Q3MHN0

PR
Gene name
PSMB6
Protein name
Proteasome subunit beta type-6
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:510069
EC number
3.4.25.1: Threonine endopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q3MHN0

Entry ID Method Resolution Chain Position Source
1IRU X-ray 275 A H/V 35-238 PDB
8FZ5 EM 223 A H/V 1-239 PDB
8FZ6 EM 254 A H/V 1-239 PDB
AF-Q3MHN0-F1 Predicted AlphaFoldDB

74 variants for Q3MHN0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs439144468 2 A>E No EVA
rs451907313 5 L>* No EVA
rs441430711 6 V>G No EVA
rs472588333 7 A>S No EVA
rs435673278 9 R>Q No EVA
rs470060720 10 G>W No EVA
rs456561579 11 T>P No EVA
rs464494973 12 R>S No EVA
rs458448028 13 P>L No EVA
rs458448028 13 P>Q No EVA
rs447477137 13 P>T No EVA
rs468394001 14 A>E No EVA
rs482724901 24 P>A No EVA
rs482724901 24 P>T No EVA
rs439231678 25 D>G No EVA
rs462637576 25 D>H No EVA
rs477021757 26 W>G No EVA
rs441505721 29 R>L No EVA
rs472676426 30 E>Q No EVA
rs455776320 30 E>V No EVA
rs442132037 31 V>G No EVA
rs476559675 33 T>A No EVA
rs477720925 37 I>S No EVA
rs443355927 62 N>T No EVA
rs471543230 69 T>P No EVA
rs457759443 73 D>A No EVA
rs452400589 74 R>H No EVA
rs472170378 75 I>S No EVA
rs433908844 79 R>H No EVA
rs455301087 81 G>A No EVA
rs454627582 90 A>T No EVA
rs436157862 96 Q>H No EVA
rs449911403 101 S>R No EVA
rs797746870 105 N>K No EVA
rs440967609 106 E>D No EVA
rs461750437 108 P>T No EVA
rs441634085 109 L>R No EVA
rs474568917 110 V>G No EVA
rs443852437 112 T>P No EVA
rs722818513 113 A>V No EVA
rs468972245 114 A>P No EVA
rs434852031 120 M>I No EVA
rs715104575 123 R>* No EVA
rs464999708 136 G>S No EVA
rs455614776 138 D>A No EVA
rs472547865 145 V>G No EVA
rs3423443302 151 G>V No EVA
rs470184469 155 V>L No EVA
rs3423464131 156 R>* No EVA
rs456473419 159 F>L No EVA
rs3423443298 161 I>T No EVA
rs464449268 162 G>A No EVA
rs433743813 163 G>A No EVA
rs3423463974 165 G>R No EVA
rs482743859 175 A>S No EVA
rs462524067 176 T>N No EVA
rs478585043 177 Y>* No EVA
rs458269807 183 K>E No EVA
rs441396339 183 K>M No EVA
rs209531241 188 Q>K No EVA
rs472590349 189 F>L No EVA
rs462145987 190 T>S No EVA
rs109808811 205 G>* No EVA
rs470910588 207 V>G No EVA
rs207820148 209 R>L No EVA
rs800667321 215 E>D No EVA
rs454010271 218 V>G No EVA
rs481633477 222 V>G No EVA
rs132681572 230 K>N No EVA
rs135110325 232 T>P No EVA
rs133758663 234 A>P No EVA
rs137521429 235 T>I No EVA
rs132929918 235 T>P No EVA
rs133642096 236 L>F No EVA

No associated diseases with Q3MHN0

1 regional properties for Q3MHN0

Type Name Position InterPro Accession
conserved_site Proteasome beta-type subunit, conserved site 38 - 85 IPR016050

Functions

Description
EC Number 3.4.25.1 Threonine endopeptidases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex.
proteasome core complex, beta-subunit complex The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus.

2 GO annotations of molecular function

Name Definition
endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
threonine-type endopeptidase activity Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.

1 GO annotations of biological process

Name Definition
proteasomal protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3T108 PSMB4 Proteasome subunit beta type-4 Bos taurus (Bovine) PR
P28072 PSMB6 Proteasome subunit beta type-6 Homo sapiens (Human) PR
10 20 30 40 50 60
MAATLVAARG TRPAPAWGPE AIAPDWENRE VSTGTTIMAV QFDGGVVLGA DSRTTTGSYI
70 80 90 100 110 120
ANRVTDKLTP IHDRIFCCRS GSAADTQAVA DAVTYQLGFH SIELNEPPLV HTAASLFKEM
130 140 150 160 170 180
CYRYREDLMA GIIIAGWDPQ EGGQVYSVPM GGMMVRQPFA IGGSGSSYIY GYVDATYREG
190 200 210 220 230
MTKEECLQFT ANALALAMER DGSSGGVIRL AAIAEPGVER QVLLGDQIPK FTIATLPPL