Q18053

PR
Gene name
hlh-26
Protein name
Helix-loop-helix protein 26
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C17C3.8
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q18053

Entry ID Method Resolution Chain Position Source
AF-Q18053-F1 Predicted AlphaFoldDB

No variants for Q18053

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q18053

No associated diseases with Q18053

2 regional properties for Q18053

Type Name Position InterPro Accession
domain Myc-type, basic helix-loop-helix (bHLH) domain 14 - 71 IPR011598-1
domain Myc-type, basic helix-loop-helix (bHLH) domain 87 - 146 IPR011598-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

4 GO annotations of biological process

Name Definition
anterior/posterior pattern specification The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
Notch signaling pathway The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
regulation of neurogenesis Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P14003 h Protein hairy Drosophila melanogaster (Fruit fly) PR
Q9Y543 HES2 Transcription factor HES-2 Homo sapiens (Human) PR
Q5TA89 HES5 Transcription factor HES-5 Homo sapiens (Human) PR
Q03062 Hes5 Transcription factor HES-5 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MSSSPTSSSS GSPSSHGHRS ETEKQRRDDT NDLLNEFKKI VQKSESEKLS KEEVLFRIVK
70 80 90 100 110 120
LLSGIQLHHE SFSTSPGPIR SIKKIKSDRE QVRRNKRVAA YRELRKFIAL NNLSSSEEID
130 140 150 160 170 180
KMENLKVLEI IFEVIRGKSI TCTVPCLPFP ILPFLPVFPV YSPLVFNSYN QFSLYPPHMP
190 200
TVQIPIVPSS SFEIDALEIE ENEKDIDIVG