P38075

PR
Gene name
PDX3 (YBR035C, YBR0321)
Protein name
Pyridoxamine 5'-phosphate oxidase
Names
PNP/PMP oxidase, PNPOx
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YBR035C
EC number
1.4.3.5: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P38075

Entry ID Method Resolution Chain Position Source
1CI0 X-ray 270 A A/B 1-228 PDB
AF-P38075-F1 Predicted AlphaFoldDB

1 variants for P38075

Variant ID(s) Position Change Description Diseaes Association Provenance
s02-306448 170 N>D No SGRP

No associated diseases with P38075

3 regional properties for P38075

Type Name Position InterPro Accession
domain Pyridoxamine 5'-phosphate oxidase, putative 56 - 129 IPR011576
domain Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal 186 - 228 IPR019576
conserved_site Pyridoxamine 5'-phosphate oxidase, conserved site 196 - 209 IPR019740

Functions

Description
EC Number 1.4.3.5 With oxygen as acceptor
Subcellular Localization
  • Mitochondrion intermembrane space
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope.

2 GO annotations of molecular function

Name Definition
FMN binding Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
pyridoxamine-phosphate oxidase activity Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide.

2 GO annotations of biological process

Name Definition
pyridoxal 5'-phosphate salvage Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis.
pyridoxine biosynthetic process The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9K3 PNPO Pyridoxine-5'-phosphate oxidase Bos taurus (Bovine) PR
Q9NVS9 PNPO Pyridoxine-5'-phosphate oxidase Homo sapiens (Human) PR
Q9ZPY1 PPOX2 Pyridoxine/pyridoxamine 5'-phosphate oxidase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTKQAEETQK PIIFAPETYQ YDKFTLNEKQ LTDDPIDLFT KWFNEAKEDP RETLPEAITF
70 80 90 100 110 120
SSAELPSGRV SSRILLFKEL DHRGFTIYSN WGTSRKAHDI ATNPNAAIVF FWKDLQRQVR
130 140 150 160 170 180
VEGITEHVNR ETSERYFKTR PRGSKIGAWA SRQSDVIKNR EELDELTQKN TERFKDAEDI
190 200 210 220
PCPDYWGGLR IVPLEIEFWQ GRPSRLHDRF VYRRKTENDP WKVVRLAP