P47150

PR
Gene name
RSM7 (YJR113C, J2020)
Protein name
37S ribosomal protein S7, mitochondrial
Names
Mitochondrial small ribosomal subunit protein uS7m
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YJR113C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for P47150

Entry ID Method Resolution Chain Position Source
5MRC EM 325 A GG 87-247 PDB
5MRE EM 375 A GG 87-247 PDB
5MRF EM 497 A GG 87-247 PDB
8D8K EM 313 A G 1-247 PDB
8D8L EM 260 A G 1-247 PDB
8OM2 EM 257 A G 1-247 PDB
8OM3 EM 287 A G 1-247 PDB
8OM4 EM 232 A G 1-247 PDB
AF-P47150-F1 Predicted AlphaFoldDB

1 variants for P47150

Variant ID(s) Position Change Description Diseaes Association Provenance
s10-638353 206 S>N No SGRP

No associated diseases with P47150

4 regional properties for P47150

Type Name Position InterPro Accession
domain Translational (tr)-type GTP-binding domain 178 - 348 IPR000795
domain Small GTP-binding protein domain 181 - 304 IPR005225
domain Translation initiation factor IF- 2, domain 3 508 - 606 IPR023115
domain Translation initiation factor IF-2, domain II 354 - 448 IPR044145

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial small ribosomal subunit The smaller of the two subunits of a mitochondrial ribosome.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.

3 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
rRNA binding Binding to a ribosomal RNA.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

3 GO annotations of biological process

Name Definition
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.
ribosomal small subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3T040 MRPS7 28S ribosomal protein S7, mitochondrial Bos taurus (Bovine) PR
Q9Y2R9 MRPS7 28S ribosomal protein S7, mitochondrial Homo sapiens (Human) PR
Q80X85 Mrps7 28S ribosomal protein S7, mitochondrial Mus musculus (Mouse) PR
Q5I0K8 Mrps7 28S ribosomal protein S7, mitochondrial Rattus norvegicus (Rat) PR
Q498Z6 mrps7 28S ribosomal protein S7, mitochondrial Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MLHCARRYML VRPRLLWQSG TCVARFQSSV RTPASEPSAE KGVDEWLEAI NELREEFSAK
70 80 90 100 110 120
EYLPETSLAP PGQSKVDLLQ GSQAGSKIKP TAEQLAQWEA LKSVPIPPRK NATLDHITNM
130 140 150 160 170 180
IMRHGKKEKA QTILSRALYL VYCQTRQDPI QALEKSLDEL APLMMTKTFN TGVAKASVIP
190 200 210 220 230 240
VPLNKRQRNR IAWNWIVQSA NQRVSSDFAV RLGEELTAIA KGTSSAFEKR DQIHKTAIAH
RAYIQLK