Q5M844

PR
Gene name
Syne4
Protein name
Nesprin-4
Names
KASH domain-containing protein 4, KASH4, Nuclear envelope spectrin repeat protein 4
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:292781
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-112 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5M844

Entry ID Method Resolution Chain Position Source
AF-Q5M844-F1 Predicted AlphaFoldDB

1 variants for Q5M844

Variant ID(s) Position Change Description Diseaes Association Provenance
rs199221444 294 F>L No EVA

No associated diseases with Q5M844

1 regional properties for Q5M844

Type Name Position InterPro Accession
domain KASH domain 283 - 340 IPR012315

Functions

Description
EC Number
Subcellular Localization
  • Nucleus outer membrane ; Single-pass type IV membrane protein
  • Localization at the nucleus outer membrane location requires the presence of SUN1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of nuclear outer membrane The component of the nuclear outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
meiotic nuclear membrane microtubule tethering complex A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
establishment of epithelial cell apical/basal polarity The specification and formation of the apicobasal polarity of an epithelial cell.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8CII8 Syne4 Nesprin-4 Mus musculus (Mouse) PR
Q5M844 Syne4 Nesprin-4 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAQFPLLGHG FPPEPVNHPL GGPRGLDVAG PTICPAPEEE PSRPEQVQAS LDAPEHFMDE
70 80 90 100 110 120
PKSTESATSP SKLPLASSHE HQDGGKPCEA LQAELQGAAE RVDALLVFGE GLAERSEPRA
130 140 150 160 170 180
WTSLEQVLRA LGTHRDTIFQ RLWQLQAQLI SYSLVLEKAN LLDQDLEVEG DSDGPAAGGV
190 200 210 220 230 240
WGPWAPSIFP TPAELEWDPA GDVGGLGPSG QKISRIPGAP CELCGYRGSQ SSGQGFEDLL
250 260 270 280 290 300
SLGLGHRKHL AAHHRRRLQK PQDKKRQGPP SLPDAMLEVD RGVPAPASRR PLTFLLLLLF
310 320 330
LLLVGATLLL PLSGVPCCSH TRLARTPYLV LSYVNGLPPI