O17554

PR
Gene name
agmo-1
Protein name
Alkylglycerol monooxygenase
Names
Transmembrane protein 195 homolog
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_BE10.2
EC number
1.14.16.5: With reduced pteridine as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

448-505 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O17554

Entry ID Method Resolution Chain Position Source
AF-O17554-F1 Predicted AlphaFoldDB

No variants for O17554

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O17554

No associated diseases with O17554

1 regional properties for O17554

Type Name Position InterPro Accession
domain Fatty acid hydroxylase 130 - 262 IPR006694

Functions

Description
EC Number 1.14.16.5 With reduced pteridine as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
glyceryl-ether monooxygenase activity Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine).
iron ion binding Binding to an iron (Fe) ion.

2 GO annotations of biological process

Name Definition
lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
membrane lipid metabolic process The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O75845 SC5D Lathosterol oxidase Homo sapiens (Human) PR
O88822 Sc5d Lathosterol oxidase Mus musculus (Mouse) PR
Q9EQS5 Sc5d Lathosterol oxidase Rattus norvegicus (Rat) PR
Q5M8F9 agmo Alkylglycerol monooxygenase Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6NYE4 agmo Alkylglycerol monooxygenase Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MNETAWLDRV FSNTSLGHRL LDRLTLTNLR HAFYLISPYE TTVESIDDVP NYNAEVSAWW
70 80 90 100 110 120
LVFLTAEFFI LFISGHEDRF ALNDSITSIC AGMLSQCFKF GGRAVAIFLY VIVWDNWRIL
130 140 150 160 170 180
ELPWDSPWTW IFCLFFQDFM YYLGHRAVHE AGFFWGLHTI HHSSEYYNFS TALRQAAIQD
190 200 210 220 230 240
AGLAIYDCIQ AFFIPPSIFL VHRYFSEIFQ FIMHTSLVDT MGPLGLVFNT PSHHRVHHGR
250 260 270 280 290 300
NPYCIDKNYG GVFIIWDKMF NTFEAERHDD PPIYGLVTNE NTFNQIYLQF HALWDILIFK
310 320 330 340 350 360
GFTKDVKGEP MFPGVVNKLK ATVFPPGWFP GVPVTPFFHW MSMVNPAHGV PEPEKPVLRY
370 380 390 400 410 420
SPPARILVKV YVASSFLLLL AIFFHFEYDR NHLSYLDCTV KIAYFVVTMQ CFGAFFDMKW
430 440 450 460 470 480
YARYIEIARC CGVLIYYGVL MFDHIGAGTH RLFVISLHIM AIALWTTDVL VEKLSQCCSK
490 500
NQSINPEKGD LERAPEIASI SKNVQ