AiPD: Autoinhibited Protein Database

Gene name	MRPS7
Protein name	28S ribosomal protein S7, mitochondrial
Names	MRP-S7, S7mt
Species	Bos taurus (Bovine)
KEGG Pathway	bta:509115
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

28-111 (Predicted disordered autoinhibitory region) PR

28-111 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
3JD5	EM	700 A	G	1-242	PDB
6NEQ	EM	332 A	G	1-242	PDB
6NF8	EM	348 A	G	1-242	PDB
AF-Q3T040-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs476339003	4	P>S	No	EVA
rs524259022	5	T>M	No	EVA
rs433345818	5	T>P	No	EVA
rs519036131	6	A>V	No	EVA
rs434288469	9	S>A	No	EVA
rs468523196	15	L>S	No	EVA
rs469497226	20	R>P	No	EVA
rs446136949	21	I>V	No	EVA
rs477773169	23	V>A	No	EVA
rs476099607	30	T>S	No	EVA
rs459132872	34	W>G	No	EVA
rs438740607	71	T>P	No	EVA
rs207718097	79	A>P	No	EVA
rs437833195	132	E>V	No	EVA
rs477383961	137	V>I	No	EVA
rs453212020	170	V>G	No	EVA
rs435973320	175	A>T	No	EVA
rs467407730	177	R>P	No	EVA
rs717568439	178	R>H	No	EVA
rs456947717	180	R>P	No	EVA
rs436860868	181	F>C	No	EVA
rs465356182	185	K>E	No	EVA
rs465356182	185	K>Q	No	EVA
rs445390072	186	W>G	No	EVA
rs445390072	186	W>R	No	EVA
rs449598228	187	M>I	No	EVA
rs479864211	187	M>L	No	EVA
rs466402897	187	M>R	No	EVA
rs480638532	188	I>T	No	EVA
rs443704630	190	E>G	No	EVA
rs478291931	191	C>G	No	EVA
rs478291931	191	C>R	No	EVA
rs458278788	194	K>E	No	EVA
rs438599122	194	K>R	No	EVA
rs453097606	198	R>G	No	EVA
rs442735029	204	K>E	No	EVA
rs473752712	205	L>M	No	EVA
rs456928011	205	L>R	No	EVA
rs464890509	211	E>G	No	EVA
rs451324438	216	R>C	No	EVA
rs434935878	221	K>R	No	EVA
rs449470031	224	H>Y	No	EVA
rs435898552	229	M>K	No	EVA
rs470512949	231	E>D	No	EVA
rs450102572	232	A>D	No	EVA
rs458218819	234	R>S	No	EVA
rs459550341	237	A>D	No	EVA
rs442650660	242	W>R	No	EVA

Type	Name	Position	InterPro Accession
domain	Ribosomal protein S7 domain	79 - 234	IPR023798

		Description
EC Number
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial small ribosomal subunit	The smaller of the two subunits of a mitochondrial ribosome.
ribosome	An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.

Name	Definition
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
rRNA binding	Binding to a ribosomal RNA.
structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.

Name	Definition
mitochondrial translation	The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.
ribosomal small subunit assembly	The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.
translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P47150	RSM7	37S ribosomal protein S7, mitochondrial	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q24186	RpS5a	40S ribosomal protein S5a	Drosophila melanogaster (Fruit fly)	PR
Q9VFE4	RpS5b	40S ribosomal protein S5b	Drosophila melanogaster (Fruit fly)	PR
Q9Y2R9	MRPS7	28S ribosomal protein S7, mitochondrial	Homo sapiens (Human)	PR
Q80X85	Mrps7	28S ribosomal protein S7, mitochondrial	Mus musculus (Mouse)	PR
Q5I0K8	Mrps7	28S ribosomal protein S7, mitochondrial	Rattus norvegicus (Rat)	PR
P49041	rps-5	40S ribosomal protein S5	Caenorhabditis elegans	PR
Q498Z6	mrps7	28S ribosomal protein S7, mitochondrial	Danio rerio (Zebrafish) (Brachydanio rerio)	PR