Q3T108

PR
Gene name
PSMB4
Protein name
Proteasome subunit beta type-4
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:506203
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for Q3T108

Entry ID Method Resolution Chain Position Source
1IRU X-ray 275 A 2/N 46-264 PDB
7DR6 EM 410 A K/V 1-264 PDB
7DR7 EM 330 A K/V 1-264 PDB
7DRW EM 420 A V/n 1-264 PDB
8FZ5 EM 223 A N/b 1-264 PDB
8FZ6 EM 254 A N/b 1-264 PDB
AF-Q3T108-F1 Predicted AlphaFoldDB

83 variants for Q3T108

Variant ID(s) Position Change Description Diseaes Association Provenance
rs450989000 3 A>E No EVA
rs463111057 3 A>S No EVA
rs477776935 4 L>I No EVA
rs459162433 6 E>* No EVA
rs472958671 7 S>* No EVA
rs440054768 7 S>A No EVA
rs461054675 10 G>V No EVA
rs442500113 11 L>R No EVA
rs475505662 12 W>R No EVA
rs457171327 13 A>T No EVA
rs432157963 14 G>V No EVA
rs471735320 15 G>C No EVA
rs466762274 20 Q>P No EVA
rs448493052 21 F>V No EVA
rs436534987 26 P>T No EVA
rs469443491 27 T>A No EVA
rs469443491 27 T>S No EVA
rs798739560 28 P>R No EVA
rs451109520 35 V>A No EVA
rs477628916 39 Y>D No EVA
rs210997959 40 G>R No EVA
rs479410119 47 Q>* No EVA
rs462068368 48 N>K No EVA
rs476541303 51 V>A No EVA
rs471920561 54 T>I No EVA
rs434990762 61 F>V No EVA
rs474355141 65 V>E No EVA
rs474355141 65 V>G No EVA
rs456014798 71 M>L No EVA
rs470489541 82 R>P No EVA
rs432720367 85 S>P No EVA
rs465716256 86 R>G No EVA
rs447266363 86 R>P No EVA
rs480226383 87 I>L No EVA
rs461966919 88 M>I No EVA
rs483028014 90 V>F No EVA
rs458021645 90 V>G No EVA
rs438844533 92 N>K No EVA
rs471756756 93 S>R No EVA
rs459846688 95 M>L No EVA
rs441294036 97 G>A No EVA
rs474319347 105 F>L No EVA
rs455902775 111 V>G No EVA
rs476968711 114 Q>K No EVA
rs436710065 117 I>T No EVA
rs448352147 124 D>V No EVA
rs435586992 126 H>P No EVA
rs449997550 138 T>N No EVA
rs483193364 158 G>R No EVA
rs446226568 159 G>A No EVA
rs458056905 159 G>C No EVA
rs460690010 160 Y>D No EVA
rs437930354 174 G>V No EVA
rs464510061 180 P>A No EVA
rs446066872 181 S>L No EVA
rs460626589 185 G>C No EVA
rs448572711 186 Y>* No EVA
rs481799410 188 A>P No EVA
rs463191028 189 Y>F No EVA
rs476961343 192 Q>K No EVA
rs455019539 204 V>L No EVA
rs457558446 211 R>G No EVA
rs465683722 215 E>D No EVA
rs432517512 215 E>K No EVA
rs447134967 216 R>P No EVA
rs467389675 217 C>* No EVA
rs434381363 217 C>G No EVA
rs448856962 218 M>R No EVA
rs482007817 220 V>G No EVA
rs445018049 222 Y>S No EVA
rs459491834 224 R>G No EVA
rs474118095 225 D>V No EVA
rs461342018 226 A>P No EVA
rs442790229 228 S>P No EVA
rs475929706 229 Y>F No EVA
rs457397005 231 R>G No EVA
rs468456732 234 I>M No EVA
rs480414976 234 I>N No EVA
rs449923486 235 A>T No EVA
rs482914789 240 K>R No EVA
rs463795301 243 E>V No EVA
rs133778975 249 S>F No EVA
rs450213149 261 S>R No EVA

No associated diseases with Q3T108

1 regional properties for Q3T108

Type Name Position InterPro Accession
conserved_site Proteasome beta-type subunit, conserved site 57 - 104 IPR016050

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex.
proteasome core complex, beta-subunit complex The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
proteasomal protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3MHN0 PSMB6 Proteasome subunit beta type-6 Bos taurus (Bovine) PR
P28070 PSMB4 Proteasome subunit beta type-4 Homo sapiens (Human) PR
P99026 Psmb4 Proteasome subunit beta type-4 Mus musculus (Mouse) PR
P34067 Psmb4 Proteasome subunit beta type-4 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MEALLESRSG LWAGGPAPGQ FYRIPPTPGS SVDPVSALYG SPITRTQNPM VTGTSVLGLK
70 80 90 100 110 120
FEGGVVIAAD MLGSYGSLAR FRNISRIMRV NNSTMLGASG DYADFQYLKQ VLGQMVIDEE
130 140 150 160 170 180
LLGDGHSYSP KAIHSWLTRA MYSRRSKMNP LWNTMVIGGY ADGESFLGYV DMLGVAYEAP
190 200 210 220 230 240
SLATGYGAYL AQPLLREVLE KQPVLSQTEA RELVERCMRV LYYRDARSYN RFQIATVTEK
250 260
GVEIEGPLSA ETNWDIAHMI SGFE