Q2KJA6

PR
Gene name
INTS9
Protein name
Integrator complex subunit 9
Names
Int9
Species
Bos taurus (Bovine)
KEGG Pathway
bta:533964
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

517-649 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2KJA6

Entry ID Method Resolution Chain Position Source
AF-Q2KJA6-F1 Predicted AlphaFoldDB

No variants for Q2KJA6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2KJA6

No associated diseases with Q2KJA6

1 regional properties for Q2KJA6

Type Name Position InterPro Accession
conserved_site Heat shock protein 70, conserved site 368 - 382 IPR018181

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integrator complex A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
snRNA processing Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. The primary function of snRNAs is processing pre-messenger RNA in the nucleus. They have also been shown to aid in the regulation of transcription factors (7SK RNA) or RNA polymerase II (B2 RNA), and maintaining the telomeres.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZKK2 INTS9 Integrator complex subunit 9 Gallus gallus (Chicken) PR
Q9NV88 INTS9 Integrator complex subunit 9 Homo sapiens (Human) PR
Q8K114 Ints9 Integrator complex subunit 9 Mus musculus (Mouse) PR
10 20 30 40 50 60
MKLYCLSGHP TLPCNVLKFK STTIMLDCGL DMTSTLNFLP LPLVQSPRLS NLPGWSLKDG
70 80 90 100 110 120
NAFLDKELKE CSGHVFVDSV PEFCLPETEL IDLSTVDVIL ISNYHCMMAL PYITEHTGFT
130 140 150 160 170 180
GTVYATEPTV QIGRLLMEEL VNFIERVPKA QSASLWKNKD IQRLLPSPLK DAVEVSTWRR
190 200 210 220 230 240
CYTMQEVNSA LSKIQLVGYS QKIELFGAVQ VTPLSSGYAL GSSNWIIQSH YEKVSYVSGS
250 260 270 280 290 300
SLLTTHPQPM DQASLKNSDV LILTGLTQIP TANPDSMVGE FCSNLALTVR NGGNVLVPCY
310 320 330 340 350 360
PSGVIYDLLE CLYQYIDSAG LSSIPFYFIS PVANSSLEFS QIFAEWLCHN KQTKVYLPEP
370 380 390 400 410 420
PFPHAELIQT NKLKHYPSIH GDFSNDFRQP CVVFTGHPSL RFGDVVHFME LWGKSSLNTV
430 440 450 460 470 480
IFTEPDFSYL EALAPYQPLA MKCIYCPIDT RLNFIQVSKL LKEVQPLHVV CPEQYTQPTP
490 500 510 520 530 540
AQSHRMDLMV DCQPPAMSYR RAEVLALPFK RRYEKIEIMP ELADSLVPME IKPGISLATV
550 560 570 580 590 600
SAVLHTKDNK HVLQPPPRPT QPTGGKKRKR ASDDIPDCKV LKPLLSGSIP VDQFVQTLEK
610 620 630 640 650
HGFSDIKVED TAKGHIVLLQ EAETLIQIEE DSTHIICDDD EVLRVRLRDL VLKFLQKF