AiPD: Autoinhibited Protein Database

Gene name	RPN3 (SUN2, YER021W)
Protein name	26S proteasome regulatory subunit RPN3
Names
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YER021W
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-57 (Predicted disordered autoinhibitory region) PR

1-57 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
3J47	EM	-	S	455-478	PDB
3JCK	EM	350 A	A	131-523	PDB
3JCO	EM	480 A	S	1-523	PDB
3JCP	EM	460 A	S	1-523	PDB
4CR2	EM	770 A	S	1-523	PDB
4CR3	EM	930 A	S	1-523	PDB
4CR4	EM	880 A	S	1-523	PDB
5A5B	EM	950 A	S	1-523	PDB
5MPB	EM	780 A	S	1-523	PDB
5MPC	EM	770 A	S	1-523	PDB
5MPD	EM	410 A	S	1-523	PDB
5MPE	EM	450 A	S	1-523	PDB
5WVI	EM	630 A	S	1-523	PDB
5WVK	EM	420 A	S	1-523	PDB
6FVT	EM	410 A	S	18-492	PDB
6FVU	EM	450 A	S	18-492	PDB
6FVV	EM	540 A	S	18-492	PDB
6FVW	EM	450 A	S	18-492	PDB
6FVX	EM	490 A	S	18-492	PDB
6FVY	EM	610 A	S	18-492	PDB
6J2C	EM	700 A	S	1-523	PDB
6J2N	EM	750 A	S	1-523	PDB
6J2Q	EM	380 A	S	1-523	PDB
6J2X	EM	380 A	S	1-523	PDB
6J30	EM	450 A	S	1-523	PDB
7QO3	EM	610 A	S	1-523	PDB
7QO5	EM	600 A	S	1-523	PDB
AF-P40016-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s05-197023	26	A>V	No	SGRP
s05-197101	52	Y>F	No	SGRP
s05-197360	138	M>I	No	SGRP
s05-198076	377	Y>C	No	SGRP
s05-198081	379	L>F	No	SGRP
s05-198250	435	K>M	No	SGRP
s05-198430	495	N>T	No	SGRP

Type	Name	Position	InterPro Accession
domain	Proteasome component (PCI) domain	270 - 468	IPR000717
domain	26S proteasome regulatory subunit, C-terminal	450 - 519	IPR013586

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
proteasome complex	A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome regulatory particle, lid subcomplex	The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.

Name	Definition
enzyme regulator activity	Binds to and modulates the activity of an enzyme.

Name	Definition
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
regulation of protein catabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2KJ46	PSMD3	26S proteasome non-ATPase regulatory subunit 3	Bos taurus (Bovine)	PR
O43242	PSMD3	26S proteasome non-ATPase regulatory subunit 3	Homo sapiens (Human)	PR
P14685	Psmd3	26S proteasome non-ATPase regulatory subunit 3	Mus musculus (Mouse)	PR