Q5E9K3
Gene name |
PNPO |
Protein name |
Pyridoxine-5'-phosphate oxidase |
Names |
Pyridoxamine-phosphate oxidase |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:512573 |
EC number |
1.4.3.5: With oxygen as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5E9K3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5E9K3-F1 | Predicted | AlphaFoldDB |
43 variants for Q5E9K3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs465341082 | 8 | V>G | No | EVA | |
| rs438244030 | 9 | I>M | No | EVA | |
| rs467993041 | 12 | F>L | No | EVA | |
| rs447359216 | 16 | A>D | No | EVA | |
| rs477058972 | 18 | W>G | No | EVA | |
| rs443500488 | 20 | R>G | No | EVA | |
| rs482964414 | 20 | R>L | No | EVA | |
| rs461019716 | 21 | C>F | No | EVA | |
| rs461019716 | 21 | C>S | No | EVA | |
| rs442559788 | 23 | R>H | No | EVA | |
| rs454099028 | 24 | H>L | No | EVA | |
| rs472531093 | 24 | H>N | No | EVA | |
| rs454099028 | 24 | H>R | No | EVA | |
| rs438851049 | 27 | S>R | No | EVA | |
| rs876518029 | 33 | D>G | No | EVA | |
| rs468079924 | 41 | Y>* | No | EVA | |
| rs438326859 | 41 | Y>F | No | EVA | |
| rs434190331 | 44 | D>E | No | EVA | |
| rs876092346 | 44 | D>G | No | EVA | |
| rs467134467 | 45 | P>T | No | EVA | |
| rs209082761 | 57 | D>N | No | EVA | |
| rs469403976 | 108 | R>C | No | EVA | |
| rs469403976 | 108 | R>S | No | EVA | |
| rs454098140 | 126 | F>L | No | EVA | |
| rs441698806 | 127 | A>D | No | EVA | |
| rs1115548764 | 146 | V>M | No | EVA | |
| rs134147767 | 157 | Y>S | No | EVA | |
| rs460933394 | 159 | H>P | No | EVA | |
| rs442925271 | 160 | S>A | No | EVA | |
| rs442925271 | 160 | S>P | No | EVA | |
| rs472726838 | 162 | P>R | No | EVA | |
| rs460533892 | 164 | S>R | No | EVA | |
| rs438759374 | 171 | V>F | No | EVA | |
| rs799209105 | 179 | P>L | No | EVA | |
| rs456839104 | 180 | D>Y | No | EVA | |
| rs452819642 | 186 | K>T | No | EVA | |
| rs478344004 | 207 | G>D | No | EVA | |
| rs444425030 | 208 | G>A | No | EVA | |
| rs480587514 | 209 | Y>N | No | EVA | |
| rs462462243 | 212 | Y>S | No | EVA | |
| rs134951409 | 224 | N>T | No | EVA | |
| rs440654356 | 239 | G>V | No | EVA | |
| rs473630796 | 248 | H>P | No | EVA |
No associated diseases with Q5E9K3
3 regional properties for Q5E9K3
Functions
| Description | ||
|---|---|---|
| EC Number | 1.4.3.5 | With oxygen as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| FMN binding | Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
| pyridoxamine-phosphate oxidase activity | Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| pyridoxal phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. |
| pyridoxine biosynthetic process | The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38075 | PDX3 | Pyridoxamine 5'-phosphate oxidase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9NVS9 | PNPO | Pyridoxine-5'-phosphate oxidase | Homo sapiens (Human) | PR |
| Q9ZPY1 | PPOX2 | Pyridoxine/pyridoxamine 5'-phosphate oxidase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIFWLRSVIV | TFGRPAEWPR | CLRHLCSRGA | AMDLGPMRKT | YRGDPEAFEE | THLTSLDPVK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QFAAWFEEAV | QCPDIMEANA | MCLATCTRDG | KPSARMVLLK | GFGKDGFRFF | TNFESRKGKE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDSNPFASLV | FYWEPLHRQV | RVEGPVKKLP | EEEAECYFHS | RPKSSQIGAV | VSHQSSVIPD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| REYLRKKNKE | LEQLYQEQEV | PKPKYWGGYI | LYPQVMEFWQ | GQTNRLHDRI | VFRRGLLTGD |
| 250 | 260 | ||||
| SPLGPMTHRG | EEDWVYERLA | P |