AiPD: Autoinhibited Protein Database

Q5VYS4

Gene name	MEDAG (AWMS3, C13orf33, MEDA4)
Protein name	Mesenteric estrogen-dependent adipogenesis protein
Names	Activated in W/Wv mouse stomach 3 homolog, hAWMS3, Mesenteric estrogen-dependent adipose 4, MEDA-4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:84935
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-46 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q5VYS4

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q5VYS4-F1	Predicted				AlphaFoldDB

304 variants for Q5VYS4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA387818393 rs964921245	2	A>E		No	ClinGen gnomAD
rs964921245 CA247889754	2	A>G		No	ClinGen gnomAD
rs776591666 CA6934906	2	A>T		No	ClinGen ExAC gnomAD
CA6934908 rs759626056	3	G>A		No	ClinGen ExAC TOPMed gnomAD
rs759626056 CA6934907	3	G>E		No	ClinGen ExAC TOPMed gnomAD
CA387818396 rs1234686895	3	G>R		No	ClinGen gnomAD
CA6934910 rs761746695	4	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1466292541 CA387818400	4	A>T		No	ClinGen gnomAD
rs761746695 CA387818404	4	A>V		No	ClinGen ExAC TOPMed gnomAD
rs750189432 CA6934912	5	A>G		No	ClinGen ExAC TOPMed gnomAD
CA247889755 rs750189432	5	A>V		No	ClinGen ExAC TOPMed gnomAD
rs200214346 CA6934913	6	C>W		No	ClinGen ExAC gnomAD
CA6934914 rs765998379	7	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA387818428 rs1203343233	8	P>L		No	ClinGen TOPMed
rs1203343233 CA387818427	8	P>R		No	ClinGen TOPMed
rs753349582 CA6934915	9	V>G		No	ClinGen ExAC gnomAD
CA387818439 rs1438066911	10	A>D		No	ClinGen gnomAD
rs1221416232 CA387818434	10	A>T		No	ClinGen TOPMed
CA387818450 rs1277004267	12	P>L		No	ClinGen gnomAD
CA6934918 rs748624460	12	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1224684966 CA387818453	13	S>C		No	ClinGen TOPMed
rs758899551 CA6934919	13	S>N		No	ClinGen ExAC TOPMed gnomAD
CA6934920 rs778021784	18	S>*		No	ClinGen ExAC TOPMed gnomAD
CA387818486 rs778021784	18	S>L		No	ClinGen ExAC TOPMed gnomAD
CA6934921 rs778021784	18	S>W		No	ClinGen ExAC TOPMed gnomAD
rs1056580047 CA247889758	19	S>F		No	ClinGen TOPMed
rs1231006195 CA387818494	20	G>E		No	ClinGen gnomAD
rs771067374 CA6934922	20	G>R		No	ClinGen ExAC gnomAD
TCGA novel	20	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1469422752 CA387818497	21	E>K		No	ClinGen gnomAD
rs776912049 CA387818506	22	L>F		No	ClinGen ExAC TOPMed gnomAD
CA6934923 rs776912049	22	L>V		No	ClinGen ExAC TOPMed gnomAD
rs71436423 CA6934924	23	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6934925 rs199670958	25	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1163609052 CA387818526	25	L>P		No	ClinGen gnomAD
rs1390775495 CA387818533	26	W>*		No	ClinGen gnomAD
CA387818530 rs1337045637	26	W>*		No	ClinGen gnomAD
CA6934926 rs774468841	28	C>R		No	ClinGen ExAC TOPMed gnomAD
CA387818546 rs1326417936	28	C>Y		No	ClinGen gnomAD
rs761869378 CA6934927	30	C>*		No	ClinGen ExAC TOPMed gnomAD
CA387818557 rs1593501069	30	C>S		No	ClinGen Ensembl
rs904771005 CA247889759	31	E>A		No	ClinGen TOPMed
rs767436094 CA6934928	31	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA387818586 rs760451601	35	L>M		No	ClinGen ExAC gnomAD
CA387818596 rs1269629919	36	P>L		No	ClinGen TOPMed
rs1211910883 CA387818601	37	L>P		No	ClinGen TOPMed gnomAD
CA247889760 rs1044282570	38	A>V		No	ClinGen Ensembl
CA387818608 rs1271138248	39	Q>E		No	ClinGen TOPMed gnomAD
rs1482812307 CA387818611	39	Q>R		No	ClinGen gnomAD
CA387818626 rs759088171	42	R>C		No	ClinGen ExAC gnomAD
CA6934933 rs759088171	42	R>S		No	ClinGen ExAC gnomAD
rs764760167 CA6934934	43	L>P		No	ClinGen ExAC TOPMed gnomAD
rs752155046 CA387818646	45	P>L		No	ClinGen ExAC gnomAD
rs752155046 CA6934935	45	P>R		No	ClinGen ExAC gnomAD
CA387818648 rs1187097973	46	G>R		No	ClinGen TOPMed gnomAD
CA387818647 rs1187097973	46	G>S		No	ClinGen TOPMed gnomAD
rs758844060 CA387818665	48	F>L		No	ClinGen ExAC gnomAD
CA387818668 rs778279697	49	Q>*		No	ClinGen ExAC gnomAD
CA6934937 rs778279697	49	Q>E		No	ClinGen ExAC gnomAD
CA6934938 rs751939702	50	L>M		No	ClinGen ExAC gnomAD
rs757630646 CA6934939	51	S>G		No	ClinGen ExAC gnomAD
rs1376906195 CA387818687	52	G>C		No	ClinGen TOPMed gnomAD
CA387818686 rs1376906195	52	G>R		No	ClinGen TOPMed gnomAD
TCGA novel	52	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6934942 rs770099315	53	D>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	53	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6934940 rs200311232	53	D>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6934941 rs200311232	53	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA247889761 rs1047640126	54	Q>H		No	ClinGen Ensembl
CA6934943 rs780299554	54	Q>L		No	ClinGen ExAC gnomAD
rs1341210773 CA387818704	55	L>F		No	ClinGen gnomAD
rs749327526 CA6934944	56	V>L		No	ClinGen ExAC TOPMed gnomAD
rs749327526 CA387818708	56	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1206087428 CA387818720	58	A>S		No	ClinGen gnomAD
CA6934945 rs9531945 VAR_030261	59	R>G		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1199858439 CA387818728	59	R>T		No	ClinGen gnomAD
CA387818725 rs9531945	59	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773196246 CA6934946	60	P>A		No	ClinGen ExAC gnomAD
rs1425419597 CA387818735	60	P>L		No	ClinGen gnomAD
rs760442815 CA6934947 CA6934948	61	G>R		No	ClinGen ExAC TOPMed gnomAD
CA6934949 rs776372402	62	E>*		No	ClinGen ExAC gnomAD
rs764811845 CA6934951	62	E>G		No	ClinGen ExAC gnomAD
CA6934950 rs776372402	62	E>K		No	ClinGen ExAC gnomAD
CA387818745 rs1438427115	63	P>T		No	ClinGen TOPMed gnomAD
CA387818755 rs1263989582	64	A>G		No	ClinGen TOPMed
rs1263989582 CA387818756	64	A>V		No	ClinGen TOPMed
rs752208437 CA6934952	65	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
COSM1198039 rs1037808910 CA247889764	66	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
CA387818768 rs1566124350	67	R>W		No	ClinGen Ensembl
CA387818775 rs1316348116	68	G>E		No	ClinGen gnomAD
rs764571813 CA6934957	68	G>R		No	ClinGen ExAC TOPMed gnomAD
CA6934956 rs764571813	68	G>W		No	ClinGen ExAC TOPMed gnomAD
rs964600358 CA247889765	69	G>A		No	ClinGen TOPMed
rs745558596	69	G>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs964600358 CA387818778	69	G>D		No	ClinGen TOPMed
rs781711508 CA6934959	69	G>S		No	ClinGen ExAC gnomAD
CA387818793 rs756415719	71	N>K		No	ClinGen ExAC gnomAD
rs750765307 CA6934960	71	N>S		No	ClinGen ExAC TOPMed gnomAD
CA387818795 rs552682755	72	V>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs552682755 CA6934962	72	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA247889766 rs954836649	74	G>D		No	ClinGen Ensembl
CA6934963 rs749394457	75	D>E		No	ClinGen ExAC gnomAD
CA247889767 rs999737739	75	D>V		No	ClinGen TOPMed gnomAD
rs564558992 CA6934964	76	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA387818820 rs564558992	76	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs564558992 CA387818819	76	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA247889769 rs955749627	78	V>E		No	ClinGen TOPMed gnomAD
rs1031639600 CA247889768	78	V>L		No	ClinGen TOPMed gnomAD
rs1031639600 CA387818830	78	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA247889770 rs777619751	79	R>C		No	ClinGen ExAC TOPMed gnomAD
rs746999388 CA387818835	79	R>H		No	ClinGen ExAC TOPMed gnomAD
rs746999388 CA387818836	79	R>L		No	ClinGen ExAC TOPMed gnomAD
rs746999388 CA6934966	79	R>P		No	ClinGen ExAC TOPMed gnomAD
CA6934965 rs777619751	79	R>S		No	ClinGen ExAC TOPMed gnomAD
rs199746106 CA247889771	81	D>H		No	ClinGen 1000Genomes gnomAD
CA387818854 rs1287608706	82	G>E		No	ClinGen gnomAD
CA387818850 rs868081002	82	G>R		No	ClinGen TOPMed gnomAD
rs868081002 CA247889772	82	G>W		No	ClinGen TOPMed gnomAD
CA6934970 rs769506777	87	L>V		No	ClinGen ExAC gnomAD
CA387818908 rs1332938649	90	Y>C		No	ClinGen TOPMed gnomAD
rs1386379216 CA387818919	92	K>Q		No	ClinGen gnomAD
CA387818930 rs1301758239	93	R>K		No	ClinGen gnomAD
CA247385414 rs921517854	94	Y>H		No	ClinGen TOPMed
rs1221919868 CA387697533	96	E>Q		No	ClinGen gnomAD
rs1266840140 CA387697563	100	Y>C		No	ClinGen gnomAD
rs371697036 CA6934991	101	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA387697575 rs1180488971	102	D>H		No	ClinGen gnomAD
rs1251485173 CA387697594	104	K>R		No	ClinGen gnomAD
rs1184932153 CA387697604	105	D>E		No	ClinGen gnomAD
rs773922479 CA6934992	105	D>N		No	ClinGen ExAC TOPMed gnomAD
rs761335981 CA6934993	106	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs768204734 CA6934994	107	R>K		No	ClinGen ExAC gnomAD
TCGA novel	108	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs150419121 CA247385421	109	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs150419121 CA6934995	109	T>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA247385425 rs200213117	110	I>M		No	ClinGen gnomAD
rs140189386 CA6934997	110	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1411635739 CA387697637	111	L>*		No	ClinGen gnomAD
rs951032321 CA247385427	114	P>A		No	ClinGen TOPMed gnomAD
CA6934998 rs754103414	114	P>L		No	ClinGen ExAC TOPMed gnomAD
rs951032321 CA387697659	114	P>T		No	ClinGen TOPMed gnomAD
CA387697676 rs1566127745	116	L>W		No	ClinGen Ensembl
rs755243659 CA6934999	117	F>L		No	ClinGen ExAC gnomAD
CA6935002 rs765309979	123	T>I		No	ClinGen ExAC TOPMed gnomAD
CA387697738 rs1483574502	125	K>E		No	ClinGen gnomAD
rs1418142218	126	D>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1186854344 CA387697745	126	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1004262664 CA247385436	127	T>N		No	ClinGen Ensembl
rs759814885 CA6935019	130	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1236229765 CA387697772	130	E>K		No	ClinGen gnomAD
CA6935021 rs138327988	132	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs138327988 CA6935020	132	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6935024 rs751592813	134	A>T		No	ClinGen ExAC gnomAD
rs142057013 CA6935025	134	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	135	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6935027 rs753728863	135	F>L		No	ClinGen ExAC gnomAD
CA6935028 rs754712447	138	N>I		No	ClinGen ExAC gnomAD
rs754712447 CA387698213	138	N>S		No	ClinGen ExAC gnomAD
CA6935029 rs189649245	139	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1220367790 CA387698222	140	R>G		No	ClinGen TOPMed gnomAD
CA387698228 rs1297399843	140	R>S		No	ClinGen Ensembl
CA6935031 rs771810248	144	I>V		No	ClinGen ExAC TOPMed gnomAD
rs777439221 CA6935032	145	R>G		No	ClinGen ExAC gnomAD
CA247386197 rs376611703	148	I>T		No	ClinGen ESP gnomAD
CA6935035 rs771537830	151	G>R		No	ClinGen ExAC gnomAD
rs776992738 CA6935037	153	D>A		No	ClinGen ExAC
CA6935039 rs770026402 CA6935040	154	M>I		No	ClinGen ExAC TOPMed gnomAD
rs759998015 CA6935038	154	M>T		No	ClinGen ExAC TOPMed gnomAD
CA387698339 rs1456590434	156	I>M		No	ClinGen TOPMed gnomAD
CA387698337 rs1409672991	156	I>T		No	ClinGen gnomAD
rs1566129066 COSM1740031 CA387698345	157	S>F	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated Ensembl
CA6935041 rs146990093	160	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA6935043 rs147606667	165	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
COSM946645 CA6935042 rs764239466	165	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1250857863 CA387698399	166	L>F		No	ClinGen TOPMed
TCGA novel CA387698409 rs1194708488	167	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen TOPMed
rs759414279 CA387698425	168	F>S		No	ClinGen ExAC TOPMed gnomAD
CA6935065 rs773303281	168	F>V		No	ClinGen ExAC gnomAD
CA6935066 rs759414279	168	F>Y		No	ClinGen ExAC TOPMed gnomAD
CA387698466 rs1411054074	174	V>M		No	ClinGen TOPMed gnomAD
CA387698484 rs1440568514	176	N>S		No	ClinGen gnomAD
rs1186253212 CA387698493	177	F>S		No	ClinGen gnomAD
rs765200612 CA6935067	179	P>L		No	ClinGen ExAC gnomAD
CA6935069 rs758256977	180	P>A		No	ClinGen ExAC
rs377025280 CA247386298	180	P>Q		No	ClinGen ESP gnomAD
rs1368498416	180	P>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	181	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6935075 rs780594359	187	G>R		No	ClinGen ExAC gnomAD
rs1356885842 CA387698655	191	S>N		No	ClinGen TOPMed
COSM1322918 rs745329303 CA6935076	191	S>R	ovary [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA6935077 rs756580451	193	A>S		No	ClinGen ExAC TOPMed gnomAD
CA6935079 rs749708186	195	E>*		No	ClinGen ExAC gnomAD
rs768983578 CA6935080	198	A>T		No	ClinGen ExAC gnomAD
CA387698782 rs1342822173	200	A>E		No	ClinGen gnomAD
CA387698828 rs1166707987	204	F>I		No	ClinGen TOPMed
rs774594489 CA6935081	204	F>L		No	ClinGen ExAC gnomAD
CA6935082 rs150178788	206	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA387698881 rs1186357568	208	F>L		No	ClinGen TOPMed gnomAD
CA387698882 rs1186357568	208	F>V		No	ClinGen TOPMed gnomAD
CA387698898 rs1449640706	209	G>W		No	ClinGen gnomAD
rs773177464 CA6935084	212	N>H		No	ClinGen ExAC gnomAD
rs147350400 CA6935085	213	S>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6935088 rs762883125	214	V>A		No	ClinGen ExAC gnomAD
rs149352249 CA387698962	214	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6935087 rs149352249	214	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs374109967 CA6935089	215	V>A		No	ClinGen ESP ExAC gnomAD
CA387698969 rs1566129358	215	V>I		No	ClinGen Ensembl
CA6935090 rs751322843	217	V>A		No	ClinGen ExAC TOPMed gnomAD
rs756878254 CA6935091	218	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1310195345 CA387699058	221	V>I		No	ClinGen gnomAD
CA247386325 rs943025022	224	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs767135524 CA6935092	226	S>G		No	ClinGen ExAC gnomAD
CA6935093 rs749965380	226	S>N		No	ClinGen ExAC gnomAD
rs1206300565 CA387699136	227	T>I		No	ClinGen TOPMed gnomAD
rs1206300565 CA387699134	227	T>R		No	ClinGen TOPMed gnomAD
rs1281000535 CA387699151	228	S>N		No	ClinGen TOPMed
rs576074999 CA6935094	229	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA387699192 rs1593511489	231	K>E		No	ClinGen Ensembl
TCGA novel	231	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1187877068 CA387699210	232	K>E		No	ClinGen gnomAD
rs955299409 CA247386331	233	E>K		No	ClinGen TOPMed
CA387699243 rs1431795181	234	T>A		No	ClinGen gnomAD
CA6935096 rs780585256	234	T>M		No	ClinGen ExAC TOPMed gnomAD
CA247386340 rs963945772	235	I>M		No	ClinGen TOPMed
CA6935098 rs754308782	235	I>N		No	ClinGen ExAC gnomAD
CA247386336 rs911052266	235	I>V		No	ClinGen TOPMed gnomAD
rs755436482 CA6935099	236	K>N		No	ClinGen ExAC TOPMed gnomAD
CA387699254 rs1387958390	236	K>T		No	ClinGen gnomAD
CA247386344 rs536772013	237	L>F		No	ClinGen 1000Genomes
CA387699274 rs1490739359	239	L>P		No	ClinGen TOPMed gnomAD
rs138341583 CA6935100	239	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA
rs748486713 CA6935102	242	M>I		No	ClinGen ExAC gnomAD
rs753872842	242	M>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA387699311 rs1179230273	243	S>N		No	ClinGen TOPMed
TCGA novel	244	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6935103 rs772250763	245	P>A		No	ClinGen ExAC TOPMed gnomAD
CA387699332 rs772250763	245	P>T		No	ClinGen ExAC TOPMed gnomAD
rs974214495 CA247386353	246	L>V		No	ClinGen TOPMed gnomAD
CA6935104 rs142828800	247	I>T		No	ClinGen ESP ExAC gnomAD
CA6935105 rs747109926	248	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1490977908 CA387699376	249	R>K		No	ClinGen TOPMed
CA6935107 CA6935106 rs555397627	250	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA387699414 rs1329217501	251	S>G		No	ClinGen gnomAD
TCGA novel	252	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs372086987 CA6935108	253	S>T		No	ClinGen ESP ExAC gnomAD
CA247386363 rs902328285	254	D>G		No	ClinGen gnomAD
CA6935109 rs768660202	254	D>N		No	ClinGen ExAC TOPMed
CA387699460 rs768660202	254	D>Y		No	ClinGen ExAC TOPMed
CA6935110 rs376683172	255	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs761660083 CA6935111	255	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA387699525 rs181484496	258	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs181484496 CA6935114	258	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs573642481 CA6935113	258	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1309306956 CA387699530	259	V>I		No	ClinGen Ensembl
CA387699572 rs1593511644	261	S>C		No	ClinGen Ensembl
rs1367681192 CA387699593	262	R>S		No	ClinGen gnomAD
CA6935140 rs758793268	266	D>H		No	ClinGen ExAC TOPMed gnomAD
CA6935139 COSM946648 rs758793268	266	D>Y	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs751918546 CA6935142	267	D>E		No	ClinGen ExAC TOPMed gnomAD
CA387700198 rs1298349879	267	D>G		No	ClinGen TOPMed
CA387700216 rs1166287390	268	V>G		No	ClinGen TOPMed
CA387700203 rs1352444923	268	V>I		No	ClinGen TOPMed
CA387700224 rs1475282812	269	F>C		No	ClinGen TOPMed
CA387700218 rs757561985	269	F>L		No	ClinGen ExAC gnomAD
CA6935147 rs781564848	269	F>L		No	ClinGen ExAC
rs757561985 CA6935144	269	F>V		No	ClinGen ExAC gnomAD
rs745999526 CA6935148	270	N>I		No	ClinGen ExAC gnomAD
CA697240863 rs1416990311	270	N>R		No	ClinGen TOPMed
CA6935149 rs756193550	271	C>R		No	ClinGen ExAC TOPMed gnomAD
rs756193550 CA6935150	271	C>S		No	ClinGen ExAC TOPMed gnomAD
CA387700244 rs1195047190	271	C>Y		No	ClinGen TOPMed
rs146086897 CA247386881	272	N>D		No	ClinGen ESP
CA6935151 rs748145597	272	N>S		No	ClinGen ExAC TOPMed gnomAD
rs760973126 CA247386884	273	L>P		No	ClinGen TOPMed gnomAD
CA387700287 rs1593513586	275	P>L		No	ClinGen Ensembl
rs1173712726 CA387700282	275	P>T		No	ClinGen gnomAD
CA387700288 rs1358147873	276	R>G		No	ClinGen gnomAD
CA387700291 rs1469991374	276	R>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA247386887 rs992261307	277	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1335558124 CA387700318	279	L>P		No	ClinGen TOPMed
CA6935152 rs771854199	281	E>Q		No	ClinGen ExAC gnomAD
CA6935153 rs773002689	283	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	283	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1270083529 CA387700382	284	L>S		No	ClinGen gnomAD
CA6935154 rs746739528	284	L>V		No	ClinGen ExAC gnomAD
rs1363292956 CA387700399	285	A>V		No	ClinGen gnomAD
CA6935156 rs776243503	286	E>*		No	ClinGen ExAC gnomAD
TCGA novel	287	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6935158 rs764835720	288	P>L		No	ClinGen ExAC gnomAD
CA387700442 rs764835720	288	P>R		No	ClinGen ExAC gnomAD
CA6935159 rs774815996	289	F>L		No	ClinGen ExAC gnomAD
TCGA novel	290	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763531328 CA6935160	291	S>G		No	ClinGen ExAC gnomAD
CA6935161 rs764445175	292	V>A		No	ClinGen ExAC TOPMed gnomAD
CA6935162 rs373323371	296	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	297	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1242575063 CA387700583	297	E>K		No	ClinGen gnomAD
rs1476355000 CA387700618	298	T>I		No	ClinGen gnomAD
rs1424189479 CA387700628	299	P>R		No	ClinGen gnomAD
rs1470169512 CA387700644	300	N>K		No	ClinGen gnomAD
CA387700637 rs1168153693	300	N>S		No	ClinGen gnomAD
rs1451894286 CA387700661	301	Q>H		No	ClinGen Ensembl
CA387700646 rs1293477486	301	Q>K		No	ClinGen Ensembl
TCGA novel rs1178104641 CA387700708	304	I>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen gnomAD

No associated diseases with Q5VYS4

No regional properties for Q5VYS4

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q5VYS4

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name	Definition
positive regulation of fat cell differentiation	Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A4IFN2	MEDAG	Mesenteric estrogen-dependent adipogenesis protein	Bos taurus (Bovine)	PR
Q14BA6	Medag	Mesenteric estrogen-dependent adipogenesis protein	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAGAACEPVA	RPSLTSISSG	ELRSLWTCDC	ELALLPLAQL	LRLQPGAFQL	SGDQLVVARP
70	80	90	100	110	120
GEPAAARGGF	NVFGDGLVRL	DGQLYRLSSY	IKRYVELTNY	CDYKDYRETI	LSKPMLFFIN
130	140	150	160	170	180
VQTKKDTSKE	RTYAFLVNTR	HPKIRRQIEQ	GMDMVISSVI	GESYRLQFDF	QEAVKNFFPP
190	200	210	220	230	240
GNEVVNGENL	SFAYEFKADA	LFDFFYWFGL	SNSVVKVNGK	VLNLSSTSPE	KKETIKLFLE
250	260	270	280	290	300
KMSEPLIRRS	SFSDRKFSVT	SRGSIDDVFN	CNLSPRSSLT	EPLLAELPFP	SVLESEETPN

QFI