Q3ZC64
PR
Gene name |
EFNA1 |
Protein name |
Ephrin-A1 |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:507319 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3ZC64
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3ZC64-F1 | Predicted | AlphaFoldDB |
56 variants for Q3ZC64
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs467070259 | 2 | E>* | No | EVA | |
| rs446877190 | 2 | E>A | No | EVA | |
| rs478318617 | 6 | A>G | No | EVA | |
| rs451163698 | 9 | L>M | No | EVA | |
| rs482503650 | 10 | G>V | No | EVA | |
| rs462454349 | 14 | S>T | No | EVA | |
| rs473773231 | 17 | A>G | No | EVA | |
| rs442384492 | 17 | A>P | No | EVA | |
| rs460165793 | 18 | A>D | No | EVA | |
| rs137335458 | 19 | N>T | No | EVA | |
| rs444240115 | 29 | N>T | No | EVA | |
| rs475492706 | 30 | P>H | No | EVA | |
| rs109275718 | 70 | Y>* | No | EVA | |
| rs445247233 | 77 | Y>S | No | EVA | |
| rs483155779 | 85 | K>Q | No | EVA | |
| rs463046186 | 123 | G>V | No | EVA | |
| rs449444414 | 124 | H>P | No | EVA | |
| rs480848892 | 125 | S>C | No | EVA | |
| rs460769599 | 126 | Y>* | No | EVA | |
| rs440702310 | 127 | Y>* | No | EVA | |
| rs472092619 | 128 | Y>N | No | EVA | |
| rs466346155 | 158 | H>Q | No | EVA | |
| rs452777051 | 160 | N>Y | No | EVA | |
| rs436876392 | 169 | D>E | No | EVA | |
| rs468278580 | 170 | D>A | No | EVA | |
| rs448266409 | 171 | P>R | No | EVA | |
| rs479577540 | 172 | E>G | No | EVA | |
| rs465980318 | 173 | V>A | No | EVA | |
| rs465980318 | 173 | V>G | No | EVA | |
| rs445921293 | 174 | Q>R | No | EVA | |
| rs477349018 | 175 | V>I | No | EVA | |
| rs481550828 | 176 | L>R | No | EVA | |
| rs461309803 | 177 | H>D | No | EVA | |
| rs441290988 | 178 | S>G | No | EVA | |
| rs472574006 | 178 | S>T | No | EVA | |
| rs458992475 | 179 | I>T | No | EVA | |
| rs439043437 | 180 | G>R | No | EVA | |
| rs476980963 | 181 | H>D | No | EVA | |
| rs456903170 | 181 | H>P | No | EVA | |
| rs456903170 | 181 | H>R | No | EVA | |
| rs436804403 | 182 | S>G | No | EVA | |
| rs436804403 | 182 | S>R | No | EVA | |
| rs474619363 | 182 | S>R | No | EVA | |
| rs454588142 | 183 | A>P | No | EVA | |
| rs454588142 | 183 | A>T | No | EVA | |
| rs465925048 | 186 | R>L | No | EVA | |
| rs465925048 | 186 | R>P | No | EVA | |
| rs445834172 | 187 | L>P | No | EVA | |
| rs470096461 | 188 | F>S | No | EVA | |
| rs461201364 | 191 | A>G | No | EVA | |
| rs458980288 | 194 | V>G | No | EVA | |
| rs478919901 | 194 | V>L | No | EVA | |
| rs439013963 | 195 | L>R | No | EVA | |
| rs463182863 | 200 | L>Q | No | EVA | |
| rs443135927 | 203 | Q>E | No | EVA | |
| rs474553153 | 203 | Q>H | No | EVA |
No associated diseases with Q3ZC64
No regional properties for Q3ZC64
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q3ZC64 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchored component of plasma membrane | The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ephrin receptor binding | Binding to an ephrin receptor. |
25 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| aortic valve morphogenesis | The process in which the structure of the aortic valve is generated and organized. |
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
| endocardial cushion to mesenchymal transition involved in heart valve formation | A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve. |
| ephrin receptor signaling pathway | The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| mitral valve morphogenesis | The process in which the structure of the mitral valve is generated and organized. |
| negative regulation of dendritic spine morphogenesis | Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. |
| negative regulation of epithelial to mesenchymal transition | Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
| negative regulation of MAPK cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. |
| negative regulation of proteolysis involved in protein catabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in protein catabolic process. |
| negative regulation of thymocyte apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of thymocyte death by apoptotic process. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| notochord formation | The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column. |
| positive regulation of amyloid-beta formation | Any process that activates or increases the frequency, rate or extent of amyloid-beta formation. |
| positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process | Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| positive regulation of protein tyrosine kinase activity | Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity. |
| protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
| regulation of angiogenesis | Any process that modulates the frequency, rate or extent of angiogenesis. |
| regulation of axonogenesis | Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. |
| regulation of blood vessel endothelial cell migration | Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels. |
| regulation of cell adhesion mediated by integrin | Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin. |
| regulation of peptidyl-tyrosine phosphorylation | Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. |
| substrate adhesion-dependent cell spreading | The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEFFWASLLG | LCCSLAAANR | HTVFWNSSNP | KFWNEDYTVH | VRIDDYLDII | CPHYEDNSVP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DAAMEQYTLY | LVEHEQYQLC | QPQPKDHARW | FCKSPKAKHG | PEKLSEKFHR | FTGFTLSKDF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KEGHSYYYIS | KPIHHQEDRC | LRLKVMIAGK | ITHSPQAHPN | AQEKRLPADD | PEVQVLHSIG |
| 190 | 200 | ||||
| HSAAPRLFPL | AWAVLLLPFL | LLQIP |