P36056

PR
Gene name
RSM22 (YKL155C, YKL610)
Protein name
Probable S-adenosyl-L-methionine-dependent RNA methyltransferase RSM22, mitochondrial
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YKL155C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-152 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P36056

Entry ID Method Resolution Chain Position Source
8D8J EM 380 A 0 1-628 PDB
8D8K EM 313 A 0 1-628 PDB
8D8L EM 260 A 0 1-628 PDB
8OM2 EM 257 A c 1-628 PDB
AF-P36056-F1 Predicted AlphaFoldDB

8 variants for P36056

Variant ID(s) Position Change Description Diseaes Association Provenance
s11-160666 228 K>E No SGRP
s11-160435 305 H>Y No SGRP
s11-160197 384 G>V No SGRP
s11-159928 474 N>D No SGRP
s11-159927 474 N>S No SGRP
s11-159681 556 L>Q No SGRP
s11-159492 619 N>S No SGRP
s11-159478 624 H>N No SGRP

No associated diseases with P36056

3 regional properties for P36056

Type Name Position InterPro Accession
active_site Methylated-DNA-[protein]-cysteine S-methyltransferase, active site 147 - 153 IPR001497
domain Methylguanine DNA methyltransferase, ribonuclease-like domain 6 - 94 IPR008332
domain Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding 98 - 179 IPR014048

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial small ribosomal subunit The smaller of the two subunits of a mitochondrial ribosome.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

2 GO annotations of biological process

Name Definition
methylation The process in which a methyl group is covalently attached to a molecule.
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2TBP8 METTL17 Methyltransferase-like protein 17, mitochondrial Bos taurus (Bovine) PR
10 20 30 40 50 60
MMKRCFSILP QNVRFSSKFT SLNLPKLDLA DFIDSNKRGI NVLPSYRDET ASTTQATNSK
70 80 90 100 110 120
ELRLLSKTLQ GQSYRDQLEL NPDVSKAINN NIMAVHIPNN LRRVATNYYK EIQEPNSLHR
130 140 150 160 170 180
PCRTKMEVDA HIASIFLQNY GSIFQSLKEL QKRVGPDNFK PQRILDVGYG PATGIVALND
190 200 210 220 230 240
ILGPNYRPDL KDAVILGNAE MQERAKIILS RQLNEVVDTV EENVSTEKEQ ETDRRNKNFQ
250 260 270 280 290 300
EDEHIGEVMT KKINIMTNLR SSIPASKEYD LIILTHQLLH DGNQFPIQVD ENIEHYLNIL
310 320 330 340 350 360
APGGHIVIIE RGNPMGFEII ARARQITLRP ENFPDEFGKI PRPWSRGVTV RGKKDAELGN
370 380 390 400 410 420
ISSNYFLKVI APCPHQRKCP LQVGNPNFYT HKEGKDLKFC NFQKSIKRPK FSIELKKGKL
430 440 450 460 470 480
LATSWDGSQG NASRLKGTGR RNGRDYEILN YSYLIFERSH KDENTLKEIK KLRNENVNGK
490 500 510 520 530 540
YDIGSLGDDT QNSWPRIIND PVKRKGHVMM DLCAPSGELE KWTVSRSFSK QIYHDARKSK
550 560 570 580 590 600
KGDLWASAAK TQIKGLGDLN VKKFHKLEKE RIKQLKKEER QKARKAMESY NELEDSLQFD
610 620
DHQFSNFEVM KKLSTFHGND FLQHVNRK