Q2KJ46
PR
Gene name |
PSMD3 |
Protein name |
26S proteasome non-ATPase regulatory subunit 3 |
Names |
26S proteasome regulatory subunit RPN3 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:504937 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2KJ46
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2KJ46-F1 | Predicted | AlphaFoldDB |
112 variants for Q2KJ46
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs135446278 | 6 | S>A | No | EVA | |
| rs437969816 | 32 | P>H | No | EVA | |
| rs471924592 | 34 | D>A | No | EVA | |
| rs451839240 | 34 | D>N | No | EVA | |
| rs133342181 | 35 | V>G | No | EVA | |
| rs454351764 | 36 | E>Q | No | EVA | |
| rs443117499 | 37 | M>V | No | EVA | |
| rs463187275 | 38 | K>* | No | EVA | |
| rs475224803 | 39 | E>* | No | EVA | |
| rs444033923 | 44 | G>D | No | EVA | |
| rs477756658 | 46 | G>* | No | EVA | |
| rs460359947 | 47 | S>* | No | EVA | |
| rs449188845 | 48 | T>N | No | EVA | |
| rs437880122 | 49 | G>R | No | EVA | |
| rs445285053 | 50 | E>* | No | EVA | |
| rs465360953 | 50 | E>A | No | EVA | |
| rs465360953 | 50 | E>G | No | EVA | |
| rs434078011 | 51 | T>A | No | EVA | |
| rs454096417 | 52 | A>S | No | EVA | |
| rs436548707 | 54 | K>N | No | EVA | |
| rs456705165 | 59 | A>G | No | EVA | |
| rs476736886 | 60 | A>D | No | EVA | |
| rs476736886 | 60 | A>G | No | EVA | |
| rs476736886 | 60 | A>V | No | EVA | |
| rs457621248 | 61 | E>* | No | EVA | |
| rs471166372 | 61 | E>G | No | EVA | |
| rs440089276 | 62 | H>D | No | EVA | |
| rs460172440 | 62 | H>P | No | EVA | |
| rs480464000 | 62 | H>Q | No | EVA | |
| rs442625971 | 63 | S>A | No | EVA | |
| rs442625971 | 63 | S>P | No | EVA | |
| rs462725731 | 64 | Q>P | No | EVA | |
| rs465367330 | 66 | E>G | No | EVA | |
| rs445115398 | 66 | E>K | No | EVA | |
| rs447770971 | 67 | L>P | No | EVA | |
| rs447770971 | 67 | L>R | No | EVA | |
| rs479022800 | 67 | L>V | No | EVA | |
| rs436472936 | 68 | D>G | No | EVA | |
| rs467880107 | 68 | D>Y | No | EVA | |
| rs456727150 | 69 | T>N | No | EVA | |
| rs456727150 | 69 | T>S | No | EVA | |
| rs432656139 | 70 | V>A | No | EVA | |
| rs432656139 | 70 | V>G | No | EVA | |
| rs470203613 | 70 | V>L | No | EVA | |
| rs471229883 | 71 | T>N | No | EVA | |
| rs452640599 | 71 | T>P | No | EVA | |
| rs473930491 | 72 | L>F | No | EVA | |
| rs439955649 | 72 | L>M | No | EVA | |
| rs453668326 | 72 | L>W | No | EVA | |
| rs442503036 | 73 | E>* | No | EVA | |
| rs462788901 | 73 | E>A | No | EVA | |
| rs462788901 | 73 | E>G | No | EVA | |
| rs437067690 | 77 | E>* | No | EVA | |
| rs470821902 | 80 | K>T | No | EVA | |
| rs439617823 | 105 | S>F | No | EVA | |
| rs473575981 | 116 | A>P | No | EVA | |
| rs442085386 | 117 | V>G | No | EVA | |
| rs462363297 | 126 | A>T | No | EVA | |
| rs482372432 | 128 | R>P | No | EVA | |
| rs444770831 | 137 | E>* | No | EVA | |
| rs462725773 | 184 | A>E | No | EVA | |
| rs136540808 | 199 | N>T | No | EVA | |
| rs476544760 | 216 | R>Q | No | EVA | |
| rs438643031 | 222 | D>G | No | EVA | |
| rs458883653 | 223 | K>E | No | EVA | |
| rs479026493 | 225 | D>E | No | EVA | |
| rs447703617 | 227 | V>G | No | EVA | |
| rs457377350 | 239 | T>P | No | EVA | |
| rs470933784 | 247 | Q>L | No | EVA | |
| rs470933784 | 247 | Q>R | No | EVA | |
| rs433290600 | 249 | T>P | No | EVA | |
| rs473477063 | 258 | Y>S | No | EVA | |
| rs453951265 | 260 | H>Q | No | EVA | |
| rs442269442 | 261 | Y>C | No | EVA | |
| rs476141541 | 264 | Y>C | No | EVA | |
| rs444703199 | 265 | D>A | No | EVA | |
| rs477017917 | 275 | V>M | No | EVA | |
| rs445740544 | 276 | F>L | No | EVA | |
| rs459416296 | 281 | N>K | No | EVA | |
| rs479293625 | 283 | N>S | No | EVA | |
| rs468197498 | 288 | Y>* | No | EVA | |
| rs437068047 | 290 | Y>D | No | EVA | |
| rs450669323 | 290 | Y>F | No | EVA | |
| rs469595887 | 324 | F>S | No | EVA | |
| rs438220946 | 325 | K>N | No | EVA | |
| rs475219468 | 330 | K>N | No | EVA | |
| rs441814755 | 366 | A>V | No | EVA | |
| rs440349726 | 407 | V>A | No | EVA | |
| rs440349726 | 407 | V>E | No | EVA | |
| rs440349726 | 407 | V>G | No | EVA | |
| rs474086394 | 408 | R>C | No | EVA | |
| rs462902996 | 411 | S>R | No | EVA | |
| rs442861792 | 411 | S>R | No | EVA | |
| rs483176483 | 413 | S>P | No | EVA | |
| rs438815048 | 416 | R>P | No | EVA | |
| rs797709824 | 420 | A>V | No | EVA | |
| rs458994471 | 422 | I>V | No | EVA | |
| rs479044687 | 433 | D>E | No | EVA | |
| rs447772166 | 436 | F>V | No | EVA | |
| rs481762625 | 438 | V>G | No | EVA | |
| rs448875671 | 440 | K>Q | No | EVA | |
| rs465109750 | 465 | D>E | No | EVA | |
| rs433655867 | 467 | Y>H | No | EVA | |
| rs447458263 | 470 | R>L | No | EVA | |
| rs467497881 | 471 | E>A | No | EVA | |
| rs456401051 | 477 | H>D | No | EVA | |
| rs476520621 | 478 | Q>H | No | EVA | |
| rs452377687 | 491 | V>I | No | EVA | |
| rs450926847 | 494 | M>L | No | EVA | |
| rs458081922 | 496 | F>L | No | EVA | |
| rs446928599 | 501 | Y>S | No | EVA | |
| rs435288098 | 518 | D>A | No | EVA |
No associated diseases with Q2KJ46
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| proteasome accessory complex | A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex. |
| proteasome regulatory particle, lid subcomplex | The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| enzyme regulator activity | Binds to and modulates the activity of an enzyme. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of protein catabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P40016 | RPN3 | 26S proteasome regulatory subunit RPN3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| O43242 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | Homo sapiens (Human) | PR |
| P14685 | Psmd3 | 26S proteasome non-ATPase regulatory subunit 3 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKQEGSARRR | GADKAKPPPG | GGEQEPPPPP | APQDVEMKEE | AAAGGGSTGE | TAGKTAAAAA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EHSQRELDTV | TLEDIKEHVK | QLEKAVSGKE | PRFVLRALRM | LPSTSRRLNH | YVLYKAVHGF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FTSNNATRDF | LLPFLEEPMD | TEADLQFRPR | TGKAASAPLL | PEVEAYLQLL | MVIFLMNSKR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YKEAQKISDD | LMQKISTQNR | RALDLVAAKC | YYYHARVYEF | LDKLDVVRSF | LHARLRTATL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RHDTDGQATL | LNLLLRNYLH | YSLYDQAEKL | VSKSVFPEQA | NNNEWARYLY | YTGRIKAIQL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EYSEARRTMT | NALRKAPQHT | AVGFKQTVHK | LLIVVELLLG | EIPDRLQFRQ | PSLKRSLMPY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FLLTQAVRTG | NLAKFNQVLD | QFGEKFQADG | TYTLIIRLRH | NVIKTGVRMI | SLSYSRISLA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DIAQKLQLDS | PEDAEFIVAK | AIRDGVIEAS | INHEKGYVQS | KEMIDIYSTR | EPQLAFHQRI |
| 490 | 500 | 510 | 520 | 530 | |
| SFCLDIHNMS | VKAMRFPPKS | YNKDLESAEE | RREREQQDLE | FAKEMAEDDD | DSFP |