Q3SX05
PR
Gene name |
ECSIT |
Protein name |
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:507245 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3SX05
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3SX05-F1 | Predicted | AlphaFoldDB |
214 variants for Q3SX05
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs449685771 | 13 | A>D | No | EVA | |
| rs477882598 | 16 | G>S | No | EVA | |
| rs457727148 | 20 | I>F | No | EVA | |
| rs440936496 | 22 | S>C | No | EVA | |
| rs478704582 | 22 | S>R | No | EVA | |
| rs462349641 | 23 | T>P | No | EVA | |
| rs442201835 | 27 | G>R | No | EVA | |
| rs476914303 | 29 | P>T | No | EVA | |
| rs133631462 | 33 | V>G | No | EVA | |
| rs440196103 | 36 | Q>H | No | EVA | |
| rs460342776 | 36 | Q>L | No | EVA | |
| rs444274698 | 39 | R>P | No | EVA | |
| rs475484632 | 40 | G>A | No | EVA | |
| rs524319287 | 42 | R>S | No | EVA | |
| rs432061864 | 43 | C>F | No | EVA | |
| rs472868937 | 45 | A>G | No | EVA | |
| rs436525884 | 52 | S>A | No | EVA | |
| rs451220106 | 56 | P>T | No | EVA | |
| rs445150747 | 61 | P>A | No | EVA | |
| rs479924763 | 63 | R>S | No | EVA | |
| rs715723409 | 64 | R>W | No | EVA | |
| rs449376255 | 73 | E>V | No | EVA | |
| rs481247495 | 74 | E>* | No | EVA | |
| rs461093966 | 76 | F>I | No | EVA | |
| rs444367626 | 102 | H>Q | No | EVA | |
| rs458560923 | 107 | V>E | No | EVA | |
| rs1114868528 | 107 | V>M | No | EVA | |
| rs438325713 | 110 | I>L | No | EVA | |
| rs472930556 | 111 | Y>C | No | EVA | |
| rs452919856 | 116 | K>N | No | EVA | |
| rs436037352 | 125 | D>A | No | EVA | |
| rs474251192 | 130 | N>T | No | EVA | |
| rs457465188 | 135 | I>S | No | EVA | |
| rs437501536 | 139 | E>G | No | EVA | |
| rs445247824 | 148 | H>L | No | EVA | |
| rs466149105 | 158 | Q>K | No | EVA | |
| rs449439855 | 170 | N>K | No | EVA | |
| rs470175741 | 173 | V>A | No | EVA | |
| rs470175741 | 173 | V>G | No | EVA | |
| rs456610793 | 175 | P>L | No | EVA | |
| rs465173793 | 177 | K>T | No | EVA | |
| rs444954596 | 179 | T>A | No | EVA | |
| rs479526767 | 181 | F>S | No | EVA | |
| rs465871258 | 182 | L>P | No | EVA | |
| rs449073329 | 183 | L>R | No | EVA | |
| rs480305158 | 189 | R>P | No | EVA | |
| rs463354046 | 191 | S>G | No | EVA | |
| rs443343655 | 192 | Y>C | No | EVA | |
| rs443343655 | 192 | Y>S | No | EVA | |
| rs441407335 | 195 | L>P | No | EVA | |
| rs458338246 | 195 | L>V | No | EVA | |
| rs472913665 | 196 | K>R | No | EVA | |
| rs442292228 | 203 | W>C | No | EVA | |
| rs462474329 | 203 | W>G | No | EVA | |
| rs476667477 | 205 | T>N | No | EVA | |
| rs456518592 | 209 | N>H | No | EVA | |
| rs433277999 | 213 | F>S | No | EVA | |
| rs470867216 | 218 | D>A | No | EVA | |
| rs451417662 | 221 | Q>H | No | EVA | |
| rs434573679 | 243 | T>N | No | EVA | |
| rs465781573 | 244 | T>P | No | EVA | |
| rs449124152 | 245 | Y>C | No | EVA | |
| rs449124152 | 245 | Y>F | No | EVA | |
| rs449124152 | 245 | Y>S | No | EVA | |
| rs468010394 | 252 | D>A | No | EVA | |
| rs450894906 | 254 | P>R | No | EVA | |
| rs526704127 | 255 | N>D | No | EVA | |
| rs721121276 | 255 | N>K | No | EVA | |
| rs442494581 | 266 | G>E | No | EVA | |
| rs457488011 | 267 | I>L | No | EVA | |
| rs443951077 | 267 | I>N | No | EVA | |
| rs443951077 | 267 | I>T | No | EVA | |
| rs451743328 | 268 | Q>E | No | EVA | |
| rs434800339 | 268 | Q>H | No | EVA | |
| rs451743328 | 268 | Q>K | No | EVA | |
| rs466148838 | 269 | S>I | No | EVA | |
| rs466148838 | 269 | S>N | No | EVA | |
| rs466148838 | 269 | S>T | No | EVA | |
| rs109667722 | 271 | E>* | No | EVA | |
| rs450625397 | 271 | E>A | No | EVA | |
| rs450625397 | 271 | E>G | No | EVA | |
| rs109667722 | 271 | E>K | No | EVA | |
| rs437074282 | 272 | Q>K | No | EVA | |
| rs465072067 | 272 | Q>P | No | EVA | |
| rs445078067 | 273 | Q>K | No | EVA | |
| rs479250846 | 273 | Q>R | No | EVA | |
| rs448884075 | 274 | S>G | No | EVA | |
| rs480304838 | 274 | S>I | No | EVA | |
| rs463936596 | 274 | S>R | No | EVA | |
| rs443813877 | 275 | A>P | No | EVA | |
| rs443813877 | 275 | A>S | No | EVA | |
| rs458462342 | 276 | L>R | No | EVA | |
| rs441530105 | 277 | A>P | No | EVA | |
| rs379266671 | 278 | R>C | No | EVA | |
| rs472625936 | 278 | R>H | No | EVA | |
| rs455675222 | 283 | R>G | No | EVA | |
| rs1117973980 | 287 | V>I | No | EVA | |
| rs476707173 | 289 | G>R | No | EVA | |
| rs436989701 | 290 | P>L | No | EVA | |
| rs464984250 | 291 | F>L | No | EVA | |
| rs445141331 | 291 | F>L | No | EVA | |
| rs434647288 | 292 | S>P | No | EVA | |
| rs465731863 | 294 | W>C | No | EVA | |
| rs448830616 | 304 | I>L | No | EVA | |
| rs480393077 | 306 | R>* | No | EVA | |
| rs463492012 | 312 | P>H | No | EVA | |
| rs449787488 | 313 | E>A | No | EVA | |
| rs1115195992 | 313 | E>K | No | EVA | |
| rs478442896 | 315 | R>G | No | EVA | |
| rs462796095 | 322 | E>D | No | EVA | |
| rs483309683 | 322 | E>G | No | EVA | |
| rs439532760 | 325 | N>D | No | EVA | |
| rs460510239 | 325 | N>K | No | EVA | |
| rs477184525 | 325 | N>T | No | EVA | |
| rs721692985 | 326 | L>I | No | EVA | |
| rs440483156 | 328 | Y>D | No | EVA | |
| rs472476462 | 330 | M>I | No | EVA | |
| rs455400257 | 332 | L>Q | No | EVA | |
| rs456153017 | 341 | W>C | No | EVA | |
| rs476469241 | 341 | W>L | No | EVA | |
| rs432774366 | 342 | D>G | No | EVA | |
| rs466769738 | 351 | V>G | No | EVA | |
| rs446620666 | 354 | G>S | No | EVA | |
| rs436315183 | 357 | F>V | No | EVA | |
| rs458327206 | 364 | A>G | No | EVA | |
| rs481632396 | 364 | A>S | No | EVA | |
| rs479547919 | 365 | H>P | No | EVA | |
| rs459929433 | 365 | H>Q | No | EVA | |
| rs479547919 | 365 | H>R | No | EVA | |
| rs474365300 | 366 | D>A | No | EVA | |
| rs474365300 | 366 | D>G | No | EVA | |
| rs442988371 | 366 | D>H | No | EVA | |
| rs474365300 | 366 | D>V | No | EVA | |
| rs464066764 | 367 | Q>E | No | EVA | |
| rs471840877 | 367 | Q>H | No | EVA | |
| rs443899776 | 367 | Q>P | No | EVA | |
| rs451670734 | 368 | A>G | No | EVA | |
| rs472713985 | 369 | T>A | No | EVA | |
| rs472713985 | 369 | T>P | No | EVA | |
| rs455727507 | 369 | T>R | No | EVA | |
| rs467360189 | 370 | L>P | No | EVA | |
| rs467360189 | 370 | L>R | No | EVA | |
| rs437053725 | 371 | A>D | No | EVA | |
| rs437053725 | 371 | A>G | No | EVA | |
| rs464835381 | 372 | K>E | No | EVA | |
| rs464835381 | 372 | K>Q | No | EVA | |
| rs444811103 | 372 | K>T | No | EVA | |
| rs448845524 | 373 | W>* | No | EVA | |
| rs465898919 | 373 | W>G | No | EVA | |
| rs465898919 | 373 | W>R | No | EVA | |
| rs463952695 | 374 | I>N | No | EVA | |
| rs463952695 | 374 | I>S | No | EVA | |
| rs463952695 | 374 | I>T | No | EVA | |
| rs480821540 | 374 | I>V | No | EVA | |
| rs478488219 | 375 | Q>H | No | EVA | |
| rs443987704 | 375 | Q>P | No | EVA | |
| rs458096658 | 376 | G>S | No | EVA | |
| rs472546157 | 377 | L>F | No | EVA | |
| rs455828603 | 377 | L>H | No | EVA | |
| rs455828603 | 377 | L>P | No | EVA | |
| rs472546157 | 377 | L>V | No | EVA | |
| rs442022837 | 378 | Q>* | No | EVA | |
| rs473850064 | 378 | Q>P | No | EVA | |
| rs473850064 | 378 | Q>R | No | EVA | |
| rs465246789 | 379 | E>G | No | EVA | |
| rs437090587 | 379 | E>K | No | EVA | |
| rs437090587 | 379 | E>Q | No | EVA | |
| rs451468550 | 380 | T>A | No | EVA | |
| rs451468550 | 380 | T>P | No | EVA | |
| rs434387944 | 380 | T>S | No | EVA | |
| rs449021019 | 381 | N>H | No | EVA | |
| rs480305483 | 381 | N>I | No | EVA | |
| rs470413411 | 381 | N>K | No | EVA | |
| rs480305483 | 381 | N>T | No | EVA | |
| rs458465118 | 383 | A>G | No | EVA | |
| rs478375469 | 383 | A>P | No | EVA | |
| rs478375469 | 383 | A>T | No | EVA | |
| rs441450913 | 384 | L>P | No | EVA | |
| rs462116344 | 385 | A>P | No | EVA | |
| rs476495340 | 386 | R>P | No | EVA | |
| rs443405288 | 387 | I>S | No | EVA | |
| rs456999904 | 387 | I>V | No | EVA | |
| rs471537234 | 388 | P>R | No | EVA | |
| rs434677521 | 389 | V>G | No | EVA | |
| rs465823169 | 390 | V>G | No | EVA | |
| rs435307645 | 391 | F>I | No | EVA | |
| rs435307645 | 391 | F>V | No | EVA | |
| rs381248760 | 392 | R>C | No | EVA | |
| rs449769454 | 392 | R>P | No | EVA | |
| rs433366876 | 396 | S>A | No | EVA | |
| rs464677247 | 397 | S>C | No | EVA | |
| rs448010533 | 399 | E>A | No | EVA | |
| rs479341909 | 400 | L>R | No | EVA | |
| rs462187223 | 401 | L>V | No | EVA | |
| rs482795764 | 402 | P>A | No | EVA | |
| rs462900051 | 404 | S>C | No | EVA | |
| rs462900051 | 404 | S>Y | No | EVA | |
| rs471657476 | 406 | E>D | No | EVA | |
| rs457859456 | 408 | E>G | No | EVA | |
| rs457859456 | 408 | E>V | No | EVA | |
| rs472461778 | 409 | E>D | No | EVA | |
| rs441132681 | 409 | E>Q | No | EVA | |
| rs455601340 | 410 | P>T | No | EVA | |
| rs476163988 | 412 | P>Q | No | EVA | |
| rs432875175 | 415 | P>L | No | EVA | |
| rs464805611 | 416 | E>K | No | EVA | |
| rs434301975 | 418 | Q>P | No | EVA | |
| rs448659150 | 419 | E>G | No | EVA | |
| rs468726674 | 419 | E>K | No | EVA | |
| rs208585232 | 421 | E>D | No | EVA | |
| rs462734791 | 426 | Q>P | No | EVA | |
| rs446148709 | 428 | Q>E | No | EVA | |
| rs477541203 | 429 | Q>K | No | EVA | |
| rs457972590 | 433 | S>R | No | EVA |
No associated diseases with Q3SX05
10 regional properties for Q3SX05
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 46 - 86 | IPR001680-1 |
| repeat | WD40 repeat | 88 - 127 | IPR001680-2 |
| repeat | WD40 repeat | 132 - 171 | IPR001680-3 |
| repeat | WD40 repeat | 185 - 225 | IPR001680-4 |
| repeat | WD40 repeat | 228 - 275 | IPR001680-5 |
| repeat | WD40 repeat | 386 - 465 | IPR001680-6 |
| repeat | WD40 repeat | 491 - 530 | IPR001680-7 |
| domain | Lethal giant larvae homologue 2 | 277 - 385 | IPR013577 |
| domain | Lethal giant larvae (Lgl)-like, C-terminal domain | 907 - 1027 | IPR013905 |
| domain | v-SNARE, coiled-coil homology domain | 1087 - 1147 | IPR042855 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| regulation of oxidoreductase activity | Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
| regulation of protein complex stability | Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9QZH6 | Ecsit | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial | Mus musculus (Mouse) | PR |
| Q5XIC2 | Ecsit | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial | Rattus norvegicus (Rat) | PR |
| Q08CK1 | ecsit | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSWAQAILLA | RGASRGWGGI | CSTALTGAPF | SQVPPQAPRG | LRCSAAAHNP | DSSLVPHPPE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPRRPVKALA | VHEELFRPAL | DGARNKANFV | RAVQNFTEYN | VHKRGHVDFI | YLALRKMREY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GVERDLSVYN | LLLDIFPKEV | FRPRNIFHSI | FLHYPRQQEC | GIAVLEQMEN | HGVMPNKETE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FLLLQIFGRK | SYPMLKLVRM | KLWFTRFKNI | NPFPVPRDLP | QDPVDLASLA | LRHMEPDLSA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RVTTYQMPLL | KDSPNAMDPT | ETHIVGIQSP | EQQSALARHD | PARPIFVEGP | FSLWLRDKCV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YYHILRADLL | PPEEREVEEI | PEEWNLYYPM | QLDLAYGRSS | WDDYEFNIDE | VEEGPVFAIC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VAGAHDQATL | AKWIQGLQET | NPALARIPVV | FRLSGSSGEL | LPSSSELEEP | PPPPPEGQEE |
| 430 | |||||
| EEDSQQRQQQ | GQS |