Q8CII8
Gene name |
Syne4 |
Protein name |
Nesprin-4 |
Names |
KASH domain-containing protein 4, KASH4, Nuclear envelope spectrin repeat protein 4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:233066 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CII8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CII8-F1 | Predicted | AlphaFoldDB |
18 variants for Q8CII8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3397323165 | 3 | L>V | No | EVA | |
| rs3388871343 | 11 | F>Y | No | EVA | |
| rs3388880826 | 13 | P>T | No | EVA | |
| rs3388885282 | 25 | E>* | No | EVA | |
| rs248678711 | 30 | G>R | No | EVA | |
| rs3388901243 | 52 | G>D | No | EVA | |
| rs3388894455 | 53 | L>M | No | EVA | |
| rs48217121 | 56 | H>Q | No | EVA | |
| rs3388895881 | 73 | L>F | No | EVA | |
| rs3388885275 | 99 | E>D | No | EVA | |
| rs243101070 | 106 | H>D | No | EVA | |
| rs3388888430 | 137 | Q>H | No | EVA | |
| rs3388898117 | 165 | E>K | No | EVA | |
| rs3388894831 | 205 | E>K | No | EVA | |
| rs3388880829 | 213 | D>V | No | EVA | |
| rs252001133 | 239 | T>I | No | EVA | |
| rs3388898110 | 309 | P>A | No | EVA | |
| rs225267251 | 317 | S>P | No | EVA |
No associated diseases with Q8CII8
1 regional properties for Q8CII8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | KASH domain | 331 - 388 | IPR012315 |
Functions
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of nuclear outer membrane | The component of the nuclear outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| meiotic nuclear membrane microtubule tethering complex | A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| establishment of epithelial cell apical/basal polarity | The specification and formation of the apicobasal polarity of an epithelial cell. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5M844 | Syne4 | Nesprin-4 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALVPPLGRE | FPPEPVNCPL | AAPRELDVVG | GTICPAPEEE | TSRPEQVQAS | LGLPEHCMGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LKSTESATSP | SRLPLASSHE | HQDGGKPCEH | SDSGLEVLEA | EQDSLHLCLL | RLNFRLQDLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RGLGSWTLAH | NRIVQMQALQ | AELRGAAERV | DALLAFGEGL | AERSEPRAWA | SLEQVLRALG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| THRDTIFQRL | WQLQAQLISY | SLVLEKANLL | DQDLEVEGDS | DGPAAGGVWG | PWAPSTFPTP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AELEWDPAGD | VGGLGPSGQK | ISRIPGAPCE | LCGYRGPQSS | GQGLEDLLSL | GLGHRKHLAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HHRRRLRKPQ | DRKRQVSPSL | PDAMLEVDRG | VPAPASKRPL | TLFFLLLFLL | LVGATLLLPL |
| 370 | 380 | ||||
| SGVSCCSHAR | LARTPYLVLS | YVNGLPPI |