Q24186
Gene name |
RpS5a (M(1)15D, RpS5, CG8922) |
Protein name |
40S ribosomal protein S5a |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG8922 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q24186
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4V6W | EM | 600 A | AF | 1-228 | PDB |
| 6XU6 | EM | 350 A | AF | 40-228 | PDB |
| 6XU7 | EM | 490 A | AF | 40-228 | PDB |
| AF-Q24186-F1 | Predicted | AlphaFoldDB |
No variants for Q24186
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q24186 | |||||
No associated diseases with Q24186
1 regional properties for Q24186
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cation efflux protein, cytoplasmic domain | 307 - 378 | IPR027470 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosolic ribosome | A ribosome located in the cytosol. |
| cytosolic small ribosomal subunit | The small subunit of a ribosome located in the cytosol. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| ribosome | An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| rRNA binding | Binding to a ribosomal RNA. |
| structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cytoplasmic translation | The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. |
| ribosomal small subunit assembly | The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit. |
| translation | The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3T040 | MRPS7 | 28S ribosomal protein S7, mitochondrial | Bos taurus (Bovine) | PR |
| Q9VFE4 | RpS5b | 40S ribosomal protein S5b | Drosophila melanogaster (Fruit fly) | PR |
| Q9Y2R9 | MRPS7 | 28S ribosomal protein S7, mitochondrial | Homo sapiens (Human) | PR |
| Q80X85 | Mrps7 | 28S ribosomal protein S7, mitochondrial | Mus musculus (Mouse) | PR |
| Q5I0K8 | Mrps7 | 28S ribosomal protein S7, mitochondrial | Rattus norvegicus (Rat) | PR |
| P49041 | rps-5 | 40S ribosomal protein S5 | Caenorhabditis elegans | PR |
| Q498Z6 | mrps7 | 28S ribosomal protein S7, mitochondrial | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEVAENVVE | TFEEPAAPME | AEVAETILET | NVVSTTELPE | IKLFGRWSCD | DVTVNDISLQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DYISVKEKFA | RYLPHSAGRY | AAKRFRKAQC | PIVERLTCSL | MMKGRNNGKK | LMACRIVKHS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FEIIHLLTGE | NPLQILVSAI | INSGPREDST | RIGRAGTVRR | QAVDVSPLRR | VNQAIWLLCT |
| 190 | 200 | 210 | 220 | ||
| GAREAAFRNI | KTIAECLADE | LINAAKGSSN | SYAIKKKDEL | ERVAKSNR |