Q5M8F9
Gene name |
agmo (tmem195) |
Protein name |
Alkylglycerol monooxygenase |
Names |
Transmembrane protein 195 |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:496770 |
EC number |
1.14.16.5: With reduced pteridine as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5M8F9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5M8F9-F1 | Predicted | AlphaFoldDB |
No variants for Q5M8F9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5M8F9 | |||||
No associated diseases with Q5M8F9
1 regional properties for Q5M8F9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Fatty acid hydroxylase | 118 - 248 | IPR006694 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.16.5 | With reduced pteridine as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| glyceryl-ether monooxygenase activity | Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine). |
| iron ion binding | Binding to an iron (Fe) ion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| ether lipid metabolic process | The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol. |
| lipid biosynthetic process | The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| membrane lipid metabolic process | The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O75845 | SC5D | Lathosterol oxidase | Homo sapiens (Human) | PR |
| O88822 | Sc5d | Lathosterol oxidase | Mus musculus (Mouse) | PR |
| Q9EQS5 | Sc5d | Lathosterol oxidase | Rattus norvegicus (Rat) | PR |
| O17554 | agmo-1 | Alkylglycerol monooxygenase | Caenorhabditis elegans | PR |
| Q6NYE4 | agmo | Alkylglycerol monooxygenase | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGGFTGQSEV | SVSQGIRMMF | YVLYPNETSF | KNVEDVPDYV | EKATVYFFIM | LILEMIISWA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WKGQPLRIND | GLTSLSAGVF | SRLPDVAFRG | VEVASYIYIW | NNYRLIELPW | DSPWTWWLTF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LGVDFGYYWF | HRMAHEVNIM | WAGHQTHHSS | EDYNLTTALR | QSFIQKYFSW | MFYWPMAFCI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PPSVFAVHIQ | FNLLYQFWIH | TELINNLGPL | EWILNTPSHH | RVHHGRNPYC | IDSNYAGTLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IWDRMFGTFV | PEKEKVLYGL | THPINTFEPF | QVQIQHCVLI | WNTFWATPGF | SNKLSVIFKG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PGWGPGKPRL | GLPEEIPQIT | GEEKPYDPKS | AGYLQCYGMM | HFLLLLAVYV | HMFEAKLILT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PATLLLRIGY | ILLTLTSLGF | IFDKRPKAAL | LETIRCLLFL | FLQKYDYMTT | DVPYLRIINE |
| 430 | 440 | ||||
| VTFSICTAAW | GLKAVKEAIE | RTKKLE |