Q4KLG2

PR
Gene name
Gimap8 (Ian9, Iant)
Protein name
GTPase IMAP family member 8
Names
Immune-associated nucleotide-binding protein 9, IAN-9, Protein IanT
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:500112
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-89 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4KLG2

Entry ID Method Resolution Chain Position Source
AF-Q4KLG2-F1 Predicted AlphaFoldDB

No variants for Q4KLG2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4KLG2

No associated diseases with Q4KLG2

3 regional properties for Q4KLG2

Type Name Position InterPro Accession
domain AIG1-type guanine nucleotide-binding (G) domain 46 - 246 IPR006703-1
domain AIG1-type guanine nucleotide-binding (G) domain 281 - 471 IPR006703-2
domain AIG1-type guanine nucleotide-binding (G) domain 472 - 681 IPR006703-3

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum
  • Golgi apparatus
  • Mitochondrion
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.

1 GO annotations of biological process

Name Definition
regulation of T cell apoptotic process Any process that modulates the occurrence or rate of T cell death by apoptotic process.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q75N62 Gimap8 GTPase IMAP family member 8 Mus musculus (Mouse) PR
P54120 IAN8 Immune-associated nucleotide-binding protein 8 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MATSSHQGAA AGSQMEHRLC ETSIGQGERP RASRGQESNF KQSQGTSTLR LLLLGKQGAG
70 80 90 100 110 120
KSATGNTILG KAVFESRFSH HMVTKRCQSE SVSVRGKQVI VIDTPDLFSS LGCPEVQQQN
130 140 150 160 170 180
LRQCLDLLAD PYVLLLVTPI GHSTEEDKKT IEGIQGVFGP QAYRHMIVVF TREDELGEDT
190 200 210 220 230 240
LQNHIESKKY LKKLIENIGS QRCCAFNNKA DKKQQELQVS QFLDAIEFLM MESPGTYFEP
250 260 270 280 290 300
LKTENSGVQG CGTGVTYKGD NLCGSKKRQP QITGPGWDRD TPELRVLLMG KRGVGKSAAG
310 320 330 340 350 360
NSILGKQVFK TQFSEKQRVT EAFASHSRLW NQKKFLIIDS PEISSWKLDE SDVKEHTFPG
370 380 390 400 410 420
PHAFLLVTPL GSSLKSGDSV FSIIKRIFGE KFIKFTIILF TRKEDFEGQD LDTFTKENDA
430 440 450 460 470 480
LCNLIQIFEG RYAVFNYRAT VEEEQSQVGK LLSQIESVVQ HHNNKPCVIR EKELLNIILL
490 500 510 520 530 540
GRSGVGKSAT GNTILGRPAF VSQLRAQPVT SRSQSGRRTL DWQDIVVVDT PSLNQMSGTE
550 560 570 580 590 600
KNPAQLKKEI KQCLLQNCEE GMKVFVLVFQ LGRFTQEDEA VVEQLEASFE ENIMKYMIVL
610 620 630 640 650 660
FTRKEDLGDG DLYDFTNNTK NKVLKRIFKK CKGRVCAFNN KETGEDQETQ VKALLTIAND
670 680
LKRSYDEHST SWMDQLKSAV GQITTVFK