P14003
PR
Gene name |
h |
Protein name |
Protein hairy |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG6494 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P14003
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P14003-F1 | Predicted | AlphaFoldDB |
2 variants for P14003
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 21 | A>S | strain: R3-6, R3-105 and R3-107 [UniProt] | No | ||
| 292 | P>S | No |
No associated diseases with P14003
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription repressor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. |
| E-box binding | Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. |
| protein dimerization activity | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| transcription factor binding | Binding to a transcription factor, a protein required to initiate or regulate transcription. |
16 GO annotations of biological process
| Name | Definition |
|---|---|
| anterior/posterior pattern specification | The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. |
| cell morphogenesis | The developmental process in which the size or shape of a cell is generated and organized. |
| membrane organization | A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| open tracheal system development | The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster. |
| periodic partitioning by pair rule gene | Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities. |
| posterior head segmentation | Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains. |
| regulation of cellular metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. |
| regulation of neurogenesis | Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| response to hypoxia | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
| salivary gland morphogenesis | The process in which the anatomical structures of the salivary gland are generated and organized. |
| trunk segmentation | Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. |
| tube morphogenesis | The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9Y543 | HES2 | Transcription factor HES-2 | Homo sapiens (Human) | PR |
| Q5TA89 | HES5 | Transcription factor HES-5 | Homo sapiens (Human) | PR |
| Q03062 | Hes5 | Transcription factor HES-5 | Rattus norvegicus (Rat) | PR |
| Q18053 | hlh-26 | Helix-loop-helix protein 26 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVTGVTAANM | TNVLGTAVVP | AQLKETPLKS | DRRSNKPIME | KRRRARINNC | LNELKTLILD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ATKKDPARHS | KLEKADILEK | TVKHLQELQR | QQAAMQQAAD | PKIVNKFKAG | FADCVNEVSR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FPGIEPAQRR | RLLQHLSNCI | NGVKTELHQQ | QRQQQQQSIH | AQMLPSPPSS | PEQDSQQGAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| APYLFGIQQT | ASGYFLPNGM | QVIPTKLPNG | SIALVLPQSL | PQQQQQQLLQ | HQQQQQQLAV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AAAAAAAAAA | QQQPMLVSMP | QRTASTGSAS | SHSSAGYESA | PGSSSSCSYA | PPSPANSSYE |
| 310 | 320 | 330 | |||
| PMDIKPSVIQ | RVPMEQQPLS | LVIKKQIKEE | EQPWRPW |