Q5I0B9

PR
Gene name
atg16 (apg16l, TEgg115a02.1)
Protein name
Autophagy-related protein 16
Names
APG16-like 1
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:550097
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-345 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5I0B9

Entry ID Method Resolution Chain Position Source
AF-Q5I0B9-F1 Predicted AlphaFoldDB

No variants for Q5I0B9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5I0B9

No associated diseases with Q5I0B9

No regional properties for Q5I0B9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5I0B9

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Preautophagosomal structure membrane ; Peripheral membrane protein
  • Recruited to omegasomes membranes by WIPI2
  • Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures
  • Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
autophagosome membrane The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
phagophore assembly site membrane A cellular membrane associated with the phagophore assembly site.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
autophagosome assembly The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
negative stranded viral RNA replication A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA).
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q676U5 ATG16L1 Autophagy-related protein 16-1 Homo sapiens (Human) PR
Q8C0J2 Atg16l1 Autophagy-related protein 16-1 Mus musculus (Mouse) PR
Q09406 atg-16.2 Autophagic-related protein 16.2 Caenorhabditis elegans PR
10 20 30 40 50 60
MAAGCRGPAC PSWRLHISRE LRRRDREQRQ VFEELISQYK RLLEKSDLQS VLADKLQAEK
70 80 90 100 110 120
YEQQSRHDSS PGPDGMRNDM LLQDMAQMRI KHQEELTELH KKRGELAQTV IELNNQMQQK
130 140 150 160 170 180
DKEIQANEEK IAKYLQTIQD LETECQDLRN KLQELERANQ TLKDEYDALQ ITFTALEDKL
190 200 210 220 230 240
RKTTEDNQEL VSRWMAEKAQ EANRLNAENE KDSKRRQARL QKELAEAAKE PLSFEHDDDI
250 260 270 280 290 300
EVLNDNADPV GDSAGAQATG RNISKRNSQP AVGGLLDSIT NIFGLSESPS LSHRSDSSRR
310 320 330 340 350 360
RSLNSFPASP DCADTPGAGN REVRVPATAV YSFDAHDGEV NAVRFSPGSR LLATGGMDRR
370 380 390 400 410 420
VKLWDVIGNK CEAKGSLTGS NAGITSIEFD SAGSYLLAAS NDFASRIWTV DDYRLRHTLT
430 440 450 460 470 480
GHSGKVLSAK FLLDNARIVS GSHDRTLKLW DLRSKVCIKT VFAGSSCNDI VCTEQCVMSG
490 500 510 520 530 540
HFDKKIRFWD IRTECIVREL ELQGRITALD LNPERTQLLS CSRDDLIKIT DLRANAVQQT
550 560 570 580 590 600
FSAPGFKCGS DWTRVIFSPD GSYVSAGSAE GTLYFWNVLT GKVERMFSKQ HSSSINAVAW
610 620
SPSGTHVVSV DKGSRGVLWS DF