AiPD: Autoinhibited Protein Database

Gene name	Sc5d (Sc5dl)
Protein name	Lathosterol oxidase
Names	C-5 sterol desaturase, Delta(7)-sterol 5-desaturase, Delta(7)-sterol C5(6)-desaturase, Lathosterol 5-desaturase, Sterol-C5-desaturase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:235293
EC number	1.14.19.20: With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

231-299 (Predicted disordered autoinhibitory region) PR

231-299 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O88822-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389040086	15	P>L	No	EVA
rs3389030500	35	L>Q	No	EVA
rs3389025630	70	K>M	No	EVA
rs3389035333	85	P>T	No	EVA
rs3389030504	99	L>R	No	EVA
rs3389035044	105	L>H	No	EVA
rs3389040098	108	D>V	No	EVA
rs3389017123	116	W>L	No	EVA
rs3389037231	122	S>N	No	EVA
rs3389042784	127	L>P	No	EVA
rs3389040046	128	F>L	No	EVA
rs3389017098	155	H>N	No	EVA
rs3389025648	167	A>V	No	EVA
rs3389037234	169	H>Q	No	EVA
rs3388986008	172	D>E	No	EVA
rs227883817	217	Q>R	No	EVA
rs3389035079	219	L>I	No	EVA
rs3389031145	241	G>R	No	EVA
rs3389030532	269	V>M	No	EVA
rs36310583	291	G>S	No	EVA

Type	Name	Position	InterPro Accession
domain	Fatty acid hydroxylase	124 - 252	IPR006694

		Description
EC Number	1.14.19.20	With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

Name	Definition
C-5 sterol desaturase activity	Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.
delta7-sterol 5(6)-desaturase activity	Catalysis of the reaction: a delta(7)-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ -> a delta(5,7)-sterol + 2 ferricytochrome b5 + 2 H2O.
iron ion binding	Binding to an iron (Fe) ion.
oxidoreductase activity	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Name	Definition
cholesterol biosynthetic process via lathosterol	The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol.
sterol biosynthetic process	The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O75845	SC5D	Lathosterol oxidase	Homo sapiens (Human)	PR
Q9EQS5	Sc5d	Lathosterol oxidase	Rattus norvegicus (Rat)	PR
O17554	agmo-1	Alkylglycerol monooxygenase	Caenorhabditis elegans	PR
Q5M8F9	agmo	Alkylglycerol monooxygenase	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6NYE4	agmo	Alkylglycerol monooxygenase	Danio rerio (Zebrafish) (Brachydanio rerio)	PR