P54120

PR
Gene name
IAN8
Protein name
Immune-associated nucleotide-binding protein 8
Names
AtIAN8, Protein AIG1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G33960
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-97 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P54120

Entry ID Method Resolution Chain Position Source
AF-P54120-F1 Predicted AlphaFoldDB

80 variants for P54120

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH01171638 8 S>G No 1000Genomes
ENSVATH01171639 8 S>N No 1000Genomes
tmp_1_12346606_A_T 18 K>* No 1000Genomes
ENSVATH12798009 29 D>N No 1000Genomes
ENSVATH14064132 35 S>L No 1000Genomes
tmp_1_12346670_C_T 39 P>L No 1000Genomes
ENSVATH00063395 48 V>D No 1000Genomes
ENSVATH04721095 49 G>W No 1000Genomes
ENSVATH04721097 51 T>S No 1000Genomes
tmp_1_12346723_G_A 57 A>T No 1000Genomes
tmp_1_12346729_G_T 59 G>W No 1000Genomes
ENSVATH04721098 61 S>N No 1000Genomes
tmp_1_12346745_G_T 64 R>I No 1000Genomes
tmp_1_12346756_T_A 68 F>I No 1000Genomes
ENSVATH04721099 73 K>N No 1000Genomes
tmp_1_12346783_G_A 77 V>I No 1000Genomes
ENSVATH00063398 78 T>A No 1000Genomes
tmp_1_12346787_C_A 78 T>K No 1000Genomes
ENSVATH12798014 79 M>L No 1000Genomes
ENSVATH00063399 90 E>* No 1000Genomes
ENSVATH00063400 92 P>S No 1000Genomes
ENSVATH04721100 94 L>F No 1000Genomes
tmp_1_12346847_A_G 98 D>G No 1000Genomes
ENSVATH04721120 106 S>* No 1000Genomes
ENSVATH04721120 106 S>L No 1000Genomes
ENSVATH04721121 110 E>K No 1000Genomes
tmp_1_12347211_G_A 119 C>Y No 1000Genomes
ENSVATH00063407 129 A>V No 1000Genomes
ENSVATH04721124 136 V>I No 1000Genomes
ENSVATH01171674 139 R>P No 1000Genomes
ENSVATH01171674 139 R>Q No 1000Genomes
ENSVATH04721125 143 E>D No 1000Genomes
ENSVATH01171675 145 E>D No 1000Genomes
tmp_1_12347310_A_T 152 Q>L No 1000Genomes
ENSVATH12798253 155 F>S No 1000Genomes
ENSVATH04721127 156 G>V No 1000Genomes
tmp_1_12347343_T_A 163 L>H No 1000Genomes
ENSVATH04721128 164 I>V No 1000Genomes
ENSVATH14064235 169 G>R No 1000Genomes
ENSVATH01171676 170 G>R No 1000Genomes
tmp_1_12347367_A_G 171 D>G No 1000Genomes
ENSVATH04721130 172 V>L No 1000Genomes
ENSVATH00063409 182 D>E No 1000Genomes
tmp_1_12347416_C_A 187 N>K No 1000Genomes
tmp_1_12347419_G_C 188 M>I No 1000Genomes
tmp_1_12347423_G_A 190 D>N No 1000Genomes
ENSVATH12798439 196 L>F No 1000Genomes
ENSVATH14064236 197 I>L No 1000Genomes
ENSVATH01171684 199 C>* No 1000Genomes
ENSVATH04721136 203 M>L No 1000Genomes
tmp_1_12347574_A_T 211 K>* No 1000Genomes
tmp_1_12347619_C_T 226 L>F No 1000Genomes
ENSVATH04721140 234 N>H No 1000Genomes
ENSVATH01171685 240 T>A No 1000Genomes
ENSVATH04721144 254 H>Y No 1000Genomes
ENSVATH01171692 260 E>K No 1000Genomes
ENSVATH00063417 266 H>Y No 1000Genomes
tmp_1_12347836_G_T 268 E>* No 1000Genomes
tmp_1_12347854_TTGATGA_T 274 L>* No 1000Genomes
tmp_1_12347864_A_G 277 E>G No 1000Genomes
ENSVATH00063418 277 E>K No 1000Genomes
tmp_1_12347866_T_A 278 L>I No 1000Genomes
ENSVATH01171693 279 Q>R No 1000Genomes
ENSVATH04721148 280 I>R No 1000Genomes
ENSVATH04721152 300 A>D No 1000Genomes
ENSVATH04721152 300 A>V No 1000Genomes
tmp_1_12348049_G_T 309 E>D No 1000Genomes
tmp_1_12348058_A_T 312 E>D No 1000Genomes
ENSVATH12798590 314 A>S No 1000Genomes
tmp_1_12348063_C_T 314 A>V No 1000Genomes
ENSVATH04721154 316 E>D No 1000Genomes
ENSVATH00063421 317 M>L No 1000Genomes
ENSVATH00063422 323 M>L No 1000Genomes
tmp_1_12348100_G_T 326 Q>H No 1000Genomes
ENSVATH04721156 328 K>R No 1000Genomes
ENSVATH04721157 329 L>F No 1000Genomes
tmp_1_12348131_C_T,A 337 R>C No 1000Genomes
tmp_1_12348131_C_T,A 337 R>S No 1000Genomes
ENSVATH04721160 347 R>H No 1000Genomes
ENSVATH01171700 351 S>N No 1000Genomes

No associated diseases with P54120

1 regional properties for P54120

Type Name Position InterPro Accession
domain AIG1-type guanine nucleotide-binding (G) domain 40 - 257 IPR006703

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.

1 GO annotations of biological process

Name Definition
response to bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6P9H5 GIMAP6 GTPase IMAP family member 6 Homo sapiens (Human) PR
Q75N62 Gimap8 GTPase IMAP family member 8 Mus musculus (Mouse) PR
Q4KLG2 Gimap8 GTPase IMAP family member 8 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MANDQKNSES FPAKEDHKKD DAAAPAEVDH KDEFSASQPH PVENIVLVGR TGNGKSATGN
70 80 90 100 110 120
SIVRSKVFKS KTKSSGVTME CHAVKAVTPE GPILNVIDTP GLFDLSVSAE FIGKEIVKCL
130 140 150 160 170 180
TLADGGLHAV LLVLSVRTRI SQEEEMVLST LQVLFGSKIV DYLIVVFTGG DVLEDDGMTL
190 200 210 220 230 240
EDYLGDNMPD FLKRVLILCG QRMILFDNKT KDDEKKTKQV HELLKLIDLV RKQNNNIPYT
250 260 270 280 290 300
DEMYHMIKEE NERHKKEQEE LESKGHSEEQ LAALMKELQI MNERNLKAMA EMMEKNMKIA
310 320 330 340 350
MEAQEKLFEQ REKAQEMSYQ QKMEMQEKLK QMEGRMRAEM EAQMLSRQQC SIL