AiPD: Autoinhibited Protein Database

Q5TDH0

Gene name	DDI2
Protein name	Protein DDI1 homolog 2
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:84301
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

51-164 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

51-164 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q5TDH0

Entry ID	Method	Resolution	Chain	Position	Source
2N7D	NMR	-	A	1-76	PDB
4RGH	X-ray	190 A	A/B	212-360	PDB
5K57	NMR	-	A	116-212	PDB
AF-Q5TDH0-F1	Predicted				AlphaFoldDB

213 variants for Q5TDH0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	11	D>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA615850 rs774392792	12	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1384906915 CA338570628	13	S>C		No	ClinGen TOPMed
rs1179005250 CA338570682	18	S>F		No	ClinGen gnomAD
rs1453273114 CA338570687	19	L>F		No	ClinGen TOPMed gnomAD
rs993388122 CA18272524 CA338570742	24	D>E		No	ClinGen TOPMed gnomAD
rs772904667 CA615853	24	D>N		No	ClinGen ExAC gnomAD
CA338570754 rs373032236	25	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA18272529 rs1030186328	25	F>L		No	ClinGen TOPMed
CA338570801 rs1301687624	29	N>S		No	ClinGen gnomAD
CA338570822 rs1236374987	31	R>C		No	ClinGen gnomAD
CA615859 rs764486414	36	L>F		No	ClinGen ExAC gnomAD
CA615858 rs764486414	36	L>V		No	ClinGen ExAC gnomAD
rs1426251270 CA338571002	42	A>T		No	ClinGen gnomAD
CA615863 rs756264292	44	E>*		No	ClinGen ExAC gnomAD
CA338571071 rs1382395013	46	Q>E		No	ClinGen gnomAD
CA338573376 rs774889431	47	I>M		No	ClinGen ExAC TOPMed gnomAD
CA615880 rs769311230	47	I>V		No	ClinGen ExAC gnomAD
CA615882 rs762325900	48	V>I		No	ClinGen ExAC gnomAD
CA338573414 rs190145902	49	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
CA615883 rs190145902	49	Y>F		No	ClinGen 1000Genomes ExAC gnomAD
rs1384277523 COSM1319832 CA338573595	57	N>S	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1307400915 CA338573732	63	S>F		No	ClinGen gnomAD
CA615887 rs77782333	66	L>F		No	ClinGen ExAC gnomAD
CA615888 rs755177299	67	K>*		No	ClinGen ExAC gnomAD
rs755177299 CA615889	67	K>E		No	ClinGen ExAC gnomAD
CA338573782 rs752722490	67	K>I		No	ClinGen ExAC TOPMed gnomAD
CA615890 rs752722490	67	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1570967814 CA338573801	68	D>E		No	ClinGen Ensembl
CA615892 rs777917292	68	D>N		No	ClinGen ExAC
rs150610844 CA338573828	70	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs921001720 CA18277636	70	D>G		No	ClinGen Ensembl
rs1570967828 CA338573848	71	V>G		No	ClinGen Ensembl
CA18277638 rs913479339	72	V>L		No	ClinGen Ensembl
CA338573874 rs1193627726	73	I>F		No	ClinGen TOPMed
rs1193627726 CA338573863	73	I>V		No	ClinGen TOPMed
CA18277639 rs374425147	75	R>Q		No	ClinGen ESP TOPMed gnomAD
TCGA novel	77	K>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs144340720 CA615895	79	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1172758195 CA338573997	81	D>H		No	ClinGen gnomAD
CA338574039 rs202121145	83	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs202121145 CA615896	83	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA615897 rs769348446	85	P>L		No	ClinGen ExAC gnomAD
CA338574090 rs1360520897	87	Q>H		No	ClinGen gnomAD
rs757208866 CA615898	88	F>L		No	ClinGen ExAC TOPMed gnomAD
CA18277641 rs942711022	90	N>D		No	ClinGen Ensembl
CA338574455 rs1341668545	92	P>L		No	ClinGen gnomAD
CA338574444 rs1163691797	92	P>S		No	ClinGen TOPMed
CA338574447 rs1163691797	92	P>T		No	ClinGen TOPMed
rs779619064 CA615917	93	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs535427500 CA18282287	96	F>S		No	ClinGen Ensembl
CA615919 rs768110369	99	I>V		No	ClinGen ExAC gnomAD
rs773869764 CA338574948	100	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs773869764 CA615920	100	A>V		No	ClinGen ExAC TOPMed gnomAD
rs371977898 CA615921	106	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA615922 rs764466841	107	P>L		No	ClinGen ExAC gnomAD
CA338575049 rs1218866996	107	P>S		No	ClinGen gnomAD
rs1218866996 CA338575045	107	P>T		No	ClinGen gnomAD
rs140092977 CA615925	108	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA615924 rs140092977 COSM2084672	108	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA615923 rs564313462	108	R>W		No	ClinGen ExAC TOPMed gnomAD
CA615926 rs757729580 COSM1194696	110	R>C	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs148633078 CA615927	110	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA338575115 rs1433275542	111	Q>H		No	ClinGen gnomAD
CA338575136 rs1570970400	113	P>Q		No	ClinGen Ensembl
rs1157565702 CA338575162	115	T>A		No	ClinGen gnomAD
CA615928 rs764221560	115	T>R		No	ClinGen ExAC gnomAD
CA615929 rs746374554	117	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA338575219 rs757198316	118	S>C		No	ClinGen ExAC gnomAD
rs757198316 CA615930	118	S>F		No	ClinGen ExAC gnomAD
rs532223617 CA615931	119	H>R		No	ClinGen 1000Genomes ExAC gnomAD
rs750222182 CA338575245	120	S>*		No	ClinGen ExAC gnomAD
rs750222182 CA615932	120	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1199146683 CA338575248	121	S>P		No	ClinGen TOPMed
rs1263185583 CA338575265	122	P>L		No	ClinGen gnomAD
rs1437621829 CA338575275	123	G>V		No	ClinGen TOPMed gnomAD
CA338575327 rs1446115383	128	S>P		No	ClinGen TOPMed
rs748839324 CA615935	129	P>H		No	ClinGen ExAC TOPMed gnomAD
CA338575359 rs748839324	129	P>L		No	ClinGen ExAC TOPMed gnomAD
CA615934 rs779927649	129	P>S		No	ClinGen ExAC gnomAD
COSM1295317 CA338575368 rs1416854324	130	Q>*	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA18282351 rs1007597309	130	Q>R		No	ClinGen Ensembl
CA18282354 rs943607068	132	L>M		No	ClinGen TOPMed gnomAD
rs1206771546 CA338575409	132	L>W		No	ClinGen gnomAD
CA338575440 rs1291945173	134	N>S		No	ClinGen gnomAD
rs1247301536 CA338575473	136	A>G		No	ClinGen gnomAD
rs1452177258 CA338575464	136	A>T		No	ClinGen gnomAD
rs771412314 CA615939	139	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1000212771 CA18282377	141	M>T		No	ClinGen TOPMed
CA615940 rs777052167	141	M>V		No	ClinGen ExAC gnomAD
rs1570970480 CA338575597	143	L>V		No	ClinGen Ensembl
rs865796587 CA338575614	144	A>G		No	ClinGen gnomAD
rs1225575960 CA338575612	144	A>S		No	ClinGen TOPMed
rs865796587 CA18282385	144	A>V		No	ClinGen gnomAD
rs1422219205 CA338575628	145	N>S		No	ClinGen gnomAD
rs746213909 CA615941	146	P>L		No	ClinGen ExAC TOPMed gnomAD
rs746213909 CA338575649	146	P>R		No	ClinGen ExAC TOPMed gnomAD
CA338575644 rs1307767204	146	P>S		No	ClinGen TOPMed
CA18282387 rs972192119	149	L>M		No	ClinGen TOPMed
rs1375179886 CA338575734	150	S>F		No	ClinGen gnomAD
COSM898045 CA18282409 rs1053156819	155	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs763211597 CA615945	155	R>H		No	ClinGen ExAC gnomAD
CA615946 rs368189349	156	N>S		No	ClinGen ExAC gnomAD
CA615949 rs767454817	162	A>S		No	ClinGen ExAC gnomAD
CA338575906 rs1198808826	164	L>F		No	ClinGen gnomAD
CA615951 rs750285872 COSM310502	165	S>C	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs750285872 CA615950	165	S>G		No	ClinGen ExAC TOPMed gnomAD
rs754242472 CA18282428	165	S>T		No	ClinGen Ensembl
CA338576082 rs1570972882	173	R>T		No	ClinGen Ensembl
rs551131914 CA18284700	174	V>L		No	ClinGen 1000Genomes
CA338576095 rs1570972889	175	L>R		No	ClinGen Ensembl
rs1318333908 CA338576127	180	Q>E		No	ClinGen TOPMed
CA18284702 rs922851617	181	D>E		No	ClinGen TOPMed
CA615976 rs777089239	182	R>*		No	ClinGen ExAC gnomAD
rs777089239 CA615977	182	R>G		No	ClinGen ExAC gnomAD
rs756578455 CA615978	182	R>Q		No	ClinGen ExAC TOPMed
CA338576143 rs1570972905	183	A>T		No	ClinGen Ensembl
rs769099374 CA615981	184	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA615980 rs749651325	184	R>W		No	ClinGen ExAC gnomAD
rs1282349622 CA338576167	187	Q>K		No	ClinGen TOPMed gnomAD
rs748318737 CA615983	190	I>V		No	ClinGen ExAC gnomAD
rs772339357 CA615984	191	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA615985 rs773160744	191	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1349592093 CA338576225	196	D>N		No	ClinGen gnomAD
CA338576273 rs1557615291	202	A>V		No	ClinGen Ensembl
TCGA novel	204	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA338576290 rs1557615300	205	K>E		No	ClinGen Ensembl
rs199886079 CA18284773	205	K>R		No	ClinGen 1000Genomes
CA338576324 rs1277952417	209	D>V		No	ClinGen TOPMed
rs1489539935 CA338576330	210	I>K		No	ClinGen gnomAD
rs1441214266 CA338576328	210	I>V		No	ClinGen TOPMed
rs770750343 CA615987	211	R>W		No	ClinGen ExAC gnomAD
rs1314068129 CA338576889	220	T>A		No	ClinGen gnomAD
rs758837543 CA616021	226	A>V		No	ClinGen ExAC gnomAD
TCGA novel	231	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA338577059 rs1209727040	234	V>M		No	ClinGen gnomAD
rs1235762935 CA338577102	238	I>V		No	ClinGen gnomAD
CA616025 rs781184565	244	G>A		No	ClinGen ExAC gnomAD
rs781184565 CA338577178	244	G>E		No	ClinGen ExAC gnomAD
CA616026 rs746015730	245	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA338578395 rs1477574744	257	M>T		No	ClinGen gnomAD
CA338578506 rs1170661072	262	Q>*		No	ClinGen gnomAD
CA18293187 rs374058645	267	R>G		No	ClinGen ESP
rs763390859 CA616041	276	R>C		No	ClinGen ExAC TOPMed gnomAD
rs764463034 CA616042	276	R>H		No	ClinGen ExAC gnomAD
rs764463034 CA338578838	276	R>P		No	ClinGen ExAC gnomAD
rs1300606561 COSM898056 CA338578846	277	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA18293213 rs6669070	278	W>R		No	ClinGen Ensembl
rs1165850708 CA338578886	279	A>V		No	ClinGen TOPMed gnomAD
CA338578954 rs1386776120	285	V>L		No	ClinGen gnomAD
rs938357515 CA18293234	287	T>I		No	ClinGen gnomAD
COSM218341 rs1369959431 CA338579005	289	K>N	pancreas [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	289	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	293	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750482430 CA616046	296	L>I		No	ClinGen ExAC gnomAD
rs754927091 CA616068	299	V>L		No	ClinGen ExAC gnomAD
TCGA novel	300	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA338579974 rs1367413243	300	Q>E		No	ClinGen gnomAD
CA338579986 rs1472728171	300	Q>H		No	ClinGen gnomAD
TCGA novel	304	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760728983 CA18298260	309	S>F		No	ClinGen Ensembl
rs747919609 CA616070	311	S>C		No	ClinGen ExAC TOPMed gnomAD
CA616071 rs771951356	312	I>L		No	ClinGen ExAC gnomAD
rs777733245 CA616072	314	E>Q		No	ClinGen ExAC gnomAD
rs1398346703 CA338580237	314	E>V		No	ClinGen gnomAD
rs1056577268 CA18298272	320	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	322	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770495140 CA616074	326	M>I		No	ClinGen ExAC
CA338580509 rs1210367910	326	M>V		No	ClinGen TOPMed
CA616075 rs776201705	329	R>Q		No	ClinGen ExAC gnomAD
rs746867512 CA616092	333	S>A		No	ClinGen ExAC gnomAD
rs535658184 CA616093	333	S>C		No	ClinGen 1000Genomes ExAC gnomAD
rs920969914 CA18300084	335	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA338581404 rs1201647951	337	K>T		No	ClinGen gnomAD
CA616095 rs147540527	338	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA338581433 rs1365098616	340	V>I		No	ClinGen TOPMed
CA18300102 rs1023503619	341	L>F		No	ClinGen TOPMed gnomAD
CA338581454 rs1193604934	342	V>M		No	ClinGen gnomAD
rs772629723 CA616099	343	I>F		No	ClinGen ExAC gnomAD
CA18300150 rs369260788	343	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs773548713 CA616100	343	I>T		No	ClinGen ExAC gnomAD
rs890895394 CA18300151	344	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA616103 rs776675686	347	G>D		No	ClinGen ExAC gnomAD
CA338581494 rs1399191853	349	Q>K		No	ClinGen TOPMed
CA616106 rs147295688	356	G>A		No	ClinGen ESP ExAC gnomAD
rs758406834 CA616107	360	E>A		No	ClinGen ExAC gnomAD
CA338581616 rs139539436	363	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA616109 rs751379257	363	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs139539436 CA616108	363	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1284500174 CA338581630	364	L>F		No	ClinGen gnomAD
rs1570987677 CA338581661	368	A>T		No	ClinGen Ensembl
rs1431618713 CA338581674	369	G>E		No	ClinGen gnomAD
rs1195759721 CA338581678	370	R>G		No	ClinGen gnomAD
rs781075305 CA616111	370	R>K		No	ClinGen ExAC gnomAD
TCGA novel	371	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1273098095 CA338581701	372	D>N		No	ClinGen TOPMed
rs1439155450 CA338581713	373	V>I		No	ClinGen gnomAD
CA338581725 rs755808289	374	R>L		No	ClinGen ExAC gnomAD
CA616113 rs755808289	374	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA616112 rs373473419	374	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs150526409 CA616114	375	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1388334338 CA338581737	376	E>Q		No	ClinGen gnomAD
rs543837249 CA616117	382	E>V		No	ClinGen 1000Genomes ExAC gnomAD
CA338581822 rs1557622271	383	L>V		No	ClinGen Ensembl
rs1027637294 CA18300243	387	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA338581871 rs1252197053	387	L>H		No	ClinGen TOPMed
rs1310884009 CA338581896	388	Q>H		No	ClinGen gnomAD
CA338581966 rs1197577226	391	A>V		No	ClinGen TOPMed
CA616119 rs771151057	394	A>P		No	ClinGen ExAC TOPMed gnomAD
rs781405060 CA616140	396	R>C		No	ClinGen ExAC gnomAD
rs200176580 CA616141	396	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA18304236 rs1051664341	398	K>*		No	ClinGen Ensembl
rs770119825 CA616142	400	P>R		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q5TDH0

3 regional properties for Q5TDH0

Type	Name	Position	InterPro Accession
domain	Ubiquitin-like domain	1 - 81	IPR000626
domain	Aspartic peptidase, DDI1-type	212 - 343	IPR019103
domain	DNA damage inducible protein 1 ubiquitin-like domain	1 - 76	IPR033882

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

3 GO annotations of molecular function

Name	Definition
aspartic-type endopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
identical protein binding	Binding to an identical protein or proteins.
ubiquitin binding	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

5 GO annotations of biological process

Name	Definition
cellular response to hydroxyurea	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.
proteasomal protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
protein processing	Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
regulation of DNA stability	Any process that modulates the stability of DNA.
regulation of protein stability	Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A2ADY9	Ddi2	Protein DDI1 homolog 2	Mus musculus (Mouse)	PR
Q497D6	ddi2	Protein DDI1 homolog 2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MLLTVYCVRR	DLSEVTFSLQ	VDADFELHNF	RALCELESGI	PAAESQIVYA	ERPLTDNHRS
70	80	90	100	110	120
LASYGLKDGD	VVILRQKENA	DPRPPVQFPN	LPRIDFSSIA	VPGTSSPRQR	QPPGTQQSHS
130	140	150	160	170	180
SPGEITSSPQ	GLDNPALLRD	MLLANPHELS	LLKERNPPLA	EALLSGDLEK	FSRVLVEQQQ
190	200	210	220	230	240
DRARREQERI	RLFSADPFDL	EAQAKIEEDI	RQQNIEENMT	IAMEEAPESF	GQVVMLYINC
250	260	270	280	290	300
KVNGHPVKAF	VDSGAQMTIM	SQACAERCNI	MRLVDRRWAG	IAKGVGTQKI	IGRVHLAQVQ
310	320	330	340	350	360
IEGDFLPCSF	SILEEQPMDM	LLGLDMLKRH	QCSIDLKKNV	LVIGTTGSQT	TFLPEGELPE
370	380	390
CARLAYGAGR	EDVRPEEIAD	QELAEALQKS	AEDAERQKP