AiPD: Autoinhibited Protein Database

Q5TA89

Gene name	HES5 (BHLHB38)
Protein name	Transcription factor HES-5
Names	Class B basic helix-loop-helix protein 38, bHLHb38, Hairy and enhancer of split 5
Species	Homo sapiens (Human)
KEGG Pathway	hsa:388585
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-47 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q5TA89

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q5TA89-F1	Predicted				AlphaFoldDB

155 variants for Q5TA89

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA541084 rs376151919	2	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1171036406 CA337998943	3	P>L		No	gnomAD ClinGen
CA337998939 rs1434198675	4	S>G		No	gnomAD ClinGen
rs1350014175 CA337998920	5	T>S		No	TOPMed ClinGen
rs761617059 CA541083	7	A>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	8	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA541080 rs374481404	8	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA16949137 rs911300495	9	E>K		No	Ensembl ClinGen
CA337998875 rs1256956275	11	L>V		No	gnomAD ClinGen
rs770377114 CA541078	12	S>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	14	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA541077 rs746394534	16	K>E		No	ExAC gnomAD ClinGen
CA16949131 rs1033348989	16	K>R		No	ClinGen TOPMed
rs1205799660 CA337998790	18	R>Q		No	gnomAD ClinGen
CA337998721 rs753373048	20	R>L		No	ClinGen ExAC gnomAD
CA541041 rs753373048	20	R>Q		No	ClinGen ExAC gnomAD
rs1224041687 CA337998724	20	R>W		No	ClinGen gnomAD
rs1385343399 CA337998719	21	K>Q		No	gnomAD ClinGen
CA541038 rs773669311	23	V>A		No	ExAC TOPMed gnomAD ClinGen
CA337998614 rs1380721046	27	M>I		No	gnomAD ClinGen
rs1274311018 CA337998624	27	M>L		No	TOPMed ClinGen
CA337998620 rs1234649558	27	M>T		No	TOPMed ClinGen
rs1333359977 CA337998610	28	R>S		No	TOPMed ClinGen
COSM3943783 CA541036 rs762103606	29	R>C	ovary [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA541034 rs201320010	30	D>A		No	ClinGen 1000Genomes ExAC gnomAD
CA16949016 rs889804585	30	D>E		No	ClinGen TOPMed gnomAD
CA337998590 rs1478611953	30	D>N		No	ClinGen gnomAD
CA16949014 rs866186692	31	R>H		No	ClinGen gnomAD
CA337998570 rs866186692	31	R>L		No	ClinGen gnomAD
rs749379887 CA541033	34	S>G		No	ClinGen ExAC TOPMed gnomAD
rs780153699 CA541032	36	I>M		No	ExAC gnomAD ClinGen
rs1200976594 CA337998506	37	E>K		No	gnomAD ClinGen
CA337998479 rs1254053214	38	Q>H		No	gnomAD ClinGen
rs1346988024 CA337998482	38	Q>R		No	gnomAD ClinGen
CA541030 rs746969697	40	K>N		No	ClinGen ExAC gnomAD
rs769957671 CA541031	40	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA337998453 rs1412391732	41	L>V		No	TOPMed ClinGen
rs1298702030 CA337998435	43	L>V		No	ClinGen gnomAD
CA541029 rs199741438	44	E>D		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA337998427 rs1437535393	44	E>Q		No	ClinGen TOPMed gnomAD
CA541026 rs778489792	46	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1302863026 CA337998401	46	E>K		No	gnomAD ClinGen
CA541027 rs747971857	46	E>V		No	ClinGen ExAC gnomAD
rs754633773 CA541025	47	F>C		No	ExAC gnomAD ClinGen
CA337998377 rs1465888071	47	F>L		No	ClinGen gnomAD
rs753325453 CA541024	48	A>P		No	ClinGen ExAC gnomAD
rs1190173761 CA337998369	48	A>V		No	gnomAD ClinGen
CA541022 rs199682108	49	R>L		No	ClinGen ExAC TOPMed gnomAD
rs199682108 CA16948983	49	R>Q		No	ExAC TOPMed gnomAD ClinGen
CA541023 rs765901251	49	R>W		No	ExAC gnomAD ClinGen
CA541021 rs573666488	50	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1249646268 CA337998340	51	Q>R		No	ClinGen TOPMed
CA337998333 rs762230250	52	P>A		No	ClinGen ExAC TOPMed gnomAD
CA337998324 rs1199802332	52	P>L		No	ClinGen TOPMed gnomAD
CA541019 rs762230250	52	P>S		No	ExAC TOPMed gnomAD ClinGen
rs764265290 CA541017	53	N>T		No	ExAC gnomAD ClinGen
CA541015 rs775526036	54	S>C		No	ExAC gnomAD ClinGen
CA541016 rs556965399	54	S>P		No	1000Genomes ExAC gnomAD ClinGen
CA337998293 rs1350066544	55	K>R		No	TOPMed ClinGen
rs770012439 CA541014	56	L>V		No	ExAC TOPMed gnomAD ClinGen
CA337998251 rs745880943	58	K>N		No	ClinGen ExAC TOPMed gnomAD
CA16948966 rs778367486	58	K>T		No	ClinGen gnomAD
rs764855346 CA541012	59	A>S		No	ClinGen ExAC TOPMed gnomAD
CA337998249 rs764855346	59	A>T		No	ExAC TOPMed gnomAD ClinGen
CA541011 rs772125059	60	D>G		No	ClinGen ExAC gnomAD
rs747940054 CA541010	61	I>V		No	ClinGen ExAC gnomAD
rs779623635 CA541006 COSM1667082	64	M>I	breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs748987789 CA541007	64	M>T		No	ClinGen ExAC gnomAD
rs1473533385 CA337998196	64	M>V		No	gnomAD ClinGen
rs1483305735 CA337998185	65	A>T		No	gnomAD ClinGen
rs1202695844 CA337998159	67	S>T		No	ClinGen gnomAD
rs755624177 CA541005	68	Y>H		No	ClinGen ExAC gnomAD
rs1415696299 CA337998133	69	L>P		No	ClinGen TOPMed
rs1447816061 CA337998116	71	H>N		No	ClinGen gnomAD
rs1233214944 CA337998100	72	S>N		No	TOPMed gnomAD ClinGen
rs1021201777 CA16948946	74	A>T		No	TOPMed gnomAD ClinGen
CA16948903 rs896087687	76	V>A		No	ClinGen TOPMed
rs779746892 CA337998031	76	V>F		No	ClinGen ExAC TOPMed gnomAD
CA540986 rs779746892	76	V>I		No	ExAC TOPMed gnomAD ClinGen
rs1192668050 CA337998018	78	A>T		No	ClinGen gnomAD
rs1291780492 CA337998013	78	A>V		No	ClinGen TOPMed
rs745424451 CA540984	81	P>A		No	ClinGen ExAC TOPMed gnomAD
rs745424451 CA337997987	81	P>S		No	ExAC TOPMed gnomAD ClinGen
rs780713859 CA540983	83	S>R		No	ExAC TOPMed gnomAD ClinGen
CA337997927 rs1557456823	86	Q>E		No	Ensembl ClinGen
rs926290877 CA16948895	87	D>E		No	TOPMed ClinGen
rs1158632818 CA337997916	87	D>N		No	ClinGen TOPMed
rs1190028370 CA337997879	89	S>R		No	TOPMed ClinGen
CA540982 rs756674081	90	E>K		No	ClinGen ExAC gnomAD
CA337997839 rs1316807197	93	S>A		No	ClinGen TOPMed gnomAD
rs752121812 CA540981	93	S>L		No	ClinGen ExAC TOPMed gnomAD
rs913614442 CA16948884	94	W>C		No	TOPMed gnomAD ClinGen
CA337997823 rs1208957959	95	C>S		No	TOPMed ClinGen
CA337997807 rs1302318042	96	L>P		No	gnomAD ClinGen
CA337997793 rs1298534855	97	Q>H		No	TOPMed ClinGen
rs988398485 CA16948880	99	A>T		No	TOPMed gnomAD ClinGen
CA337997764 rs1453006708	100	V>M		No	ClinGen gnomAD
CA337997751 rs1359623062	101	Q>*		No	ClinGen gnomAD
CA337997744 rs1165727910	101	Q>H		No	TOPMed gnomAD ClinGen
rs1432651303 CA337997726	103	L>P		No	ClinGen TOPMed
CA337997718 rs1178103718	104	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1320221304 CA337997707	106	H>R		No	ClinGen TOPMed
CA337997709 rs1412609512	106	H>Y		No	ClinGen gnomAD
rs1173261363 CA337997701	107	A>P		No	gnomAD ClinGen
rs1450250369 CA337997691	108	A>S		No	TOPMed gnomAD ClinGen
rs1450250369 CA337997693	108	A>T		No	TOPMed gnomAD ClinGen
CA337997681 rs1347076967	109	S>R		No	ClinGen TOPMed
TCGA novel	110	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs986028820 CA16948872	110	D>N		No	TOPMed gnomAD ClinGen
rs1413930504 CA337997652	111	T>K		No	TOPMed ClinGen
CA337997627 rs1448117650	113	M>T		No	TOPMed ClinGen
CA337997630 rs1184270454	113	M>V		No	ClinGen TOPMed gnomAD
CA337997570 rs1485569287	118	H>Y		No	TOPMed gnomAD ClinGen
CA540978 rs753102026	120	Q>R		No	ExAC gnomAD ClinGen
rs1027647005 CA16948866	121	R>W		No	TOPMed gnomAD ClinGen
rs1208848205 CA337997525	122	P>L		No	ClinGen TOPMed
TCGA novel	123	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs867697758 CA337997496	125	A>P		No	gnomAD ClinGen
rs867697758 CA16948861	125	A>T		No	gnomAD ClinGen
rs1483311413 CA337997444	130	A>S		No	ClinGen TOPMed gnomAD
rs1301257329 CA337997432	131	K>E		No	TOPMed ClinGen
rs1304571819 CA337997428	131	K>T		No	ClinGen TOPMed gnomAD
CA16948848 rs1014986514	134	K>T		No	TOPMed ClinGen
rs1014849600 CA16948845	135	A>S		No	ClinGen TOPMed
rs1014849600 CA337997380	135	A>T		No	TOPMed ClinGen
CA337997374 rs1374628915	135	A>V		No	gnomAD ClinGen
CA337997367 rs1171602558	136	P>R		No	ClinGen TOPMed
CA337997353 rs1202707316	138	A>T		No	gnomAD ClinGen
CA337997318 rs1483330478	141	P>Q		No	ClinGen TOPMed
CA16948840 rs529118406	141	P>S		No	1000Genomes TOPMed gnomAD ClinGen
CA337997301 rs1271306832	143	A>T		No	TOPMed ClinGen
rs942995118 CA16948837	144	L>F		No	ClinGen TOPMed gnomAD
CA16948834 rs567343294	145	S>C		No	ClinGen 1000Genomes
rs550513919 CA16948833	146	A>V		No	1000Genomes TOPMed ClinGen
CA337997238 rs1265711380	149	T>A		No	ClinGen TOPMed gnomAD
rs904751282 CA16948828	150	A>D		No	ClinGen TOPMed gnomAD
CA16948830 rs937587295	150	A>T		No	TOPMed gnomAD ClinGen
rs1043787911 CA16948825	152	A>P		No	ClinGen TOPMed
rs1319469098 CA337997198	153	A>T		No	ClinGen gnomAD
CA337997182 rs1289608156	154	A>T		No	gnomAD ClinGen
rs1463857688 CA337997179	154	A>V		No	ClinGen TOPMed
rs1230787389 CA337997173	155	A>G		No	ClinGen TOPMed gnomAD
rs1230787389 CA337997171	155	A>V		No	TOPMed gnomAD ClinGen
rs1487414460 CA337997159	156	H>Q		No	TOPMed ClinGen
CA337997168 rs1351599195	156	H>Y		No	TOPMed gnomAD ClinGen
CA337997146 rs1264611661	157	Q>H		No	ClinGen TOPMed
rs530921518 CA16948814	158	P>H		No	1000Genomes gnomAD ClinGen
rs530921518 CA337997138	158	P>L		No	1000Genomes gnomAD ClinGen
rs1244385331 CA337997133	159	A>T		No	ClinGen TOPMed
rs1335771036 CA337997123	159	A>V		No	TOPMed ClinGen
CA337997116 rs1570560700	160	C>Y		No	ClinGen Ensembl
rs1390078712 CA337997098	162	L>I		No	TOPMed gnomAD ClinGen
CA16948811 rs1052180176	162	L>P		No	TOPMed ClinGen
rs1390078712 CA337997097	162	L>V		No	ClinGen TOPMed gnomAD
CA337997057 rs1393313834	165	P>H		No	ClinGen gnomAD

No associated diseases with Q5TA89

2 regional properties for Q5TA89

Type	Name	Position	InterPro Accession
domain	Orange domain	86 - 128	IPR003650
domain	Myc-type, basic helix-loop-helix (bHLH) domain	16 - 78	IPR011598

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

6 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription repressor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
protein dimerization activity	The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

46 GO annotations of biological process

Name	Definition
anterior/posterior pattern specification	The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
astrocyte differentiation	The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
BMP signaling pathway	The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
brain development	The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
camera-type eye development	The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
cartilage development	The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
cell adhesion	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cell maturation	A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
central nervous system myelination	The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
comma-shaped body morphogenesis	The process in which the comma-shaped body is generated and organized. The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron.
establishment of epithelial cell polarity	The specification and formation of anisotropic intracellular organization of an epithelial cell.
forebrain radial glial cell differentiation	The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
glial cell fate commitment	The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell.
inner ear auditory receptor cell differentiation	The process in which a relatively unspecialized inner cell acquires specialized features of an auditory hair cell.
inner ear receptor cell stereocilium organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells.
metanephric nephron tubule morphogenesis	The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros.
negative regulation of astrocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation.
negative regulation of forebrain neuron differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation.
negative regulation of inner ear auditory receptor cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation.
negative regulation of neuron differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
negative regulation of oligodendrocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.
negative regulation of pro-B cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of pro-B cell differentiation.
negative regulation of stem cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
neural tube development	The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
neuronal stem cell population maintenance	Any process in by an organism or tissue maintains a population of neuronal stem cells.
Notch signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
oligodendrocyte development	The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
positive regulation of BMP signaling pathway	Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of Notch signaling pathway	Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
positive regulation of receptor signaling pathway via JAK-STAT	Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
positive regulation of smooth muscle cell proliferation	Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of tyrosine phosphorylation of STAT protein	Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
protein-containing complex assembly	The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
regulation of cell differentiation	Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
regulation of epithelial cell proliferation	Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
regulation of myelination	Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
regulation of neurogenesis	Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
S-shaped body morphogenesis	The process in which the S-shaped body is generated and organized. The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron.
smoothened signaling pathway	The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
specification of loop of Henle identity	The process in which the loop of Henle of the kidney nephron acquires its identity.
telencephalon development	The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P14003	h	Protein hairy	Drosophila melanogaster (Fruit fly)	PR
Q9Y543	HES2	Transcription factor HES-2	Homo sapiens (Human)	PR
Q03062	Hes5	Transcription factor HES-5	Rattus norvegicus (Rat)	PR
Q18053	hlh-26	Helix-loop-helix protein 26	Caenorhabditis elegans	PR

10	20	30	40	50	60
MAPSTVAVEL	LSPKEKNRLR	KPVVEKMRRD	RINSSIEQLK	LLLEQEFARH	QPNSKLEKAD
70	80	90	100	110	120
ILEMAVSYLK	HSKAFVAAAG	PKSLHQDYSE	GYSWCLQEAV	QFLTLHAASD	TQMKLLYHFQ
130	140	150	160
RPPAAPAAPA	KEPKAPGAAP	PPALSAKATA	AAAAAHQPAC	GLWRPW