AiPD: Autoinhibited Protein Database

Gene name	Cnnm2 (Acdp2)
Protein name	Metal transporter CNNM2
Names	Ancient conserved domain-containing protein 2, mACDP2, Cyclin-M2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:94219
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

716-797 (Predicted disordered autoinhibitory region) PR

716-797 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
4P1G	X-ray	260 A	A	430-580	PDB
4P1O	X-ray	306 A	A/B	430-580	PDB
5LXQ	X-ray	333 A	A/H	430-584	PDB
5MMZ	X-ray	240 A	A	430-584	PDB
6WUS	X-ray	276 A	A	430-580	PDB
AF-Q3TWN3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389493219	130	P>S	No	EVA
rs31283046	131	S>G	No	EVA
rs3389548774	147	P>H	No	EVA
rs3389555892	149	R>C	No	EVA
rs3389555868	166	N>D	No	EVA
rs3389538412	169	T>I	No	EVA
rs3389493179	177	I>T	No	EVA
rs3389523821	192	C>S	No	EVA
rs257830709	211	T>A	No	EVA
rs3409212043	256	W>*	No	EVA
rs3409753231	257	L>Q	No	EVA
rs3389501404	279	L>H	No	EVA
rs3389537839	291	Q>L	No	EVA
rs3389555827	330	L>I	No	EVA
rs3389538345	388	P>S	No	EVA
rs3389537809	445	T>M	No	EVA
rs3389544772	465	L>M	No	EVA
rs3389560476	530	K>E	No	EVA
rs3389511468	533	A>T	No	EVA
rs3389555909	552	N>D	No	EVA
rs3412733134	554	E>G	No	EVA
rs3389554649	563	V>L	No	EVA
rs3389538394	573	I>V	No	EVA
rs3389545218	609	F>L	No	EVA
rs3389555882	619	K>*	No	EVA
rs3389546187	640	S>I	No	EVA
rs3389538376	710	F>L	No	EVA
rs3389554644	719	T>I	No	EVA
rs3389493155	731	F>I	No	EVA
rs3389511487	753	P>T	No	EVA
rs3389501380	759	S>L	No	EVA
rs3389523826	820	R>W	No	EVA
rs3389545185	854	L>P	No	EVA
rs3389523828	856	E>*	No	EVA
rs3389560531	859	C>F	No	EVA
rs3389538353	867	H>Q	No	EVA
rs3389452662	868	S>C	No	EVA
rs3389554703	876	I>L	No	EVA

Type	Name	Position	InterPro Accession
domain	CBS domain	518 - 584	IPR000644
domain	CNNM, transmembrane domain	251 - 431	IPR002550
domain	Ion transporter-like, CBS domain	445 - 574	IPR044751

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
basolateral plasma membrane	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion transmembrane transporter activity	Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other.
transmembrane transporter activity	Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Name	Definition
magnesium ion homeostasis	Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell.
magnesium ion transport	The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6P4Q7	CNNM4	Metal transporter CNNM4	Homo sapiens (Human)	PR
Q8NE01	CNNM3	Metal transporter CNNM3	Homo sapiens (Human)	PR
Q9H8M5	CNNM2	Metal transporter CNNM2	Homo sapiens (Human)	PR
Q69ZF7	Cnnm4	Metal transporter CNNM4	Mus musculus (Mouse)	PR
P0C588	Cnnm4	Metal transporter CNNM4	Rattus norvegicus (Rat)	PR
Q8RY60	CBSDUF7	DUF21 domain-containing protein At1g47330	Arabidopsis thaliana (Mouse-ear cress)	PR