 rs1302603829	587	A>G		No	ClinGen TOPMed
rs751357555 CA5107521	597	D>H		No	ClinGen ExAC TOPMed gnomAD
CA373941337 rs1478049544	597	D>V		No	ClinGen gnomAD
rs759615890 CA5107522	598	M>I		No	ClinGen ExAC gnomAD
CA5107524 rs113466696	599	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs755639991 CA5107525	600	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1421464565 CA373941386	601	K>N		No	ClinGen TOPMed gnomAD
CA5107527 rs141080071	603	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756918123 CA5107528	603	R>H		No	ClinGen ExAC TOPMed gnomAD
CA373941401 rs141080071	603	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	604	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779209602 CA5107529	605	P>L		No	ClinGen ExAC TOPMed gnomAD
CA195526932 rs771344254	609	L>F		No	ClinGen Ensembl
CA5107531 rs201797022	611	S>R		No	ClinGen ExAC TOPMed gnomAD
CA195526938 rs886282097	613	Q>R		No	ClinGen Ensembl
rs1587671959 CA373941554	615	R>Q		No	ClinGen Ensembl
CA5107533 rs747121540	624	N>D		No	ClinGen ExAC gnomAD
CA5107534 rs370126583	624	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA373941701 rs1171190839	627	M>I		No	ClinGen TOPMed gnomAD
CA5107535 rs776750225	628	T>P		No	ClinGen ExAC gnomAD
rs776821188 CA5107539 COSM1463420	630	P>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	633	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1291494797 CA373942510	639	E>G		No	ClinGen gnomAD
CA5107561 rs776016210	642	D>E		No	ClinGen ExAC gnomAD
rs142358554 CA5107562	646	Y>C		No	ClinGen ESP ExAC gnomAD
TCGA novel	647	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM487630 CA195527162 rs995902177	648	P>L	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1165455353 CA373942574	648	P>S		No	ClinGen gnomAD
CA195527167 rs113767428	650	P>T		No	ClinGen Ensembl
rs1471752424 CA373942602	652	S>F		No	ClinGen gnomAD
rs150870092 CA5107564	653	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA195527172 rs150870092	653	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA195527179 rs903528634	654	E>Q		No	ClinGen Ensembl
CA5107565 rs758023664	654	E>V		No	ClinGen ExAC gnomAD
rs766787456 CA373942614	655	L>M		No	ClinGen ExAC TOPMed gnomAD
rs1162265822 CA373942653	661	K>E		No	ClinGen gnomAD
rs751917730 CA5107567	661	K>R		No	ClinGen ExAC gnomAD
CA373942655 rs751917730	661	K>T		No	ClinGen ExAC gnomAD
rs956389575 CA195527208	672	N>S		No	ClinGen gnomAD
rs185346638 CA5107569	676	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5107570 rs752744872	676	P>L		No	ClinGen ExAC gnomAD
rs749574848 CA5107573	678	H>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5107575 rs779996526	678	H>R		No	ClinGen ExAC TOPMed gnomAD
rs749574848 CA5107574	678	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1202430388 CA373942800	680	V>I		No	ClinGen gnomAD
rs201988672 CA195528596	685	K>E		No	ClinGen 1000Genomes
TCGA novel	694	M>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5107588 rs767944019	694	M>V		No	ClinGen ExAC gnomAD
TCGA novel	700	G>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1379544674 CA373942945	701	H>D		No	ClinGen gnomAD
CA373942968 rs1260734622	704	E>K		No	ClinGen gnomAD
rs1299485273 CA373942985	706	K>R		No	ClinGen TOPMed
CA5107612 rs201363050	707	V>F		No	ClinGen ExAC TOPMed gnomAD
CA373943002 rs201363050	707	V>I		No	ClinGen ExAC TOPMed gnomAD
CA5107613 rs764687730	712	D>H		No	ClinGen ExAC gnomAD
TCGA novel	713	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1212254253 CA373943063	716	H>Y		No	ClinGen gnomAD
rs1271702483 CA373943073	717	K>T		No	ClinGen gnomAD
CA373943100 rs1343407875	721	V>I		No	ClinGen TOPMed
rs1039677307 CA195529195	723	K>Q		No	ClinGen Ensembl
rs757383749 CA5107615	725	V>A		No	ClinGen ExAC gnomAD

No associated diseases with Q5VZE5

No regional properties for Q5VZE5

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q5VZE5

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
NatC complex	A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name	Definition
N-terminal peptidyl-methionine acetylation	The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine.
N-terminal protein amino acid acetylation	The acetylation of the N-terminal amino acid of proteins.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
smooth muscle cell proliferation	The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q02197	MAK10	N-alpha-acetyltransferase 35, NatC auxiliary subunit	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q9W1A2	Naa35	N-alpha-acetyltransferase 35, NatC auxiliary subunit homolog	Drosophila melanogaster (Fruit fly)	PR

10	20	30	40	50	60
MVMKASVDDD	DSGWELSMPE	KMEKSNTNWV	DITQDFEEAC	RELKLGELLH	DKLFGLFEAM
70	80	90	100	110	120
SAIEMMDPKM	DAGMIGNQVN	RKVLNFEQAI	KDGTIKIKDL	TLPELIGIMD	TCFCCLITWL
130	140	150	160	170	180
EGHSLAQTVF	TCLYIHNPDF	IEDPAMKAFA	LGILKICDIA	REKVNKAAVF	EEEDFQSMTY
190	200	210	220	230	240
GFKMANSVTD	LRVTGMLKDV	EDDMQRRVKS	TRSRQGEERD	PEVELEHQQC	LAVFSRVKFT
250	260	270	280	290	300
RVLLTVLIAF	TKKETSAVAE	AQKLMVQAAD	LLSAIHNSLH	HGIQAQNDTT	KGDHPIMMGF
310	320	330	340	350	360
EPLVNQRLLP	PTFPRYAKII	KREEMVNYFA	RLIDRIKTVC	EVVNLTNLHC	ILDFFCEFSE
370	380	390	400	410	420
QSPCVLSRSL	LQTTFLVDNK	KVFGTHLMQD	MVKDALRSFV	SPPVLSPKCY	LYNNHQAKDC
430	440	450	460	470	480
IDSFVTHCVR	PFCSLIQIHG	HNRARQRDKL	GHILEEFATL	QDEAEKVDAA	LHTMLLKQEP
490	500	510	520	530	540
QRQHLACLGT	WVLYHNLRIM	IQYLLSGFEL	ELYSMHEYYY	IYWYLSEFLY	AWLMSTLSRA
550	560	570	580	590	600
DGSQMAEERI	MEEQQKGRSS	KKTKKKKKVR	PLSREITMSQ	AYQNMCAGMF	KTMVAFDMDG
610	620	630	640	650	660
KVRKPKFELD	SEQVRYEHRF	APFNSVMTPP	PVHYLQFKEM	SDLNKYSPPP	QSPELYVAAS
670	680	690	700	710	720
KHFQQAKMIL	ENIPNPDHEV	NRILKVAKPN	FVVMKLLAGG	HKKESKVPPE	FDFSAHKYFP

VVKLV