Q3V1L4

PR
Gene name
Nt5c2
Protein name
Cytosolic purine 5'-nucleotidase
Names
Cytosolic nucleoside phosphotransferase 5'N
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:76952
EC number
2.7.1.77: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

474-560 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3V1L4

Entry ID Method Resolution Chain Position Source
AF-Q3V1L4-F1 Predicted AlphaFoldDB

31 variants for Q3V1L4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389545449 12 A>V No EVA
rs3389452647 24 L>V No EVA
rs3389560539 27 Y>H No EVA
rs3389523844 49 F>L No EVA
rs3389538379 117 N>K No EVA
rs3389511483 141 F>C No EVA
rs3389540955 181 C>Y No EVA
rs3389493146 296 F>L No EVA
rs3389555834 300 T>I No EVA
rs3389493214 303 R>S No EVA
rs3389555870 328 S>L No EVA
rs3389511479 337 D>E No EVA
rs3389493202 338 L>* No EVA
rs3389548834 338 L>R No EVA
rs3389554643 366 W>E No EVA
rs3389546221 388 L>F No EVA
rs3389544840 399 L>S No EVA
rs3389523818 402 L>F No EVA
rs3389545447 416 I>V No EVA
rs3409130078 431 D>A No EVA
rs3409304939 431 D>Y No EVA
rs3389540942 439 S>I No EVA
rs3409513977 466 I>T No EVA
rs3389538418 493 T>M No EVA
rs3389523748 505 A>V No EVA
rs3409217848 513 D>A No EVA
rs3407306630 513 D>Y No EVA
rs3409130099 514 F>L No EVA
rs3408254295 516 D>A No EVA
rs3409329443 516 D>Y No EVA
rs3389511481 522 H>Y No EVA

No associated diseases with Q3V1L4

No regional properties for Q3V1L4

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q3V1L4

Functions

Description
EC Number 2.7.1.77 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

8 GO annotations of molecular function

Name Definition
5'-nucleotidase activity Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GMP 5'-nucleotidase activity Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate.
identical protein binding Binding to an identical protein or proteins.
IMP 5'-nucleotidase activity Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate.
metal ion binding Binding to a metal ion.
nucleoside phosphotransferase activity Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate.
XMP 5'-nucleosidase activity Catalysis of the reaction: 5'XMP + H20 = phosphate + xanthosine.

10 GO annotations of biological process

Name Definition
adenosine metabolic process The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.
allantoin metabolic process The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism.
dGMP catabolic process The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate).
dGMP metabolic process The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate).
GMP catabolic process The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate.
GMP catabolic process to guanine The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including guanine.
GMP metabolic process The chemical reactions and pathways involving GMP, guanosine monophosphate.
IMP catabolic process The chemical reactions and pathways resulting in the breakdown of IMP, inosine monophosphate.
IMP metabolic process The chemical reactions and pathways involving IMP, inosine monophosphate.
nucleotide phosphorylation The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P49902 NT5C2 Cytosolic purine 5'-nucleotidase Homo sapiens (Human) PR
Q3UHB1 Nt5dc3 5'-nucleotidase domain-containing protein 3 Mus musculus (Mouse) PR
10 20 30 40 50 60
MTTSWSDRLQ NAADVPANMD KHALKKYRRE AYHRVFVNRS LAMEKIKCFG FDMDYTLAVY
70 80 90 100 110 120
KSPEYESLGF ELTVERLVSI GYPQELLSFA YDSTFPTRGL VFDTLYGNLL KVDAYGNLLV
130 140 150 160 170 180
CAHGFNFIRG PETREQYPNK FIQRDDTERF YILNTLFNLP ETYLLACLVD FFTNCPRYTS
190 200 210 220 230 240
CDTGFKDGDL FMSYRSMFQD VRDAVDWVHY KGSLKEKTVE NLEKYVVKDG KLPLLLSRMK
250 260 270 280 290 300
EVGKVFLATN SDYKYTDKIM TYLFDFPHGP KPGSSHRPWQ SYFDLILVDA RKPLFFGEGT
310 320 330 340 350 360
VLRQVDTKTG KLKIGTYTGP LQHGIVYSGG SSDTICDLLG AKGKDILYIG DHIFGDILKS
370 380 390 400 410 420
KKRQGWRTFL VIPELAQELH VWTDKSSLFE ELQSLDIFLA ELYKHLDSSS NERPDISSIQ
430 440 450 460 470 480
RRIKKVTHDM DMCYGMMGSL FRSGSRQTLF ASQVMRYADL YAASFINLLY YPFSYLFRAA
490 500 510 520 530 540
HVLMPHESTV EHTHVDINEM ESPLATRNRT SVDFKDTDYK RHQLTRSISE IKPPNLFPLA
550
PQEITHCHDE DDDEEEEEEE