Q2TBP8
Gene name |
METTL17 |
Protein name |
Methyltransferase-like protein 17, mitochondrial |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:514880 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2TBP8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2TBP8-F1 | Predicted | AlphaFoldDB |
No variants for Q2TBP8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q2TBP8 | |||||
No associated diseases with Q2TBP8
12 regional properties for Q2TBP8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 1079 - 1346 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 1079 - 1337 | IPR001245 |
| domain | Sema domain | 27 - 516 | IPR001627 |
| repeat | Plexin repeat | 521 - 562 | IPR002165 |
| domain | IPT domain | 563 - 656 | IPR002909-1 |
| domain | IPT domain | 657 - 740 | IPR002909-2 |
| domain | IPT domain | 742 - 837 | IPR002909-3 |
| domain | IPT domain | 839 - 935 | IPR002909-4 |
| active_site | Tyrosine-protein kinase, active site | 1201 - 1213 | IPR008266 |
| domain | PSI domain | 520 - 563 | IPR016201 |
| binding_site | Protein kinase, ATP binding site | 1085 - 1111 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 1079 - 1338 | IPR020635 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. |
| S-adenosyl-L-methionine binding | Binding to S-adenosyl-L-methionine. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| methylation | The process in which a methyl group is covalently attached to a molecule. |
| ribosomal small subunit biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. |
| translation | The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P36056 | RSM22 | Probable S-adenosyl-L-methionine-dependent RNA methyltransferase RSM22, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9H7H0 | METTL17 | Methyltransferase-like protein 17, mitochondrial | Homo sapiens (Human) | PR |
| Q3U2U7 | Mettl17 | Methyltransferase-like protein 17, mitochondrial | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATGRGSRYL | LTIGRWRRSF | GIAPQFRALA | ALVPGVSHVD | NKSDFLGKRP | HRRHPGILQL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SCVRLPQALA | EAGQLLLLGS | AMPNMEKQVQ | ALTNYLWSRH | LPVEPEELQR | RAVLLEKKIL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ENADSCQTEK | HHEEILHALR | RTTYHWQELS | YSEGLSLVYM | AARLDGGFAA | VSRAFHEIQA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RLPEFQPQTL | MDFGSGTGSV | TWAAHSTWGQ | SLREYMCVDS | SAAMLELAEK | LLKGGSGSGM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PCVPGVFFRQ | FLPVSPKVQF | DVVVAAFSLS | ELPSKADRTD | VVQTLWRKTG | HFLVLIENGT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KAGHSLLMDA | RDLVLNGKEK | SPLDPRPGFV | FAPCPHELPC | PQLTASKPLA | CSFSQAYYPI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PFSWNKKPKE | EKFSLVILAR | GSPEKANRWP | RITQPVLKRP | RHVHCHLCCP | DGHMQHAVIT |
| 430 | 440 | 450 | 460 | ||
| ARRHGRDLYR | CARVSSWGDL | LPVITPLELP | PSAQDAQDAP | ES |