AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

49-219 (Predicted disordered autoinhibitory region) PR

49-219 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-A2ADY9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs254133516	43	A>P	No	EVA
rs254133516	43	A>S	No	EVA
rs3388726240	51	E>*	No	EVA
rs3388723132	104	T>R	No	EVA
rs3388713863	107	P>L	No	EVA
rs3388725286	131	G>A	No	EVA
rs3388729498	152	L>M	No	EVA
rs3388723161	158	P>S	No	EVA
rs3388719738	162	A>T	No	EVA
rs3388732894	168	L>H	No	EVA
rs3388723172	228	E>G	No	EVA
rs3388735143	316	Q>K	No	EVA
rs3388725208	328	K>R	No	EVA
rs3388719705	339	N>I	No	EVA
rs3388719752	344	G>D	No	EVA
rs3388723107	346	T>M	No	EVA
rs3388722782	349	Q>R	No	EVA
rs3388725176	352	F>L	No	EVA
rs3388729435	361	C>Y	No	EVA
rs3388726259	370	R>G	No	EVA
rs3388735141	379	A>V	No	EVA

Type	Name	Position	InterPro Accession
domain	Ubiquitin-like domain	1 - 81	IPR000626
domain	Aspartic peptidase, DDI1-type	212 - 343	IPR019103
domain	DNA damage inducible protein 1 ubiquitin-like domain	1 - 76	IPR033882

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

Name	Definition
aspartic-type endopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
identical protein binding	Binding to an identical protein or proteins.
ubiquitin binding	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

Name	Definition
cellular response to hydroxyurea	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.
proteasomal protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
protein processing	Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
regulation of DNA stability	Any process that modulates the stability of DNA.
regulation of protein stability	Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5TDH0	DDI2	Protein DDI1 homolog 2	Homo sapiens (Human)	PR
Q497D6	ddi2	Protein DDI1 homolog 2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR