AiPD: Autoinhibited Protein Database

P28072

Gene name	PSMB6 (LMPY, Y)
Protein name	Proteasome subunit beta type-6
Names	Macropain delta chain, Multicatalytic endopeptidase complex delta chain, Proteasome delta chain, Proteasome subunit Y
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5694
EC number	3.4.25.1: Threonine endopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-54 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

84 structures for P28072

Entry ID	Method	Resolution	Chain	Position	Source
4R3O	X-ray	260 A	H/V	35-236	PDB
4R67	X-ray	289 A	H/V/j/x	35-236	PDB
5A0Q	EM	350 A	H/V	35-239	PDB
5GJQ	EM	450 A	a/o	1-239	PDB
5GJR	EM	350 A	a/o	1-239	PDB
5L4G	EM	402 A	6/Z	1-239	PDB
5LE5	X-ray	180 A	N/b	35-239	PDB
5LEX	X-ray	220 A	N/b	35-239	PDB
5LEY	X-ray	190 A	N/b	35-239	PDB
5LEZ	X-ray	219 A	N/b	35-239	PDB
5LF0	X-ray	241 A	N/b	35-239	PDB
5LF1	X-ray	200 A	N/b	35-239	PDB
5LF3	X-ray	210 A	N/b	36-239	PDB
5LF4	X-ray	199 A	N/b	35-239	PDB
5LF6	X-ray	207 A	N/b	35-239	PDB
5LF7	X-ray	200 A	N/b	35-239	PDB
5LN3	EM	680 A	1	1-239	PDB
5M32	EM	380 A	N/b	1-239	PDB
5T0C	EM	380 A	AN/BN	2-239	PDB
5T0G	EM	440 A	N	2-239	PDB
5T0H	EM	680 A	N	2-239	PDB
5T0I	EM	800 A	N	2-239	PDB
5T0J	EM	800 A	N	2-239	PDB
5VFO	EM	350 A	N/n	35-225	PDB
5VFP	EM	420 A	N/n	35-225	PDB
5VFQ	EM	420 A	N/n	35-225	PDB
5VFR	EM	490 A	N/n	35-225	PDB
5VFS	EM	360 A	N/n	35-225	PDB
5VFT	EM	700 A	N/n	35-225	PDB
5VFU	EM	580 A	N/n	35-225	PDB
6KWY	EM	272 A	N/b	1-239	PDB
6MSB	EM	300 A	N/n	2-239	PDB
6MSD	EM	320 A	N/n	2-239	PDB
6MSE	EM	330 A	N/n	2-239	PDB
6MSG	EM	350 A	N/n	2-239	PDB
6MSH	EM	360 A	N/n	2-239	PDB
6MSJ	EM	330 A	N/n	2-239	PDB
6MSK	EM	320 A	N/n	2-239	PDB
6R70	EM	350 A	N/b	35-237	PDB
6REY	EM	300 A	H/V	35-239	PDB
6RGQ	EM	260 A	H/V	35-239	PDB
6WJD	EM	480 A	N/n	2-239	PDB
6WJN	EM	570 A	N/n	35-225	PDB
6XMJ	EM	300 A	H	35-236	PDB
7LXV	EM	340 A	N/b	35-239	PDB
7NAN	EM	280 A	N/b	1-239	PDB
7NAO	EM	290 A	N/b	1-239	PDB
7NAP	EM	320 A	N/b	1-239	PDB
7NAQ	EM	320 A	N/b	1-239	PDB
7NHT	EM	280 A	N	1-239	PDB
7PG9	EM	370 A	H/V	35-239	PDB
7QXN	EM	370 A	N/n	2-239	PDB
7QXP	EM	360 A	N/n	2-239	PDB
7QXU	EM	430 A	N/n	2-239	PDB
7QXW	EM	410 A	N/n	2-239	PDB
7QXX	EM	440 A	N/n	2-239	PDB
7QY7	EM	470 A	N/n	2-239	PDB
7QYA	EM	480 A	N/n	2-239	PDB
7QYB	EM	410 A	N/n	2-239	PDB
7V5G	EM	447 A	A/H	35-239	PDB
7V5M	EM	388 A	H/V	35-239	PDB
7W37	EM	300 A	N/n	1-239	PDB
7W38	EM	310 A	N/n	1-239	PDB
7W39	EM	320 A	N/n	1-239	PDB
7W3A	EM	350 A	N/n	1-239	PDB
7W3B	EM	360 A	N/n	1-239	PDB
7W3C	EM	340 A	N/n	1-239	PDB
7W3F	EM	330 A	N/n	1-239	PDB
7W3G	EM	320 A	N/n	1-239	PDB
7W3H	EM	320 A	N/n	1-239	PDB
7W3I	EM	350 A	N/n	1-239	PDB
7W3J	EM	350 A	N/n	1-239	PDB
7W3K	EM	360 A	N/n	1-239	PDB
7W3M	EM	350 A	N/n	1-239	PDB
8BZL	X-ray	214 A	N/b	1-239	PDB
8CVR	EM	270 A	H/V	35-239	PDB
8CVS	EM	310 A	N/b	35-239	PDB
8CVT	EM	300 A	N/n	1-239	PDB
8CXB	EM	290 A	N/b	1-239	PDB
8QYN	EM	288 A	Q	1-239	PDB
8QYO	EM	284 A	N/b	1-239	PDB
8QYS	EM	389 A	Q/h	35-231	PDB
8UD9	EM	204 A	H/V	35-239	PDB
AF-P28072-F1	Predicted				AlphaFoldDB

182 variants for P28072

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1204392723 CA397281821	2	A>T		No	ClinGen gnomAD
rs749731543 CA8310819	3	A>P		No	ClinGen ExAC gnomAD
rs771111047 CA8310820	4	T>A		No	ClinGen ExAC TOPMed gnomAD
rs771111047 CA397281861	4	T>P		No	ClinGen ExAC TOPMed gnomAD
CA8310821 rs200484344	5	L>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1435860259 CA397281975	8	A>S		No	ClinGen gnomAD
CA397282009 rs1168577648	8	A>V		No	ClinGen gnomAD
CA8310825 rs761713056	9	R>L		No	ClinGen ExAC TOPMed gnomAD
rs371587768 CA8310824	9	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA397282059 rs980249539	10	G>E		No	ClinGen TOPMed gnomAD
CA287177311 rs980249539	10	G>V		No	ClinGen TOPMed gnomAD
CA287177326 rs140751461	11	A>D		No	ClinGen 1000Genomes gnomAD
rs1366407685 CA397282073	11	A>P		No	ClinGen gnomAD
CA397282065 rs1366407685	11	A>T		No	ClinGen gnomAD
CA8310826 rs764908804	12	G>R		No	ClinGen ExAC gnomAD
rs1272469828 CA397282146	13	P>L		No	ClinGen gnomAD
TCGA novel	13	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1227552805 CA397282135	13	P>S		No	ClinGen gnomAD
TCGA novel	14	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA397282191 rs1256483754	15	P>Q		No	ClinGen TOPMed
rs750440943 CA8310827	15	P>S		No	ClinGen ExAC gnomAD
CA397282239 rs1223360638	16	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1217513442 CA397282294	17	W>C		No	ClinGen TOPMed
CA8310829 rs766281129	17	W>L		No	ClinGen ExAC gnomAD
CA397282261 rs1252466180	17	W>R		No	ClinGen TOPMed gnomAD
rs751075026 CA8310830	18	G>R		No	ClinGen ExAC
CA8310833 rs752324933	19	P>L		No	ClinGen ExAC gnomAD
CA397282367 rs780845009	19	P>S		No	ClinGen ExAC gnomAD
CA8310832 rs780845009	19	P>T		No	ClinGen ExAC gnomAD
CA8310835 rs778000428	20	E>K		No	ClinGen ExAC gnomAD
CA397282410 rs1417923958	20	E>V		No	ClinGen gnomAD
rs938713750 CA287177371	21	A>V		No	ClinGen TOPMed
rs1567516862 CA397282550	23	T>I		No	ClinGen Ensembl
rs1327566969 CA397282595	24	P>R		No	ClinGen gnomAD
rs1433999842 CA397282626	25	D>E		No	ClinGen gnomAD
rs1371451553 CA397282598	25	D>Y		No	ClinGen gnomAD
CA8310839 rs745965445	29	R>*		No	ClinGen ExAC
rs772252014 CA8310840	30	E>K		No	ClinGen ExAC TOPMed gnomAD
CA8310841 rs775892066	31	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA397282916 rs1273782199	32	S>F		No	ClinGen TOPMed gnomAD
rs780266728 CA8310860	36	T>A		No	ClinGen ExAC gnomAD
rs1213363628 CA397283267	37	I>T		No	ClinGen TOPMed
CA8310861 rs747052551	38	M>V		No	ClinGen ExAC gnomAD
CA8310862 rs768763951	39	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA397283364 rs1567517041	40	V>L		No	ClinGen Ensembl
rs928708017 CA287177717	41	Q>R		No	ClinGen TOPMed
CA8310866 rs143768117	44	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8310865 rs143768117	44	G>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8310870 rs760167981	50	A>T		No	ClinGen ExAC gnomAD
rs753501942 CA8310872	53	R>T		No	ClinGen ExAC gnomAD
CA397284623 rs1269569061	56	T>A		No	ClinGen TOPMed
rs1455471170	57	G>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA287178449 rs141042303	58	S>Y		No	ClinGen ESP TOPMed gnomAD
CA397284951 rs1460423458	61	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA397284970 rs1263627997	62	N>H		No	ClinGen gnomAD
CA8310902 rs182638722	62	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs748430072 CA8310903	63	R>*		No	ClinGen ExAC gnomAD
CA397284993 rs748430072	63	R>G		No	ClinGen ExAC gnomAD
rs1443496514 CA397285110	68	L>V		No	ClinGen gnomAD
rs771829144 CA8310907	70	P>R		No	ClinGen ExAC TOPMed gnomAD
CA397285145 rs1326320092	70	P>S		No	ClinGen gnomAD
rs1339549445 COSM980687 CA397285213	73	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA8310910 rs768105769	74	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8310911 rs776218041	74	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1485634812 CA397285294	77	C>F		No	ClinGen TOPMed
CA397285351 rs1260813123	78	C>*		No	ClinGen gnomAD
CA8310914 rs772949966	82	S>L		No	ClinGen ExAC gnomAD
CA397285476 rs1206996001	83	A>P		No	ClinGen TOPMed
rs1001789495 CA287178603	84	A>T		No	ClinGen TOPMed
CA287178605 rs1057338477	85	D>E		No	ClinGen TOPMed
rs763461081 CA8310915	87	Q>H		No	ClinGen ExAC gnomAD
CA397285645 rs1392498926	89	V>A		No	ClinGen gnomAD
CA397285729 COSM178974 rs1294459124	92	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1381006278 CA397285735	93	V>I		No	ClinGen gnomAD
rs766735155 CA8310916	95	Y>H		No	ClinGen ExAC gnomAD
CA397285903 rs371370042	98	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs371370042 CA8310919	98	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1567517386 CA397285923	98	G>V		No	ClinGen Ensembl
rs1354753654 CA397285935	99	F>I		No	ClinGen TOPMed
CA397285989 rs1336438585	100	H>Q		No	ClinGen TOPMed gnomAD
TCGA novel	101	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1161682393 CA397286199	104	L>V		No	ClinGen TOPMed gnomAD
rs59124255 CA287178829	106	E>D		No	ClinGen Ensembl
rs2304974 CA8310941 VAR_020030	107	P>A		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs2304974 CA8310942	107	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8310943 rs368699351	108	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA397286285 rs1312425998	110	V>I		No	ClinGen TOPMed gnomAD
rs1448052163 CA397286348	113	A>P		No	ClinGen gnomAD
rs781327581 CA8310946	113	A>V		No	ClinGen ExAC gnomAD
rs1392817087 CA397286406	114	A>G		No	ClinGen gnomAD
CA397286441 rs2304975	115	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8310948 rs769496105	115	S>T		No	ClinGen ExAC TOPMed gnomAD
rs149312249 CA287178907	122	Y>*		No	ClinGen ESP TOPMed
CA397286662 rs1460527381	123	R>*		No	ClinGen TOPMed
CA8310950 rs144706895	123	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200783412 CA287178950	125	R>Q		No	ClinGen TOPMed
CA8310952 rs773838062	129	M>I		No	ClinGen ExAC gnomAD
CA397286898 rs1250859844	130	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA397286970 rs1191482242	133	I>T		No	ClinGen TOPMed
rs1450869965 CA397287025	135	A>T		No	ClinGen TOPMed
rs1273612090 CA397287042	135	A>V		No	ClinGen TOPMed
CA397287073 rs1239155948	137	W>S		No	ClinGen gnomAD
rs1454058158 CA397287089	138	D>N		No	ClinGen gnomAD
CA8310956 rs761154471	139	P>L		No	ClinGen ExAC gnomAD
rs764525435 CA8310957	140	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs761758329 CA8310959	142	G>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel CA8310958 rs776695359	142	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC gnomAD
TCGA novel	144	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1597310878 CA397287386	145	V>G		No	ClinGen Ensembl
rs755934836 CA8310983	145	V>M		No	ClinGen ExAC gnomAD
rs756836433 CA8310986	148	V>L		No	ClinGen ExAC gnomAD
rs1044855414 CA287179174	150	M>I		No	ClinGen TOPMed gnomAD
COSM436794 CA8310987 rs778268975	150	M>V	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	152	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA397287516 rs1567517575	153	M>V		No	ClinGen Ensembl
rs1240803023	153	M>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA397287565 rs1193701659	155	V>I		No	ClinGen TOPMed gnomAD
CA8310988 rs148466899	159	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1474008466 CA397287678	160	A>G		No	ClinGen gnomAD
rs758048137 CA8310989	161	I>V		No	ClinGen ExAC gnomAD
CA8310991 rs747395317	162	G>A		No	ClinGen ExAC gnomAD
CA397287798 rs1400581334	166	S>N		No	ClinGen gnomAD
rs1298866065 CA397287825	167	S>F		No	ClinGen gnomAD
rs1354969847 CA397287855	169	I>V		No	ClinGen TOPMed gnomAD
rs769974567 CA8310995	173	V>G		No	ClinGen ExAC gnomAD
rs1235608302 CA397287967	174	D>H		No	ClinGen TOPMed
CA8310997 rs763062365	176	T>A		No	ClinGen ExAC gnomAD
CA397288033 rs1223525417	177	Y>S		No	ClinGen gnomAD
CA8311001 rs760599519	178	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8311000 rs760599519	178	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs774669346 CA8310999	178	R>W		No	ClinGen ExAC TOPMed gnomAD
rs753866752 CA8311002	179	E>Q		No	ClinGen ExAC
CA397288085 rs1256177779	180	G>V		No	ClinGen gnomAD
rs1189023671 CA397288099	181	M>K		No	ClinGen gnomAD
rs761666299 CA8311003	181	M>L		No	ClinGen ExAC TOPMed gnomAD
rs761666299 CA397288092	181	M>V		No	ClinGen ExAC TOPMed gnomAD
CA8311005 rs749930693	183	K>R		No	ClinGen ExAC TOPMed gnomAD
CA287179289 rs113625242	187	L>P		No	ClinGen Ensembl
rs199961729 CA8311008	189	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8311009 rs755401852	191	A>V		No	ClinGen ExAC gnomAD
CA8311010 rs376453032	192	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1567517644 CA397288309	193	A>T		No	ClinGen Ensembl
CA8311026 rs751271152	195	A>D		No	ClinGen ExAC TOPMed gnomAD
CA397288697 rs553921552	195	A>P		No	ClinGen ExAC TOPMed gnomAD
rs553921552 CA8311025	195	A>T		No	ClinGen ExAC TOPMed gnomAD
CA397288772 rs1567517685	197	A>V		No	ClinGen Ensembl
rs1462851615 CA397288805	198	M>T		No	ClinGen TOPMed
rs1403060312 CA397288799	198	M>V		No	ClinGen gnomAD
CA397288835 rs1392168790	199	E>A		No	ClinGen TOPMed
rs150542791 CA8311029	200	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs767131809 CA8311028	200	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1567517698 CA397288868	201	D>N		No	ClinGen Ensembl
CA8311031 rs547244513	208	I>S		No	ClinGen 1000Genomes ExAC gnomAD
CA397289115 rs547244513	208	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA287179408 rs952750072	209	R>C		No	ClinGen gnomAD
rs952750072 CA397289126	209	R>G		No	ClinGen gnomAD
rs1236134203 CA397289134	209	R>H		No	ClinGen TOPMed gnomAD
CA8311033 rs757483744	212	A>T		No	ClinGen ExAC gnomAD
rs1420941869 CA397289216	213	I>S		No	ClinGen TOPMed
CA397289253 rs1259530338	215	E>D		No	ClinGen gnomAD
CA397289243 rs1193582566	215	E>K		No	ClinGen gnomAD
rs908573412 CA287179422	219	E>G		No	ClinGen Ensembl
CA397289325 rs755217976	220	R>L		No	ClinGen ExAC TOPMed gnomAD
COSM178976 rs755217976 CA8311034	220	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA397289342 rs1250949301	222	V>I		No	ClinGen gnomAD
rs1199565466 CA397289366	225	G>E		No	ClinGen gnomAD
CA8311035 rs745872929	225	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
CA8311036 rs772211985	226	D>N		No	ClinGen ExAC
rs775729803 CA8311037	228	I>T		No	ClinGen ExAC
rs917481855 CA287179437	228	I>V		No	ClinGen Ensembl
CA397289403 rs1253283971	229	P>L		No	ClinGen TOPMed
CA8311038 rs747940154	230	K>N		No	ClinGen ExAC
TCGA novel	232	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs143389701 CA8311040	232	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8311042 rs201170982	233	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8311043 rs201170982	233	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs374601335 CA8311044	234	A>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs575136248 CA8311045	235	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8311046 rs752361110	238	P>R		No	ClinGen ExAC gnomAD
CA8311048 rs148379239	239	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1804248 CA287179522	240	A>L		No	ClinGen TOPMed
rs1804248 CA397289538	240	A>S		No	ClinGen TOPMed

No associated diseases with P28072

1 regional properties for P28072

Type	Name	Position	InterPro Accession
conserved_site	Proteasome beta-type subunit, conserved site	38 - 85	IPR016050

Functions

		Description
EC Number	3.4.25.1	Threonine endopeptidases
Subcellular Localization	Cytoplasm Nucleus	Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
proteasome complex	A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome core complex	A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex.
proteasome core complex, beta-subunit complex	The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus.

3 GO annotations of molecular function

Name	Definition
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
endopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
threonine-type endopeptidase activity	Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.

2 GO annotations of biological process

Name	Definition
proteasomal protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3MHN0	PSMB6	Proteasome subunit beta type-6	Bos taurus (Bovine)	PR
P28070	PSMB4	Proteasome subunit beta type-4	Homo sapiens (Human)	PR

10	20	30	40	50	60
MAATLLAARG	AGPAPAWGPE	AFTPDWESRE	VSTGTTIMAV	QFDGGVVLGA	DSRTTTGSYI
70	80	90	100	110	120
ANRVTDKLTP	IHDRIFCCRS	GSAADTQAVA	DAVTYQLGFH	SIELNEPPLV	HTAASLFKEM
130	140	150	160	170	180
CYRYREDLMA	GIIIAGWDPQ	EGGQVYSVPM	GGMMVRQSFA	IGGSGSSYIY	GYVDATYREG
190	200	210	220	230
MTKEECLQFT	ANALALAMER	DGSSGGVIRL	AAIAESGVER	QVLLGDQIPK	FAVATLPPA