AiPD: Autoinhibited Protein Database

O00763

Gene name	ACACB
Protein name	Acetyl-CoA carboxylase 2
Names	ACC-beta
Species	Homo sapiens (Human)
KEGG Pathway	hsa:32
EC number	6.4.1.2: Forming carbon-carbon bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-280 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-280 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

12 structures for O00763

Entry ID	Method	Resolution	Chain	Position	Source
2DN8	NMR	-	A	885-971	PDB
2HJW	X-ray	250 A	A	217-775	PDB
2KCC	NMR	-	A	891-965	PDB
3FF6	X-ray	319 A	A/B/C/D	1693-2450	PDB
3GID	X-ray	230 A	A/B	238-760	PDB
3GLK	X-ray	210 A	A	238-760	PDB
3JRW	X-ray	260 A	A	217-775	PDB
3JRX	X-ray	250 A	A	217-775	PDB
3TDC	X-ray	241 A	A	1690-2445	PDB
4HQ6	X-ray	270 A	A	217-776	PDB
5KKN	X-ray	260 A	B/C	238-760	PDB
AF-O00763-F1	Predicted				AlphaFoldDB

2144 variants for O00763

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs2044635183 RCV001291444	655	S>G	Autism spectrum disorder [ClinVar]	Yes	ClinVar dbSNP
rs757532146 CA6772853	2	V>F		No	ClinGen ExAC gnomAD
CA6772854 rs753987065 CA6772855	3	L>F		No	ClinGen ExAC TOPMed gnomAD
rs765824239 CA6772856	4	L>F		No	ClinGen ExAC gnomAD
CA386459012 rs1160656072	4	L>P		No	ClinGen gnomAD
CA6772858 COSM430281 rs376872449	9	C>F	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA386459042 rs376872449	9	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6772859 rs376872449	9	C>Y	Variant assessed as Somatic; 4.623e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6772860 rs370340277	13	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6772861 rs754732999	14	C>R		No	ClinGen ExAC TOPMed gnomAD
CA386459070 rs754732999	14	C>S		No	ClinGen ExAC TOPMed gnomAD
CA6772862 rs780843060	14	C>Y		No	ClinGen ExAC gnomAD
CA6772863 rs747698774	16	T>N		No	ClinGen ExAC gnomAD
rs144316349 CA6772865	17	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1292643887 CA386459125	20	L>I		No	ClinGen TOPMed
rs1205070780 CA386459142	21	K>Q		No	ClinGen TOPMed
rs749213609 CA6772867	24	G>R		No	ClinGen ExAC gnomAD
rs1468809525 CA386459202	25	K>N		No	ClinGen gnomAD
rs770693620 CA6772869	27	T>K		No	ClinGen ExAC TOPMed gnomAD
CA6772868 rs770693620	27	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1197918261 CA386459217	27	T>P		No	ClinGen gnomAD
TCGA novel	30	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6772872 rs776672844	31	P>L		No	ClinGen ExAC TOPMed gnomAD
CA386459327 rs776672844	31	P>R		No	ClinGen ExAC TOPMed gnomAD
CA386459397 rs1370263523	34	K>T		No	ClinGen gnomAD
CA6772875 rs750878973	35	S>N		No	ClinGen ExAC TOPMed gnomAD
rs766749273 CA6772877	36	K>I		No	ClinGen ExAC TOPMed gnomAD
rs766749273 CA386459429	36	K>R		No	ClinGen ExAC TOPMed gnomAD
CA386459448 rs1449416193	38	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1406432298 CA386459466	39	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA6772879 rs527664804	40	N>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1593385580 CA386459485	40	N>T		No	ClinGen Ensembl
rs767325347 CA6772880	41	L>P		No	ClinGen ExAC gnomAD
CA386459521 rs1393935663	42	I>M		No	ClinGen gnomAD
rs142445607 CA6772881	43	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	43	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386459556 rs1217523404	45	Q>E		No	ClinGen gnomAD
rs139767464 RCV000971937 CA6772883	45	Q>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA386459574 rs1319943340	46	E>K		No	ClinGen TOPMed gnomAD
rs531976358 CA6772884	47	P>H		No	ClinGen 1000Genomes ExAC gnomAD
CA243379632 rs1033644454	49	P>L		No	ClinGen TOPMed
CA386459625 rs1033644454	49	P>Q		No	ClinGen TOPMed
CA243379631 rs905134619	49	P>T		No	ClinGen gnomAD
CA386459670 rs756710601	52	D>E		No	ClinGen TOPMed gnomAD
rs550116625 CA6772885	55	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1475560239 CA386459730	56	E>G		No	ClinGen gnomAD
rs778648797 CA6772886	57	T>A		No	ClinGen ExAC gnomAD
rs769946341 COSM1739937 CA6772888	58	P>L	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs769946341 CA6772889	58	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA386459763 rs769946341	58	P>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	60	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386459804 rs1593385748	61	N>K		No	ClinGen Ensembl
rs769849813 CA386459808	62	G>A		No	ClinGen ExAC TOPMed gnomAD
rs769849813 CA6772891	62	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1329869338 CA386459829	65	H>R		No	ClinGen gnomAD
CA6772892 rs773226498	66	T>I		No	ClinGen ExAC gnomAD
CA386459832 rs1593385776	66	T>P		No	ClinGen Ensembl
CA6772893 rs763514954	67	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6772895 rs375344890	70	T>I		No	ClinGen ESP ExAC gnomAD
CA243379678 rs866351563	71	P>S		No	ClinGen Ensembl
TCGA novel	73	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1342223412 CA386459924	74	A>P		No	ClinGen gnomAD
rs1342223412 CA386459919	74	A>T		No	ClinGen gnomAD
rs755735357 CA6772899	75	E>K		No	ClinGen ExAC gnomAD
CA386459960 rs1261728583	76	P>S		No	ClinGen TOPMed
CA386460022 rs1486134700	80	K>E		No	ClinGen gnomAD
rs753327617 CA6772903	82	P>S		No	ClinGen ExAC
CA6772905 rs778771224	84	D>N		No	ClinGen ExAC gnomAD
rs371386144 CA6772908	86	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs769981426 CA243379727	87	R>P		No	ClinGen ExAC TOPMed gnomAD
CA6772910 rs769981426	87	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs551468976 CA6772909	87	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs200591816 CA6772913	88	R>Q	Variant assessed as Somatic; 9.243e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs140156252 CA6772912	88	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
COSM934694 rs774959869 CA6772914	89	R>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA386460221 rs1365446192	93	P>L		No	ClinGen TOPMed gnomAD
rs767936750 CA6772917 COSM1721422	94	P>L	NS [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1348793127 CA386460279	97	Q>K		No	ClinGen gnomAD
rs763702236 CA6772920	99	P>H		No	ClinGen ExAC TOPMed gnomAD
rs753548861 CA6772921	100	P>A		No	ClinGen ExAC gnomAD
rs201767549 CA6772923	102	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA386460357 rs1487797108	105	S>F		No	ClinGen gnomAD
rs758383786 CA6772926	109	A>P		No	ClinGen ExAC TOPMed gnomAD
CA6772927 rs758383786	109	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	116	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1347990740 CA386460440	118	N>S		No	ClinGen gnomAD
rs771068523 CA6772932	119	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1205894206 CA386460478	124	G>D		No	ClinGen TOPMed
CA386460475 rs1365009684	124	G>S		No	ClinGen gnomAD
rs951672585 CA243379831	125	L>P		No	ClinGen TOPMed gnomAD
rs149916132 CA386460491	126	E>D		No	ClinGen ESP TOPMed
rs1353133373 CA386460486	126	E>Q		No	ClinGen gnomAD
rs1224349958 CA386460512	128	T>A		No	ClinGen gnomAD
CA386460529 rs1289244176	129	D>Y		No	ClinGen gnomAD
CA6772934 rs746364518	130	T>A		No	ClinGen ExAC TOPMed gnomAD
CA6772935 rs145000590	130	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA386460634 rs1254232341	136	S>A		No	ClinGen gnomAD
CA6772936 rs149092322	137	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs769094389 CA6772938	138	R>S		No	ClinGen ExAC gnomAD
rs760897574 CA6772937	138	R>T		No	ClinGen ExAC gnomAD
CA6772939 rs776077835	139	P>L		No	ClinGen ExAC gnomAD
rs761464809 CA6772940	140	Q>R		No	ClinGen ExAC gnomAD
CA243379860 rs1002257498	141	G>S		No	ClinGen TOPMed
rs1593386365 CA386460728	142	Q>*		No	ClinGen Ensembl
CA6772942 rs201076011	142	Q>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1165537149 CA386460789	145	G>D		No	ClinGen gnomAD
rs766355541 CA6772944	148	S>Y		No	ClinGen ExAC gnomAD
rs1337686177 CA386460846	149	K>E		No	ClinGen gnomAD
CA386460881 rs1443197697	151	D>N		No	ClinGen gnomAD
TCGA novel	152	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386461054 rs1274313088	160	Q>*		No	ClinGen gnomAD
CA386461114 rs754691654	162	M>K		No	ClinGen ExAC TOPMed gnomAD
CA6772947 rs754691654	162	M>R		No	ClinGen ExAC TOPMed gnomAD
CA6772948 rs577730043	164	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1275558780 CA386461161	165	F>L		No	ClinGen TOPMed gnomAD
rs1389153480 CA386461180	166	I>V		No	ClinGen gnomAD
CA386461222 rs1438828145	169	S>P		No	ClinGen gnomAD
CA386461257 rs1186389914	171	D>E		No	ClinGen gnomAD
CA386461262 rs1475886067	172	D>G		No	ClinGen gnomAD
rs1235433928 CA386461260	172	D>Y		No	ClinGen gnomAD
CA6772950 rs757611160	173	Y>C		No	ClinGen ExAC gnomAD
rs753949478 CA6772949	173	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA386461266 rs753949478	173	Y>N		No	ClinGen ExAC TOPMed gnomAD
CA6772951 rs200440063	174	S>F		No	ClinGen ExAC TOPMed gnomAD
CA386461274 rs1308392719	174	S>P		No	ClinGen TOPMed gnomAD
CA6772953 rs772298957	176	D>N		No	ClinGen ExAC TOPMed gnomAD
CA6772954 rs772298957	176	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA6772957 rs777108289	177	E>G		No	ClinGen ExAC gnomAD
CA6772956 rs199642143	177	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1416647816 CA386461314	178	D>H		No	ClinGen gnomAD
CA386461374 rs1340381824	181	A>V		No	ClinGen gnomAD
CA243379928 rs961248756	182	G>D		No	ClinGen TOPMed
CA386461377 rs1217336608	182	G>S		No	ClinGen gnomAD
CA386461403 rs1340472855	183	S>L		No	ClinGen gnomAD
CA6772960 COSM1358576 rs772690862	185	R>C	biliary_tract Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs147024369 CA6772961	185	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6772962 rs147024369	185	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1593386710 CA386461456	187	S>P		No	ClinGen Ensembl
rs1486454889 CA386461469	188	T>P		No	ClinGen gnomAD
CA6772963 rs118018469	189	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA243379937 rs997993423	189	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA386461497 rs1476587747	190	K>E		No	ClinGen gnomAD
CA6772965 rs201599513	191	G>D		No	ClinGen ExAC TOPMed gnomAD
CA386461535 rs1319263037	192	S>C		No	ClinGen TOPMed
CA386461538 rs1424041266	192	S>I		No	ClinGen TOPMed
CA386461550 rs1477550372	193	R>G		No	ClinGen TOPMed gnomAD
VAR_062667	193	R>L	a pancreatic ductal adenocarcinoma sample; somatic mutation [UniProt]	No	UniProt
CA6772966 rs767203808	193	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1477550372 CA386461552	193	R>W		No	ClinGen TOPMed gnomAD
CA386461572 rs752604541	194	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1373806485 CA386461566	194	A>T		No	ClinGen gnomAD
rs752604541 CA6772967	194	A>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	198	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6772968 rs757531247	198	A>T		No	ClinGen ExAC gnomAD
TCGA novel	198	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386461642 rs1320815668	201	L>P		No	ClinGen gnomAD
rs1252666278 CA386461646	202	E>K		No	ClinGen gnomAD
CA6772970 rs750704133	204	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA386461797 rs1242302544	208	G>R		No	ClinGen TOPMed
rs780194137 CA6772972	211	E>D		No	ClinGen ExAC gnomAD
CA6772971 rs191751311	211	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1234550776 CA386461908	212	T>N		No	ClinGen gnomAD
COSM1510762 rs747456016 CA6772973	213	R>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs560908915 CA6772974	213	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs373214045 COSM934695 CA6772976	214	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1450979137 CA386462006	216	T>A		No	ClinGen gnomAD
CA6772977 rs770169502	217	M>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	218	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386466972 rs1434094294	218	R>S		No	ClinGen TOPMed
CA6772993 rs17848820	219	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	220	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386467029 rs1397361680	221	M>T		No	ClinGen gnomAD
rs778125313 CA6772995	221	M>V		No	ClinGen ExAC TOPMed gnomAD
CA6772996 rs748928594	222	S>L		No	ClinGen ExAC gnomAD
CA243394205 rs373292549	223	G>E		No	ClinGen TOPMed gnomAD
CA243394207 rs373292549	223	G>V		No	ClinGen TOPMed gnomAD
CA243394214 rs527512063	224	L>P		No	ClinGen ExAC TOPMed gnomAD
CA6772998 rs527512063	224	L>R		No	ClinGen ExAC TOPMed gnomAD
rs745333353 CA6772999	225	H>Y		No	ClinGen ExAC gnomAD
rs775499731 CA6773001	227	V>M		No	ClinGen ExAC gnomAD
rs760700219 CA6773002	229	R>K		No	ClinGen ExAC TOPMed gnomAD
rs768555581 CA243394263	229	R>S		No	ClinGen ExAC gnomAD
CA386467176 rs528602761	231	R>G		No	ClinGen TOPMed gnomAD
rs776631835 CA6773004 COSM200736	231	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA243394266 rs528602761	231	R>W		No	ClinGen TOPMed gnomAD
CA6773005 rs141887668	234	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs990499643 CA243394301	236	L>P		No	ClinGen TOPMed
TCGA novel	237	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386467340 rs1565880437	239	H>R		No	ClinGen Ensembl
CA386467389 rs1193892503	241	D>E		No	ClinGen TOPMed
CA386467373 rs1185924009	241	D>N		No	ClinGen gnomAD
rs1457087688 CA386467403	242	F>V		No	ClinGen TOPMed
CA386467431 rs1437884886	244	V>A		No	ClinGen TOPMed
COSM1181495 CA6773010 rs753146594	244	V>M	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1565880484 CA386467441	245	A>V		No	ClinGen Ensembl
CA6773011 rs756674820	247	P>S		No	ClinGen ExAC gnomAD
rs781314104 CA6773014	248	A>S		No	ClinGen ExAC TOPMed gnomAD
rs781314104 CA6773013	248	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs778588229 CA6773015	249	E>G		No	ClinGen ExAC
CA6773017 rs745510148	250	F>C		No	ClinGen ExAC gnomAD
rs1593448395 CA386467493	250	F>V		No	ClinGen Ensembl
rs771552176 CA6773018	252	T>I		No	ClinGen ExAC gnomAD
rs149394526 CA6773020	253	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs149394526 CA386467528	253	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA6773021 rs146370716	253	R>H		No	ClinGen ESP ExAC gnomAD
rs768750072 CA6773022	254	F>S		No	ClinGen ExAC gnomAD
CA6773025 rs146426104	255	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs146426104 CA6773024	255	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA386467556 rs1376532694	255	G>W		No	ClinGen TOPMed
rs774568250 CA6773027	256	G>E		No	ClinGen ExAC gnomAD
COSM117329 CA386467564 rs1355122797	256	G>R	ovary Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs768607691	257	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs768607691	257	D>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA243394499 rs998573576	257	D>N		No	ClinGen TOPMed gnomAD
CA386467570 rs998573576	257	D>Y		No	ClinGen TOPMed gnomAD
CA6773029 rs144515904	258	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs759694366 CA6773028	258	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs146179662 CA6773031	261	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs780584088 CA6773059	263	V>G		No	ClinGen ExAC gnomAD
COSM3687937 CA6773058 rs754475585	263	V>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1211963744 CA386467645	267	N>T		No	ClinGen TOPMed
CA6773062 rs533919628	269	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs533919628 CA243395395	269	G>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6773063 rs749130358	271	A>G		No	ClinGen ExAC gnomAD
rs1252965239 CA386467671	271	A>T		No	ClinGen TOPMed gnomAD
rs749130358 CA243395410	271	A>V		No	ClinGen ExAC gnomAD
rs775622765 CA6773065	272	A>T		No	ClinGen ExAC TOPMed gnomAD
CA6773067 rs768707560	273	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs776640811 CA6773068	275	C>Y		No	ClinGen ExAC gnomAD
CA386467700 rs1164093227	276	M>L		No	ClinGen gnomAD
rs368005004 CA6773069	276	M>T		No	ClinGen ESP ExAC TOPMed
rs370590640 CA6773070	277	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
COSM278567 CA6773071 rs773787420	277	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs763366636 CA6773072	278	S>C		No	ClinGen ExAC gnomAD
CA6773073 rs763366636	278	S>F		No	ClinGen ExAC gnomAD
rs1460449551 CA386467723	280	R>C		No	ClinGen TOPMed
rs754737585 CA6773075	280	R>H		No	ClinGen ExAC gnomAD
rs754737585 CA6773076	280	R>P		No	ClinGen ExAC gnomAD
rs1375580583 CA386467735	282	W>*		No	ClinGen gnomAD
rs1187424946 CA386467741	283	A>T		No	ClinGen gnomAD
CA386467751 rs1224433870	284	Y>C		No	ClinGen gnomAD
TCGA novel	285	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386467782 rs1215870490	288	R>C		No	ClinGen TOPMed gnomAD
CA6773080 rs777523810	288	R>H	Variant assessed as Somatic; 4.623e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA243395557 rs150967404	289	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
COSM223588 rs756987109 CA6773082	290	E>K	Variant assessed as Somatic; 0.0 impact. skin endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs778738335 CA6773083	291	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA386467800 rs1268082822	291	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1479984413 CA386467805	292	A>D		No	ClinGen TOPMed
CA6773084 rs747227529	292	A>S		No	ClinGen ExAC gnomAD
CA386467809 rs1277382971	293	I>V		No	ClinGen TOPMed
CA6773086 rs781305786	294	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs144382279 CA6773085	294	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs990365203 CA243395589	298	M>I		No	ClinGen TOPMed gnomAD
rs1408035343 CA386467842	298	M>T		No	ClinGen TOPMed gnomAD
CA386467839 rs1395471639	298	M>V		No	ClinGen gnomAD
rs1442947187 CA386467849	299	V>A		No	ClinGen gnomAD
CA6773088 rs573637382	299	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6773089 rs573637382	299	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386467859 rs1292751431	301	P>S		No	ClinGen TOPMed gnomAD
rs763571331 CA6773090	302	E>K		No	ClinGen ExAC TOPMed gnomAD
rs763571331 CA386467864	302	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA243395665 rs774926883	303	D>G		No	ClinGen ExAC TOPMed gnomAD
CA6773092 rs774926883	303	D>V		No	ClinGen ExAC TOPMed gnomAD
CA386467876 rs1172028568	304	L>F		No	ClinGen TOPMed
CA243395696 rs201630101	305	K>M		No	ClinGen Ensembl
CA6773093 rs759233676	305	K>N		No	ClinGen ExAC gnomAD
rs1274617682 CA386467891	306	A>D		No	ClinGen gnomAD
CA6773094 rs767124185	307	N>S		No	ClinGen ExAC TOPMed gnomAD
rs78715638 CA6773096	308	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs763672231 CA6773097	308	A>V		No	ClinGen ExAC gnomAD
CA386468992 rs1173214456	309	E>A		No	ClinGen gnomAD
TCGA novel	312	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386469029 rs1436610572	313	M>I		No	ClinGen gnomAD
rs746301361 CA243401965	314	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6773113 rs545842213	315	D>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA243401974 rs996330530	317	Y>H		No	ClinGen Ensembl
rs1429113872 CA386469098	318	V>A		No	ClinGen TOPMed
CA386469093 rs372405230	318	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA6773115 rs372405230	318	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1174715821 CA386469105	319	P>S		No	ClinGen TOPMed
CA6773117 COSM1946166 rs189283811	320	V>I	central_nervous_system [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1300739181 CA386469134	321	P>R		No	ClinGen gnomAD
rs1176157643 CA386469146	322	G>E		No	ClinGen TOPMed
CA386469182 rs1239447082	325	N>H		No	ClinGen TOPMed
CA6773119 rs750388902	325	N>S		No	ClinGen ExAC TOPMed gnomAD
CA243402023 rs985802557	327	N>S		No	ClinGen TOPMed gnomAD
rs963075043 CA243402024	329	Y>C		No	ClinGen Ensembl
rs201273973 CA6773123	331	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6773121 rs766213742	331	N>S		No	ClinGen ExAC gnomAD
CA6773124 rs777972630	332	V>M		No	ClinGen ExAC TOPMed gnomAD
rs749429433 CA6773125	333	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1223408099 CA386469350	335	I>T		No	ClinGen TOPMed
CA6773126 rs757435011	336	V>E		No	ClinGen ExAC gnomAD
CA243402041 rs779523944	337	D>E		No	ClinGen ExAC TOPMed gnomAD
rs917086257 CA243402046	338	I>T		No	ClinGen Ensembl
rs1390044511 CA386469394	338	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	342	I>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1305911149 CA386469498	344	V>E		No	ClinGen gnomAD
CA6773131 rs138145479	344	V>M		No	ClinGen ESP ExAC gnomAD
rs746611312 CA6773132	345	Q>H		No	ClinGen ExAC gnomAD
rs575445770	346	A>=	Variant assessed as Somatic; 4.625e-05 impact. [NCI-TCGA]	No	NCI-TCGA
rs753447548 CA6773142	346	A>E		No	ClinGen ExAC TOPMed gnomAD
CA6773141 rs753447548	346	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1593462666 CA386469609	347	V>G		No	ClinGen Ensembl
rs754146596 CA6773144	347	V>L		No	ClinGen ExAC gnomAD
TCGA novel	348	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	349	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386469630 rs1207644249	349	A>T		No	ClinGen gnomAD
CA6773146 rs757340908	349	A>V		No	ClinGen ExAC gnomAD
TCGA novel	350	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386469686 rs1485413114	352	G>D		No	ClinGen TOPMed gnomAD
CA386469754 rs1424711229	356	E>G		No	ClinGen gnomAD
CA386469828 rs1434187370	358	P>R		No	ClinGen gnomAD
rs1370918967 CA386469869 COSM242767	360	L>F	prostate [Cosmic]	No	ClinGen cosmic curated gnomAD
CA6773149 rs199655635	361	P>L		No	ClinGen ExAC TOPMed gnomAD
rs200334384 CA243402351	361	P>S		No	ClinGen 1000Genomes
CA6773151 rs780259117	364	L>P		No	ClinGen ExAC gnomAD
CA386469953 rs780259117	364	L>Q		No	ClinGen ExAC gnomAD
rs769036400 CA6773153	365	C>F		No	ClinGen ExAC TOPMed gnomAD
rs747346637 CA6773152	365	C>G		No	ClinGen ExAC gnomAD
TCGA novel	366	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1251195640 CA386470074	370	A>S		No	ClinGen TOPMed
rs770380543 CA6773177	374	P>T		No	ClinGen ExAC gnomAD
rs774280400 CA6773178	376	S>R		No	ClinGen ExAC gnomAD
CA386470634 rs1189642865	379	M>I		No	ClinGen gnomAD
TCGA novel	380	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6773180 rs149147459	380	W>R		No	ClinGen ESP TOPMed gnomAD
CA6773185 rs561181524	387	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA386470809 rs1346927261	388	S>P		No	ClinGen gnomAD
CA386470834 rs1188879747	389	T>I		No	ClinGen TOPMed
CA6773189 rs550167301	390	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs377615413 CA6773191 COSM3739412	392	A>T	liver [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1206962294 CA386470892	393	Q>R		No	ClinGen TOPMed
rs376114199 CA6773193	394	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs370777901 CA6773195	396	Q>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201859471 CA6773196	396	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1272945595 CA386470955	397	V>A		No	ClinGen gnomAD
CA386471048 rs1246950867	402	W>*		No	ClinGen gnomAD
rs947797808 CA243403528	402	W>*		No	ClinGen TOPMed
rs772184272 CA6773199	403	S>N		No	ClinGen ExAC gnomAD
rs775589806 CA6773200	404	G>*		No	ClinGen ExAC gnomAD
rs148317452	405	S>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA6773202 rs771971405	406	G>S		No	ClinGen ExAC TOPMed gnomAD
rs746953280 CA6773219	409	V>A		No	ClinGen ExAC gnomAD
CA386472468 rs1157144715	409	V>M		No	ClinGen TOPMed
rs1285141316 CA386472531	411	W>R		No	ClinGen gnomAD
rs1458519738 CA386472610	412	T>R		No	ClinGen TOPMed
CA386472645 rs1358903417	413	E>D		No	ClinGen gnomAD
rs1412305833 CA386472650	414	D>N		No	ClinGen TOPMed
rs1041691571 CA243404776	419	G>E		No	ClinGen TOPMed gnomAD
CA6773220 rs537194068	419	G>R		No	ClinGen 1000Genomes ExAC gnomAD
CA386472876 rs1209564809	420	K>R		No	ClinGen gnomAD
CA6773222 rs749497970	421	R>I		No	ClinGen ExAC gnomAD
CA386472899 rs749497970	421	R>K		No	ClinGen ExAC gnomAD
rs146350192 CA243404784	421	R>S		No	ClinGen ESP
CA386472959 rs1473972441	423	S>I		No	ClinGen TOPMed
CA386473078 rs1188165889	426	E>D		No	ClinGen TOPMed
CA243404794 rs930121684	426	E>Q		No	ClinGen Ensembl
rs1241276662 CA386473119	429	Y>H		No	ClinGen gnomAD
CA6773224 rs774582095	430	D>H		No	ClinGen ExAC TOPMed gnomAD
rs774582095 CA243404807	430	D>N		No	ClinGen ExAC TOPMed gnomAD
CA386473203 rs1173106019	432	G>D		No	ClinGen gnomAD
rs751113525 CA6773228	434	V>L		No	ClinGen ExAC gnomAD
rs751113525 CA6773227	434	V>M		No	ClinGen ExAC gnomAD
CA6773229 rs764516576	435	K>R		No	ClinGen ExAC TOPMed gnomAD
rs184816447 CA6773230	436	D>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201786970 CA6773231	437	V>I		No	ClinGen 1000Genomes ExAC gnomAD
rs12826842 CA243404847	438	D>N		No	ClinGen Ensembl
CA386473312 rs1365475858	439	E>A		No	ClinGen gnomAD
rs1232845435 CA386473318	439	E>D		No	ClinGen TOPMed gnomAD
rs1346563177 CA386473327	440	G>A		No	ClinGen gnomAD
rs764942932 CA6773232	440	G>S		No	ClinGen ExAC gnomAD
TCGA novel	443	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386473558 rs1593471913	447	I>T		No	ClinGen Ensembl
rs1268989078 CA386473577	448	G>A		No	ClinGen TOPMed
CA386473566 rs1338800693	448	G>S		No	ClinGen TOPMed
CA386473620 rs1325577547	451	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA386473644 rs1265560616	452	M>I		No	ClinGen gnomAD
CA6773258 rs780956007	452	M>T		No	ClinGen ExAC gnomAD
rs752688339 CA6773259	453	I>T		No	ClinGen ExAC TOPMed gnomAD
CA386473665 rs1162438692	454	K>E		No	ClinGen gnomAD
CA6773260 rs755845802	455	A>V		No	ClinGen ExAC gnomAD
CA386473730 rs1471886738	456	S>Y		No	ClinGen gnomAD
CA6773264 CA6773265 rs780343613	460	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6773267 rs776945727	461	G>R		No	ClinGen ExAC gnomAD
CA6773269 rs762436207	462	K>T		No	ClinGen ExAC TOPMed gnomAD
rs770275246 CA6773270	464	I>M		No	ClinGen ExAC TOPMed gnomAD
rs146160862 CA6773272	465	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA6773271 rs146160862	465	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1230117884 CA386473912	465	R>W		No	ClinGen gnomAD
TCGA novel	466	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766083485 CA6773273	468	E>D		No	ClinGen ExAC gnomAD
CA6773274 rs751259499	469	S>C		No	ClinGen ExAC gnomAD
CA386474066 rs758908393	470	A>S		No	ClinGen ExAC gnomAD
CA6773275 rs758908393	470	A>T		No	ClinGen ExAC gnomAD
CA6773276 rs202035669	470	A>V		No	ClinGen ExAC TOPMed gnomAD
rs756114866 CA6773278	471	E>D		No	ClinGen ExAC gnomAD
CA243405121 rs1040911903	471	E>G		No	ClinGen TOPMed gnomAD
rs777515316 CA6773279	474	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1437383134 CA386474265	475	I>V		No	ClinGen TOPMed
CA6773281 rs757072944 COSM1746723	477	F>L	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1475048593 CA386474348	477	F>S		No	ClinGen gnomAD
CA386474363 rs1593472320	478	R>G		No	ClinGen Ensembl
rs780070984 CA6773282	478	R>S		No	ClinGen ExAC gnomAD
CA386474416 rs747264955	479	Q>*		No	ClinGen ExAC gnomAD
CA6773283 rs747264955	479	Q>E		No	ClinGen ExAC gnomAD
rs1454356092 CA386474735	480	V>I		No	ClinGen TOPMed
rs1374378198 CA386474764	481	Q>L		No	ClinGen gnomAD
rs1034665502 CA243406989	482	S>G		No	ClinGen Ensembl
CA386474785 rs1464475497	482	S>N		No	ClinGen gnomAD
rs1162220161 CA386474808	483	E>K		No	ClinGen TOPMed
CA6773296 rs760586285	484	I>T		No	ClinGen ExAC gnomAD
CA386474858 rs1379567547	485	P>S		No	ClinGen gnomAD
CA6773297 rs763977187	487	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1275438984 CA386474927	488	P>L		No	ClinGen gnomAD
CA6773299 rs756985067	488	P>S		No	ClinGen ExAC gnomAD
CA6773301 rs751726366	489	I>V		No	ClinGen ExAC TOPMed gnomAD
rs781109291 CA386476063	492	M>L		No	ClinGen ExAC TOPMed gnomAD
rs139024189 CA6773304	492	M>T		No	ClinGen ESP ExAC gnomAD
CA6773303 rs781109291	492	M>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	493	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	493	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386476089 rs1245756599	493	K>R		No	ClinGen gnomAD
TCGA novel	498	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6773306 rs143885746	498	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA243407146 rs978164597	499	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs201408408 CA6773307	499	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA386476190 rs1359678433	500	H>R		No	ClinGen gnomAD
rs1318285669 CA386476289	506	L>F		No	ClinGen gnomAD
TCGA novel	506	L>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6773309 rs574173923	507	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386476334 rs1298675443	509	Q>*		No	ClinGen gnomAD
CA243407165 rs771809689 CA6773311	509	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs745482115 CA6773310	509	Q>R		No	ClinGen ExAC gnomAD
rs1344891763 CA386476406	513	A>T		No	ClinGen TOPMed
rs1266617876 CA386476426	514	V>E		No	ClinGen gnomAD
CA386476422 rs1228379160	514	V>L		No	ClinGen gnomAD
TCGA novel	516	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA243407188 rs199948166	518	G>D		No	ClinGen Ensembl
rs754977294 CA6773315	519	R>C		No	ClinGen ExAC gnomAD
rs754977294 CA6773316	519	R>G		No	ClinGen ExAC gnomAD
CA386476497 rs1487182342	519	R>H		No	ClinGen TOPMed gnomAD
rs764908876 CA386476498	520	D>H		No	ClinGen ExAC gnomAD
rs764908876 CA6773318	520	D>N		No	ClinGen ExAC gnomAD
rs1593478913 CA386476509	521	C>Y		No	ClinGen Ensembl
CA6773320 rs750279555	522	S>C		No	ClinGen ExAC TOPMed gnomAD
rs758149057 CA6773321	523	I>T		No	ClinGen ExAC gnomAD
rs756205551 CA6773324	525	R>Q		No	ClinGen ExAC gnomAD
CA6773322 rs767740857	525	R>W		No	ClinGen ExAC gnomAD
rs778057425 CA6773325	526	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA386476535 rs1170701780	526	R>W		No	ClinGen TOPMed
rs757826653 CA6773328	531	V>I		No	ClinGen ExAC TOPMed gnomAD
rs757826653 CA386476583	531	V>L		No	ClinGen ExAC TOPMed gnomAD
rs746197448 CA6773330	532	E>Q		No	ClinGen ExAC gnomAD
rs772324658 CA6773331	534	A>V		No	ClinGen ExAC gnomAD
rs779621331 COSM1639026 CA6773332	535	P>L	stomach [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1593479109 CA386476693	538	I>L		No	ClinGen Ensembl
CA243407289 rs147821902	539	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA gnomAD
CA6773336 rs776158563	540	P>L		No	ClinGen ExAC gnomAD
rs769720984 CA6773338	542	A>S		No	ClinGen ExAC TOPMed gnomAD
rs773052620 CA386476769	543	I>L		No	ClinGen ExAC gnomAD
rs773052620 CA6773339	543	I>V		No	ClinGen ExAC gnomAD
TCGA novel	544	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762744729 CA6773340	545	E>K		No	ClinGen ExAC TOPMed gnomAD
CA386476835 rs766291285	547	M>L		No	ClinGen ExAC TOPMed gnomAD
CA6773341 rs766291285	547	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1409307195 CA386476858	548	E>Q		No	ClinGen gnomAD
CA6773356 rs16940029 VAR_031255	552	I>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA6773357 rs374758183	553	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs376035720 CA6773358	553	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs376035720 CA243407895	553	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1038693489 CA243407902	556	K>N		No	ClinGen TOPMed gnomAD
rs1362080629 CA386477151	557	T>S		No	ClinGen TOPMed gnomAD
CA6773360 rs556775153	558	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1475796328 CA386477210	560	Y>H		No	ClinGen TOPMed gnomAD
rs370344183 CA6773361	561	V>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA386477271 rs1593481254	562	S>N		No	ClinGen Ensembl
rs754041618 CA6773362	563	A>T		No	ClinGen ExAC TOPMed gnomAD
rs765287680 CA6773364	566	V>A		No	ClinGen ExAC gnomAD
CA386477404 rs1565893525	567	E>G		No	ClinGen Ensembl
rs1593481322 CA386477413	568	Y>S		No	ClinGen Ensembl
CA6773365 rs145285048	570	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA243407971 rs188194445	572	Q>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6773366 rs188194445	572	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs780374696 CA6773367	572	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	574	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386477715 rs1219811843	576	F>C		No	ClinGen gnomAD
CA386477745 rs1232696084	578	F>L		No	ClinGen gnomAD
CA386477771 rs1267228825 CA386477768	578	F>L		No	ClinGen TOPMed gnomAD
rs140894897 CA6773370	584	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1250169428 CA386477902 COSM1244059	584	R>H	oesophagus [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1250169428 CA386477904	584	R>L		No	ClinGen TOPMed gnomAD
rs1198270225 CA386477967	587	V>G		No	ClinGen gnomAD
rs191387263 CA243408018	588	E>V		No	ClinGen 1000Genomes
CA386478045 rs1376050338	590	P>L		No	ClinGen gnomAD
rs1479286702 CA386478053	591	C>S		No	ClinGen gnomAD
rs755638623 CA6773372	592	T>I		No	ClinGen ExAC gnomAD
CA6773374 rs749219076	594	M>I		No	ClinGen ExAC gnomAD
CA6773375 rs771044060	596	A>G		No	ClinGen ExAC gnomAD
CA386478206 rs11065772	597	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200954726 CA386478213	598	V>F		No	ClinGen ExAC TOPMed gnomAD
rs200954726 CA6773377 COSM934714	598	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1321011420 CA386478228	599	N>S		No	ClinGen gnomAD
rs776895831 CA6773379	601	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6773380 rs776895831	601	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs375366307 CA6773383	603	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1181496 CA6773382 rs375366307	603	A>T	lung Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA386478277 rs1270188084	603	A>V		No	ClinGen gnomAD
rs766830119 CA6773384	604	Q>H		No	ClinGen ExAC gnomAD
rs1351654628 CA386478280	604	Q>K		No	ClinGen gnomAD
rs1490132544 CA386478287	604	Q>R		No	ClinGen TOPMed
rs1251763163 CA386478304	606	Q>*		No	ClinGen gnomAD
rs748376417 CA6773398	608	A>T		No	ClinGen ExAC TOPMed gnomAD
CA6773399 rs540118947	610	G>D		No	ClinGen 1000Genomes ExAC
CA386478812 rs1188331811	610	G>R		No	ClinGen TOPMed
rs567060031 CA6773402	611	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs762951275 CA6773401	611	V>M		No	ClinGen ExAC TOPMed gnomAD
CA386478827 rs1401173668	612	P>A		No	ClinGen gnomAD
TCGA novel	612	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386478846 rs1394100325	614	H>Y		No	ClinGen gnomAD
rs1389218832 CA386478857	615	R>Q		No	ClinGen gnomAD
CA6773403 COSM77199 rs145713657	615	R>W	ovary large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1247062162 CA386478870	617	K>E		No	ClinGen gnomAD
CA243412726 rs978350193	619	I>T		No	ClinGen Ensembl
CA386478901 rs1207186713	620	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs753053412 CA6773406	620	R>W		No	ClinGen ExAC TOPMed gnomAD
rs140603461 CA6773407	624	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs202162559 CA386478945	625	E>K		No	ClinGen 1000Genomes ExAC TOPMed
CA6773410 rs202162559	625	E>Q		No	ClinGen 1000Genomes ExAC TOPMed
rs989626934 CA243412757	625	E>V		No	ClinGen Ensembl
CA386478959 rs1238219120	626	S>P		No	ClinGen gnomAD
rs1444863810 CA386478980	628	W>*		No	ClinGen gnomAD
rs1444863810 CA386478983	628	W>L		No	ClinGen gnomAD
CA386478978 rs1308853674	628	W>R		No	ClinGen gnomAD
rs1363004243 CA386478992	629	G>R		No	ClinGen TOPMed
CA386478998 rs1187581386	630	V>M		No	ClinGen TOPMed gnomAD
rs1450816537 CA386479040	634	S>Y		No	ClinGen gnomAD
CA386479060 rs1393480967	636	E>Q		No	ClinGen TOPMed
rs1593495402 CA386479071	637	T>P		No	ClinGen Ensembl
rs778629713 CA6773413	638	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA6773414 rs750352442	640	N>I		No	ClinGen ExAC gnomAD
CA386479103 rs750352442	640	N>T		No	ClinGen ExAC gnomAD
CA386479129 rs1403882575	643	L>F		No	ClinGen TOPMed
CA6773416 rs111403940 COSM1358578	644	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA6773418 rs142989070	645	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA386479153 rs142989070	645	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA6773419 rs202062595	645	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs372168822 CA386479164	646	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA6773421 rs372168822	646	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs372168822 CA6773420	646	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA386479173 rs1239449209	647	H>L		No	ClinGen TOPMed gnomAD
rs773903038 CA386479175	647	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA386479172 rs1239449209	647	H>R		No	ClinGen TOPMed gnomAD
CA386479182 rs1265349355	648	V>D		No	ClinGen gnomAD
rs376760625 CA6773424	648	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs776099794 CA6773425	649	I>V		No	ClinGen ExAC gnomAD
rs2300455 CA386479207	651	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6773427 VAR_031256 rs2300455	651	A>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs753532997 CA6773428	652	R>G		No	ClinGen ExAC
CA386479219 rs1486523139	652	R>K		No	ClinGen gnomAD
CA243412898 rs894138200	658	P>A		No	ClinGen TOPMed
CA6773432 COSM278568 rs757955756	660	E>K	lung Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA243418402 rs907874044	664	P>L		No	ClinGen TOPMed
rs747449313 CA6773460	667	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1288744010 CA386479960	668	T>I		No	ClinGen gnomAD
CA6773462 rs777305943	669	V>I		No	ClinGen ExAC TOPMed gnomAD
rs772984491 CA6773465	675	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs202216589 CA6773464	675	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs373217436 CA6773466	677	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs765777312 CA6773467	677	S>R		No	ClinGen ExAC gnomAD
CA6773472 rs755847339	680	V>A		No	ClinGen ExAC gnomAD
rs201520813 CA6773471	680	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201520813 CA6773470	680	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386480269 rs1262624309	686	V>L		No	ClinGen TOPMed
CA386480285 rs1283180486	687	A>D		No	ClinGen gnomAD
CA386480301 rs1315104452	688	A>G		No	ClinGen TOPMed gnomAD
TCGA novel	688	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386480296 rs1247806490	688	A>T		No	ClinGen gnomAD
rs747068694 CA6773478	690	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1209175525 CA386480350	692	L>Q		No	ClinGen gnomAD
rs748721206 CA386480380	694	E>*		No	ClinGen ExAC TOPMed gnomAD
CA6773481 rs748721206	694	E>K		No	ClinGen ExAC TOPMed gnomAD
CA6773482 rs770277458	695	F>L		No	ClinGen ExAC TOPMed gnomAD
CA386480404 rs1423483752	695	F>Y		No	ClinGen TOPMed
rs1165405300 CA386480416	696	A>T		No	ClinGen TOPMed
CA6773483 rs773666938 COSM351951	696	A>V	lung Variant assessed as Somatic; 0.0 impact. endometrium [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1422290007 CA386480464	698	S>F		No	ClinGen TOPMed gnomAD
CA6773486 rs773907696	701	G>R		No	ClinGen ExAC TOPMed gnomAD
rs771586214 CA6773488	708	E>Q		No	ClinGen ExAC gnomAD
rs1225546821 CA386480587	710	R>L		No	ClinGen TOPMed gnomAD
rs1225546821 CA386480584	710	R>Q		No	ClinGen TOPMed gnomAD
CA6773489 rs201035398	710	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA6773490 rs760676161	712	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1339974206 CA386480614	713	A>T		No	ClinGen gnomAD
CA386480633 rs1484045330	714	I>N		No	ClinGen gnomAD
CA386480626 rs1593502488	714	I>V		No	ClinGen Ensembl
rs753617014 COSM1181494 CA6773492	715	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA386481527 rs1464071620	717	M>I		No	ClinGen gnomAD
CA386481532 rs1333818588	718	V>A		No	ClinGen gnomAD
CA386481530 rs1287459385	718	V>L		No	ClinGen gnomAD
rs778605951 CA243421077	720	A>G		No	ClinGen TOPMed gnomAD
CA386481544 rs1281526262	720	A>P		No	ClinGen TOPMed gnomAD
rs1281526262 CA386481547	720	A>T		No	ClinGen TOPMed gnomAD
rs1565904663 CA386481613	724	L>P		No	ClinGen Ensembl
rs1410441808 CA386481630	725	S>F		No	ClinGen TOPMed
rs1018207163 CA243421112 COSM1181487	727	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA6773535 rs562094257	727	R>Q		No	ClinGen ExAC gnomAD
rs761608576 CA386481726	731	R>K		No	ClinGen ExAC TOPMed gnomAD
rs761608576 CA6773538	731	R>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6773539 rs764997444	731	R>S		No	ClinGen ExAC gnomAD
CA386481744 rs1364034009	732	T>I		No	ClinGen gnomAD
rs1565904738 CA386481755	733	T>S		No	ClinGen Ensembl
CA6773542 rs145001704	734	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6773541 rs145001704	734	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA607601123 rs1425202455	736	Y>*		No	ClinGen gnomAD
rs1483652086 CA386481831	738	I>F		No	ClinGen TOPMed
rs1307369571 CA386481860	740	L>F		No	ClinGen TOPMed gnomAD
rs1307369571 CA386481858	740	L>V		No	ClinGen TOPMed gnomAD
CA386481897 rs1338339371	742	E>D		No	ClinGen gnomAD
rs1394021305 CA386481903	743	T>S		No	ClinGen gnomAD
rs967160470 CA243421181	744	E>K		No	ClinGen TOPMed gnomAD
rs1331067133 CA386481928	745	S>N		No	ClinGen gnomAD
rs756295416 CA6773544	747	Q>H		No	ClinGen ExAC gnomAD
CA386481964 rs1361743300	750	D>N		No	ClinGen TOPMed gnomAD
rs1251272751 COSM1628361 CA386481973	751	I>V	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
rs757630628 CA6773547	752	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs745491556 CA386481993 CA6773549	754	G>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	754	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386482005 rs1386512707	755	W>C		No	ClinGen gnomAD
CA386482010 rs1565904901	756	L>W		No	ClinGen Ensembl
rs1444752611 CA386482014	757	D>Y		No	ClinGen gnomAD
CA243421279 rs1012906544	762	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA6773551 rs779707974	763	K>E		No	ClinGen ExAC gnomAD
rs1371276453 CA386482062	764	V>M		No	ClinGen gnomAD
CA243421288 rs1025233099	765	Q>H		No	ClinGen Ensembl
CA386482072 rs1463512497	765	Q>R		No	ClinGen gnomAD
CA6773570 rs754505331	766	A>V		No	ClinGen ExAC TOPMed gnomAD
CA6773572 rs372425748	769	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6773574 rs372425748	769	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6773573 rs372425748	769	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1021514420 CA243421440	770	D>G		No	ClinGen TOPMed gnomAD
CA6773576 rs542111056	770	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs760875080 CA6773578	772	M>T		No	ClinGen ExAC gnomAD
CA6773577 rs775845125	772	M>V		No	ClinGen ExAC gnomAD
rs761980605 CA6773581	774	G>A		No	ClinGen ExAC TOPMed gnomAD
rs761980605 CA386482137	774	G>E		No	ClinGen ExAC TOPMed gnomAD
rs199632157 CA6773580	774	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1294083236 CA386482141	775	V>L		No	ClinGen gnomAD
rs1369095847 CA386482148	776	V>A		No	ClinGen gnomAD
rs770255172 CA6773582	776	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	777	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6773584 rs375473600	778	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs766795247 CA6773585	778	G>V		No	ClinGen ExAC gnomAD
CA386482164 rs1365496868	779	A>D		No	ClinGen gnomAD
CA6773586 rs751179466	779	A>S		No	ClinGen ExAC gnomAD
CA386482180 rs776023628	781	N>K		No	ClinGen ExAC TOPMed gnomAD
CA6773588 rs142240913	782	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs539307430 CA243421487 COSM3398314	783	A>T	central_nervous_system [Cosmic]	No	ClinGen cosmic curated Ensembl
rs757403439 CA243421498	784	D>G		No	ClinGen TOPMed gnomAD
rs368443757 CA6773592	784	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs368443757 CA6773591	784	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs200732483 CA243421511	785	A>E		No	ClinGen ExAC TOPMed gnomAD
CA6773593 rs770847703	785	A>P		No	ClinGen ExAC TOPMed gnomAD
rs200732483 CA6773594	785	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA243421514 rs371618576	786	M>V		No	ClinGen TOPMed
CA243421517 rs941660768	789	T>A		No	ClinGen TOPMed
CA243421519 rs749816455	789	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6773596 rs749816455	789	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1176768494 CA386482228	790	C>S		No	ClinGen gnomAD
CA386482233 rs1406084359	790	C>W		No	ClinGen TOPMed gnomAD
rs769916189 CA6773599	793	D>N		No	ClinGen ExAC gnomAD
rs1322885982 CA386482258	794	F>L		No	ClinGen TOPMed
rs763489136 CA6773601	796	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1489474249 CA386482330	798	L>Q		No	ClinGen gnomAD
rs1305507948 CA386482342	799	E>*		No	ClinGen gnomAD
rs1366539512 CA386482345	799	E>V		No	ClinGen gnomAD
rs1024779023 CA243422790	803	V>I		No	ClinGen TOPMed gnomAD
rs759763354 CA6773622	805	P>L		No	ClinGen ExAC gnomAD
TCGA novel	805	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6773626 rs763677490	810	L>P		No	ClinGen ExAC gnomAD
rs145681259 CA243422866	813	V>A		No	ClinGen ESP gnomAD
CA6773627 rs367805487	813	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA6773628 rs371701828	814	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1185482040 CA386482645	814	D>G		No	ClinGen gnomAD
TCGA novel	814	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778653268 CA6773629	815	V>M		No	ClinGen ExAC gnomAD
rs1185309598 CA386482654	816	E>*		No	ClinGen gnomAD
rs779935990 CA6773632	820	G>E		No	ClinGen ExAC gnomAD
COSM934724 CA6773631 rs550603462	820	G>R	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs748293791 CA6773633	821	G>D		No	ClinGen ExAC gnomAD
CA386482694 rs748293791	821	G>V		No	ClinGen ExAC gnomAD
rs762516264 CA243422887	822	V>F		No	ClinGen Ensembl
CA386482715 rs1172072857	823	K>R		No	ClinGen TOPMed
CA386482741 rs1470792649	825	I>V		No	ClinGen gnomAD
CA386482762 rs1334217412	827	K>E		No	ClinGen gnomAD
rs747315043 CA6773663	828	V>L		No	ClinGen ExAC gnomAD
CA386483470 rs1180739442	829	A>S		No	ClinGen TOPMed gnomAD
rs1236640081 CA386483480	829	A>V		No	ClinGen gnomAD
rs769197510 CA6773664	830	R>Q		No	ClinGen ExAC gnomAD
rs1291454767 CA386483484	830	R>W		No	ClinGen TOPMed
rs1163625872 CA386483504	831	Q>R		No	ClinGen TOPMed gnomAD
rs1174190986 CA386483524	832	S>F		No	ClinGen TOPMed
rs1435081011 CA386483541	834	T>A		No	ClinGen TOPMed
rs776415103 CA6773665	834	T>S		No	ClinGen ExAC TOPMed gnomAD
rs17848802 CA6773666	835	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6773668 rs772727257	837	V>I		No	ClinGen ExAC gnomAD
CA386483659 rs1490950801	840	M>T		No	ClinGen gnomAD
rs1593529067 CA386483692	842	G>A		No	ClinGen Ensembl
CA6773671 rs771700854	843	C>R		No	ClinGen ExAC gnomAD
rs754754767 CA6773672	843	C>Y		No	ClinGen ExAC gnomAD
CA6773673 rs767367796	845	I>S		No	ClinGen ExAC TOPMed gnomAD
rs570024928 CA243426358	845	I>V		No	ClinGen 1000Genomes gnomAD
rs371416586 CA6773675	846	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1367133950 CA386483724	847	I>N		No	ClinGen TOPMed gnomAD
rs1367133950 CA386483725	847	I>T		No	ClinGen TOPMed gnomAD
rs779029093 CA6773676	849	A>S		No	ClinGen ExAC TOPMed gnomAD
CA386483736 rs779029093	849	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1328002586 CA386483744	850	H>P		No	ClinGen gnomAD
CA243426381 rs367885804	851	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA6773679 rs780689830	851	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6773678 rs367885804	851	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA386483784 rs1593529253	857	L>I		No	ClinGen Ensembl
rs1210793795 CA386483796	859	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA386483811 rs1183598692	861	Y>C		No	ClinGen gnomAD
CA386483807 rs1435684013	861	Y>H		No	ClinGen TOPMed gnomAD
rs1435684013 CA386483809	861	Y>N		No	ClinGen TOPMed gnomAD
rs748481689 CA6773684	862	N>S		No	ClinGen ExAC gnomAD
CA386483837 rs1441879635	865	S>G		No	ClinGen gnomAD
CA386483851 rs1304331497	866	Y>*		No	ClinGen TOPMed
rs1458408808 CA386483865	869	Y>H		No	ClinGen gnomAD
CA386483876 rs1381853025	870	M>T		No	ClinGen gnomAD
rs772744233 CA6773686	875	D>E		No	ClinGen ExAC gnomAD
CA386483921 rs1158195178	876	S>N		No	ClinGen TOPMed
rs778064707 CA6773722	878	R>*		No	ClinGen ExAC gnomAD
rs755846803 COSM934725 CA243428669	878	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1009799722 CA243428683	882	G>S		No	ClinGen TOPMed gnomAD
CA386484338 rs745338655	883	N>D		No	ClinGen ExAC gnomAD
CA6773726 rs745338655	883	N>H		No	ClinGen ExAC gnomAD
CA6773727 rs201708270	883	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs775472026 CA6773729	885	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6773733 rs761707822	886	C>R		No	ClinGen ExAC gnomAD
rs766670302 CA6773734	889	E>K		No	ClinGen ExAC gnomAD
CA386484444 rs1217315017	889	E>V		No	ClinGen gnomAD
TCGA novel	890	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1345000403 CA386484458	890	K>Q		No	ClinGen TOPMed
TCGA novel	893	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759667024 CA6773736	893	D>N		No	ClinGen ExAC gnomAD
CA6773737 rs138636393	895	T>I		No	ClinGen ESP ExAC gnomAD
TCGA novel	896	V>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6773740 rs764674504	899	S>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	901	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA243428772 rs375290298	901	S>L		No	ClinGen ESP TOPMed gnomAD
rs1295989616 CA386484650	902	A>G		No	ClinGen TOPMed
CA386484653 rs1403511025	903	G>R		No	ClinGen gnomAD
rs745564909 CA6773744	906	T>I		No	ClinGen ExAC gnomAD
CA6773745 rs757903127	907	Q>R		No	ClinGen ExAC gnomAD
CA243428837 rs910765182	909	T>A		No	ClinGen Ensembl
CA386484727 rs1304206625	909	T>I		No	ClinGen gnomAD
rs779492116 CA6773746	911	E>Q		No	ClinGen ExAC gnomAD
CA6773747 rs746545179	913	G>R		No	ClinGen ExAC gnomAD
rs747905047 CA386484790	915	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA386484806 rs1565913509	916	V>A		No	ClinGen Ensembl
CA386484797 rs1247107221	916	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA386484816 rs1488915679	917	E>K		No	ClinGen gnomAD
CA6773751 rs769761227	918	A>S		No	ClinGen ExAC gnomAD
rs966180894 CA243428873	918	A>V		No	ClinGen Ensembl
rs1159716906 CA386484861	921	S>N		No	ClinGen TOPMed gnomAD
rs1159716906 CA386484862	921	S>T		No	ClinGen TOPMed gnomAD
rs1250054732 CA386484873	923	A>T		No	ClinGen TOPMed
rs1404168033 CA386484893	925	M>I		No	ClinGen gnomAD
CA386484888 rs1357834405	925	M>V		No	ClinGen Ensembl
rs373683126 CA6773754	926	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	929	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6773780 rs763408635	930	M>V		No	ClinGen ExAC gnomAD
CA386485263 rs1262536501	932	M>V		No	ClinGen TOPMed gnomAD
CA6773781 rs370837345	933	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs751276030 CA6773782	934	L>V		No	ClinGen ExAC gnomAD
CA6773783 rs754415842	935	N>K		No	ClinGen ExAC TOPMed gnomAD
CA6773785 rs752667004	936	V>I		No	ClinGen ExAC gnomAD
CA6773786 rs375016692	937	Q>*		No	ClinGen ESP ExAC gnomAD
CA386485369 rs1477914359	938	E>G		No	ClinGen gnomAD
CA386485360 rs1426293977	938	E>K		No	ClinGen gnomAD
CA6773787 rs777855927	939	R>I		No	ClinGen ExAC gnomAD
rs144385811 CA6773789 CA6773788	939	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM3398315 CA6773791 rs747291562	941	R>Q	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6773790 rs780115048	941	R>W	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs776638245 CA6773793	946	K>R		No	ClinGen ExAC TOPMed gnomAD
CA6773794 rs373882930	947	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6773796 rs181685208	947	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs181685208 CA6773795	947	R>L		No	ClinGen 1000Genomes ExAC gnomAD
CA243430376 rs373882930	947	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6773797 rs376816430	949	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1593541717 CA386485539	949	G>V		No	ClinGen Ensembl
rs1342890033 CA386485557	951	V>L		No	ClinGen gnomAD
CA386485583 rs1279471517	953	E>K		No	ClinGen gnomAD
CA386486172 rs1371962054	954	A>S		No	ClinGen gnomAD
rs767290540 CA6773802	954	A>V		No	ClinGen ExAC TOPMed gnomAD
rs147358100 CA6773805	957	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6773804 rs147358100	957	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV001812397 rs139511102 CA6773806	958	V>M		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA243430430 rs1050222575	960	R>G		No	ClinGen TOPMed gnomAD
rs143533866 CA6773807	960	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs140972865 CA6773809	963	L>I		No	ClinGen 1000Genomes ExAC
CA6773812 rs748180603	964	D>E		No	ClinGen ExAC gnomAD
RCV000994971 rs150559547 CA6773811	964	D>N		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs374059185 CA6773813	965	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA386486316 rs1329530168	965	D>G		No	ClinGen gnomAD
CA243430460 rs1051038480	968	K>N		No	ClinGen Ensembl
CA386486340 rs1350083088	969	V>F		No	ClinGen gnomAD
rs749872855 CA6773815	969	V>G		No	ClinGen ExAC gnomAD
rs201086081 CA6773816	970	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA6773818 rs759824633	971	P>L		No	ClinGen ExAC TOPMed gnomAD
rs759824633 CA6773819	971	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA6773817 COSM1706242 rs774719378	971	P>S	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1413183436	972	A>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386460508 rs1369912084	972	A>G		No	ClinGen gnomAD
CA386460504 rs544990923	972	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA6773838 rs544990923	972	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1369912084 CA386460509	972	A>V		No	ClinGen gnomAD
CA6773839 rs768264013	974	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM394946 rs768264013 CA386460530	974	P>Q	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1030324410 CA243389294	976	T>I		No	ClinGen Ensembl
CA386460590 rs1473163729	980	P>S		No	ClinGen TOPMed
rs765175424 CA6773843 COSM1510758	982	Q>H	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA6773844 rs750379973	983	Q>*		No	ClinGen ExAC gnomAD
rs949345193 CA243389332	985	L>P		No	ClinGen TOPMed
rs536491553 CA243389334	986	P>S		No	ClinGen TOPMed
rs536491553 CA386460649	986	P>T		No	ClinGen TOPMed
rs752903306 CA6773847	987	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	989	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770852910 CA6773848	989	G>R		No	ClinGen ExAC TOPMed gnomAD
CA6773849 rs144642580	990	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA243389348 rs776789021	992	L>P		No	ClinGen Ensembl
CA386460734 rs1333998714	994	Q>H		No	ClinGen TOPMed
rs753913766 CA6773850	995	V>A		No	ClinGen ExAC gnomAD
rs572071754 CA6773852	999	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA243389360 rs201793928	1002	N>K		No	ClinGen TOPMed gnomAD
rs1442998693 CA386460824	1003	L>F		No	ClinGen gnomAD
rs772558737 CA6773854	1004	T>I		No	ClinGen ExAC gnomAD
rs938035930 CA243389389	1005	N>S		No	ClinGen TOPMed gnomAD
COSM1639027 CA6773857 rs768386735	1006	V>I	Variant assessed as Somatic; 0.0 impact. stomach [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
COSM546188 CA6773860 rs769231625	1007	M>I	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	1007	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761367358 CA6773859	1007	M>V		No	ClinGen ExAC gnomAD
TCGA novel	1008	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773198261 CA6773861	1008	S>R		No	ClinGen ExAC gnomAD
rs1425900342 CA386460895	1010	F>L		No	ClinGen TOPMed
CA243389449 rs888561348	1011	C>R		No	ClinGen TOPMed
CA6773862 rs762938664	1011	C>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1013	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6773865 rs759357613	1016	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1278455426 CA386460983	1018	S>N		No	ClinGen gnomAD
rs1381309570 CA386461000	1019	I>M		No	ClinGen gnomAD
rs764328291 CA6773866	1020	K>T		No	ClinGen ExAC gnomAD
CA386461731 rs1177813039	1024	W>C		No	ClinGen TOPMed
rs1378984891 CA386461727	1024	W>S		No	ClinGen gnomAD
CA386461798 rs1483232601	1028	L>V		No	ClinGen TOPMed
CA386461828 rs1319706956	1029	M>I		No	ClinGen gnomAD
CA386461811 rs1288823399	1029	M>V		No	ClinGen gnomAD
CA386461845 rs1219572920	1030	M>I		No	ClinGen gnomAD
CA386461863 rs1241814191	1031	T>I		No	ClinGen TOPMed
rs1593566807 CA386461858	1031	T>P		No	ClinGen Ensembl
CA386461877 rs1593566844	1032	L>P		No	ClinGen Ensembl
COSM1165898 rs761995492 CA6773888	1033	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
COSM3772242 CA6773887 rs776904109	1033	R>W	Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1593566913 CA386461902	1034	H>P		No	ClinGen Ensembl
rs1198051357 CA386461909	1034	H>Q		No	ClinGen gnomAD
rs750458750 CA6773890	1035	P>L		No	ClinGen ExAC gnomAD
CA6773889 rs765506891	1035	P>S		No	ClinGen ExAC gnomAD
rs752155886 CA6773893	1038	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1453204864 CA386462028	1042	L>P		No	ClinGen TOPMed
TCGA novel	1042	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA243391397 rs893134672	1043	Q>*		No	ClinGen TOPMed
rs893134672 CA243391383	1043	Q>K		No	ClinGen TOPMed
CA386462041 rs1464816657	1043	Q>R		No	ClinGen gnomAD
CA386462077 rs1383997643	1044	E>D		No	ClinGen TOPMed
CA386462060 rs1423303041	1044	E>K		No	ClinGen TOPMed
CA386462122 rs1392365429	1047	T>A		No	ClinGen gnomAD
rs755368659 CA6773894	1047	T>N		No	ClinGen ExAC TOPMed gnomAD
CA386462130 rs1447338267	1048	S>G		No	ClinGen gnomAD
CA243391410 rs781468323	1048	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1447338267 CA386462129	1048	S>R		No	ClinGen gnomAD
rs553109112 CA6773896	1049	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs553109112 COSM1244061 CA386462136	1049	V>M	oesophagus [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA6773897 rs376848216	1050	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1229815938 CA386462142	1050	A>P		No	ClinGen TOPMed gnomAD
rs1335695943 CA386462149	1051	G>D		No	ClinGen gnomAD
CA6773898 rs777435824	1052	R>C	Variant assessed as Somatic; 4.73e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6773899 rs748746665	1054	P>A		No	ClinGen ExAC gnomAD
CA243391457 rs61934316	1055	A>G		No	ClinGen 1000Genomes ExAC gnomAD
CA6773901 rs373113364	1055	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6773902 rs61934316	1055	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1482603356 CA386462198	1056	P>H		No	ClinGen gnomAD
CA386462227 rs1593567438	1058	E>G		No	ClinGen Ensembl
CA386462250 rs1246655754	1060	S>T		No	ClinGen TOPMed
rs1183932981 CA386462263	1061	V>D		No	ClinGen gnomAD
rs372040414 CA6773903	1062	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6773904 rs775085787	1062	R>H		No	ClinGen ExAC TOPMed gnomAD
rs775085787 CA6773905	1062	R>L		No	ClinGen ExAC TOPMed gnomAD
CA386462271 rs1410025561	1063	R>K		No	ClinGen gnomAD
TCGA novel	1063	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386462281 rs1593567571	1064	V>G		No	ClinGen Ensembl
TCGA novel	1065	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1066	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1067	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773620750 CA6773907	1068	Y>F		No	ClinGen ExAC gnomAD
rs763097067 CA6773908	1070	S>N		No	ClinGen ExAC TOPMed gnomAD
rs141278003 CA6773909	1072	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1593567645 CA386462339	1073	T>P		No	ClinGen Ensembl
rs376684937 CA386462348	1074	S>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6773911 rs376684937	1074	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768076267 CA6773912	1075	V>M		No	ClinGen ExAC gnomAD
TCGA novel	1077	C>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386462363 rs1457534140	1077	C>Y		No	ClinGen TOPMed
TCGA novel	1078	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752965758 CA6773913	1080	P>R		No	ClinGen ExAC gnomAD
rs954256087 CA243391569	1081	S>R		No	ClinGen TOPMed gnomAD
CA6773914 rs756522714	1083	Q>*		No	ClinGen ExAC gnomAD
rs376285991 CA6773915	1083	Q>H		No	ClinGen ESP ExAC gnomAD
CA386462877 rs1190675259	1085	A>V		No	ClinGen TOPMed gnomAD
CA386462879 rs1420652647	1086	T>A		No	ClinGen TOPMed
CA386462907 rs1182887923	1090	C>Y		No	ClinGen TOPMed
rs151299707 CA6773934	1091	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA386462983 rs369101174	1097	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6773936 rs369101174	1097	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6773935 rs778538004	1097	R>W		No	ClinGen ExAC gnomAD
rs757945449 CA6773937	1101	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA243395693 rs905355339	1101	R>L		No	ClinGen TOPMed
rs779827964 CA6773938	1102	E>V		No	ClinGen ExAC gnomAD
rs747037918 CA6773939 COSM158837	1103	V>I	NS [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA6773941 rs768562087	1105	F>L		No	ClinGen ExAC gnomAD
CA6773940 rs768562087	1105	F>V		No	ClinGen ExAC gnomAD
CA386463099 rs1311860104	1106	I>M		No	ClinGen gnomAD
rs747961113 CA6773942	1106	I>V		No	ClinGen ExAC gnomAD
rs1351851277 CA386463111	1107	N>S		No	ClinGen gnomAD
rs771240116 CA6773943	1108	T>I		No	ClinGen ExAC gnomAD
CA386463118 rs1381258524	1108	T>P		No	ClinGen TOPMed
rs759510702 CA6773945	1109	Q>K		No	ClinGen ExAC gnomAD
rs772231098 CA6773946	1110	S>N		No	ClinGen ExAC gnomAD
rs373495005 CA6773948	1112	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs754130864 CA6773950	1113	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs764594952 CA6773949	1113	Q>P		No	ClinGen ExAC gnomAD
rs762193492 CA6773951	1114	L>S		No	ClinGen ExAC gnomAD
COSM691354 CA386463217 rs1384434815	1116	Q>*	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
rs764817905 CA6773952	1117	R>G		No	ClinGen ExAC gnomAD
rs150478780 CA6773965	1119	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6773966 rs376968963	1119	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs765703397 CA6773969	1121	G>R		No	ClinGen ExAC TOPMed gnomAD
CA6773970 rs138522645	1122	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6773971 rs762611929	1123	R>C		No	ClinGen ExAC TOPMed gnomAD
rs765956673 CA6773972	1123	R>H		No	ClinGen ExAC TOPMed gnomAD
CA386463963 rs1255975590	1124	G>D		No	ClinGen TOPMed gnomAD
COSM287177 CA6773974 rs567554237	1124	G>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1565935782 CA386463976	1125	Y>C		No	ClinGen Ensembl
rs767542059 CA6773975 COSM3792155	1126	M>V	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	1130	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386464014 rs1368571140	1130	V>M		No	ClinGen TOPMed
CA243398378 rs867570382	1136	R>G		No	ClinGen Ensembl
rs1228931233 CA386464060	1137	Y>H		No	ClinGen gnomAD
rs777681543 CA6773979	1139	R>C		No	ClinGen ExAC gnomAD
rs758575862 CA6773982	1139	R>H		No	ClinGen ExAC TOPMed gnomAD
CA6773981 rs758575862	1139	R>P		No	ClinGen ExAC TOPMed gnomAD
CA6773980 rs777681543	1139	R>S		No	ClinGen ExAC gnomAD
CA386464086 rs1198693226	1141	E>G		No	ClinGen gnomAD
rs1192740349 CA386464126	1146	Q>L		No	ClinGen gnomAD
CA386464130 rs1565935939	1147	A>T		No	ClinGen Ensembl
rs1344122684 CA386464154	1148	H>Q		No	ClinGen TOPMed
rs1434765559 CA386464151	1148	H>R		No	ClinGen TOPMed
rs771242906 CA6774012 CA6774010	1149	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA386464155 rs1565936150	1149	Y>D		No	ClinGen Ensembl
rs146920013 COSM1322022 CA6774013	1150	D>N	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs146920013 CA386464162	1150	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs200543599 CA386464175	1151	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1565936208 CA386464177	1152	C>R		No	ClinGen Ensembl
CA243398565 rs994372838	1153	V>M		No	ClinGen gnomAD
rs760130044 CA6774015	1154	I>L		No	ClinGen ExAC gnomAD
CA6774016 rs200668190	1154	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA6774017 rs753766230	1159	Q>E		No	ClinGen ExAC gnomAD
rs1261520626 CA386464227	1159	Q>P		No	ClinGen gnomAD
CA386464242 rs1211864636	1161	K>T		No	ClinGen gnomAD
CA243398597 rs149482651	1162	P>S		No	ClinGen ESP TOPMed gnomAD
CA6774018 rs761635431	1163	D>A		No	ClinGen ExAC TOPMed gnomAD
CA386464260 rs1213696969	1164	M>L		No	ClinGen TOPMed
rs1483598910 CA386464262	1164	M>T		No	ClinGen TOPMed
CA6774019 rs765078219	1166	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs750235294 CA6774020	1167	V>L		No	ClinGen ExAC gnomAD
CA6774022 rs781428706	1169	D>E		No	ClinGen ExAC TOPMed gnomAD
CA6774023 rs752773911	1170	C>Y		No	ClinGen ExAC gnomAD
rs756198206 CA6774024	1172	F>V		No	ClinGen ExAC TOPMed gnomAD
CA243398608 rs1005596879	1173	S>A		No	ClinGen gnomAD
rs1023312890 CA243398613	1173	S>F		No	ClinGen Ensembl
TCGA novel	1175	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs969688290 CA243398618	1175	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1295008109 CA386464333	1175	A>V		No	ClinGen TOPMed
CA6774025 rs184066600	1177	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA243398620 rs184066600	1177	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA386464354 rs1375521964	1179	K>E		No	ClinGen gnomAD
CA386464357 rs1224128465	1179	K>R		No	ClinGen TOPMed gnomAD
CA6774027 rs372095862	1180	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA6774026 rs372095862	1180	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6774029 rs539224114	1186	M>I		No	ClinGen 1000Genomes ExAC gnomAD
rs866468688 CA243398628	1186	M>K		No	ClinGen TOPMed
rs866468688 CA386464403	1186	M>T		No	ClinGen TOPMed
CA6774028 rs779361484	1186	M>V		No	ClinGen ExAC gnomAD
rs771810361 CA6774030	1187	L>M		No	ClinGen ExAC gnomAD
rs775299699 CA6774031	1188	I>L		No	ClinGen ExAC gnomAD
CA386464418 rs1198153672	1188	I>M		No	ClinGen TOPMed gnomAD
CA386465327 rs1309731039	1190	E>K		No	ClinGen gnomAD
CA6774048 rs746182542	1191	L>P		No	ClinGen ExAC gnomAD
CA386465340 rs375330223	1192	C>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA6774050 rs375330223	1192	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA243401919 rs746703562	1194	P>A		No	ClinGen ExAC gnomAD
CA243401942 rs776001518	1194	P>R		No	ClinGen Ensembl
rs746703562 CA6774052	1194	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1593619573 CA386465358	1195	D>A		No	ClinGen Ensembl
rs768370789 CA6774053	1195	D>N		No	ClinGen ExAC
CA386465369 rs1184239234	1197	S>P		No	ClinGen gnomAD
rs1300418762 CA386465375	1198	L>P		No	ClinGen TOPMed
rs368193601 CA6774054	1198	L>V		No	ClinGen ExAC gnomAD
rs763388361 CA6774055	1199	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA386465385 rs1358635617	1200	D>Y		No	ClinGen TOPMed
rs146250483 CA6774058	1201	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs369575164 CA6774059	1203	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA386465411 rs1356312009	1204	S>A		No	ClinGen TOPMed gnomAD
rs1356312009 CA386465409	1204	S>T		No	ClinGen TOPMed gnomAD
CA6774060 rs775770446	1206	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1206	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775770446 CA386465422	1206	L>V		No	ClinGen ExAC TOPMed gnomAD
rs760748409 CA6774061	1207	N>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1208	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757434963 CA6774064	1208	E>D		No	ClinGen ExAC gnomAD
rs774642233 CA6774063	1208	E>K		No	ClinGen ExAC TOPMed gnomAD
CA6774066 rs144155916	1210	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA386465448 rs1213433006	1210	T>S		No	ClinGen TOPMed gnomAD
rs758828359 CA6774067	1211	Q>L		No	ClinGen ExAC gnomAD
rs758828359 CA386465455	1211	Q>R		No	ClinGen ExAC gnomAD
CA386465482 rs1213215559	1215	S>N		No	ClinGen gnomAD
CA6774070 rs754548594	1216	E>G		No	ClinGen ExAC gnomAD
rs193086924 CA6774069	1216	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1224691339 CA386465505	1218	C>S		No	ClinGen gnomAD
CA6774073 rs769337328	1220	V>A		No	ClinGen ExAC TOPMed gnomAD
CA243402062 rs866344256	1221	A>V		No	ClinGen Ensembl
rs773133189 CA6774074	1222	L>F		No	ClinGen ExAC gnomAD
CA6774076 rs371796559	1223	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs373323478 CA6774077	1223	R>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1347235133 CA386465540	1224	A>G		No	ClinGen gnomAD
rs1347235133 CA386465541	1224	A>V		No	ClinGen gnomAD
CA386465544 rs762060491	1225	R>P		No	ClinGen TOPMed gnomAD
rs762060491 CA243402071	1225	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6774078 rs759403747	1225	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA386465629 rs1396378667	1228	L>M		No	ClinGen TOPMed gnomAD
rs1390189451 CA386465654	1229	I>M		No	ClinGen gnomAD
rs759818869 CA6774106	1231	S>P		No	ClinGen ExAC gnomAD
CA386465694 rs1593621126	1232	H>P		No	ClinGen Ensembl
CA386465689 rs1336728209	1232	H>Y		No	ClinGen gnomAD
CA386465721 rs1336580479	1234	P>L		No	ClinGen gnomAD
rs755699505 CA6774109	1235	S>A		No	ClinGen ExAC gnomAD
rs777432178 CA6774110	1236	Y>C		No	ClinGen ExAC
CA6774112 rs778737669	1237	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA243402302 rs965439360	1239	R>Q		No	ClinGen TOPMed gnomAD
rs367785362 CA6774113	1239	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6774114 rs371205831	1240	H>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs771749905 CA6774115	1243	V>G		No	ClinGen ExAC TOPMed gnomAD
rs943818474 CA243402321	1244	E>K		No	ClinGen TOPMed gnomAD
CA386465857 rs1399524267	1244	E>V		No	ClinGen TOPMed
CA386465867 rs1372608762	1245	S>A		No	ClinGen gnomAD
CA6774117 rs746832888	1245	S>Y		No	ClinGen ExAC gnomAD
rs1170161442 CA386465885	1246	I>M		No	ClinGen gnomAD
rs1373229262 CA386465948	1251	I>S		No	ClinGen TOPMed
rs368475621 CA243402329	1251	I>V		No	ClinGen ESP TOPMed gnomAD
rs1281617397 CA386465978	1253	M>T		No	ClinGen gnomAD
rs770093451 CA386466003	1254	Y>*		No	ClinGen ExAC gnomAD
CA386465993 rs1434483100	1254	Y>N		No	ClinGen TOPMed gnomAD
CA386466007 rs566751207	1255	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	1255	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6774119 rs566751207	1255	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386466028 rs749297152	1256	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1423463022 CA386466024	1256	H>R		No	ClinGen TOPMed
RCV000949786 CA6774121 rs146002202	1257	Q>E		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs374625291 CA6774122	1259	C>*		No	ClinGen 1000Genomes ExAC gnomAD
CA243402346 rs932552749	1260	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA386466076 rs1229048378	1260	P>S		No	ClinGen gnomAD
CA6774123 rs760033014	1261	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1266	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745423076 CA243403088	1267	I>L		No	ClinGen gnomAD
rs1248750694 CA386466281	1268	L>P		No	ClinGen gnomAD
rs369724495 CA6774140	1269	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs771075563 CA6774139	1269	S>T		No	ClinGen ExAC gnomAD
rs760992843 CA6774144	1275	D>G		No	ClinGen ExAC gnomAD
CA386466323 rs1361682154	1275	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs764509094 CA6774145	1276	V>I		No	ClinGen ExAC gnomAD
CA6774146 rs776133087	1278	P>R		No	ClinGen ExAC gnomAD
CA6774147 rs201850400	1279	T>A		No	ClinGen ExAC TOPMed gnomAD
rs149793040 CA6774148	1282	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA386466367 rs1327824066	1282	Y>H		No	ClinGen gnomAD
CA6774149 rs749901306	1283	H>N		No	ClinGen ExAC
CA386466376 rs1390574769	1283	H>R		No	ClinGen gnomAD
rs567861529 CA6774151	1284	A>S		No	ClinGen 1000Genomes TOPMed
CA243403151 rs567861529	1284	A>T		No	ClinGen 1000Genomes TOPMed
CA386466386 rs1315304117	1285	N>H		No	ClinGen gnomAD
rs1353111195 CA386466393	1286	K>E		No	ClinGen TOPMed gnomAD
rs1268778982 CA386466398	1286	K>N		No	ClinGen gnomAD
CA6774153 rs766389079	1286	K>T		No	ClinGen ExAC gnomAD
rs1032749170 CA243403171	1287	V>I		No	ClinGen TOPMed gnomAD
rs754810954 CA6774155	1288	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs781080304 CA6774156	1290	M>V		No	ClinGen ExAC TOPMed gnomAD
CA386466428 rs1248897552	1291	A>E		No	ClinGen gnomAD
CA6774159 rs779023143	1292	S>T		No	ClinGen ExAC gnomAD
CA6774160 rs745935779	1292	S>Y		No	ClinGen ExAC
CA386466769 rs1216543819	1297	V>A		No	ClinGen gnomAD
rs769110318 CA386466763	1297	V>L		No	ClinGen ExAC gnomAD
rs769110318 CA6774181	1297	V>M		No	ClinGen ExAC gnomAD
rs372460687 CA6774183	1298	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs781600908 CA386466774	1298	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1212587259 CA386466784	1299	R>K		No	ClinGen gnomAD
CA6774184 rs138720409	1299	R>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1211371912 CA386466799	1300	G>D		No	ClinGen gnomAD
CA386466812 rs1474789751	1301	Y>C		No	ClinGen gnomAD
CA386466810 rs1474789751	1301	Y>S		No	ClinGen gnomAD
CA386466823 rs772906903	1302	I>N		No	ClinGen ExAC TOPMed gnomAD
CA6774185 rs772906903	1302	I>T		No	ClinGen ExAC TOPMed gnomAD
rs201010974 CA6774187	1303	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs759142692 CA6774189	1304	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs773962004 CA6774188	1304	Y>N		No	ClinGen ExAC gnomAD
rs76165721 CA243405870	1307	N>T		No	ClinGen Ensembl
rs370089652 CA386466948	1312	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs763849845 CA386466954	1312	R>L		No	ClinGen ExAC TOPMed gnomAD
CA6774193 rs763849845	1312	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs370089652 CA6774192	1312	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA386466958 rs1476143440	1313	Q>E		No	ClinGen gnomAD
rs1328049549 CA386466979	1314	L>F		No	ClinGen TOPMed
rs752132829 CA243405895	1315	P>L		No	ClinGen gnomAD
CA386467021 rs60293430	1317	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6774196 rs60293430	1317	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs755091102 CA243405944	1318	T>I		No	ClinGen ExAC TOPMed gnomAD
CA6774198 rs755091102	1318	T>N		No	ClinGen ExAC TOPMed gnomAD
CA6774199 rs781720922	1319	C>Y		No	ClinGen ExAC gnomAD
CA6774201 rs376807259	1320	V>M		No	ClinGen ESP ExAC gnomAD
rs547866870 CA6774202	1321	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA386467113 rs565341019	1323	F>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs565341019 CA6774203	1323	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6774204 rs770661460	1324	Q>L		No	ClinGen ExAC gnomAD
rs962217558 CA243405992	1325	F>L		No	ClinGen Ensembl
COSM934731 CA6774205 rs774198876	1328	P>L	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1388208166 CA386467235	1329	S>Y		No	ClinGen TOPMed
rs760471189 CA6774209	1334	R>Q		No	ClinGen ExAC gnomAD
rs775480453 CA6774208	1334	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1440536152 CA386467926	1335	M>I		No	ClinGen gnomAD
rs371118054 CA6774232	1337	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA6774233 rs759610928	1338	P>L		No	ClinGen ExAC gnomAD
CA386467961 rs1336806065	1341	I>V		No	ClinGen gnomAD
CA6774234 rs767816226	1343	N>D		No	ClinGen ExAC TOPMed gnomAD
rs1271953515 CA386467977	1343	N>I		No	ClinGen gnomAD
rs371889237 CA243410755	1346	L>P		No	ClinGen Ensembl
rs1026093247 CA243410757	1347	L>V		No	ClinGen TOPMed
CA6774235 rs752675320	1349	H>R		No	ClinGen ExAC TOPMed gnomAD
CA386468011 rs1183809237	1349	H>Y		No	ClinGen gnomAD
CA243410765 rs374741330	1350	S>G		No	ClinGen ESP TOPMed
TCGA novel	1350	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1350	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1473072052 CA386468024	1351	T>A		No	ClinGen gnomAD
rs764668971 CA386468035	1352	E>D		No	ClinGen ExAC gnomAD
rs1291239963 CA386468052	1355	M>V		No	ClinGen Ensembl
rs1474024972 CA386468072	1357	S>N		No	ClinGen gnomAD
CA6774240 rs546114684	1358	G>C		No	ClinGen ExAC TOPMed gnomAD
rs546114684 CA6774239	1358	G>S		No	ClinGen ExAC TOPMed gnomAD
rs757947070 CA6774242	1360	S>A		No	ClinGen ExAC TOPMed gnomAD
CA6774243 rs779776432	1360	S>F		No	ClinGen ExAC gnomAD
rs757947070 CA386468089	1360	S>P		No	ClinGen ExAC TOPMed gnomAD
CA386468097 rs1290833579	1361	P>L		No	ClinGen gnomAD
CA386468094 rs1483685368	1361	P>S		No	ClinGen TOPMed
CA6774245 rs768222838	1364	Q>P		No	ClinGen ExAC gnomAD
COSM1181492 CA6774246 rs146916735	1365	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs146916735 CA243410863	1365	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs748021201 CA6774247	1365	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs748021201 CA386468120	1365	R>P		No	ClinGen ExAC TOPMed gnomAD
CA386468123 rs199811101	1366	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6774248 rs199811101	1366	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs762833132 CA6774250	1370	V>G		No	ClinGen ExAC TOPMed gnomAD
CA386468151 rs1210450430	1370	V>I		No	ClinGen TOPMed gnomAD
CA386468153 rs1210450430	1370	V>L		No	ClinGen TOPMed gnomAD
CA243410932 rs996022400	1371	A>S		No	ClinGen TOPMed gnomAD
rs1372985052 CA386468176	1374	R>G		No	ClinGen TOPMed gnomAD
rs772164929 CA6774251	1375	F>L		No	ClinGen ExAC gnomAD
rs1391174151 CA386468190	1376	E>K		No	ClinGen gnomAD
CA386468249 rs1327136003	1382	F>L		No	ClinGen gnomAD
TCGA novel	1382	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6774275 rs750978502	1383	D>N		No	ClinGen ExAC gnomAD
rs763215607 CA6774277	1384	E>D		No	ClinGen ExAC gnomAD
rs1593655124 CA386468274	1385	V>A		No	ClinGen Ensembl
rs751876382 CA6774278	1389	F>V		No	ClinGen ExAC TOPMed gnomAD
rs199563607 CA6774280	1390	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA386468314 rs1433364441	1391	N>I		No	ClinGen gnomAD
CA386468316 rs181464188	1391	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs528800239 CA6774282 COSM1358583	1392	V>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs777571000 CA6774283	1395	D>G		No	ClinGen ExAC gnomAD
rs749302696 CA6774284	1396	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs749302696 CA386468346	1396	T>N		No	ClinGen ExAC gnomAD
rs1368067515 CA386468353	1397	P>H		No	ClinGen gnomAD
CA386468354 rs1228509137	1398	L>I		No	ClinGen TOPMed
TCGA novel	1398	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1565953344	1398	L>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA386468373 rs1306520641	1400	S>N		No	ClinGen gnomAD
rs768950144 CA6774288	1401	E>K		No	ClinGen ExAC TOPMed gnomAD
CA6774290 rs748208069	1402	A>D		No	ClinGen ExAC gnomAD
CA6774289 rs777040512	1402	A>T		No	ClinGen ExAC gnomAD
CA386468389 rs1297313839	1403	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs779738351 CA6774291	1403	R>H		No	ClinGen ExAC gnomAD
TCGA novel	1403	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773179278 CA6774292	1404	T>A		No	ClinGen ExAC TOPMed gnomAD
CA6774293 COSM77200 rs763451255	1404	T>I	ovary [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6774295 rs774729759	1408	S>C		No	ClinGen ExAC gnomAD
rs185761261 CA6774298	1409	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA243412252 rs532331584	1410	D>V		No	ClinGen Ensembl
CA243412255 rs1022801654	1411	D>E		No	ClinGen Ensembl
CA386468443 rs1421935887	1412	C>R		No	ClinGen TOPMed gnomAD
rs1421935887 CA386468442	1412	C>S		No	ClinGen TOPMed gnomAD
rs1166803314 CA386468453	1412	C>W		No	ClinGen gnomAD
rs1382189506 CA386468514	1414	S>N		No	ClinGen TOPMed gnomAD
rs377006264 CA243412505	1415	L>P		No	ClinGen TOPMed
rs993289256 CA243412512	1416	R>K		No	ClinGen Ensembl
CA386468567 rs1295797664	1418	E>G		No	ClinGen gnomAD
CA386468590 rs1269445680	1420	I>L		No	ClinGen TOPMed
rs1229656161 CA386468593	1420	I>T		No	ClinGen TOPMed gnomAD
CA386468588 rs1269445680	1420	I>V		No	ClinGen TOPMed
CA386468638 rs1279154799	1422	I>M		No	ClinGen gnomAD
rs1211543293 CA386468651	1424	N>H		No	ClinGen gnomAD
rs1196055604 CA386468657	1424	N>I		No	ClinGen gnomAD
rs577879487 CA243412529	1425	V>L		No	ClinGen Ensembl
CA6774324 rs779929141	1426	S>P		No	ClinGen ExAC TOPMed
rs751432143 CA6774325	1427	I>T		No	ClinGen ExAC gnomAD
CA386468710 CA6774327 rs777908450	1428	Q>H		No	ClinGen ExAC gnomAD
CA386468708 rs1186616731	1428	Q>R		No	ClinGen gnomAD
CA386468716 rs1449847504	1429	C>R		No	ClinGen gnomAD
rs867354965 CA243412555	1430	A>T		No	ClinGen TOPMed
rs887481398 CA243412563	1430	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1047151757 CA243412603	1431	D>E		No	ClinGen TOPMed
CA6774328 rs749359243	1431	D>H		No	ClinGen ExAC gnomAD
CA386468739 rs749359243	1431	D>N		No	ClinGen ExAC gnomAD
rs770985671 CA6774329	1432	H>N		No	ClinGen ExAC TOPMed gnomAD
rs1310947968 CA386468768	1433	L>P		No	ClinGen TOPMed
CA386468802 rs1178277494	1436	E>K		No	ClinGen gnomAD
CA386468832 rs1421308095	1438	L>R		No	ClinGen TOPMed gnomAD
rs190169259 CA6774333	1440	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386468883 rs768329852	1443	R>P		No	ClinGen ExAC gnomAD
CA6774336 rs768329852	1443	R>Q		No	ClinGen ExAC gnomAD
rs200412699 CA6774335	1443	R>W		No	ClinGen ExAC gnomAD
rs1008357337 CA243412644	1444	T>A		No	ClinGen TOPMed gnomAD
CA6774337 rs776186327	1444	T>I		No	ClinGen ExAC gnomAD
rs1206360026 CA386468913	1446	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA386468950 rs1371470741	1448	S>T		No	ClinGen TOPMed
rs1415839369 CA386468960	1449	K>*		No	ClinGen TOPMed gnomAD
CA6774339 rs764898073	1449	K>T		No	ClinGen ExAC gnomAD
CA6774361 rs766389372	1450	K>R		No	ClinGen ExAC gnomAD
rs774223316 CA6774362	1451	N>S		No	ClinGen ExAC gnomAD
rs1350546192 CA386469844	1454	V>L		No	ClinGen gnomAD
rs1350546192 CA386469840	1454	V>M		No	ClinGen gnomAD
rs759365037 CA6774363	1459	R>*		No	ClinGen ExAC TOPMed gnomAD
CA6774364 rs375855495	1459	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs752545205 CA6774365	1460	R>*		No	ClinGen ExAC TOPMed gnomAD
CA386469925 rs1203304904	1460	R>Q		No	ClinGen gnomAD
CA6774366 rs757426324	1461	I>M		No	ClinGen ExAC gnomAD
CA6774368 rs750476301	1464	L>V		No	ClinGen ExAC gnomAD
CA386469969 rs1367178998	1464	L>W		No	ClinGen gnomAD
CA6774369 rs758510596	1465	I>T		No	ClinGen ExAC TOPMed gnomAD
CA243413976 rs978621100	1465	I>V		No	ClinGen TOPMed gnomAD
CA243414002 rs370218754	1466	A>D		No	ClinGen ESP TOPMed gnomAD
CA386470152 rs1565955523	1469	K>E		No	ClinGen Ensembl
rs374477026 CA6774388	1470	E>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs751664483 CA6774389	1472	P>L		No	ClinGen ExAC gnomAD
TCGA novel	1472	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1002227016 COSM934736 CA243414301	1474	F>L	endometrium [Cosmic]	No	ClinGen cosmic curated Ensembl
rs980728534 CA243414312	1476	T>S		No	ClinGen TOPMed gnomAD
CA243414320 rs17848825	1480	R>K		No	ClinGen Ensembl
rs1555229521 CA386470310	1481	D>E		No	ClinGen Ensembl
RCV000973712 rs113524436 CA6774391	1481	D>V		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs748432369 CA6774392	1482	E>K		No	ClinGen ExAC TOPMed gnomAD
CA243421526 rs775506034	1484	A>V		No	ClinGen Ensembl
rs1367890585 CA386470497	1487	R>C		No	ClinGen TOPMed gnomAD
CA6774418 COSM1181490 rs754289848	1487	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA386470499 rs754289848	1487	R>L		No	ClinGen ExAC gnomAD
COSM1358585 rs756806908 CA6774419	1490	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs200016239 CA6774420	1490	R>H	Variant assessed as Somatic; 0.0001848 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs200016239 CA6774421	1490	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA386470530 rs1177288212	1491	H>Q		No	ClinGen TOPMed
CA6774422 rs771676923	1492	L>*		No	ClinGen ExAC gnomAD
CA386470613 rs1308328092	1499	Q>*		No	ClinGen gnomAD
rs776370396 CA6774426	1499	Q>R		No	ClinGen ExAC
TCGA novel	1501	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386470664 rs1321703659	1502	L>F		No	ClinGen TOPMed gnomAD
CA6774427 rs761645142	1502	L>H		No	ClinGen ExAC gnomAD
CA386470662 rs1321703659	1502	L>V		No	ClinGen TOPMed gnomAD
CA386470682 rs1490398179	1503	N>I		No	ClinGen gnomAD
rs1024359271 CA243421597	1503	N>K		No	ClinGen Ensembl
rs549887432 COSM934740 CA6774431	1504	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA6774430 rs759522981	1504	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs752832246 CA6774432	1506	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs376720236 CA6774433	1506	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA6774437 rs146231935	1509	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA6774436 rs146231935	1509	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA386470811 rs1593665591	1510	L>M		No	ClinGen Ensembl
rs202085678 CA243421665	1511	T>P		No	ClinGen gnomAD
rs779472077 CA6774441	1512	A>S		No	ClinGen ExAC TOPMed gnomAD
rs779472077 CA6774440	1512	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6774442 rs754860995	1513	V>M		No	ClinGen ExAC TOPMed gnomAD
CA386470888 rs1394828261	1514	P>A		No	ClinGen gnomAD
rs1394828261 CA386470889	1514	P>S		No	ClinGen gnomAD
rs200232907 CA243421709	1515	C>Y		No	ClinGen Ensembl
rs747892426 CA6774444	1517	N>I		No	ClinGen ExAC TOPMed gnomAD
CA386470938 rs747892426	1517	N>S		No	ClinGen ExAC TOPMed gnomAD
CA386470975 rs1442014927	1519	K>T		No	ClinGen TOPMed
TCGA novel	1520	M>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386471012 rs1228219666	1521	H>R		No	ClinGen gnomAD
rs1381484897 CA386471018	1522	L>I		No	ClinGen TOPMed
CA386471063 rs1422164268	1524	L>P		No	ClinGen TOPMed
CA386471058 rs1343872980	1524	L>V		No	ClinGen gnomAD
rs142663570 CA6774447	1525	G>D		No	ClinGen ESP ExAC gnomAD
rs772898022 CA6774446	1525	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1528	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760881766 CA386471174	1531	E>D		No	ClinGen ExAC TOPMed gnomAD
CA6774449 rs775667215	1531	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1388487680 CA386471180	1532	G>D		No	ClinGen gnomAD
CA386471188 rs1171171145	1533	V>M		No	ClinGen TOPMed gnomAD
rs934187721 CA243421800	1535	V>M		No	ClinGen gnomAD
rs762073299 CA6774453	1536	T>M		No	ClinGen ExAC TOPMed gnomAD
CA6774452 rs777340971	1536	T>P		No	ClinGen ExAC TOPMed
rs1295869222 CA386471234	1537	D>V		No	ClinGen gnomAD
CA243421846 rs750758828	1538	H>Q		No	ClinGen ExAC gnomAD
rs758029445 CA6774456	1539	R>G		No	ClinGen ExAC gnomAD
CA6774457 rs766042270	1540	F>S		No	ClinGen ExAC gnomAD
rs774245896 CA6774458	1543	R>C		No	ClinGen ExAC TOPMed gnomAD
COSM430289 CA6774459 rs527660684	1543	R>H	Variant assessed as Somatic; 0.0 impact. endometrium breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs774245896 CA243421893	1543	R>S		No	ClinGen ExAC TOPMed gnomAD
CA6774460 rs374544605	1544	A>T	Variant assessed as Somatic; 0.0001387 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs756007626 CA386471356	1548	H>N		No	ClinGen ExAC TOPMed gnomAD
rs756007626 CA6774462	1548	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1187303491 CA386471392	1551	L>P		No	ClinGen gnomAD
rs777581519 CA6774463	1551	L>V		No	ClinGen ExAC gnomAD
rs146039140 CA6774465	1553	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1178696725 CA386471414	1553	T>I		No	ClinGen gnomAD
CA386471841 rs1593673180	1555	E>G		No	ClinGen Ensembl
rs935320132 CA386471853	1556	A>D		No	ClinGen TOPMed gnomAD
CA243424176 rs935320132	1556	A>G		No	ClinGen TOPMed gnomAD
rs1391872215 CA386471867	1557	S>A		No	ClinGen TOPMed
COSM691350 CA6774480 rs756027386	1559	E>K	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA386471914 rs1476380806	1561	L>V		No	ClinGen TOPMed
rs148713212 CA243424202	1562	Q>K		No	ClinGen ESP TOPMed gnomAD
rs1290127029 CA386471928	1562	Q>R		No	ClinGen gnomAD
rs1253869504 CA386471967	1564	E>A		No	ClinGen gnomAD
rs753641748 CA6774482	1564	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA386471957 rs753641748	1564	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1320093586 CA386471986	1565	G>S		No	ClinGen gnomAD
CA6774484 rs780413964	1567	R>Q		No	ClinGen ExAC gnomAD
CA6774483 rs757188313	1567	R>W		No	ClinGen ExAC TOPMed gnomAD
CA6774485 rs747173827	1569	L>P		No	ClinGen ExAC
CA386472042 rs1482766823	1569	L>V		No	ClinGen gnomAD
rs948165947 CA243424230	1573	M>T		No	ClinGen TOPMed
CA6774486 rs769005711	1574	D>G		No	ClinGen ExAC gnomAD
rs1191533987 CA386472151	1575	E>K		No	ClinGen TOPMed gnomAD
rs1470799574 CA386472227	1577	E>D		No	ClinGen TOPMed gnomAD
CA386472232 rs1593673473	1578	V>G		No	ClinGen Ensembl
TCGA novel	1579	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1045179377 CA243424252	1579	A>V		No	ClinGen TOPMed gnomAD
CA386472275 rs1593673509	1580	F>V		No	ClinGen Ensembl
CA6774489 rs374516918	1581	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6774491 rs763290011	1583	T>N		No	ClinGen ExAC TOPMed gnomAD
CA386472348 rs1593673554	1583	T>P		No	ClinGen Ensembl
CA6774493 rs774700704	1584	S>I		No	ClinGen ExAC gnomAD
CA6774495 rs767175687	1585	V>M		No	ClinGen ExAC TOPMed gnomAD
rs752226105 CA6774496	1586	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA6774497 rs142393083	1586	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142393083 CA386472466	1586	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753780968 CA6774499	1588	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1341739656 CA386472569	1589	C>G		No	ClinGen gnomAD
TCGA novel	1589	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs568586081 CA6774500	1591	H>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386472634 rs568586081	1591	H>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386472770 rs1187429871	1595	N>S		No	ClinGen gnomAD
rs755204288 CA386472821	1596	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1236307555 CA386472801	1596	F>V		No	ClinGen gnomAD
rs781319143 CA6774504	1597	V>M		No	ClinGen ExAC gnomAD
rs199709974 CA6774507	1601	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs749726682 CA6774508	1605	F>L		No	ClinGen ExAC gnomAD
rs776234149	1607	I>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA243425231 rs776234149	1607	I>M		No	ClinGen ExAC TOPMed gnomAD
CA386473871 rs1281495349	1607	I>V		No	ClinGen gnomAD
CA6774535 rs374379639	1608	E>K		No	ClinGen ESP ExAC gnomAD
CA6774536 rs368342694	1609	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6774538 rs17848829	1612	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs375124672 CA6774540	1612	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA386473995 rs375124672	1612	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6774539 rs17848829	1612	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756239363 CA6774541	1613	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA386474017 rs756239363	1613	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs1196080261 CA386474052	1615	V>I		No	ClinGen gnomAD
CA6774542 rs764424142	1616	M>I		No	ClinGen ExAC gnomAD
rs1430817667 CA386474065	1616	M>T		No	ClinGen gnomAD
rs753880349 CA6774543	1617	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs547366413 CA6774544	1617	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs562107218 CA6774546	1618	Y>N		No	ClinGen 1000Genomes ExAC gnomAD
CA6774548 rs780244896	1619	G>S		No	ClinGen ExAC TOPMed gnomAD
rs768173224 CA6774550	1620	S>R		No	ClinGen ExAC gnomAD
CA6774552 rs143327495	1621	R>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs143327495 CA6774551	1621	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1405698927 CA386474178	1621	R>W		No	ClinGen TOPMed gnomAD
rs75780692 CA243425353	1624	K>E		No	ClinGen Ensembl
rs199820674 CA6774554	1624	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA243425386 rs569275472	1625	L>F		No	ClinGen 1000Genomes
CA386474256 rs1355149533	1625	L>H		No	ClinGen gnomAD
CA386474251 rs1355149533	1625	L>P		No	ClinGen gnomAD
rs1219770419 CA386474259 COSM467753	1626	R>C	kidney [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA6774555 rs762757492	1626	R>H		No	ClinGen ExAC gnomAD
rs773991465 CA6774557	1631	E>K		No	ClinGen ExAC gnomAD
CA243425418 rs1039065105	1631	E>V		No	ClinGen gnomAD
CA386474374 rs1593677390	1632	V>G		No	ClinGen Ensembl
CA386474391 rs1565961854	1633	K>E		No	ClinGen Ensembl
rs764292369 CA6774559	1633	K>R		No	ClinGen ExAC gnomAD
CA6774560 rs754114281	1635	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1593677467 CA386474461	1636	I>T		No	ClinGen Ensembl
TCGA novel	1637	R>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs998286464 CA243425445	1637	R>C		No	ClinGen TOPMed gnomAD
rs777709102 CA6774562	1637	R>H		No	ClinGen ExAC TOPMed gnomAD
rs750550202 CA6774563	1638	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA386474498 rs1593677536	1640	T>P		No	ClinGen Ensembl
CA243425483 rs201003033	1641	T>A		No	ClinGen TOPMed
CA386474510 rs201003033	1641	T>P		No	ClinGen TOPMed
CA6774566 rs370014234	1642	G>D		No	ClinGen ESP TOPMed
rs780660597 CA6774565	1642	G>S		No	ClinGen ExAC gnomAD
rs997770121 CA243425492	1643	S>R		No	ClinGen Ensembl
CA386474542 rs1244317550	1644	A>G		No	ClinGen gnomAD
CA6774568 rs372735105	1644	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA6774571 rs747735569	1645	V>A		No	ClinGen ExAC TOPMed gnomAD
CA6774570 rs140946857	1645	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1206402963 CA386474565	1647	I>N		No	ClinGen gnomAD
CA386474575 rs1481359214	1648	R>C		No	ClinGen gnomAD
CA6774573 rs777367863	1648	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA386474580 rs1565962009	1649	L>V		No	ClinGen Ensembl
CA386474602 rs1255471859	1650	F>L		No	ClinGen gnomAD
CA386474587 rs1244632552	1650	F>L		No	ClinGen TOPMed
CA386474607 rs1315481067	1651	I>N		No	ClinGen TOPMed
rs886638088 CA243425559	1652	T>A		No	ClinGen Ensembl
CA6774574 rs748877113	1652	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1387239626 CA386474629	1653	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs774411305 CA386474655	1655	S>*		No	ClinGen ExAC TOPMed gnomAD
rs774411305 CA6774576	1655	S>L		No	ClinGen ExAC TOPMed gnomAD
CA243425586 rs878855330	1656	G>A		No	ClinGen Ensembl
CA6774579 rs775273258	1660	D>A		No	ClinGen ExAC TOPMed gnomAD
CA386474722 rs1299237566	1661	I>T		No	ClinGen gnomAD
CA6774580 rs761986226	1662	S>C		No	ClinGen ExAC gnomAD
CA6774581 rs765469286	1662	S>N		No	ClinGen ExAC TOPMed gnomAD
CA6774582 rs750449470	1663	L>I		No	ClinGen ExAC TOPMed gnomAD
CA243425639 rs981830602	1664	Y>C		No	ClinGen TOPMed gnomAD
rs981830602 CA386474761	1664	Y>F		No	ClinGen TOPMed gnomAD
TCGA novel	1666	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6774584 rs766791907	1666	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1308748956 CA386474819	1667	V>G		No	ClinGen gnomAD
CA386474837 rs1204679079	1669	D>Y		No	ClinGen gnomAD
CA386474859 rs1459927338	1670	S>C		No	ClinGen TOPMed gnomAD
rs1459927338 CA386474856	1670	S>F		No	ClinGen TOPMed gnomAD
CA386474851 rs1255283228	1670	S>P		No	ClinGen gnomAD
CA6774585 rs534595742	1671	R>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	1672	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs553023607 CA6774586	1673	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs553023607 CA6774587	1673	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA243426599 rs927523122	1675	I>F		No	ClinGen gnomAD
rs937603520 CA243426608	1675	I>N		No	ClinGen TOPMed gnomAD
rs1341618669 CA386475010	1676	M>V		No	ClinGen TOPMed
CA386475053 rs1283832745	1679	S>F		No	ClinGen TOPMed gnomAD
rs375445592 CA6774618	1681	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs375445592 CA6774617	1681	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA386475114 rs1286114860	1682	N>S		No	ClinGen gnomAD
CA6774619 rs771079880	1683	K>E		No	ClinGen ExAC gnomAD
rs144908726 CA6774620	1683	K>R		No	ClinGen ESP ExAC
CA6774622 rs768131062	1685	G>E		No	ClinGen ExAC gnomAD
CA6774624 rs61739667	1686	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV000908829 rs61739667 CA6774623	1686	P>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1201705276 CA386475204	1688	H>R		No	ClinGen gnomAD
rs149012129 CA6774626	1689	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA6774627 rs756889633	1690	M>L		No	ClinGen ExAC gnomAD
rs199831967 CA6774628	1692	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6774629 rs143004298	1693	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs566589314 CA386475279	1693	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs566589314 CA6774630	1693	N>T		No	ClinGen 1000Genomes ExAC gnomAD
rs779955322 CA6774631	1694	T>I		No	ClinGen ExAC gnomAD
CA243426736 rs61746004	1695	P>A		No	ClinGen TOPMed gnomAD
CA386475302 rs1377834861	1695	P>L		No	ClinGen gnomAD
rs754877670 CA6774633	1696	Y>C		No	ClinGen ExAC gnomAD
CA6774635 rs747942138	1697	V>I		No	ClinGen ExAC TOPMed gnomAD
CA386475328 rs1565963454	1698	T>A		No	ClinGen Ensembl
rs1357564043 CA386475381	1702	L>P		No	ClinGen gnomAD
rs200000830 CA386475396	1703	Q>H		No	ClinGen TOPMed
CA6774637 rs774503137	1706	R>*		No	ClinGen ExAC gnomAD
CA243426789 rs946165056	1706	R>Q		No	ClinGen TOPMed
CA243426809 rs777619662	1708	Q>R		No	ClinGen Ensembl
TCGA novel	1712	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1437363763 CA386475517	1713	G>E		No	ClinGen gnomAD
rs1412786797 CA386475525	1714	T>I		No	ClinGen TOPMed gnomAD
CA386475533 rs1333568959	1715	T>A		No	ClinGen TOPMed gnomAD
CA6774639 rs772219142	1716	Y>C		No	ClinGen ExAC gnomAD
rs1565963526 CA386475542	1716	Y>H		No	ClinGen Ensembl
CA6774640 rs775712406	1717	I>V		No	ClinGen ExAC gnomAD
rs1470708892 CA386475570	1718	Y>C		No	ClinGen TOPMed gnomAD
CA6774641 rs746961901	1721	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6774643 rs372726643 CA386475641	1723	M>I		No	ClinGen ESP ExAC gnomAD
CA6774644 rs762128526	1725	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1283768924 CA386475659	1725	R>K		No	ClinGen TOPMed
CA6774645 rs375618828	1726	Q>R		No	ClinGen ESP ExAC gnomAD
rs767475237 CA386476579	1727	A>D		No	ClinGen ExAC gnomAD
rs767475237 CA6774672	1727	A>G		No	ClinGen ExAC gnomAD
CA6774673 rs151146449	1728	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1340657903 CA386476592	1729	F>L		No	ClinGen TOPMed
rs756078266 CA386476604	1730	K>*		No	ClinGen ExAC gnomAD
rs756078266 CA6774674	1730	K>E		No	ClinGen ExAC gnomAD
CA386476608 rs1593690212	1730	K>I		No	ClinGen Ensembl
rs1444958372 CA386476612	1731	L>M		No	ClinGen gnomAD
CA243429407 rs927699772	1732	W>*		No	ClinGen Ensembl
rs753705502 CA6774676	1733	G>S		No	ClinGen ExAC gnomAD
rs563629211 CA243429417	1736	D>G		No	ClinGen Ensembl
rs758673805 CA6774677	1736	D>H		No	ClinGen ExAC gnomAD
rs545762685 CA6774678	1739	P>R		No	ClinGen 1000Genomes ExAC gnomAD
CA386476749 rs1384753429	1744	T>A		No	ClinGen TOPMed
TCGA novel	1745	Y>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747111652 CA6774679	1746	T>S		No	ClinGen ExAC gnomAD
CA386476813 rs1341207989	1749	V>A		No	ClinGen gnomAD
rs547982339 CA6774682	1751	D>G		No	ClinGen 1000Genomes
CA6774681 rs140188899	1751	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1169241340 CA386476880	1755	Q>H		No	ClinGen TOPMed
CA6774684 rs145398869	1755	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1477309746 CA386476909	1757	V>A		No	ClinGen gnomAD
rs1234374487 CA386476924	1759	M>L		No	ClinGen gnomAD
rs147443159 CA6774685	1760	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6774687 rs568475654	1761	R>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs770566091 CA6774688	1761	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA919171222 rs1593690600	1762	L>H		No	ClinGen Ensembl
CA386476994 rs1196665853	1764	G>V		No	ClinGen gnomAD
rs1480739582 CA386477008	1766	N>I		No	ClinGen gnomAD
TCGA novel	1767	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6774712 rs776770321	1768	V>L		No	ClinGen ExAC gnomAD
rs1593692080 CA386477140	1769	G>S		No	ClinGen Ensembl
CA386477168 rs1453752071	1771	V>M		No	ClinGen TOPMed
CA6774713 rs142599425	1772	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	1772	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386477194 rs1198616474	1772	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA6774714 rs765057691	1774	K>R		No	ClinGen ExAC gnomAD
CA243429977 rs144793901	1776	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs144793901 CA6774715	1776	R>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1249480636 CA386477259	1776	R>W		No	ClinGen gnomAD
rs1004234768 CA243429999	1778	K>*		No	ClinGen Ensembl
CA6774716 rs755107823	1779	T>A		No	ClinGen ExAC gnomAD
rs1459847727 CA386477361	1779	T>I		No	ClinGen gnomAD
rs138629237 CA6774717	1780	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs138629237 CA386477362	1780	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1035181444 CA243430031	1782	Y>C		No	ClinGen gnomAD
rs372356232 CA6774718	1783	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6774720 RCV000972084 rs144673785	1786	R>Q		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA6774719 rs149326318	1786	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs113691648 CA386477551	1787	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6774721 rs754273647	1787	D>V		No	ClinGen ExAC gnomAD
rs746289601 CA6774724	1788	V>A		No	ClinGen ExAC gnomAD
rs143901792 RCV000994972 CA6774723	1788	V>M		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs376636256 CA6774726	1790	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1381125002 CA386477601	1790	V>I	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs200927603 CA243430132	1791	I>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386477616 rs1219138053	1791	I>T		No	ClinGen gnomAD
CA6774727 rs200927603	1791	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs767320354 CA6774729 COSM1358591	1792	G>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA
CA243430149 rs369716482	1793	N>S		No	ClinGen gnomAD
rs1565967967 CA386477632	1794	D>Y		No	ClinGen Ensembl
rs761802046 CA6774730	1795	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1205308997 CA386477667	1796	T>A		No	ClinGen TOPMed
CA6774732 rs368377350	1798	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs368377350 CA243430158	1798	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147281050 CA6774734	1798	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs147281050 CA6774733	1798	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs944628807 CA243430184	1799	I>L		No	ClinGen Ensembl
rs944628807 CA243430185	1799	I>V		No	ClinGen Ensembl
CA386477760 rs1348905142	1800	G>E		No	ClinGen TOPMed
CA386477848 rs1178732191	1806	E>K		No	ClinGen gnomAD
rs752858458 CA6774736	1807	D>G		No	ClinGen ExAC gnomAD
CA6774735 rs752858458	1807	D>V		No	ClinGen ExAC gnomAD
rs1237700765 CA386477891	1808	L>P		No	ClinGen TOPMed
CA6774737 rs764114949	1809	L>P		No	ClinGen ExAC gnomAD
rs753933435 CA6774738	1810	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA6774740 rs201217547	1812	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA6774739 rs757735587	1812	R>W	Variant assessed as Somatic; 0.000231 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs920176873 CA243430259	1814	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs750750723 CA386477968	1814	S>P		No	ClinGen ExAC TOPMed gnomAD
CA6774741 rs750750723	1814	S>T		No	ClinGen ExAC TOPMed gnomAD
CA6774743 rs61752535	1815	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768455977 CA6774745	1816	M>I		No	ClinGen ExAC gnomAD
rs151300416 COSM934748 CA6774746	1818	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA386478021 rs1194484880	1818	R>W		No	ClinGen TOPMed gnomAD
CA6774747 rs747711310	1819	A>E		No	ClinGen ExAC gnomAD
TCGA novel	1821	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386478076 rs1426277634	1821	G>D		No	ClinGen TOPMed gnomAD
CA243430293 rs755812772	1822	I>L		No	ClinGen Ensembl
TCGA novel	1822	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386478157 rs773257728	1826	Y>*		No	ClinGen ExAC TOPMed gnomAD
rs563984467 CA6774750	1827	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs770693613 CA6774751	1828	A>T		No	ClinGen ExAC gnomAD
rs1363583791 CA386478188	1830	N>D		No	ClinGen gnomAD
rs1040141279 CA243430338	1830	N>S		No	ClinGen TOPMed
CA6774753 rs760833780	1833	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA386478231 rs1227635489	1833	A>V		No	ClinGen TOPMed
CA6774755 rs753882249	1834	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs369007554 CA6774756	1834	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs765652687 CA6774757	1835	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1339445294 CA386478257	1836	G>D		No	ClinGen TOPMed
CA243430369 rs892730248	1837	M>K		No	ClinGen TOPMed gnomAD
CA386478276 rs1418231763	1838	A>T		No	ClinGen TOPMed
CA6774759 rs758838058	1839	E>K		No	ClinGen ExAC TOPMed
rs754719145 CA386478303	1840	E>*		No	ClinGen ExAC TOPMed gnomAD
rs751996107 CA386478312	1840	E>D		No	ClinGen ExAC TOPMed gnomAD
rs754719145 CA6774760	1840	E>K		No	ClinGen ExAC TOPMed gnomAD
CA6774762 rs754655827	1841	I>M		No	ClinGen ExAC gnomAD
rs552607556 CA6774763	1844	M>I		No	ClinGen 1000Genomes ExAC gnomAD
rs186791789 CA243430417	1845	F>Y		No	ClinGen 1000Genomes TOPMed gnomAD
CA6774764 rs200269069	1847	V>M		No	ClinGen ExAC TOPMed gnomAD
rs377282068 CA243430424	1848	A>S		No	ClinGen Ensembl
CA386478392 rs1593693227	1850	V>G		No	ClinGen Ensembl
rs777152194 CA6774767	1852	P>A		No	ClinGen ExAC gnomAD
CA386478420 rs1353864389	1854	D>E		No	ClinGen gnomAD
CA6774769 rs770791529	1855	P>L		No	ClinGen ExAC gnomAD
CA243430465 rs919136966	1857	K>E		No	ClinGen Ensembl
CA6774797 rs762985234	1858	G>E		No	ClinGen ExAC gnomAD
rs1195739386 CA386478458	1859	F>L		No	ClinGen TOPMed gnomAD
CA243431517 rs941823205	1860	K>R		No	ClinGen Ensembl
rs766991887 CA386478476	1861	Y>C		No	ClinGen ExAC gnomAD
CA6774798 rs766991887	1861	Y>F		No	ClinGen ExAC gnomAD
rs766991887 CA386478475	1861	Y>S		No	ClinGen ExAC gnomAD
CA386478482 rs1296546691	1862	L>P		No	ClinGen TOPMed
rs760123410 CA6774800	1863	Y>C		No	ClinGen ExAC gnomAD
rs774939307 CA6774799	1863	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs552016893 CA6774801	1864	L>M		No	ClinGen 1000Genomes ExAC gnomAD
CA243431534 rs369637962	1867	Q>E		No	ClinGen ESP TOPMed
CA386478522 rs1325925078	1869	Y>H		No	ClinGen gnomAD
rs760349515 CA6774803	1870	T>A		No	ClinGen ExAC gnomAD
CA6774804 rs763690194	1871	R>G		No	ClinGen ExAC TOPMed gnomAD
CA6774805 rs753381133	1871	R>T		No	ClinGen ExAC TOPMed gnomAD
rs1254607487 CA386478540	1872	I>V		No	ClinGen gnomAD
CA6774806 rs756815651	1873	S>R		No	ClinGen ExAC TOPMed gnomAD
rs890012204 CA243431560	1875	L>P		No	ClinGen TOPMed
TCGA novel	1877	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201210568 CA6774808	1878	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1480715439 CA386478585	1879	H>R		No	ClinGen TOPMed
CA6774810 rs369208008	1879	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs534560643 CA6774811	1880	C>*		No	ClinGen 1000Genomes ExAC gnomAD
rs1263755103 CA386478592	1880	C>Y		No	ClinGen gnomAD
CA386478601 rs1565970018	1881	K>I		No	ClinGen Ensembl
CA6774812 rs746829930	1882	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA6774814 rs769016037	1883	I>V		No	ClinGen ExAC gnomAD
CA6774816 rs771066298	1884	E>K		No	ClinGen ExAC TOPMed gnomAD
CA243431618 rs771066298	1884	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA386478636 rs1417866380	1886	G>V		No	ClinGen gnomAD
rs200447481 CA243431619	1889	S>C		No	ClinGen TOPMed gnomAD
rs745985251 CA6774840	1892	M>V		No	ClinGen ExAC gnomAD
CA6774841 COSM1358593 rs772701854	1894	T>M	large_intestine Variant assessed as Somatic; 4.631e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs761256936 CA6774843	1895	D>G		No	ClinGen ExAC gnomAD
CA386479397 rs1204450065	1896	I>V		No	ClinGen TOPMed
CA6774844 rs3742025	1898	G>R		No	ClinGen ExAC TOPMed gnomAD
CA386479431 rs1370651167	1899	K>R		No	ClinGen gnomAD
TCGA novel	1901	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs951118683 CA243433039	1901	D>N		No	ClinGen TOPMed
CA243433042 rs763187516	1902	G>D		No	ClinGen Ensembl
CA6774846 rs182648370 COSM3398319	1905	V>M	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA386479501 rs1311758591	1906	E>*		No	ClinGen TOPMed
rs1019749237 CA243433083	1910	G>C		No	ClinGen TOPMed gnomAD
rs1381592742 CA386479557	1911	S>L		No	ClinGen gnomAD
rs1331542979 CA386479553	1911	S>P		No	ClinGen gnomAD
CA386479581 rs1565972674	1913	M>I		No	ClinGen Ensembl
CA386479576 rs1565972667	1913	M>T		No	ClinGen Ensembl
CA243433088 rs370565979	1913	M>V		No	ClinGen ESP TOPMed
rs1240209209 CA386479596	1914	I>M		No	ClinGen Ensembl
rs1393751059 CA386479588	1914	I>V		No	ClinGen gnomAD
CA386479640 rs1385951692	1919	S>F		No	ClinGen TOPMed
TCGA novel	1919	S>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs113576948 CA6774851	1923	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs113576948 CA6774850	1923	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1199040454 CA386479689	1924	E>K		No	ClinGen gnomAD
CA386479716 rs1483058438 COSM3396051	1926	V>F	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
CA386479713 rs1483058438	1926	V>I		No	ClinGen gnomAD
CA243434362 rs908651756	1932	T>P		No	ClinGen Ensembl
CA6774873 rs756030544	1933	C>W		No	ClinGen ExAC
rs763992618 CA6774874	1934	R>*		No	ClinGen ExAC TOPMed gnomAD
rs763992618 CA386479920	1934	R>G		No	ClinGen ExAC TOPMed gnomAD
COSM1244056 CA243434374 rs1049370630	1934	R>Q	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA243434379 rs1006807395	1935	A>T		No	ClinGen gnomAD
CA243434400 rs145331950	1936	I>F		No	ClinGen ESP
rs750604068 CA6774875	1938	I>F		No	ClinGen ExAC TOPMed gnomAD
rs1297454252 CA386479980	1938	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA386480002 rs1292013476	1939	G>A		No	ClinGen Ensembl
rs747162842 CA6774878	1945	L>P		No	ClinGen ExAC TOPMed gnomAD
CA243434423 rs747162842	1945	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA386480128 rs1593708276	1947	Q>R		No	ClinGen Ensembl
CA6774880 COSM934754 rs554134867	1948	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs748501859 CA6774881	1948	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs770089749 CA6774883	1951	Q>H		No	ClinGen ExAC gnomAD
CA243434442 rs201515530	1953	E>G		No	ClinGen gnomAD
CA386480240 rs1193313772	1955	S>Y		No	ClinGen gnomAD
rs768497415 CA386480247	1956	H>D		No	ClinGen ExAC gnomAD
rs768497415 CA6774884	1956	H>Y		No	ClinGen ExAC gnomAD
rs770662949 CA6774887	1958	I>T		No	ClinGen ExAC TOPMed gnomAD
rs759151956 CA6774889	1961	G>*		No	ClinGen ExAC gnomAD
CA6774890 rs772121085	1965	L>V		No	ClinGen ExAC gnomAD
rs1372411670 CA386480430	1966	N>K		No	ClinGen gnomAD
rs1299837600 CA386480924	1970	G>E		No	ClinGen gnomAD
rs1265910496 CA386480952	1974	Y>C		No	ClinGen TOPMed
CA6774911 rs17848833	1975	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386480966 rs1186463927	1976	S>F		No	ClinGen gnomAD
CA386480963 rs1229125408	1976	S>T		No	ClinGen gnomAD
CA6774912 rs761735425	1977	N>H		No	ClinGen ExAC TOPMed gnomAD
CA6774913 rs766501542	1977	N>I		No	ClinGen ExAC gnomAD
rs766501542 CA386480970	1977	N>S		No	ClinGen ExAC gnomAD
CA243440477 rs773088100	1979	Q>E		No	ClinGen Ensembl
rs150383484 CA6774914	1979	Q>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA6774916 rs138134900	1983	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6774917 rs752819679	1986	M>I		No	ClinGen ExAC gnomAD
CA386481025 rs1593710903	1986	M>V		No	ClinGen Ensembl
rs1342179071 CA386481053	1989	N>K		No	ClinGen TOPMed
rs756578908 CA6774918	1989	N>S		No	ClinGen ExAC gnomAD
rs778315261 CA6774919	1990	G>D		No	ClinGen ExAC gnomAD
CA386481061 rs1593710978	1991	V>F		No	ClinGen Ensembl
rs187297100 CA6774921	1995	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1340487891 CA386481091	1995	T>I		No	ClinGen gnomAD
rs1340487891 CA386481089	1995	T>N		No	ClinGen gnomAD
CA6774923 rs138582469	1996	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6774924 rs771875652	1997	P>S		No	ClinGen ExAC TOPMed gnomAD
rs779690066 CA6774925	1998	D>Y		No	ClinGen ExAC gnomAD
rs1165811168 CA386481144	2003	V>A		No	ClinGen TOPMed
CA386481140 rs1418410802	2003	V>F		No	ClinGen TOPMed
CA6774927 rs768710971	2005	T>A		No	ClinGen ExAC gnomAD
CA386481157 COSM200747 rs1210244624	2005	T>I	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs961822385 CA243440526	2010	L>P		No	ClinGen TOPMed
CA386481193 rs1593711180	2011	S>A		No	ClinGen Ensembl
CA386481196 rs1265795868	2011	S>F		No	ClinGen TOPMed
rs780066853 CA243440534	2012	Y>C		No	ClinGen Ensembl
TCGA novel	2012	Y>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6774930 rs769568596	2013	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1185933720 CA386481237	2016	D>N		No	ClinGen TOPMed
rs775631148 CA6774953	2017	N>K		No	ClinGen ExAC gnomAD
rs764191587 CA6774955	2026	P>S		No	ClinGen ExAC gnomAD
rs17848835 CA6774956	2027	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs17848835 CA386481314	2027	T>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA386481324 rs1593713684	2029	P>T		No	ClinGen Ensembl
CA386481333 rs1290862244	2030	I>T		No	ClinGen gnomAD
rs76447919 CA6774959	2030	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1002314071 CA386481341	2031	D>E		No	ClinGen Ensembl
rs202214692 CA243441037	2031	D>N		No	ClinGen 1000Genomes gnomAD
CA6774960 rs758892562	2031	D>V		No	ClinGen ExAC gnomAD
CA243441060 rs910034631	2034	I>T		No	ClinGen TOPMed
CA6774961 rs766867483	2034	I>V		No	ClinGen ExAC gnomAD
CA386481379 rs751194997	2037	L>F		No	ClinGen ExAC gnomAD
rs751194997 CA6774962	2037	L>V		No	ClinGen ExAC gnomAD
rs1219133501 CA386481392	2039	S>Y		No	ClinGen gnomAD
COSM1706246 CA6774964 rs780707436	2044	D>N	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs747649594 CA6774965	2045	P>T		No	ClinGen ExAC gnomAD
rs148572580 CA6774967	2046	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756072465 CA6774966	2046	R>W		No	ClinGen ExAC TOPMed gnomAD
CA6774968 rs749234124	2047	W>C		No	ClinGen ExAC gnomAD
CA386481439 rs1282187226	2047	W>R		No	ClinGen TOPMed
rs1246649143 CA386481456	2049	L>F		No	ClinGen TOPMed
rs1037280241 CA243441082	2049	L>R		No	ClinGen TOPMed
rs1297446012 CA386481464	2050	A>V		No	ClinGen TOPMed
rs770645594 CA6774969	2052	R>S		No	ClinGen ExAC gnomAD
rs866739492 CA243441092	2055	P>S		No	ClinGen Ensembl
rs768920623 CA6774994	2056	T>I		No	ClinGen ExAC
CA6774995 rs142964772	2060	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs766323958 CA6774998	2061	W>*		No	ClinGen ExAC gnomAD
rs150701956 CA6775000	2064	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
TCGA novel	2065	F>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1409317544 CA386481649 TCGA novel	2065	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen TOPMed gnomAD
rs377624412 CA6775001	2066	F>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs774849156 CA6775002	2068	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1381592318 CA386481685	2068	H>Y		No	ClinGen gnomAD
rs201323153 CA6775004	2069	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs143974380 CA386481764	2075	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6775005 rs143974380	2075	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1302937131 CA386481781	2076	A>V		No	ClinGen TOPMed
rs990567251 CA243442110	2078	W>*		No	ClinGen TOPMed
CA386481810 rs760406701	2079	A>P		No	ClinGen ExAC TOPMed gnomAD
rs760406701 CA386481812	2079	A>S		No	ClinGen ExAC TOPMed gnomAD
CA6775006 rs760406701	2079	A>T		No	ClinGen ExAC TOPMed gnomAD
CA6775007 rs763546332	2079	A>V		No	ClinGen ExAC TOPMed gnomAD
CA6775008 rs753394219	2080	Q>R		No	ClinGen ExAC gnomAD
rs558993185 CA243442128	2081	T>N		No	ClinGen Ensembl
CA386481841 rs1170639005	2082	V>M		No	ClinGen gnomAD
rs778889891 CA6775010	2083	V>M		No	ClinGen ExAC TOPMed gnomAD
CA386481866 rs1304054803	2084	T>A		No	ClinGen gnomAD
CA386481878 rs1482420345	2085	G>R		No	ClinGen gnomAD
rs1399317882 CA386481887	2086	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs758071550 CA6775012	2086	R>Q		No	ClinGen ExAC gnomAD
rs1462003565 CA386481894	2087	A>P		No	ClinGen TOPMed
TCGA novel	2089	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386482287 rs1177499354	2090	G>E		No	ClinGen TOPMed
rs1217182399 CA386482290	2091	G>R		No	ClinGen gnomAD
rs751366693	2092	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6775034 rs778196187	2093	P>A		No	ClinGen ExAC TOPMed gnomAD
CA6775035 rs778196187	2093	P>S		No	ClinGen ExAC TOPMed gnomAD
CA6775037 rs146424440	2094	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA386482331 rs1255740316	2095	G>E		No	ClinGen TOPMed
TCGA novel	2095	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA243443196 rs917086033	2096	V>A		No	ClinGen TOPMed
CA386482349 rs1438496584	2097	I>F		No	ClinGen gnomAD
CA386482360 rs1484145030	2098	A>S		No	ClinGen TOPMed
rs746310831 CA6775038	2098	A>V		No	ClinGen ExAC gnomAD
CA386482373 rs1401190747	2099	V>A		No	ClinGen TOPMed gnomAD
rs1409590054 CA386482368	2099	V>L		No	ClinGen gnomAD
rs373662394 CA6775039	2101	T>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA6775041 rs368938120	2102	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6775040 rs747445383	2102	R>W		No	ClinGen ExAC TOPMed gnomAD
rs768285792 CA6775042	2104	V>M		No	ClinGen ExAC TOPMed gnomAD
rs776208578 CA6775043	2106	V>M		No	ClinGen ExAC TOPMed gnomAD
CA6775044 rs761460741	2107	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs764688506 CA6775045	2107	A>V		No	ClinGen ExAC TOPMed gnomAD
CA6775047 rs762779977	2108	V>G		No	ClinGen ExAC TOPMed gnomAD
rs772804579 CA6775046	2108	V>I		No	ClinGen ExAC gnomAD
rs766383618 CA6775048	2109	P>A		No	ClinGen ExAC gnomAD
CA6775049 rs751311068	2114	N>D		No	ClinGen ExAC gnomAD
CA6775050 rs754757968	2114	N>S		No	ClinGen ExAC gnomAD
rs140894382 CA243443259	2119	A>G		No	ClinGen ESP TOPMed gnomAD
CA386482490 rs1387119399	2119	A>T		No	ClinGen TOPMed
rs140894382 CA386482494	2119	A>V		No	ClinGen ESP TOPMed gnomAD
rs767421139 CA6775051	2120	K>Q		No	ClinGen ExAC gnomAD
CA386482498 rs1470255097	2120	K>R		No	ClinGen gnomAD
rs1565981760 CA386482531	2123	Q>R		No	ClinGen Ensembl
CA386482536 rs1427291466	2124	Q>E		No	ClinGen TOPMed gnomAD
rs1427291466 CA386482535	2124	Q>K		No	ClinGen TOPMed gnomAD
CA386482538 rs1383902989	2124	Q>P		No	ClinGen TOPMed
rs1003623660 CA243443638	2126	G>R		No	ClinGen gnomAD
rs762094121 CA6775077	2127	Q>*		No	ClinGen ExAC gnomAD
CA6775078 rs765561863	2127	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA243443647 rs1050966102	2127	Q>P		No	ClinGen TOPMed gnomAD
rs1433685343 CA386482696	2128	V>M		No	ClinGen TOPMed
rs373328609 CA6775079	2130	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs377654795 CA6775080	2132	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1425654392 CA386482776	2133	S>A		No	ClinGen TOPMed
CA6775081 rs369413010	2134	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs752022633 CA6775082	2135	Y>S		No	ClinGen ExAC gnomAD
CA6775083 rs755503238	2137	T>I		No	ClinGen ExAC TOPMed gnomAD
rs145553418 CA6775085	2138	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA6775086 rs769331822	2138	A>V		No	ClinGen ExAC TOPMed
rs1475845404 CA386482826	2140	A>V		No	ClinGen gnomAD
CA6775088 VAR_031257 rs2075260	2141	V>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA6775089 rs770430319	2142	K>E		No	ClinGen ExAC gnomAD
rs759521668 CA6775091	2145	N>I		No	ClinGen ExAC TOPMed gnomAD
CA6775092 rs759521668	2145	N>S		No	ClinGen ExAC TOPMed gnomAD
CA386482858 rs759521668	2145	N>T		No	ClinGen ExAC TOPMed gnomAD
CA6775093 rs374132389	2146	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA386482862 COSM2150980 rs1380838784	2146	R>W	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA386482872 rs1327433127	2147	E>D		No	ClinGen gnomAD
rs143558242 CA6775094	2148	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA386482890 rs1300821089	2150	P>H		No	ClinGen gnomAD
rs750592937 CA6775096	2151	L>P		No	ClinGen ExAC gnomAD
CA6775095 rs763809724	2151	L>V		No	ClinGen ExAC gnomAD
rs763118062 CA6775097	2152	M>K		No	ClinGen ExAC gnomAD
CA6775098 rs766434655	2153	I>M		No	ClinGen ExAC TOPMed gnomAD
CA6775099 rs751690673	2155	A>G		No	ClinGen ExAC gnomAD
CA386482920 rs1206864081	2155	A>S		No	ClinGen TOPMed gnomAD
rs755448815 CA6775100	2156	N>K		No	ClinGen ExAC gnomAD
CA243443721 rs942712421	2156	N>S		No	ClinGen gnomAD
CA386482935 rs1455612943	2157	W>*		No	ClinGen gnomAD
rs1251379555 CA386482932	2157	W>*		No	ClinGen gnomAD
rs866743131 CA243443730	2158	R>K		No	ClinGen Ensembl
rs866743131 CA386482941	2158	R>M		No	ClinGen Ensembl
CA6775101 rs768083563	2159	G>E		No	ClinGen ExAC gnomAD
CA6775102 rs148052616	2162	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs756430740 CA6775103	2164	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1408784649 CA386482977	2164	M>T		No	ClinGen TOPMed
rs930244308 CA243443745	2164	M>V		No	ClinGen Ensembl
TCGA novel	2165	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386483196 rs1268669464	2166	D>G		No	ClinGen Ensembl
rs778025671 CA6775104	2166	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1047587347 CA243444364	2167	M>L		No	ClinGen TOPMed gnomAD
TCGA novel	2169	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs906556852 CA243444367	2170	Q>E		No	ClinGen TOPMed
rs1259332969 CA386483268	2176	A>G		No	ClinGen gnomAD
TCGA novel	2176	A>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6775152 rs781052311	2178	I>V		No	ClinGen ExAC gnomAD
rs748133359 CA6775153	2179	V>M		No	ClinGen ExAC TOPMed gnomAD
rs769515194 CA243444391	2180	D>E		No	ClinGen ExAC TOPMed gnomAD
CA6775155 rs530383151	2181	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	2183	R>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6775157 rs772317756	2186	K>E		No	ClinGen ExAC gnomAD
rs775631853 CA6775158	2187	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA243444409 rs775631853	2187	Q>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	2188	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6775160 rs146283042	2192	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1321419779 CA386483379	2193	I>T		No	ClinGen gnomAD
CA6775161 rs139082246	2194	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1371906682 CA386483389	2195	P>S		No	ClinGen gnomAD
rs1305513603 CA386483397	2196	Y>C		No	ClinGen gnomAD
rs143111072 CA6775166	2197	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs143111072 COSM200752 CA6775165	2197	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs751071189 CA6775169	2200	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs766014747 CA6775168	2200	R>W		No	ClinGen ExAC gnomAD
COSM1244058 rs754391562 CA6775170	2201	G>R	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA243444465 rs866118060	2203	S>Y		No	ClinGen Ensembl
CA6775172 rs752524224	2204	W>*		No	ClinGen ExAC TOPMed gnomAD
CA6775171 rs570493501	2204	W>R		No	ClinGen 1000Genomes ExAC gnomAD
CA6775173 rs756090747	2207	I>M		No	ClinGen ExAC gnomAD
rs777510923 CA6775174	2211	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6775175 rs372069080	2213	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA386483601 rs1458647667	2218	M>I		No	ClinGen TOPMed gnomAD
CA386483598 rs1593733861	2218	M>T		No	ClinGen Ensembl
rs747258931 CA6775178	2219	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	2219	Y>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386483644 rs1479869354	2222	K>T		No	ClinGen TOPMed
CA6775179 rs368094089	2223	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs776795041 CA6775180	2224	S>N		No	ClinGen ExAC gnomAD
CA243445092 rs139062970	2226	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756933792 CA6775193	2226	G>S		No	ClinGen ExAC gnomAD
CA6775194 rs139062970	2226	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1185055620 CA386483946	2228	V>I		No	ClinGen gnomAD
rs747150912 CA6775195	2229	L>M		No	ClinGen ExAC gnomAD
rs967146071 CA243445097	2229	L>P		No	ClinGen TOPMed gnomAD
CA6775196 rs755278354	2232	E>A		No	ClinGen ExAC gnomAD
CA243445102 rs1023404958	2236	E>Q		No	ClinGen TOPMed
CA6775198 rs748306546	2237	I>N		No	ClinGen ExAC gnomAD
CA386484005 rs748306546	2237	I>T		No	ClinGen ExAC gnomAD
COSM138897 rs573571761 CA6775199	2240	R>*	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA6775200 COSM1358605 rs773800691	2240	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1449142569 CA386484034	2242	K>Q		No	ClinGen TOPMed
rs749821054 CA6775201	2243	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	2243	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6775202 rs771163687	2245	I>M		No	ClinGen ExAC gnomAD
rs1031038503 CA243445111	2248	M>L		No	ClinGen gnomAD
rs149957235 CA6775203	2250	R>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1349923714 CA386484102	2252	D>N		No	ClinGen TOPMed gnomAD
rs774964456 CA6775206	2253	P>R		No	ClinGen ExAC gnomAD
CA6775205 rs200696584	2253	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386484110 rs200696584	2253	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA243445117 rs921895997	2254	A>T		No	ClinGen Ensembl
CA6775208 rs763597132	2259	M>I		No	ClinGen ExAC TOPMed gnomAD
CA6775207 rs760118179	2259	M>T		No	ClinGen ExAC TOPMed gnomAD
CA386484150 rs1445076672	2259	M>V		No	ClinGen gnomAD
CA386484161 rs765591079	2260	E>D		No	ClinGen gnomAD
CA6775209 rs79982724	2260	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA386484170 rs1565985179	2261	Q>H		No	ClinGen Ensembl
CA386484168 rs1193064359	2261	Q>P		No	ClinGen gnomAD
CA6775210 rs757239951	2262	L>I		No	ClinGen ExAC
rs764919005 CA6775212	2263	G>R		No	ClinGen ExAC TOPMed gnomAD
CA6775211 rs764919005	2263	G>W		No	ClinGen ExAC TOPMed gnomAD
CA6775231 rs554851210	2264	E>*		No	ClinGen 1000Genomes ExAC gnomAD
rs768199367 CA386484197	2265	P>A		No	ClinGen ExAC TOPMed gnomAD
rs768199367 CA6775232	2265	P>S		No	ClinGen ExAC TOPMed gnomAD
CA243445453 rs768199367	2265	P>T		No	ClinGen ExAC TOPMed gnomAD
CA6775235 rs777982597	2266	D>Y		No	ClinGen ExAC
CA6775236 rs754010885	2267	L>F		No	ClinGen ExAC TOPMed
CA6775240 rs764352111	2269	D>H		No	ClinGen ExAC gnomAD
rs764352111 CA6775239	2269	D>N		No	ClinGen ExAC gnomAD
CA6775241 rs772380197	2270	K>E		No	ClinGen ExAC gnomAD
CA6775242 rs200890630	2272	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA386484257 rs200890630	2272	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs746633480 CA386484261	2272	R>L		No	ClinGen ExAC TOPMed gnomAD
rs746633480 CA6775243	2272	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1593744290 CA386484291	2275	L>P		No	ClinGen Ensembl
CA386484306 rs1418115427	2277	G>S		No	ClinGen TOPMed
rs374238980 CA6775247	2277	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA386484314 rs199967038	2278	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6775249 rs762817382	2278	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs199967038 CA6775248	2278	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6775250 rs766233619	2279	L>R		No	ClinGen ExAC TOPMed gnomAD
CA386484327 rs1185041978	2280	K>E		No	ClinGen gnomAD
CA386484335 rs950982550	2280	K>N		No	ClinGen TOPMed
CA243445455 rs140157645	2280	K>R		No	ClinGen ESP TOPMed
CA386484340 rs1316543956	2281	A>V		No	ClinGen TOPMed
CA6775252 rs537638499	2282	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA386484346 rs537638499	2282	R>G		No	ClinGen 1000Genomes ExAC gnomAD
rs565580708 CA6775253	2282	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386484351 rs565580708	2282	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA243445457 rs751883969	2283	E>G		No	ClinGen Ensembl
CA6775254 rs754013468	2283	E>K		No	ClinGen ExAC TOPMed gnomAD
CA386484368 rs1593744496	2284	D>A		No	ClinGen Ensembl
rs778883908 CA6775256	2285	L>P		No	ClinGen ExAC TOPMed gnomAD
CA6775259 rs758944938	2289	I>F		No	ClinGen ExAC
rs1354513681 CA386484450	2292	Q>*		No	ClinGen TOPMed gnomAD
CA386484474 rs1291617779	2294	A>T		No	ClinGen gnomAD
rs139826793 CA6775261	2294	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA386484487 rs1250814181	2295	V>L		No	ClinGen gnomAD
CA6775264 rs747767589	2298	A>T		No	ClinGen ExAC TOPMed gnomAD
rs772625780 CA6775266	2299	D>N		No	ClinGen ExAC gnomAD
CA386484560 rs1258750802	2301	H>N		No	ClinGen gnomAD
rs749202356 CA6775267	2303	T>A		No	ClinGen ExAC TOPMed
CA6775270 rs140217207	2305	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA243445460 rs985569218	2306	R>G		No	ClinGen TOPMed gnomAD
RCV000963972 rs149917930 CA6775271	2306	R>Q		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs985569218 CA243445459	2306	R>W		No	ClinGen TOPMed gnomAD
rs776865424 CA6775272	2307	M>V		No	ClinGen ExAC gnomAD
CA386484656 rs1432844241	2310	K>N		No	ClinGen gnomAD
CA6775274 rs765330713	2311	G>D		No	ClinGen ExAC gnomAD
CA6775276 rs374342222	2312	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1295128208 CA386484681	2313	I>V		No	ClinGen TOPMed gnomAD
rs756781717 CA6775302	2315	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1023866977 CA243445535	2316	I>T		No	ClinGen Ensembl
rs889421938 CA243445534	2316	I>V		No	ClinGen TOPMed gnomAD
CA6775303 rs778599057	2318	E>V		No	ClinGen ExAC gnomAD
TCGA novel	2320	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386484828 rs1156628506	2321	T>N		No	ClinGen TOPMed gnomAD
RCV000144494 CA233224 rs587776495	2322	A>T		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA6775305 rs779886492	2323	R>C		No	ClinGen ExAC TOPMed gnomAD
CA6775306 rs147616769	2323	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA243445537 rs147616769	2323	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6775308 rs773362975	2324	T>A		No	ClinGen ExAC TOPMed gnomAD
rs763182651 CA386484912	2324	T>N		No	ClinGen ExAC TOPMed gnomAD
rs773362975 CA386484909	2324	T>P		No	ClinGen ExAC TOPMed gnomAD
rs763182651 CA6775309	2324	T>S		No	ClinGen ExAC TOPMed gnomAD
CA386484919 rs1391367247	2325	F>L		No	ClinGen gnomAD
CA6775310 rs770956314	2325	F>S		No	ClinGen ExAC gnomAD
CA243445538 rs374601185	2327	Y>C		No	ClinGen Ensembl
CA6775311 rs560469698	2329	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA6775312 rs146268113	2329	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs147871680 COSM4135715 CA6775315	2331	R>C	pancreas [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs367989648 CA6775316	2331	R>H		No	ClinGen ESP ExAC gnomAD
CA6775318 rs753504188	2332	R>C		No	ClinGen ExAC TOPMed gnomAD
CA386484954 rs753504188	2332	R>G		No	ClinGen ExAC TOPMed gnomAD
CA6775319 rs778545831	2332	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6775317 rs753504188	2332	R>S		No	ClinGen ExAC TOPMed gnomAD
CA6775320 rs750013056	2333	L>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	2336	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6775321 rs758352184	2337	D>E		No	ClinGen ExAC gnomAD
rs1472798707 CA386484985	2337	D>G		No	ClinGen gnomAD
TCGA novel	2338	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA243445539 rs952057988	2339	V>L		No	ClinGen TOPMed
rs1403865212 CA386485002	2340	K>E		No	ClinGen gnomAD
CA6775322 rs779789094	2343	I>F		No	ClinGen ExAC gnomAD
rs746978944 CA6775324	2343	I>M		No	ClinGen ExAC TOPMed gnomAD
rs947597320 CA243445541	2343	I>N		No	ClinGen Ensembl
rs371799472 CA6775325	2344	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs749479081 CA6775326	2346	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1410849544 CA386485047	2347	S>G		No	ClinGen gnomAD
CA386485054 CA6775328 rs368598355	2348	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA6775329 rs759471647	2349	E>K		No	ClinGen ExAC
CA6775330 rs772210651	2349	E>V		No	ClinGen ExAC
rs1457429304 CA386485073	2351	S>N		No	ClinGen gnomAD
CA6775331 rs200707789	2352	H>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200707789 CA386485079	2352	H>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386485086 rs764524027	2353	V>L		No	ClinGen ExAC gnomAD
CA6775333 rs764524027	2353	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA243445543 rs942852049	2355	I>T		No	ClinGen Ensembl
CA6775334 rs754305943	2356	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs117537396 CA6775336	2358	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs763392961 CA243445544 COSM1181500	2360	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
COSM934767 CA6775337 rs750093564	2360	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs372645487 CA6775338	2361	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA386485136 rs1414559790	2361	R>H		No	ClinGen gnomAD
CA243445545 rs202202415	2363	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA386485155 rs552167251	2364	V>L		No	ClinGen ExAC TOPMed gnomAD
CA6775340 rs552167251	2364	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1430991724 CA386485160	2365	E>K		No	ClinGen gnomAD
COSM1244060 CA6775341 rs754980151	2366	T>M	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1045463282 CA243445546	2369	A>P		No	ClinGen TOPMed gnomAD
rs1593747954 CA386485198	2369	A>V		No	ClinGen Ensembl
CA243445558 rs143664715	2372	A>V		No	ClinGen ESP TOPMed
CA6775373 rs773664849	2375	W>*		No	ClinGen ExAC gnomAD
CA243445560 rs868387365	2379	Q>*		No	ClinGen Ensembl
CA386485351 rs1429694512	2379	Q>H		No	ClinGen TOPMed
rs148106171 CA6775374	2380	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA6775376 rs773725666	2381	V>A		No	ClinGen ExAC gnomAD
CA6775375 rs141894238	2381	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs373300737 CA6775377	2382	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA386485385 rs1278737592	2383	Q>*		No	ClinGen gnomAD
rs1270275506 CA386485399	2384	W>*		No	ClinGen TOPMed gnomAD
rs564704950 CA6775379	2384	W>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201163993 CA6775380	2386	E>G		No	ClinGen ExAC gnomAD
CA386485423 rs753726473	2387	Q>*		No	ClinGen ExAC gnomAD
CA386485424 rs753726473	2387	Q>E		No	ClinGen ExAC gnomAD
CA6775382 rs753726473	2387	Q>K		No	ClinGen ExAC gnomAD
CA243445561 rs113795346	2387	Q>R		No	ClinGen Ensembl
rs377337560 CA6775383	2390	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs751845562 CA6775385	2394	G>V		No	ClinGen ExAC gnomAD
rs755059216 CA6775386	2395	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6775389 rs770471527	2396	R>C		No	ClinGen ExAC TOPMed gnomAD
rs777984086 CA6775390	2396	R>H		No	ClinGen ExAC TOPMed gnomAD
CA386485527 rs368703551	2397	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs138987031 CA243445563	2397	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs138987031 CA6775391	2397	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA6775392 rs368703551	2397	S>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs774009369 CA6775393	2398	T>A		No	ClinGen ExAC gnomAD
CA386485528 rs774009369	2398	T>P		No	ClinGen ExAC gnomAD
rs200727585 CA6775394	2398	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1309922426 CA386485545	2399	I>L		No	ClinGen TOPMed
CA386485551 rs1288792968	2399	I>T		No	ClinGen gnomAD
rs775033613 CA6775396	2400	R>C		No	ClinGen ExAC TOPMed gnomAD
CA6775397 rs368161191	2400	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1263753550 CA386485560	2401	E>K		No	ClinGen TOPMed gnomAD
rs764160682 CA6775398	2402	N>S		No	ClinGen ExAC gnomAD
rs1467795383 CA386485590	2403	I>T		No	ClinGen TOPMed
rs1041265067 CA243445564	2403	I>V		No	ClinGen gnomAD
CA6775399 rs753723591	2404	T>A		No	ClinGen ExAC gnomAD
CA6775400 rs761612668	2404	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1593749068 CA386485604	2405	Y>S		No	ClinGen Ensembl
CA386485628 rs941070297	2408	H>Q		No	ClinGen TOPMed gnomAD
rs1369634080 CA386485624	2408	H>Y		No	ClinGen gnomAD
CA6775406 rs139766548	2409	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs144520667 CA6775405	2409	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6775407 rs778271612	2410	S>F		No	ClinGen ExAC gnomAD
CA6775409 rs749768594	2412	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	2414	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386485686 rs1593749200	2414	T>P		No	ClinGen Ensembl
CA6775412 rs745499690	2415	I>V		No	ClinGen ExAC gnomAD
CA6775413 rs771773850 COSM3687938	2416	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6775414 rs201073233	2416	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386485719 rs1565989459	2417	G>C		No	ClinGen Ensembl
rs1051688848 CA243445638	2419	V>A		No	ClinGen TOPMed gnomAD
TCGA novel	2419	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	2421	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386485845 rs1593751156	2422	N>T		No	ClinGen Ensembl
rs762766039 CA6775438	2423	P>T		No	ClinGen ExAC gnomAD
rs775802513 CA6775440	2424	E>K		No	ClinGen ExAC TOPMed gnomAD
CA386485883 rs1441671018	2425	V>A		No	ClinGen TOPMed gnomAD
rs1441671018 CA386485884	2425	V>G		No	ClinGen TOPMed gnomAD
CA6775442 rs746443616	2427	V>M		No	ClinGen ExAC TOPMed gnomAD
rs757781859 CA6775444	2429	C>G		No	ClinGen ExAC gnomAD
TCGA novel	2430	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765667379 CA6775445	2431	I>T		No	ClinGen ExAC TOPMed gnomAD
rs750941564 CA6775446	2432	Y>D		No	ClinGen ExAC gnomAD
CA386485985 rs1362672345	2434	S>N		No	ClinGen TOPMed
CA243445639 CA386485991 COSM430293 rs1017078502	2434	S>R	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated TOPMed NCI-TCGA
rs1010092113 CA243445640	2436	H>N		No	ClinGen TOPMed
rs770528273 CA243445641	2436	H>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	2438	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386486048 rs1330553155	2439	P>L		No	ClinGen gnomAD
rs780429705 CA6775448	2441	E>K		No	ClinGen ExAC TOPMed gnomAD
CA6775451 rs540153010	2442	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs746640949 CA6775450	2442	R>W		No	ClinGen ExAC gnomAD
CA6775452 rs780740079	2443	A>V		No	ClinGen ExAC TOPMed gnomAD
rs765367679 CA243445642	2445	V>F		No	ClinGen ExAC TOPMed gnomAD
CA386486104 rs765367679	2445	V>I		No	ClinGen ExAC TOPMed gnomAD
rs765367679 CA6775455	2445	V>L		No	ClinGen ExAC TOPMed gnomAD
CA386486109 rs551014194	2446	V>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6775457 rs551014194 COSM934771	2446	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1210304724 CA386486140	2449	L>V		No	ClinGen gnomAD
CA6775459 rs760943186	2451	T>A		No	ClinGen ExAC gnomAD
rs1368683298 CA386486178	2452	M>I		No	ClinGen gnomAD
rs1295815113 CA386486173	2452	M>T		No	ClinGen gnomAD
rs1409631810 CA386486180	2453	D>N		No	ClinGen gnomAD
rs1286884708 CA386486222	2454	S>R		No	ClinGen gnomAD
CA6775460 rs775854758	2455	P>L		No	ClinGen ExAC TOPMed gnomAD
CA386486226 rs1351922103	2455	P>S		No	ClinGen gnomAD
rs372784451 CA6775462	2456	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA386486249 rs1593751648	2457	S>P		No	ClinGen Ensembl
CA6775464 rs750890672	2458	T>P		No	ClinGen ExAC
CA6775465 rs763489374	2459	T>C		No	ClinGen ExAC

No associated diseases with O00763

10 regional properties for O00763

Type	Name	Position	InterPro Accession
domain	Biotin/lipoyl attachment	888 - 962	IPR000089
domain	Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain	431 - 614	IPR005479
domain	Biotin carboxylase-like, N-terminal domain	260 - 379	IPR005481
domain	Biotin carboxylase, C-terminal	650 - 757	IPR005482
domain	ATP-grasp fold	414 - 609	IPR011761
domain	Acetyl-coenzyme A carboxyltransferase, N-terminal	1695 - 2025	IPR011762
domain	Acetyl-coenzyme A carboxyltransferase, C-terminal	2029 - 2345	IPR011763
domain	Biotin carboxylation domain	259 - 761	IPR011764
domain	Acetyl-CoA carboxylase, central domain	962 - 1688	IPR013537
domain	Acetyl-CoA carboxylase	1780 - 2333	IPR034733

Functions

		Description
EC Number	6.4.1.2	Forming carbon-carbon bonds
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrial outer membrane	The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name	Definition
acetyl-CoA carboxylase activity	Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
biotin binding	Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.
identical protein binding	Binding to an identical protein or proteins.
metal ion binding	Binding to a metal ion.

14 GO annotations of biological process

Name	Definition
acetyl-CoA metabolic process	The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
energy homeostasis	Any process involved in the balance between food intake (energy input) and energy expenditure.
fatty acid biosynthetic process	The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
malonyl-CoA biosynthetic process	The chemical reactions and pathways resulting in the formation of malonyl-CoA, the S-malonyl derivative of coenzyme A.
negative regulation of catalytic activity	Any process that stops or reduces the activity of an enzyme.
negative regulation of fatty acid beta-oxidation	Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation.
negative regulation of gene expression	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of heart growth	Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.
positive regulation of lipid storage	Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
protein homotetramerization	The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
regulation of glucose metabolic process	Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
response to nutrient levels	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
response to organic cyclic compound	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P11029	ACAC	Acetyl-CoA carboxylase	Gallus gallus (Chicken)	PR
Q13085	ACACA	Acetyl-CoA carboxylase 1	Homo sapiens (Human)	PR
Q5SWU9	Acaca	Acetyl-CoA carboxylase 1	Mus musculus (Mouse)	PR
E9Q4Z2	Acacb	Acetyl-CoA carboxylase 2	Mus musculus (Mouse)	PR
P11497	Acaca	Acetyl-CoA carboxylase 1	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MVLLLCLSCL	IFSCLTFSWL	KIWGKMTDSK	PITKSKSEAN	LIPSQEPFPA	SDNSGETPQR
70	80	90	100	110	120
NGEGHTLPKT	PSQAEPASHK	GPKDAGRRRN	SLPPSHQKPP	RNPLSSSDAA	PSPELQANGT
130	140	150	160	170	180
GTQGLEATDT	NGLSSSARPQ	GQQAGSPSKE	DKKQANIKRQ	LMTNFILGSF	DDYSSDEDSV
190	200	210	220	230	240
AGSSRESTRK	GSRASLGALS	LEAYLTTGEA	ETRVPTMRPS	MSGLHLVKRG	REHKKLDLHR
250	260	270	280	290	300
DFTVASPAEF	VTRFGGDRVI	EKVLIANNGI	AAVKCMRSIR	RWAYEMFRNE	RAIRFVVMVT
310	320	330	340	350	360
PEDLKANAEY	IKMADHYVPV	PGGPNNNNYA	NVELIVDIAK	RIPVQAVWAG	WGHASENPKL
370	380	390	400	410	420
PELLCKNGVA	FLGPPSEAMW	ALGDKIASTV	VAQTLQVPTL	PWSGSGLTVE	WTEDDLQQGK
430	440	450	460	470	480
RISVPEDVYD	KGCVKDVDEG	LEAAERIGFP	LMIKASEGGG	GKGIRKAESA	EDFPILFRQV
490	500	510	520	530	540
QSEIPGSPIF	LMKLAQHARH	LEVQILADQY	GNAVSLFGRD	CSIQRRHQKI	VEEAPATIAP
550	560	570	580	590	600
LAIFEFMEQC	AIRLAKTVGY	VSAGTVEYLY	SQDGSFHFLE	LNPRLQVEHP	CTEMIADVNL
610	620	630	640	650	660
PAAQLQIAMG	VPLHRLKDIR	LLYGESPWGV	TPISFETPSN	PPLARGHVIA	ARITSENPDE
670	680	690	700	710	720
GFKPSSGTVQ	ELNFRSSKNV	WGYFSVAATG	GLHEFADSQF	GHCFSWGENR	EEAISNMVVA
730	740	750	760	770	780
LKELSIRGDF	RTTVEYLINL	LETESFQNND	IDTGWLDYLI	AEKVQAEKPD	IMLGVVCGAL
790	800	810	820	830	840
NVADAMFRTC	MTDFLHSLER	GQVLPADSLL	NLVDVELIYG	GVKYILKVAR	QSLTMFVLIM
850	860	870	880	890	900
NGCHIEIDAH	RLNDGGLLLS	YNGNSYTTYM	KEEVDSYRIT	IGNKTCVFEK	ENDPTVLRSP
910	920	930	940	950	960
SAGKLTQYTV	EDGGHVEAGS	SYAEMEVMKM	IMTLNVQERG	RVKYIKRPGA	VLEAGCVVAR
970	980	990	1000	1010	1020
LELDDPSKVH	PAEPFTGELP	AQQTLPILGE	KLHQVFHSVL	ENLTNVMSGF	CLPEPVFSIK
1030	1040	1050	1060	1070	1080
LKEWVQKLMM	TLRHPSLPLL	ELQEIMTSVA	GRIPAPVEKS	VRRVMAQYAS	NITSVLCQFP
1090	1100	1110	1120	1130	1140
SQQIATILDC	HAATLQRKAD	REVFFINTQS	IVQLVQRYRS	GIRGYMKTVV	LDLLRRYLRV
1150	1160	1170	1180	1190	1200
EHHFQQAHYD	KCVINLREQF	KPDMSQVLDC	IFSHAQVAKK	NQLVIMLIDE	LCGPDPSLSD
1210	1220	1230	1240	1250	1260
ELISILNELT	QLSKSEHCKV	ALRARQILIA	SHLPSYELRH	NQVESIFLSA	IDMYGHQFCP
1270	1280	1290	1300	1310	1320
ENLKKLILSE	TTIFDVLPTF	FYHANKVVCM	ASLEVYVRRG	YIAYELNSLQ	HRQLPDGTCV
1330	1340	1350	1360	1370	1380
VEFQFMLPSS	HPNRMTVPIS	ITNPDLLRHS	TELFMDSGFS	PLCQRMGAMV	AFRRFEDFTR
1390	1400	1410	1420	1430	1440
NFDEVISCFA	NVPKDTPLFS	EARTSLYSED	DCKSLREEPI	HILNVSIQCA	DHLEDEALVP
1450	1460	1470	1480	1490	1500
ILRTFVQSKK	NILVDYGLRR	ITFLIAQEKE	FPKFFTFRAR	DEFAEDRIYR	HLEPALAFQL
1510	1520	1530	1540	1550	1560
ELNRMRNFDL	TAVPCANHKM	HLYLGAAKVK	EGVEVTDHRF	FIRAIIRHSD	LITKEASFEY
1570	1580	1590	1600	1610	1620
LQNEGERLLL	EAMDELEVAF	NNTSVRTDCN	HIFLNFVPTV	IMDPFKIEES	VRYMVMRYGS
1630	1640	1650	1660	1670	1680
RLWKLRVLQA	EVKINIRQTT	TGSAVPIRLF	ITNESGYYLD	ISLYKEVTDS	RSGNIMFHSF
1690	1700	1710	1720	1730	1740
GNKQGPQHGM	LINTPYVTKD	LLQAKRFQAQ	TLGTTYIYDF	PEMFRQALFK	LWGSPDKYPK
1750	1760	1770	1780	1790	1800
DILTYTELVL	DSQGQLVEMN	RLPGGNEVGM	VAFKMRFKTQ	EYPEGRDVIV	IGNDITFRIG
1810	1820	1830	1840	1850	1860
SFGPGEDLLY	LRASEMARAE	GIPKIYVAAN	SGARIGMAEE	IKHMFHVAWV	DPEDPHKGFK
1870	1880	1890	1900	1910	1920
YLYLTPQDYT	RISSLNSVHC	KHIEEGGESR	YMITDIIGKD	DGLGVENLRG	SGMIAGESSL
1930	1940	1950	1960	1970	1980
AYEEIVTISL	VTCRAIGIGA	YLVRLGQRVI	QVENSHIILT	GASALNKVLG	REVYTSNNQL
1990	2000	2010	2020	2030	2040
GGVQIMHYNG	VSHITVPDDF	EGVYTILEWL	SYMPKDNHSP	VPIITPTDPI	DREIEFLPSR
2050	2060	2070	2080	2090	2100
APYDPRWMLA	GRPHPTLKGT	WQSGFFDHGS	FKEIMAPWAQ	TVVTGRARLG	GIPVGVIAVE
2110	2120	2130	2140	2150	2160
TRTVEVAVPA	DPANLDSEAK	IIQQAGQVWF	PDSAYKTAQA	VKDFNREKLP	LMIFANWRGF
2170	2180	2190	2200	2210	2220
SGGMKDMYDQ	VLKFGAYIVD	GLRQYKQPIL	IYIPPYAELR	GGSWVVIDAT	INPLCIEMYA
2230	2240	2250	2260	2270	2280
DKESRGGVLE	PEGTVEIKFR	KKDLIKSMRR	IDPAYKKLME	QLGEPDLSDK	DRKDLEGRLK
2290	2300	2310	2320	2330	2340
AREDLLLPIY	HQVAVQFADF	HDTPGRMLEK	GVISDILEWK	TARTFLYWRL	RRLLLEDQVK
2350	2360	2370	2380	2390	2400
QEILQASGEL	SHVHIQSMLR	RWFVETEGAV	KAYLWDNNQV	VVQWLEQHWQ	AGDGPRSTIR
2410	2420	2430	2440	2450
ENITYLKHDS	VLKTIRGLVE	ENPEVAVDCV	IYLSQHISPA	ERAQVVHLLS	TMDSPAST