AiPD: Autoinhibited Protein Database

Gene name	Gulo
Protein name	L-gulonolactone oxidase
Names	LGO, L-gulono-gamma-lactone oxidase, GLO
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:268756
EC number	1.1.3.8: With oxygen as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

57-140 (Predicted disordered autoinhibitory region) PR

57-140 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P58710-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389338034	2	V>*	No	EVA
rs3389292175	13	W>*	No	EVA
rs3389338020	56	P>L	No	EVA
rs3389340607	58	D>Y	No	EVA
rs3389262060	90	G>D	No	EVA
rs3389353476	99	Q>*	No	EVA
rs3389328709	119	G>S	No	EVA
rs3389353477	127	H>Y	No	EVA
rs31067467	151	T>A	No	EVA
rs219467087	153	L>V	No	EVA
rs3389301529	203	L>I	No	EVA
rs3389309848	268	R>E*	No	EVA
rs3389338037	270	V>G	No	EVA
rs3389344521	285	K>N	No	EVA
rs3389342007	373	D>E	No	EVA
rs3389332598	429	M>K	No	EVA
rs3389335370	429	M>L	No	EVA
rs3405211060	430	F>*	No	EVA
rs3404977929	441	Y>L	No	EVA
rs3405301332	441	Y>Y	No	EVA

Type	Name	Position	InterPro Accession
binding_site	Oxygen oxidoreductase covalent FAD-binding site	21 - 54	IPR006093
domain	FAD linked oxidase, N-terminal	21 - 156	IPR006094
domain	D-arabinono-1,4-lactone oxidase, C-terminal domain	180 - 437	IPR007173
domain	FAD-binding domain, PCMH-type	17 - 187	IPR016166

		Description
EC Number	1.1.3.8	With oxygen as acceptor
Subcellular Localization	Microsome membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
D-arabinono-1,4-lactone oxidase activity	Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+).
FAD binding	Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
flavin adenine dinucleotide binding	Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
L-gulonolactone oxidase activity	Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2.
oxidoreductase activity	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Name	Definition
L-ascorbic acid biosynthetic process	The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3ZC33	GULO	L-gulonolactone oxidase	Bos taurus (Bovine)	PR
Q8HXW0	GULO	L-gulonolactone oxidase	Sus scrofa (Pig)	PR
P10867	Gulo	L-gulonolactone oxidase	Rattus norvegicus (Rat)	PR
Q2QXY1	GLDH2	L-galactono-1,4-lactone dehydrogenase 2, mitochondrial	Oryza sativa subsp japonica (Rice)	PR
Q2RAP0	GLDH1	L-galactono-1,4-lactone dehydrogenase 1, mitochondrial	Oryza sativa subsp japonica (Rice)	PR