Q5SWU9
PR
Gene name |
Acaca |
Protein name |
Acetyl-CoA carboxylase 1 |
Names |
ACC1, ACC-alpha, Acetyl-CoA carboxylase 265 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:107476 |
EC number |
6.4.1.2: Forming carbon-carbon bonds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5SWU9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5SWU9-F1 | Predicted | AlphaFoldDB |
81 variants for Q5SWU9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389164108 | 30 | E>D | No | EVA | |
| rs3389164088 | 31 | D>E | No | EVA | |
| rs3389185152 | 77 | S>R | No | EVA | |
| rs3402822099 | 85 | K>* | No | EVA | |
| rs3402612632 | 85 | K>I | No | EVA | |
| rs3402139086 | 86 | Q>L | No | EVA | |
| rs3402612604 | 88 | R>Q | No | EVA | |
| rs3401301045 | 89 | D>A | No | EVA | |
| rs3389182884 | 122 | I>V | No | EVA | |
| rs3389196456 | 176 | P>T | No | EVA | |
| rs3389187161 | 177 | V>L | No | EVA | |
| rs3389201882 | 181 | P>T | No | EVA | |
| rs3389157534 | 200 | P>S | No | EVA | |
| rs3389182914 | 205 | W>C | No | EVA | |
| rs3389187166 | 215 | P>Q | No | EVA | |
| rs3389187138 | 334 | R>* | No | EVA | |
| rs3389182845 | 335 | Q>* | No | EVA | |
| rs3389164121 | 399 | V>L | No | EVA | |
| rs3389191014 | 401 | E>K | No | EVA | |
| rs3389196494 | 434 | F>L | No | EVA | |
| rs3389157493 | 445 | H>D | No | EVA | |
| rs3389201845 | 451 | V>L | No | EVA | |
| rs3389164145 | 464 | A>V | No | EVA | |
| rs3389164131 | 476 | R>H | No | EVA | |
| rs3389157491 | 478 | M>I | No | EVA | |
| rs3389196534 | 495 | A>T | No | EVA | |
| rs3389191079 | 530 | F>I | No | EVA | |
| rs3389182842 | 565 | N>I | No | EVA | |
| rs3389196512 | 720 | S>R | No | EVA | |
| rs3402631910 | 786 | M>* | No | EVA | |
| rs3389151562 | 823 | S>I | No | EVA | |
| rs3389187703 | 828 | A>D | No | EVA | |
| rs3389187115 | 871 | P>S | No | EVA | |
| rs3389201851 | 930 | S>T | No | EVA | |
| rs3389196455 | 982 | M>I | No | EVA | |
| rs3389164107 | 1001 | Q>H | No | EVA | |
| rs3389151546 | 1077 | A>T | No | EVA | |
| rs3389175079 | 1122 | L>F | No | EVA | |
| rs3389187173 | 1198 | R>K | No | EVA | |
| rs3401878963 | 1235 | M>K | No | EVA | |
| rs3402409217 | 1236 | V>A | No | EVA | |
| rs3389175056 | 1279 | V>D | No | EVA | |
| rs3389124103 | 1300 | D>E | No | EVA | |
| rs3389191031 | 1301 | D>N | No | EVA | |
| rs3389187719 | 1313 | Q>* | No | EVA | |
| rs3389157490 | 1413 | T>I | No | EVA | |
| rs3389188159 | 1431 | L>P | No | EVA | |
| rs3389188131 | 1458 | V>D | No | EVA | |
| rs3389188162 | 1460 | F>C | No | EVA | |
| rs3389151551 | 1485 | S>T | No | EVA | |
| rs3389185141 | 1553 | A>T | No | EVA | |
| rs3402524482 | 1600 | I>V | No | EVA | |
| rs3389185156 | 1613 | E>K | No | EVA | |
| rs3389124131 | 1619 | A>G | No | EVA | |
| rs3389164139 | 1738 | V>I | No | EVA | |
| rs3389124130 | 1744 | Y>F | No | EVA | |
| rs3389124159 | 1756 | D>G | No | EVA | |
| rs3402409824 | 1810 | Y>* | No | EVA | |
| rs3401878946 | 1811 | D>N | No | EVA | |
| rs3402285526 | 1815 | T>P | No | EVA | |
| rs3389175074 | 1879 | V>F | No | EVA | |
| rs3389175074 | 1879 | V>I | No | EVA | |
| rs3402633853 | 1885 | C>R | No | EVA | |
| rs3389201863 | 1907 | S>I | No | EVA | |
| rs3389182850 | 1987 | V>L | No | EVA | |
| rs3389189813 | 2016 | V>I | No | EVA | |
| rs3389199324 | 2073 | C>Y | No | EVA | |
| rs3401880613 | 2084 | Q>P | No | EVA | |
| rs3389176514 | 2168 | K>N | No | EVA | |
| rs3389151539 | 2207 | W>* | No | EVA | |
| rs3389187176 | 2207 | W>* | No | EVA | |
| rs3389182844 | 2207 | W>R | No | EVA | |
| rs3413120334 | 2210 | S>T | No | EVA | |
| rs3389203391 | 2218 | L>M | No | EVA | |
| rs3389191067 | 2232 | H>Y | No | EVA | |
| rs3389191010 | 2283 | V>I | No | EVA | |
| rs3389191085 | 2294 | I>F | No | EVA | |
| rs3389182924 | 2305 | S>N | No | EVA | |
| rs3389187734 | 2305 | S>R | No | EVA | |
| rs3389187195 | 2323 | Q>H | No | EVA | |
| rs3389203365 | 2325 | I>L | No | EVA |
No associated diseases with Q5SWU9
11 regional properties for Q5SWU9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Biotin/lipoyl attachment | 744 - 818 | IPR000089 |
| binding_site | Biotin-binding site | 775 - 792 | IPR001882 |
| domain | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain | 287 - 469 | IPR005479 |
| domain | Biotin carboxylase-like, N-terminal domain | 117 - 236 | IPR005481 |
| domain | Biotin carboxylase, C-terminal | 506 - 613 | IPR005482 |
| domain | ATP-grasp fold | 274 - 465 | IPR011761 |
| domain | Acetyl-coenzyme A carboxyltransferase, N-terminal | 1575 - 1913 | IPR011762 |
| domain | Acetyl-coenzyme A carboxyltransferase, C-terminal | 1917 - 2233 | IPR011763 |
| domain | Biotin carboxylation domain | 116 - 617 | IPR011764 |
| domain | Acetyl-CoA carboxylase, central domain | 818 - 1568 | IPR013537 |
| domain | Acetyl-CoA carboxylase | 1668 - 2221 | IPR034733 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.4.1.2 | Forming carbon-carbon bonds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| acetyl-CoA carboxylase activity | Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| biotin binding | Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. |
| identical protein binding | Binding to an identical protein or proteins. |
| kinase binding | Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
| metal ion binding | Binding to a metal ion. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| acetyl-CoA metabolic process | The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. |
| cellular response to prostaglandin E stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. |
| fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. |
| lipid homeostasis | Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. |
| lipid metabolic process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. |
| malonyl-CoA biosynthetic process | The chemical reactions and pathways resulting in the formation of malonyl-CoA, the S-malonyl derivative of coenzyme A. |
| protein homotetramerization | The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. |
| protein metabolic process | The chemical reactions and pathways involving a protein. Includes protein modification. |
| response to organic cyclic compound | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. |
| tissue homeostasis | A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P11029 | ACAC | Acetyl-CoA carboxylase | Gallus gallus (Chicken) | PR |
| O00763 | ACACB | Acetyl-CoA carboxylase 2 | Homo sapiens (Human) | PR |
| Q13085 | ACACA | Acetyl-CoA carboxylase 1 | Homo sapiens (Human) | PR |
| E9Q4Z2 | Acacb | Acetyl-CoA carboxylase 2 | Mus musculus (Mouse) | PR |
| P11497 | Acaca | Acetyl-CoA carboxylase 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDEPSPLAKT | LELNQHSRFI | IGSVSEDNSE | DEISNLVKLD | LEEKEGSLSP | ASVSSDTLSD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGISGLQDGL | AFHMRSSMSG | LHLVKQGRDR | KKIDSQRDFT | VASPAEFVTR | FGGNKVIEKV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LIANNGIAAV | KCMRSIRRWS | YEMFRNERAI | RFVVMVTPED | LKANAEYIKM | ADHYVPVPGG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PNNNNYANVE | LILDIAKRIP | VQAVWAGWGH | ASENPKLPEL | LLKNGIAFMG | PPSQAMWALG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DKIASSIVAQ | TAGIPTLPWS | GSGLRVDWQE | NDFSKRILNV | PQDLYEKGYV | KDVDDGLKAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EEVGYPVMIK | ASEGGGGKGI | RKVNNADDFP | NLFRQVQAEV | PGSPIFVMRL | AKQSRHLEVQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ILADQYGNAI | SLFGRDCSVQ | RRHQKIIEEA | PAAIATPAVF | EHMEQCAVKL | AKMVGYVSAG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TVEYLYSQDG | SFYFLELNPR | LQVEHPCTEM | VADVNLPAAQ | LQIAMGIPLF | RIKDIRMMYG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VSPWGDAPID | FENSAHVPCP | RGHVIAARIT | SENPDEGFKP | SSGTVQELNF | RSNKNVWGYF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SVAAAGGLHE | FADSQFGHCF | SWGENREEAI | SNMVVALKEL | SIRGDFRTTV | EYLIKLLETE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SFQLNRIDTG | WLDRLIAEKV | QAERPDTMLG | VVCGALHVAD | VSLRNSISNF | LHSLERGQVL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PAHTLLNTVD | VELIYEGIKY | VLKVTRQSPN | SYVVIMNGSC | VEVDVHRLSD | GGLLLSYDGS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SYTTYMKEEV | DRYRITIGNK | TCVFEKENDP | SVMRSPSAGK | LIQYIVEDGG | HVFAGQCYAE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| IEVMKMVMTL | TAVESGCIHY | VKRPGAALDP | GCVIAKMQLD | NPSKVQQAEL | HTGSLPQIQS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TALRGEKLHR | VFHYVLDNLV | NVMNGYCLPD | PFFSSRVKDW | VERLMKTLRD | PSLPLLELQD |
| 910 | 920 | 930 | 940 | 950 | 960 |
| IMTSVSGRIP | LNVEKSIKKE | MAQYASNITS | VLCQFPSQQI | ANILDSHAAT | LNRKSEREVF |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| FMNTQSIVQL | VQRYRSGIRG | HMKAVVMDLL | RQYLRVETQF | QNGHYDKCVF | ALREENKSDM |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| NTVLNYIFSH | AQVTKKNLLV | TMLIDQLCGR | DPTLTDELLN | ILTELTQLSK | TTNAKVALRA |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| RQVLIASHLP | SYELRHNQVE | SIFLSAIDMY | GHQFCIENLQ | KLILSETSIF | DVLPNFFYHS |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| NQVVRMAALE | VYVRRAYIAY | ELNSVQHRQL | KDNTCVVEFQ | FMLPTSHPNR | GNIPTLNRMS |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| FASNLNHYGM | THVASVSDVL | LDNAFTPPCQ | RMGGMVSFRT | FEDFVRIFDE | IMGCFCDSPP |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| QSPTFPESGH | TSLYDEDKVP | RDEPIHILNV | AIKTDGDIED | DRLAAMFREF | TQQNKATLVE |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| HGIRRLTFLV | AQKDFRKQVN | CEVDQRFHRE | FPKFFTFRAR | DKFEEDRIYR | HLEPALAFQL |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| ELNRMRNFDL | TAIPCANHKM | HLYLGAAKVE | VGTEVTDYRF | FVRAIIRHSD | LVTKEASFEY |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| LQNEGERLLL | EAMDELEVAF | NNTNVRTDCN | HIFLNFVPTV | IMDPSKIEES | VRSMVMRYGS |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| RLWKLRVLQA | ELKINIRLTT | TGKAIPIRLF | LTNESGYYLD | ISLYKEVTDS | RTAQIMFQAY |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| GDKQGPLHGM | LINTPYVTKD | LLQSKRFQAQ | SLGTTYIYDI | PEMFRQSLIK | LWESMSTQAF |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| LPSPPLPSDI | LTYTELVLDD | QGQLVHMNRL | PGGNEIGMVA | WKMSLKSPEY | PDGRDIIVIG |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| NDITYRIGSF | GPQEDLLFLR | ASELARAEGI | PRIYVAANSG | ARIGLAEEIR | HMFHVAWVDP |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| EDPYKGYKYL | YLTPQDYKRV | SALNSVHCEH | VEDEGESRYK | ITDIIGKEEG | LGAENLRGSG |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| MIAGESSLAY | DEVITISLVT | CRAIGIGAYL | VRLGQRTIQV | ENSHLILTGA | GALNKVLGRE |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| VYTSNNQLGG | IQIMHNNGVT | HSTVCDDFEG | VFTVLHWLSY | MPKSVHSSVP | LLNSKDPIDR |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| IIEFVPTKAP | YDPRWMLAGR | PHPTQKGQWL | SGFFDYGSFS | EIMQPWAQTV | VVGRARLGGI |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| PVGVVAVETR | TVELSIPADP | ANLDSEAKII | QQAGQVWFPD | SAFKTYQAIK | DFNREGLPLM |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| VFANWRGFSG | GMKDMYDQVL | KFGAYIVDGL | RECSQPVMVY | IPPQAELRGG | SWVVIDPTIN |
| 2110 | 2120 | 2130 | 2140 | 2150 | 2160 |
| PRHMEMYADR | ESRGSVLEPE | GTVEIKFRKK | DLVKTMRRVD | PVYIRLAERL | GTPELSPTER |
| 2170 | 2180 | 2190 | 2200 | 2210 | 2220 |
| KELESKLKER | EEFLIPIYHQ | VAVQFADLHD | TPGRMQEKGV | INDILDWKTS | RTFFYWRLRR |
| 2230 | 2240 | 2250 | 2260 | 2270 | 2280 |
| LLLEDLVKKK | IHNANPELTD | GQIQAMLRRW | FVEVEGTVKA | YVWDNNKDLV | EWLEKQLTEE |
| 2290 | 2300 | 2310 | 2320 | 2330 | 2340 |
| DGVRSVIEEN | IKYISRDYVL | KQIRSLVQAN | PEVAMDSIVH | MTQHISPTQR | AEVVRILSTM |
| DSPST |