AiPD: Autoinhibited Protein Database

Gene name	GULO
Protein name	L-gulonolactone oxidase
Names	LGO, L-gulono-gamma-lactone oxidase, GLO
Species	Bos taurus (Bovine)
KEGG Pathway	bta:286812
EC number	1.1.3.8: With oxygen as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

70-147 (Predicted disordered autoinhibitory region) PR

70-147 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3ZC33-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs444247689	36	V>A	No	EVA
rs444247689	36	V>G	No	EVA
rs3423270410	64	G>S	No	EVA
rs474739878	73	N>T	No	EVA
rs440110540	74	R>P	No	EVA
rs442926088	97	H>P	No	EVA
rs459812486	99	Q>H	No	EVA
rs479875490	105	L>Q	No	EVA
rs442619002	112	A>D	No	EVA
rs459534233	116	V>G	No	EVA
rs438508531	133	H>R	No	EVA
rs458545681	134	G>A	No	EVA
rs468366601	140	V>A	No	EVA
rs468366601	140	V>G	No	EVA
rs718115122	149	N>S	No	EVA
rs464214657	158	S>A	No	EVA
rs432790009	164	F>Y	No	EVA
rs455964447	179	T>A	No	EVA
rs476744829	189	H>R	No	EVA
rs442256682	198	T>P	No	EVA
rs472793936	201	E>A	No	EVA
rs208467135	220	W>R	No	EVA
rs434670338	233	D>A	No	EVA
rs451463527	236	N>T	No	EVA
rs469102728	258	F>L	No	EVA
rs454497410	261	W>L	No	EVA
rs475136762	263	S>I	No	EVA
rs471459263	264	T>I	No	EVA
rs443242183	265	F>Y	No	EVA
rs463342293	266	L>M	No	EVA
rs449614218	270	V>L	No	EVA
rs460030551	273	I>M	No	EVA
rs1116688779	283	N>S	No	EVA
rs476246991	287	E>*	No	EVA
rs454301509	317	K>E	No	EVA
rs464766536	317	K>R	No	EVA
rs464766536	317	K>T	No	EVA
rs433369608	318	E>K	No	EVA
rs442069219	344	T>P	No	EVA
rs455752398	349	I>M	No	EVA
rs472551402	350	L>M	No	EVA
rs440300075	350	L>R	No	EVA
rs460356297	351	L>M	No	EVA
rs439379499	358	D>V	No	EVA
rs462520474	360	C>*	No	EVA
rs482506513	363	N>T	No	EVA
rs448056275	368	R>M	No	EVA
rs445284789	394	P>A	No	EVA
rs465323240	395	H>P	No	EVA
rs472939185	400	H>N	No	EVA
rs432675668	400	H>R	No	EVA
rs452642791	401	N>K	No	EVA
rs444590065	405	K>T	No	EVA
rs461315858	406	D>E	No	EVA
rs208119989	411	Y>*	No	EVA
rs458819154	428	G>A	No	EVA
rs467539229	433	A>V	No	EVA
rs481174816	438	V>E	No	EVA

Type	Name	Position	InterPro Accession
domain	GINS subunit, domain A	50 - 126	IPR021151
domain	DNA replication complex GINS protein SLD5, C-terminal	165 - 223	IPR031633
domain	GINS complex protein Sld5, alpha-helical domain	26 - 146	IPR038749

		Description
EC Number	1.1.3.8	With oxygen as acceptor
Subcellular Localization	Microsome membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
D-arabinono-1,4-lactone oxidase activity	Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+).
FAD binding	Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
flavin adenine dinucleotide binding	Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
L-gulonolactone oxidase activity	Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2.
oxidoreductase activity	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Name	Definition
L-ascorbic acid biosynthetic process	The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P58710	Gulo	L-gulonolactone oxidase	Mus musculus (Mouse)	PR
Q8HXW0	GULO	L-gulonolactone oxidase	Sus scrofa (Pig)	PR
P10867	Gulo	L-gulonolactone oxidase	Rattus norvegicus (Rat)	PR
Q2QXY1	GLDH2	L-galactono-1,4-lactone dehydrogenase 2, mitochondrial	Oryza sativa subsp japonica (Rice)	PR
Q2RAP0	GLDH1	L-galactono-1,4-lactone dehydrogenase 1, mitochondrial	Oryza sativa subsp japonica (Rice)	PR