AiPD: Autoinhibited Protein Database

Gene name	Psmd3 (P91a, Tstap91a)
Protein name	26S proteasome non-ATPase regulatory subunit 3
Names	26S proteasome regulatory subunit RPN3, 26S proteasome regulatory subunit S3, Proteasome subunit p58, Transplantation antigen P91A, Tum-P91A antigen
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:22123
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-84 (Predicted disordered autoinhibitory region) PR

1-84 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P14685-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389195388	39	A>V	No	EVA
rs3389195457	75	V>M	No	EVA
rs3389197371	87	P>T	No	EVA
rs3389201618	100	T>M	No	EVA
rs3389213427	101	S>P	No	EVA
rs3389169561	102	R>H	No	EVA
rs3389173642	103	R>C	No	EVA
rs3389200048	103	R>H	No	EVA
rs3389206871	133	E>Q	No	EVA
rs3389133867	149	K>Q	No	EVA
rs3389186450	154	P>S	No	EVA
rs3389133871	179	E>D	No	EVA
rs3389202914	186	D>V	No	EVA
rs3402283519	188	M>L	No	EVA
rs3389213439	189	Q>H	No	EVA
rs3389161711	196	R>C	No	EVA
rs3389192729	204	A>V	No	EVA
rs3389201609	209	Y>C	No	EVA
rs3389133820	234	A>D	No	EVA
rs3389161670	291	I>F	No	EVA
rs27041233	332	E>V	No	EVA
rs3389201595	384	T>R	No	EVA
rs3389202910	401	T>A	No	EVA
rs3389213458	509	E>V	No	EVA
rs3389186525	516	E>K	No	EVA

Type	Name	Position	InterPro Accession
domain	Proteasome component (PCI) domain	282 - 479	IPR000717
domain	26S proteasome regulatory subunit, C-terminal	461 - 527	IPR013586

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
proteasome accessory complex	A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.
proteasome complex	A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome regulatory particle	A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex.
proteasome regulatory particle, lid subcomplex	The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.

Name	Definition
enzyme regulator activity	Binds to and modulates the activity of an enzyme.

Name	Definition
regulation of protein catabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P40016	RPN3	26S proteasome regulatory subunit RPN3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q2KJ46	PSMD3	26S proteasome non-ATPase regulatory subunit 3	Bos taurus (Bovine)	PR
O43242	PSMD3	26S proteasome non-ATPase regulatory subunit 3	Homo sapiens (Human)	PR