Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q08CK1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q08CK1-F1 | Predicted | AlphaFoldDB |
No variants for Q08CK1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q08CK1 | |||||
No associated diseases with Q08CK1
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| regulation of oxidoreductase activity | Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
| regulation of protein complex stability | Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SX05 | ECSIT | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial | Bos taurus (Bovine) | PR |
| Q9QZH6 | Ecsit | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial | Mus musculus (Mouse) | PR |
| Q5XIC2 | Ecsit | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSASHHLLRL | QCVRCVSHFL | GTPVRQVILP | GRAHLQTPGS | QHIYVQLLRP | FHRSAVCSTD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RQNRTDIEKL | VEDETHHKDK | TLVTHDDIFD | RAAGDSKTKV | EFNRVVDVFK | SKDIRRRGHV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EFIYAALKKM | PEFGVECDVT | VYNKLLDVFP | KEVFVPQNFI | QRMFNHYPRQ | QECGVQVLEQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MENYGVMPNI | ETKVLLVQIF | GEKSHPIRKF | QRIMYWFPKF | KHTNPYPVPH | VLPSDPVDLA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QFSLTRIAAD | LDAKITIYQY | PSTDITETGE | EITRPHIVGI | QSPDQRSLLA | KHNPCKPVFV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EGPYPLWLRQ | KCVHYYLLRA | DPIPPEEKVE | EEIDPEMICP | EQSLFFPQRV | ELDLKVDMGD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DHSFNVDEVE | EGAVYAMCMA | GQGDQATLSQ | WISGLQETCP | ILGQIPTVFR | LESGPRELQT |
| 430 | 440 | 450 | |||
| STDDHQRPEQ | EAETDQIIED | DEEPRHSRGV | KQ |