Q497D6

PR
Gene name
ddi2
Protein name
Protein DDI1 homolog 2
Names
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:619368
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

56-151 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q497D6

Entry ID Method Resolution Chain Position Source
AF-Q497D6-F1 Predicted AlphaFoldDB

No variants for Q497D6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q497D6

No associated diseases with Q497D6

3 regional properties for Q497D6

Type Name Position InterPro Accession
domain Ubiquitin-like domain 1 - 81 IPR000626
domain Aspartic peptidase, DDI1-type 207 - 338 IPR019103
domain DNA damage inducible protein 1 ubiquitin-like domain 1 - 76 IPR033882

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
aspartic-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
identical protein binding Binding to an identical protein or proteins.

5 GO annotations of biological process

Name Definition
cellular response to hydroxyurea Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.
proteasomal protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
regulation of DNA stability Any process that modulates the stability of DNA.
regulation of protein stability Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5TDH0 DDI2 Protein DDI1 homolog 2 Homo sapiens (Human) PR
A2ADY9 Ddi2 Protein DDI1 homolog 2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MLITVYCVRR DLSEVTFSLE VDGDFELENF RALCELESGI PASETLIVYA ERPLTNNQRS
70 80 90 100 110 120
LASYGLKDGD VVILRQRETP EARPAAPFPG LDFSTIAVPG SSSQPAPSQP QAPPPPPPDT
130 140 150 160 170 180
SSFPQGLDNP ALLREMLLAN PHELSLLKER NPPLAEALLS GDLEKFTKVL LEQQQERARR
190 200 210 220 230 240
EQERIRLYSA DPFDLEAQAK IEEDIRQQNI EENMTIAMEE APESFGQVVM LYINCKVNGY
250 260 270 280 290 300
PVKAFVDSGA QMTIMSQACA ERCHIMRLVD RRWAGIAKGV GTQKIIGRVH LAQVQIEGDF
310 320 330 340 350 360
LPCSFSILEE QPMDMLLGLD MLKRHQCSID LEKNVLVIGT TGTRTSFLPE GELPECARLA
370 380 390
YGPGREEVRP EEIADRELAE VLQKSAEEAD QQKP