Q38846

PR
Gene name
ERS1 (ERS, At2g40940, T20B5.14)
Protein name
Ethylene response sensor 1
Names
AtERS1, Protein ERS1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G40940
EC number
2.7.13.3: Protein-histidine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

95-164 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q38846

Entry ID Method Resolution Chain Position Source
4MT8 X-ray 190 A A/B 308-407 PDB
4MTX X-ray 215 A A/B/C/D 308-407 PDB
AF-Q38846-F1 Predicted AlphaFoldDB

14 variants for Q38846

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_2_17086161_C_T 220 S>N No 1000Genomes
tmp_2_17086147_G_A 225 H>Y No 1000Genomes
ENSVATH14603407 256 H>Y No 1000Genomes
tmp_2_17086032_C_T 263 S>N No 1000Genomes
tmp_2_17085973_C_A 283 D>Y No 1000Genomes
tmp_2_17085241_C_T 468 M>I No 1000Genomes
ENSVATH05694014 483 I>V No 1000Genomes
ENSVATH13600508 496 P>T No 1000Genomes
ENSVATH01974451 523 H>N No 1000Genomes
tmp_2_17084713_G_C 588 C>W No 1000Genomes
ENSVATH00268173 590 G>S No 1000Genomes
ENSVATH05694007 591 P>S No 1000Genomes
tmp_2_17084681_G_C 599 A>G No 1000Genomes
tmp_2_17084648_G_T 610 P>Q No 1000Genomes

No associated diseases with Q38846

6 regional properties for Q38846

Type Name Position InterPro Accession
domain GAF domain 158 - 317 IPR003018
domain Histidine kinase/HSP90-like ATPase 455 - 587 IPR003594
domain Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 343 - 408 IPR003661
domain Signal transduction histidine kinase-related protein, C-terminal 511 - 525 IPR004358-1
domain Signal transduction histidine kinase-related protein, C-terminal 546 - 564 IPR004358-2
domain Histidine kinase domain 350 - 589 IPR005467

Functions

Description
EC Number 2.7.13.3 Protein-histidine kinases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ethylene binding Binding to ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator.
ethylene receptor activity Combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity.
metal ion binding Binding to a metal ion.
phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
protein histidine kinase activity Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
negative regulation of ethylene-activated signaling pathway Any process that stops or prevents ethylene (ethene) signal transduction.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A1A696 HK3 Probable histidine kinase 3 Oryza sativa subsp japonica (Rice) PR
Q0DWC7 ETR3 Ethylene receptor 3 Oryza sativa subsp japonica (Rice) PR
Q53RH0 ERS1 Probable ethylene response sensor 1 Oryza sativa subsp japonica (Rice) PR
Q0DKM0 ERS2 Probable ethylene response sensor 2 Oryza sativa subsp japonica (Rice) PR
O49187 ETR2 Ethylene receptor 2 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MESCDCFETH VNQDDLLVKY QYISDALIAL AYFSIPLELI YFVQKSAFFP YKWVLMQFGA
70 80 90 100 110 120
FIILCGATHF INLWMFFMHS KAVAIVMTIA KVSCAVVSCA TALMLVHIIP DLLSVKNREL
130 140 150 160 170 180
FLKKKADELD REMGLILTQE ETGRHVRMLT HGIRRTLDRH TILRTTLVEL GKTLCLEECA
190 200 210 220 230 240
LWMPSQSGLY LQLSHTLSHK IQVGSSVPIN LPIINELFNS AQAMHIPHSC PLAKIGPPVG
250 260 270 280 290 300
RYSPPEVVSV RVPLLHLSNF QGSDWSDLSG KGYAIMVLIL PTDGARKWRD HELELVENVA
310 320 330 340 350 360
DQVAVALSHA AILEESMHAR DQLMEQNFAL DKARQEAEMA VHARNDFLAV MNHEMRTPMH
370 380 390 400 410 420
AIISLSSLLL ETELSPEQRV MIETILKSSN LVATLISDVL DLSRLEDGSL LLENEPFSLQ
430 440 450 460 470 480
AIFEEVISLI KPIASVKKLS TNLILSADLP TYAIGDEKRL MQTILNIMGN AVKFTKEGYI
490 500 510 520 530 540
SIIASIMKPE SLQELPSPEF FPVLSDSHFY LCVQVKDTGC GIHTQDIPLL FTKFVQPRTG
550 560 570 580 590 600
TQRNHSGGGL GLALCKRFVG LMGGYMWIES EGLEKGCTAS FIIRLGICNG PSSSSGSMAL
610
HLAAKSQTRP WNW